A new specific, selective and inexpensive spectrofluorophotometric method has been developed for determination of Nelfinavir mesylate in bulk drug and its dosage form. Fluorescence spectrum of Nelfinavir mesylate in methanol showed excitation wavelength at 253 nm and emission wavelength at 508 nm. The calibration curve for Nelfinavir mesylate was found to be linear over the concentration range of ...
THE EFFECTIVE ROLE OF URSOLIC ACID AND OCIMUM SANCTUM (LINN.) LEAF EXTRACT ON SOME MARKER CARBOHYDRATE METABOLITES IN MALE ALBINO RATS
Ursolic acid is a pentacyclic triterpinoid compound, the major constituents of the Tulsi leaves, has been suggested to possess anti-fertility effect in rats of both sexes. This study has attempted to investigate the anti-fertility potentials of Ocimum sanctum leaf extract and ursolic acid in male albino rats. Three groups of male albino rats were taken, first group as control, second group were ad...
CHARACTERISTICS OF DIGESTION IN HIGH-PRODUCING COWS: DEPENDENCE ON THE FAT CONСENTRATION IN THE RATION DRY MATTER
Lipid metabolism in animals has recently gained growing interest among researchers. Among organic compounds, it is only protein and nucleic acids that for a long time have remained in primary focus of research, though lipids are now known to be essential for the origin of life and development of organic forms. Metabolic processes are very active in the bodies of high-producing cows. Large amounts ...
DETECTION OF ANTI-QUORUM SENSING ACTIVITY OF ROSEMARINUS OFFICINALIS AND VALERIANA OFFICINALIS USING MICROBIAL BIOSENSOR STRAIN
Quorum-sensing is a phenomenon in which bacteria exhibit several density dependent phenotypes. Quorum-sensing is achieved through production of auto - inducer which on acquiring a threshold concentration, activates the genes, bringing into effect the concerned phenotypes. Ayurvedic medicinal plant extracts are being used to treat a plethora of infectious disease and are known to be rich in phytoch...
Cardiotoxicity associated with the clinically used drugs is a global concern of safety for healthcare professionals. Various animal models have been used to study the drug-induced cardiotoxicity but the exact molecular involvement of toxicity is not much clear. Despite the recurrent occurrence of toxicities, drugs such as doxorubicin, calcium channel blockers, antiarrhythmics and immunomodulators ...
Vitamin B12 plays an important role in building of genetic material, in development of normal red blood cells and in maintenance of nervous system. Major deficiency symptoms of Vitamin B12 include anemia and neurological disorders. The daily recommended intake of vitamin B12 for an adult is 1.5μg a day. Eating a diet containing required amount of vitamin B12 is the best way to treat the condition...
A study was conducted to investigate the effect of different pH, on the growth and biopigment accumulation of a green alga Dunaliella salina isolates from Sambhar salt lake, Rajasthan (India). In order to monitor the impact of pH an algal samples of D. salina was exposed to different pH regimes (6 -10 pH) along with control (8.5 pH) over a period of 30 days. Set of experiments was conducted to stu...
BINUCLEAR Fe(III), Co(II), Ni(II), Cu(II) AND ZN(II) COMPLEXES WITH SCHIFF BASE 4, 4-(1, 4-PHENYLENE BIS(AZAN-1-YL-1- YLIDENE)) BIS(METHAN-1-YL-1-1-YLIDENE)-1, 2-DIOL. SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION
Condensation reaction of 1, 4-phenylene diamine and Protochatechu aldehyde in 1:2 molar ratio resulted in the formation of new Schiff base ligand 4, 4-(1,4-phenylene bis(azan-1-yl-1-ylidene))bis(methan-1-yl-1-1-ylidene)-1, 2-diol; (H4L) .From the direct reaction of the ligand (1) with Co(II), Ni(II) and Cu(II) chlorides and Fe(III) and Zn(II)nitrates in 2M:1L molar ratio, the five new neutral comp...
Elaeocarpus ganitrus Roxb. is reported to exhibit multifarious pharmacological activities. However no scientific study has been conducted to evaluate antiatherosclerotic /lipid lowering activity of E. ganitrus Roxb. The present study was designed to investigate the antihyperlipidaemic and antioxidant activity of 70% ethanolic extract of E. ganitrus seed (EGEE) in cholesterol fed hyperlipidaemic ra...
INVESTIGATING THE LINK BETWEEN TRANSFORMATIONAL LEADERSHIP, PSYCHOLOGICAL EMPOWERMENT, AFFECTIVE COMMITMENT AND ORGANIZATIONAL CITIZENSHIP BEHAVIOR IN THE PHARMACEUTICAL SECTOR OF INDONESIA
Modern organizations face increasing competition due to globalization, technological change, politics and economics. In order to cope with these, public organizations, including organizations at the central and local government levels, must improve their efficiency and performance to reflect the presence of organization in other countries. Leaders, therefore, must act more quickly in encouraging a...