PREVALENCE OF DIETARY SUPPLEMENTS AND AYURVEDIC MEDICINES’ INTAKE BY PATIENTS TAKING PRESCRIBED ALLOPATHIC MEDICINES AT LUCKNOW
Aim: Present study was done to know the prevalence of the use of dietary supplements and ayurvedic drugs by patients taking allopathic drugs. Introduction: Allopathic drugs are likely to act with ayurvedic drugs and dietary supplements and concurrently used. This concept is usually not recognized by the patients and physicians. Sometimes this may prove dangerous. Present study was done to find ...
The present study on Embilica officinalis, a common household remedy and the present study describes the inhibition of enzyme xanthine oxidase (XO) with in vitro analyses and assenting in silico study to produce an effective phytoconstituents. The results explained the ethanolic extract of Embilica officinalis (EOEt) exhibited antioxidant and defensive oxidative stress and allied with its total ph...
The Present Study was planned to assess the acute toxicity of Solanum lycopersicum Leaf. The study was designed according to the OECD guidelines as per that the dose level used as 5, 50, 300, 2000, 4000 mg/kg. Mice were orally administrated single dose of 200 and 400 mg/kg of ethanolic extract of Solanum lycopersicum. Physical, Biochemical, Hematological as well as histopathological parameters wer...
Antimicrobial peptides (AMPs) are the crucial factors, which plays an important role in host defense mechanisms. AMPs are ubiquitous and found in diverse organisms ranging from microorganisms to animals. Plants are the precious source of natural antimicrobial molecules including antimicrobial peptides known as plant antimicrobial peptides (PAMPs). PAMPs can be divided into different families based...
A sensitive, precise and accurate reverse phase high performance liquid chromatographic method (RP-HPLC) using an isocratic elution of 0.1 M NaH2PO4 (pH 3.0) and acetonitrile (80:20 v/v) with a flow rate of 1.0 mL/min, a column temperature of 30 °C and UV detection at 254 nm was developed for the estimation of metformin and benfotiamine simultaneously. The method was validated following guideline...
STUDIES ON ANTI-INFLAMMATORY EFFECT OF MESUA FERREA LINN. IN ACUTE AND CHRONIC INFLAMMATION OF EXPERIMENTAL ANIMALS
Mesua ferrea Linn. (M. ferrea) is an endemic medicinal plant used for the treatment of inflammation, rheumatism, bronchitis, fever, headache, asthma and skin diseases. The aim of this study was to investigate the anti-inﬂammatory activities of 80% ethanol extract from stem bark of Mesua ferrea Linn. using animal models. Female Wistar albino rats weighing (150-200g) were used for the study. Anti-...
EFFECTS OF BETA-ADRENOCEPTOR BLOCKERS ON THE PLATELET AND CARDIOMETABOLIC INDICES IN UNCONTROLLED HYPERTENSION
Background: Metabolic derangement in term of glucose dysregulation, dyslipidemia, and electrolyte disturbances are the adverse reactions of beta-adrenoceptor blockers that limit their use. Aims: To investigate the effect of BARBs on the cardio-metabolic risk factors and platelet indices that play a role in accelerating the atherogenicity. Materials and methods: This observational clinical study wa...
Paliperidone is a new active substance, belonging to the class of atypical antipsychotic, and is the active metabolite of a well-known active substance, risperidone that has been used for the last 3 years. A randomized, double-blind, multicentric, study to evaluate the safety and efficacy of Paliperidone ER compared to Olanzapine in patients with Schizophrenia was conducted in Indian schizophrenic...
Centella asiatica (CA) is a reputed medicinal plant that has been shown to have pharmacological effect on skin wound healing. The aim of the study was done to assess the effects of aqueous extract of CA on human dermal fibroblasts in an in vitro model of wound healing. Dermal fibroblasts were cultured with or without supplementation of aqueous extract of CA. Viability and proliferation of the fibr...
Pharmacogenomics is the branch of pharmacology and genomics that deals with the influence of genetic variation on drug response in patients by correlating molecular expressions and single-nucleotide polymorphisms with a drug's efficacy or toxicity. Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with mi...