Herbal drugs are emerging as a leading area for new drug discovery and development, and are being looked at seriously for health problem. Plants, especially used in Ayurvedic can provide biologically active molecules and lead structures for the development of modified derivatives with enhanced activity and or reduced toxicity. Exposure of toxicants manifests variety of pathological lesions in vari...
MICRO-ELECTROPHORETIC MOBILITY STUDY OF THE INFLUENCE OF CHLORPROMAZINE HYDROCHLORIDE ON DIMYRSTOYLPHOSPHATIDYLCHOLINE LIPOSOMES IN DIFFERENT MEDIA
In this study, the possible influence of the model, cationic drug chlorpromazine hydrochloride (CPZ-HCl) concentration on the micro-electrophoretic mobility of neutral large multi-lamellar dimyrstoylphosphatidylcholine (DMPC) liposomes was investigated in various media at both 25oC and 37oC. In addition the effect CPZ-HCl concentration on the micro-electrophoretic mobility of both positively charg...
BIOEFFICACY OF PREMNA CORYMBOSA ROTTL. (VERBANACEAE) WITH SPECIAL REFERENCE TO ITS ANTIOXIDANT ACTIVITY
In the present investigation, the bioefficacy of an indigenous plant was investigated with special reference to its antioxidant potential. Antioxidant effects of Methanolic, Chloroform and Ethyl acetate extracts of the leaves of Premna corymbosa Rottl. (family Verbanaceae) were tested on the basis of DPPH (1, 1-diphenyl-2-picryl-hydrazyl), phosphomolybdenium assay, super oxide radical scavenging a...
FORMULATION DEVELOPMENT AND EVALUATION OF FENOFIBRATE AND ROSUVASTATIN IN COMBINATION TABLETS AND RELEASE RATE IMPROVEMENT
The work was aimed to develop an immediate release tablet formulation of Fenofibrate and Rosuvastatin in combination for better treatment as well as management of hypercholesterolemia and prevention of cardiovascular diseases. The target was also set to improve the dissolution profile of poorly soluble Fenofibrate. For manufacturing these immediate release combined formulation tablets, Hot-Melt Te...
The safe use of medicines is a critical issue for all health care professionals, including physicians, pharmacists and nurses as well as public. Adverse drug reactions (ADRs) are unwanted effects that are the major cause of morbidity and mortality in whole world also has prolongation of hospital stay and increase visiting of emergency department. The present review dealt to assess the knowledge, a...
PRODUCTION OF EXTRACELLULAR CELLULASE USING BACILLUS SPECIES ISOLATED FROM RED SOIL AND OPTIMIZATION OF CELLULASE ACTIVITY
Enzymes plays a major role in industries like textile, leather, sugar, paper, rubber, tea etc., Microbes plays important role in enzyme production due to their fast growth rate, easy to manipulate for getting highly stable enzymes through genetic engineering and requires shorter time for production and purification steps. In our present study, we concentrated on the enzymes used in textile industr...
Background: Oxystelma esculentum is used traditionally as diuretic, laxative, hepatoprotective and anti-ulcer. Objectives: The present work deals with the isolation and structure elucidation of Epicatechin from O. esculentum. Methods: Methanolic extract of the entire plant of O. esculentum was subjected to pilot TLC experiments and column chromatography. Results: This yielded a pure, whit...
Seven parts of Pistacia atlantica were collected from Tlemcen in Algeria (fruits, leaves, buds, stems, roots internal and external trunk barks). Tannin content was determined and antioxidant activity of tannic extracts were measured using different assays: Total antioxidant capacity, 2,2-diphenyl-1-picrylhydrazyl (DPPH), reducing power (FRAP) and β-carotene bleaching assay The results showed that...
The research was carried out to formulate and evaluate ophthalmic solutions of Ofloxacin with amino acid transporters and compare the transcorneal permeation of Oflaxacin with that of the standard. In the study three different eye drop formulations were prepared by conjugation of the drug with different amino acids such as Alanine, Glycine and Leucine by solvent evaporation technique, the extent o...
EVALUATION OF NUTRITIONAL AND PHYSICO-CHEMICAL CHARACTERISTICS OF DIETARY FIBRE ENRICHED WITH CARROT POMACE PASTA
ABSTRACT: Fibre rich pasta were prepared by substituting refined wheat flour with carrot pomace powder (CPP) at 5%, 15%, and 25% and evaluated for its physical properties, chemical composition, textural properties and sensory characteristics. The fat content of the pasta showed no pronounced variation. The hardness of the pasta increased with increase in the level of incorporation of CPP in the fl...