The aim of current research work was to develop sustain release formulation of Theophylline. Modified plant derived Fenugreek gum (FG) polymer was synthesized and used as matrix forming agent. Matrix tablet formulations were prepare by wet granulation technique using modified fenugreek gum in different concentration. The prepared formulations were evaluated for physical properties such as tablet h...
INTERACTION OF TETRACYCLINE HYDROCHLORIDE WITH IRON: KINETIC SPECTROPHOTOMETRIC AND CONDUCTOMETRIC INVESTIGATIONS
The interaction of the antibiotic, tetracycline hydrochloride (TC.HCl) has been investigated employing three simple spectrophotometric and conductometric methods. In methods (A and B), a kinetic spectrophotometric procedure based on the oxidation of (TC.HCl) by Fe3+ ion in the presence of 1, 10 - Phenanthroline (o-phen) (A) and 2, 2′- Bipyridyl (bipy) (B) was developed. The formation of the ferr...
STUDY OF ANTIULCER ACTIVITY OF ANGIOTENSIN RECEPTOR ANTAGONISTS IN EXPERIMENTALLY INDUCED GASTRIC ULCERS IN RATS
Background: Peptic ulcer is one of the common diseases affecting the mankind. Many studies reveal co-occurrence of both peptic ulcer and hypertension in humans. So, it might be beneficial to choose an optimal drug that will target both these conditions. The role of renin-angiotensin system in the pathogenesis of peptic ulcer is well known. AT receptor antagonists which prevent binding of AT-II to ...
Present investigation provides evidence for complex formation of Ibuprofen (Ib) with Go-Ghrita (GG). Ibuprofen binary mixture in (1:0.5), (1:1), (1:2), (1:3) w/w proportions were prepared by adding to molten Go-Ghrita kept over a water bath at 65-70oC with continuous stirring. Organoleptic and Physico-chemical properties of GG (procured from Magan Sangrahalaya, Wardha) were as per the specificat...
DESGINING, METHOD DEVELOPMENT AND STANDARDIZATION OF PROCESS FOR EXTRACTION OF MARKER COMPOUND FROM TERMINALIA CHEBULA FRUIT
The present study is done to study and optimize the process of enzyme-assisted extraction of Chebulinic acid from the dried fruit of Terminalia chebula. A selective extraction process after the treatment with enzymes is proposed by using 30% (v/v) methanol which releases increased yield of the Chebulinic acid, present in the dried fruit compare to aqueous extract. The optimal conditions were as fo...
The present research work was conducted to formulate and evaluate Anthralin microemulsion gel using Karanj oil with an objective of improving solubility of the Anthralin. The pseudo ternary phase diagrams were developed for combinations of Karanj oil as the oil phase, Span-20 as surfactant and as Capryol 90 as cosurfactant using water titration method. Microemulsions obtained were analyzed for top...
The present study report deals with the medicinal plants used by the irular tribal people of Coimbatore against pyogenic infections. Five different plants like Abutilon indicum, Datura metel, Lantana Camaro, Tridax procumbens and Leucas aspera were collected and their antimicrobial activity were tested against bacteria such as Staphylococcus aureus, Streptococcus pyogenes, Bacillus anthracis, Ps...
Genistein is a soy phytoestrogen that mediates its functions by interacting with the endogenous estrogen receptor β. To investigate the effect of 10mg/kg body weight/ day genistein administration up to 90 days on the ovarian folliculogenesis and its correlation with serum gonadotropins and estrogen, adult Mus musculus were either administered with 1:4 DMSO : PBS (vehicle) or with 10mg genistein/k...
The present study aims to explore the ethnomedicinal knowledge of the plants and their preparations used to cure diabetes by the tribes of Mananthavady, Bathery and Vythiri taluks of Wayanad district, Kerala. Preparation of ethnomedicine using various plant parts and other information related to tribes associated; habitat, habit and status of medicinal plants recorded are highlighted. Documentatio...
IMMOBILIZED BACTERIOPHAGE USED FOR SPECIFIC DETECTION OF E.COLI USING ELECTROCHEMICAL IMPEDANCE SENSING
In the present study, bacteriophage based electrochemical analysis is applied to detect pathogenic E.coli bacteria. Phages are parasites that only infect one specific bacteria, can be useful to identify bacterial contaminants in food, water, etc. Phage has been isolated from various water sources such as waste, stagnant and sewage water by overlay method against host bacteria. Titer of phages was ...