Organisms containing integrated sequences of cloned DNA (transgenes), transferred using techniques of genetic engineering (to include those of gene transfer and gene substitution) are called transgenic animals. The development of transgenic animals has been part of biotechnology research which has been expanding rapidly. Transgenic animals produced with the purpose of producing better and good qua...
Dengue fever is an important public health problem in tropical and sub-tropical Continent. Recently the number of severe forms of the disease, dengue hemorrhagic fever, and dengue shock syndrome are increased. Dengue virus, a arbo-virus responsible for dengue fever and spread through its vector, Aedes aegypti. Controlling the mosquito is the good strategy to prevent this disease. The traditional c...
EFFECT OF POLYMER RATIO AND EXCIPIENTS ON METOPROLOL TARTRATE RELEASE FROM CHITOSAN – SODIUM ALGINATE POLYMERIC IMPLANTS
Natural biodegradable chitosan-sodium alginate polymer combination is a promising candidate for preparing drug-loaded implants because of the availability and inexpensiveness of the polymers over the semi synthetic biodegradable ones. The main objective of this research was to prepare and evaluate a biodegradable implantable system of the drug metoprolol tartrate because it plays an important role...
Objective of the present study is to investigate the chemical composition of methanol extract of stem bark of Ficus benghalensis Linn. (Indian Banyan Tree). Shade and air dried stem bark were powdered and extract was prepared according to selective sequential extraction using different solvents of increasing polarity. Methanol extract of stem bark of this plant was further subjected to gas chromat...
EVALUATION OF DATE PALM POLYSACCHARIDE (DPP) AS A BIOMUCOADHESENT AND ITS COMPARISON WITH VARIOUS MUCOADHESIVE POLYMERS
The mucoadhesive disks of various polymers were fabricated with objective of comparing the mucoadhesive strength and mucoretentability with the isolated DPP. The mucoadhesive polymers used in formulations were sodium carboxy methyl cellulose, carbopol (cp934), hydroxyl propyl methyl cellulose (HPMC K4M), and date palm fruit pulp polysaccharide (DPP). These formulations were characterized for physi...
FORMULATION AND EVALUATION OF IN-SITU NASAL GEL OF MONTELUKAST SODIUM FOR THE EFFECTIVE TREATMENT OF ASTHMA
In this research work an attempt was made to formulate and evaluate in-situ gel for the intranasal delivery of montelukast sodium for the effective treatment of asthma. Thermally gelling in-situ gel formulations for nasal administration were prepared by using polymers such as poloxamer 407 and HPMC K4M in varying concentrations by using cold method. The formulated in-situ gels were evaluated for c...
A PRELIMINARY STUDY ON TOTAL PHENOLIC CONTENT AND ANTIOXIDANT ACTIVITIES OF CALYCOPTERIS FLORIBUNDA ROOT EXTRACTS
We evaluated the total phenolic acid content and antioxidant activity of methanolic and aqueous extracts of Calycopteris floribunda roots. Antioxidant activity of the extracts was determined using Reducing Power Assay and Total Antioxidant Capacity (TAC) assays. Preliminary phytochemical analysis of the extracts revealed the presence of various phytochemicals. The total phenolic content of the ext...
The antibacterial and antifungal activity of methanolic extract of Asteracantha longifolia Nees has been evaluated against 4 Gram positive bacteria, 7 Gram negative bacteria and 7 fungi. Ciprofloxacin and fluconazole used as standards for bacteria and fungi, respectively. The extract showed varying degrees of antimicrobial activity with zone of inhibition ranging from 15.0 to 26.0 mm. A. longifoli...
FORMULATION, CHARACTERISATION AND IN-VITRO EVALUATION OF NOVEL IONICALLY CROSS LINKED CASEIN NANOPARTICLES FOR MEMANTINE HYDRO-CHLORIDE DELIVERY
The objective of the study was to fabricate protein nanoparticles for better controlled and targeting action of drug, which can also overcome the problems like multidose therapy, poor patient compliance and high cost associated with conventional formulations. Memantine HCl loaded casein nanoparticles (F1 to F6) were prepared by ionically cross-linked method. The formulated nanoparticles were evalu...
Context: Acne vulgaris, a very common malady of adolescents, is well known and easily recognized. Acne is a “polymorphic” disorder which exhibits series of widespread and diverse lesions. Four key factors have been identified in the etiology of acne: increased sebum production, follicular hyperkeratinization, colonization of the pilosebaceous unit with Propioni bacterium acnes and the producti...