DEVELOPMENT AND VALIDATION OF FIRST ORDER DERIVATIVE SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF PREGABALIN, METHYCOBAMIN, AND ALPHA LIPOIC ACID IN MULTICOMPONENT DOSAGE FORM
Objective: To develop and validate a novel and easy first order derivative spectroscopic method for the simultaneous determination of multicomponent dosage form which contains Methylcobalmine, Alpha lipoic acid and Pregabaline. Method: Measurement was achieved by selecting different Zero crossing points i.e ZCP for Methylcobalamine and Alpha lipoic acid at 436.24 nm, ZCP for Alpha lipoic acid and ...
Effervescent tablets or granules are uncoated and generally contain acidic substances and carbonate or bicarbonate which reacts rapidly to release carbon dioxide when dissolved in water. There are various advantages of effervescent formulations such as fast onset of action, good stomach tolerance, improves palatability, enhanced permeability, but a major problem which is associated with these form...
EFFECT OF ORAL ADMINISTRATION OF VITAMIN A ON BLOOD GLUCOSE LEVEL IN RABBITS AND ITS POSSIBLE INTERACTIONS WITH COMMONLY USED ORAL ANTIDIABETIC AGENTS
In diabetes mellitus antioxidant vitamins are commonly employed to prevent or mitigate the long term complications of the disorder. Diabetic retinopathy, nephropathy, coronary and cerebral vascular insufficiency are examples of such complications. They are more common in Type 2 diabetes mellitus. The present study was conducted to observe the effect of Vit A on blood glucose level and its possible...
DESIRE FOR FERTILITY AND ASSOCIATED FACTORS AMONG PEOPLE LIVING WITH HIV/AIDS (PLWHA) IN SELECTED ANTIRETROVIRAL THERAPY (ART) CLINICS OF HORRO GUDURU WOLLEGA ZONE, NORTH WEST OROMIA, ETHIOPIA- A CROSS SECTIONAL STUDY
Background: Most recently fertility issues in HIV positive men and women are becoming increasingly important. Because of ART access and its good life effect, it is expected that the need and desire to get married, to have children and to have sexual partners for PLWHA would change with the regard to reproductive health. In Ethiopia HIV positive individuals may or may not have desire to have childr...
Protein kinases are key players in cellular signal transduction and perturbations in its activity leads to cancer. Targeting these seems to be sufficient to provoke apoptotic response, thus limiting the process of tumorogenesis. Among kinase inhibitors, imatinib has demonstrated magnificent clinical efficacy. But patients with advanced disease harbor faces resistance. Currently there is requisite ...
TOXICOLOGICAL EVALUATION OF FIVE SRI LANKAN MEDICINAL PLANTS: A BIOCHEMICAL, HAEMATOLOGICAL AND HISTOPATHOLOGICAL ASSESSMENT
Asteracantha longifolia, Asparagus falcatus, Vetiveria zizanioides, Coriandrum sativum and Epaltes divaricate have proven hepatoprotective and antioxidative effects against carbon tetrachloride and paracetamol induced hepatotoxicity in mice and are widely used in Sri Lanka for the treatment of liver disorders. However, toxicological information regarding their safety after exposure to experimental...
EFFECT OF ETHANOLIC EXTRACT OF LEAVES OF PASSIFLORA INSARNATA LINN. IN STREPTOZOTOCIN-INDUCED DIABETES IN RATS
The worldwide prevalence of diabetes mellitus (DM) has risen dramatically over the past two decades; based on current trends, more than 360 million individuals will be having diabetes by year 2030. The present study was designed to investigate the hypoglycemic of effect of ethanolic extract of leaves of Passiflora insarnata linn. in streptozotocin-induced diabetes in rat. The pharmacological inves...
Benign Prostatic Hyperplasia (BPH) is a common progressive disease among men, with an incidence that is high among elderly. Velvanga parpam (VP) has been employed as traditional remedy for Benign Prostatic Hyperplasia (BPH) which is a herbo mineral formulation. As a mandate, steps were taken to evaluate safety profile of VP in rats and mice following OECD guidelines. Acute toxicity studies, diff...
The glutathione S-transferase (GST) isoenzyme superfamilies detoxify a wide-range of toxic chemicals and environmental substances are extensively expressed in mammalian tissues. Liver and pancreas are the sites where cytosolic Phase I and phase II biotransformation GSTs enzymes have characteristic expression. GSTs play a key role in the deactivation of reactive oxygen species (ROS) and the metabol...
The aim of this research was to formulate a matrix-type transdermal therapeutic system containing drug ciprofloxacin with different ratios of hydrophobic (ethyl cellulose) polymer by solvent evaporation technique, using 15% w/w of dibutyl phthalate to the polymer weight, incorporated as plasticizer. Different concentrations of isopropyl myristate were used to enhance the transdermal permeation of ...