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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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39.

PHARMACEUTICAL VALIDATION & PROCESS CONCEPTUALISATION OF ANCIENT INDIAN CALCIUM PREPARATION: SHANKHA BHASMA

In the present study, the pharmaceutical and therapeutic dimensions of Shankha Bhasma (Classical Ayurvedic marine medicine) is explored as a substitute for calcium supplements available in the market. Shankha Bhasma was prepared & standardized by Ayurvedic pharmaceutical procedure accordingly in Rasa Tarangini (a classical 20th-century book on Ayurvedic pharmaceutical medicine). Conch shell (S...

V. Meena *, S. Bhushan and A. Chaudhary

Department of Rasa Shastra & Bhaishajya Kalpana, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(10).4724-30

4724-4730

3072

1176

9.

ANTIBIOTIC RESISTANCE ISSUES IN CLINICAL PATHOGENS: A REVIEW

Antibiotic resistance in pathogens is on the increase but in the past few decades this problem raised a deepening concern among scientific community in terms of the clinical management of infectious diseases. In this review, the common gram negative clinically significant pathogenic bacteria who have acquired resistance with passage of time like Shigella dysenteriae, Sh. Boydii, Sh. Flexneri, List...

Sikandar Khan Sherwani*1 Aisha Irshad , Muhammad Ajmal Shah , Munazza Ajaz and Haroon Ahmad

Lecturer at Department of Microbiology, Federal Urdu University of Arts, Science and Technology, Gulshan Iqbal, Karachi-75300, Pakistan.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(5).1725-29

1725-1729

3071

986

42.

ANTIBIOTIC SUSCEPTIBILITY PATTERN OF METHICILLIN RESISTANCE STAPHYLOCOCCUS AUREUS IN TERTIARY CARE CENTER AT SOUTHERN RAJASTHAN

The objective of this study was to determine antibiotic susceptibility pattern of methicillin resistance Staphylococcus aureus in tertiary care center at Southern Rajasthan. Modified Kirby Baurer disc diffusion method was used for antimicrobial sensitivity testing of all samples.  Maximum resistance among Staphylococcus aureus isolates (n=400) was observed against Methicillin (59%), Amikacin (53%...

Harcharan Singh*, Meena Atray, and Pankaj Kumar Modi

Department of Pharmacology, RNT Medical College, near Court circle, Udaipur- 313003, Rajasthan, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(2).607-11

607-611

3071

1083

30.

AUTHENTICATION OF MORPHOLOGICALLY SIMILAR RHIZOME DRUGS BASED ON TLC FINGERPRINT PROFILES AND VALERENIC ACID CONTENT

Objective: Present study involved comparison of thin layer chromatograms and quantification of valerenic acid (VA) in four morphologically similar rhizome drugs – Valeriana jatamansi, Nordostachys jatamansi, Selinum vaginatum and Ferula sumbul. Materials and methods: Ethanol extract of the four drugs were prepared under standard conditions and VA content was determined using TLC densitometry. Re...

Sonali Batra, Ashwani Kumar* and Anupam Sharma

University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India

DOI: 10.13040/IJPSR.0975-8232.7(8).3428-31

3428-31

3071

1297

7.

VIRTUAL SCREENING OF SAPONIN DERIVATIVES TARGETING ENZYMES ENDOTHELIAL NITRIC OXIDE SYNTHASE AND CYTOCHROME P450 2E1

Saponin derivatives from Vietnamese ginseng are proven for their efficacies in modulating oxidative stress, but there had been no reports about the interaction between them and two enzymes, endothelial nitric oxide synthase (eNOS) and cytochrome P450 2E1 (CYP2E1). eNOS and CYP2E1 are proposed to be attractive targets for the development of inhibitors against oxidative stress, a contributing factor...

T. T. T. Do, H. T. T. Nguyen, Q. H. T. Duong, S. H. Le and P. T. V. Nguyen *

Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, 41 Đinh Tien Hoang Street, Ben Nghe Ward, District 1, Ho Chi Minh City, Vietnam.

DOI: 10.13040/IJPSR.0975-8232.10(1).70-82

70-82

3071

1286

10.

BLOOD CHOLESTEROL LOWERING EFFECT OF ADENANTHERA PAVONINA SEED EXTRACT ON ATHEROGENIC DIET INDUCED HYPERLIPIDEMIA RATS

The effect of Adenanthera pavonina (AP) seed extract on the blood cholesterol level of atherogenic diet rats was evaluated. Twelve adult male Wistar rats divided into 3 groups of 4 animals each were used and were treated orally with normal saline (Control group), atherogenic diet (Positive control) and 200mg/kg of AP seed extract (treatment) over a 4-week period. The present study was undertaken t...

Vettae Gounder Maruthappan * and Kumaravelu Sakthi Shree

Unit of Endocrinology, Department of Zoology, Bharathiar University, Coimbatore, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(7).87-94

87-94

3070

1180

49.

HYPERDENSE INTRACRANIAL VESSELS IN NON-CONTRAST COMPUTED TOMOGRAPHY SCAN OF BRAIN-A CASE REPORT

A 20-year-old male patient reported to ophthalmology outpatient department with complaint of loss of vision in right eye since childhood and diminished vision in left eye for 1month of duration. Funduscopy revealed right side optic atrophy and left sided vitreous hemorrhage. Non-contrast computed tomography study of head showed hyperdense circle of Willis and cerebral venous sinuses. No contrast w...

Ranjan Kumar Sahoo*, P Bahinipati, Suresh Kumar Behera and Niranjan Sahu

Department of Radio-diagnosis, IMS & SUM Hospital, Bhubaneswar, Odisha, India

DOI: 10.13040/IJPSR.0975-8232.6(10).4503-05

4503-05

3069

1142

10.

ROLE OF N-ACETYLCYSTEINE IN RESCUE OF MICE HEART

An imbalance between oxidants and antioxidants generates the oxidative stress. Oxidative stress is the major cause of many diseases like cardiovascular, respiratory disease, renal diseases, neurological diseases, cancer, and aging. Cardiovascular complications are the leading cause of mortality in patients so the purpose of this review is to evaluate the effectiveness of N-acetylcysteine (NAC) in ...

Fatima Ali*, Nadia Wajid, Hina Yousaf and Maria Anwer

Institute of Biotechnology and Biochemistry, The University of Lahore, Lahore, Pakistan

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1178-82

1178-1182

3068

1140

7.

DEVELOPMENT AND VALIDATION OF A HPLC METHOD WITH UV DETECTOR FOR QUANTIFICATION OF GEMIFLOXACIN IN HUMAN PLASMA: APPLICATION TO BIOEQUIVALENCE STUDY

A simple, sensitive, high throughput and specific HPLC method with UV detection was developed and validated to according to the FDA guideline for quantification of gemifloxacin in human plasma. The bioanalytical method consists of liquid-liquid extraction and quantification by UV detection. The analyte was separated isocratically on a Cyano column (250 X 4.6 mm, 5µ particle size) with a mobile ph...

Ayan Das, Sanmoy Karmakar and Tapan Kumar Pal*

Bioequivalence Study Center, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.2(3).534-42

534-542

3068

1485

42.

ANTIOXIDANT POTENTIAL OF Mn2+ IN THE HUMAN EJACULATED SPERMATOZOA UNDER OXIDATIVE STRESS

Reactive oxygen species (ROS) formation from fertile volunteer donor measured by thiobarbuteric acid reactive substances (TBARS). Spermatozoal suspension was treated or not with nicotine and supplemented or not with Mn2+. The same protocol followed when we used ferrous ascorbate promoter system and calculates the Cmax and kc value of the reaction using Lineweaver-burk double reciprocal plot. For c...

Kuldeep Kaushik *, Pawan Kumar Mittal and Natwar Raj Kalla

Head & Assistant Professor Department of Zoology, Dev Samaj Post Graduate College for Women Ferozepur City, Punjab India.

DOI: 10.13040/IJPSR.0975-8232.6(5).2153-62

2153-62

3068

1415