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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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39.

DEVELOPMENT AND VALIDATION OF A LIQUID CHROMATOGRAPHIC METHOD FOR ESTIMATION OF GLIMEPIRIDE IN TABLET DOSAGE FORM

An accurate, sensitive and precise RP-HPLC method has been developed and validated for the estimation of Glimepiride (GLM) from bulk drug and Pharmaceutical Dosage form. The separation was achieved by Hypersil C18 column (250mm X 4.6mm, 5μm) in isocratic mode, with mobile phase comprises of Acetonitrile : Buffer in proportion of 60:40v/v, buffer was 0.02M Potassium Di-hydrogen Phosphate (pH 4.5 a...

Vaishali V. Karkhanis* and Anandkumari D. Captain

A.R. College of Pharmacy , Vallabh Vidhyanagar - 388120, Dist: Anand, Gujarat, India

DOI: 10.13040/IJPSR.0975-8232.4(7).2742-45

2742-2745

2666

979

18.

ANTIOXIDANT EFFECT OF THE STEM AND LEAVES OF HIBISCUS ESCULENTUS LINN.

The ethanol extract of Hibiscus esculentus Linn roots inhibited the formation of oxygen derived free radicals were screened for their in vitro antioxidant activity. Stems leaves and root of selected plants were dried at 45°C and powdered for extraction. Extraction was performed with methanol. By employing DPPH (2, 2-diphenyl-1picrylhydrazyl radical) scavenging assays, it was shown that all the et...

Dinanath D. Patil*, Dnyandeo K. Mhaske and Gurumeet C. Wadhawa

Department of Chemistry and Research Centre, R.B.N.B. College, Shrirampur, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.2(6).1464-66

1464-1466

2666

968

62.

CLINICAL EVALUATION OF T-AYU-HMTM IN THE MANAGEMENT OF SICKLE CELL ANEMIA

Sickle cell anemia is a hemoglobin disorder, which is an autosomal recessive type affects millions of children of underprivileged and tribal area every year. Because of its devastating complications sickle cell is considered a major health problem in India and the entire world. Since many years, majority of the tribal population in the South Gujarat region are suffering from this lifelong disorder...

A. M. Desai *, M. N. Saraf, C. Desai, H. Desai and M. Dalal

Dhanvantari Clinic, Ayurveda Health Care and Research Center, Vyara, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3573-78

3573-3578

2666

851

45.

DESIGN, FORMATION AND EVALUATION OF A CO-DRIED DIRECTLY COMPRESSIBLE EXCIPIENT “TSAG-15” AND ITS UTILIZATION IN THE FORMULATION OF A RAPID RELEASE-MOUTH DISINTEGRATING ASCORBIC ACID TABLETS

A research was conducted to design a directly compressible filler binder characterized with rapid release and mouth disintegrating. Acacia gum was obtained from local source and was purified using a standard method. Tapioca starch was also extracted from cassava tuber using a standard method. Both primary excipients were evaluated for power properties and coprocessed at varying concentration using...

A.O. Shittu*, C. C. Yakubu, A.B. Isah and A.R.Oyi

Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, University of Jos, Nigeria

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(6).2427-34

2427-2434

2665

1084

51.

PREVALENCE AND RISK FACTORS OF METABOLIC SYNDROME IN ADULT TUNISIAN PATIENTS

Background: Metabolic syndrome (MetS) is a cluster of diseases, including hypertension, obesity, dyslipidemia, and hyperglycemia. We therefore aimed to estimate MetS prevalence and to determine risk factors for MetS. Methods: In the present study, we recruited 209 adult Tunisian MetS patients (57 males and 152 females, mean age 58.9±10.7 years) matched by gender and ethnic origin to 193 healthy i...

J. Abir *, S. Sondes, E. Rania, K. Latifa, B. D. Mokhles, B. Nedia, B. Hadj Md Manel, K. Souhir, G. Hejer, F. Salima and M. Abdelhedi

Biochemistry Laboratory CHU Farhat HACHED, Sousse, Tunisia

DOI: 10.13040/IJPSR.0975-8232.8(3).1368-74

1368-1374

2665

870

7.

POSSIBLE LINKS BETWEEN OBESITY AND TYPE 2 DIABETES MELLITUS

In this article, an attempt has been made to explore a positive correlation between obesity and type 2 diabetes mellitus. The possible role of several important agents in causing both has been discussed in detail. From the discussion, it seems that obesity is definitely and intimately linked to type 2 diabetes....

C.K. Chakraborti

K. M. Institute of Pharmaceutical Sciences, Rourkela- 769 015, Orissa, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(7).1935-45

1935-1945

2664

1277

9.

SYNTHESIS AND EVALUATION OF SOME ALDEHYDE DERIVATIVES OF 1, 4 DI-HYDRO PYRIDINE AND THEIR BIOLOGICAL EVALUVATION

Synthesis of some aldehyde derivatives of 1, 4 di- hydro pyridine has been done. The entire synthesized compounds were characterized by UV, IR and 1HNMR spectroscopy. The anticonvulsant and antimicrobial activity were also evaluated. The present investigation deals with the synthesized compounds possessing good anticonvulsant, analgesic and antimicrobial activity. Synthesized compounds like PNH, P...

S Venkataraman*, Anitha, R Meera, P Muthumani, R Xavier Arullapa, P Devi and N Chidambaranathan

Department of Pharmaceutical Chemistry, K M College of Pharmacy, Uthangudi, Madurai, TamilNadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(9).63-77

63-77

2663

1166

38.

A STUDY ON HEPATOPROTECTIVE ACTIVITY OF ETHANOL EXTRACT OF ZANTHOXYLUM ARMATUM DC (MUKTHRUBI) LEAVES IN EXPERIMENTAL ANIMAL

Zanthoxylum armatum is administered as a hepatoprotective agent during indigestion and hepatic related diseases by traditional healers. So, the aim of this study was to investigate the hepatoprotective activity of ethanol extract of Z. armatum (ZAE) in Paracetamol induced hepatotoxicity in albino rats in comparison with the activities of the known and potent hepatoprotective standard drug Silymari...

J. Oinam, I. Raleng, P. Meitankeishangbam, B. R. Kumari, S. Laishram*

Department of Pharmacology, Jawaharlal Nehru Institute of Medical Sciences, Imphal, Manipur, India.

DOI: 10.13040/IJPSR.0975-8232.8(7).3025-29

3025-3029

2663

1011

48.

COMPARATIVE STUDIES ON BIOCHEMICAL, HISTOPATHOLOGICAL AND FTIR-ATR SPECTRAL STUDIES OF HYPERLIPIDEMIA INDUCED BY CHOLESTEROL-RICH DIET IN RATS

Objective: To compare the routine biochemical and histological techniques with FTIR-ATR spectroscopic methods in diagnosing hyperlipidemia. Materials: Compositional changes in the serum and tissues reflects the healthy and pathological status of animals. FTIR-ATR was attempted as an additional tool for evaluating the composition in the serum as well as in tissues materials. To achieve this Wistar ...

S. Khatheeja *, A. Safiullah, M. Alsawalha, A. R. Prabhakaran, V. P. Veeraraghavan and S. K. Mohan

Department of Physics, Justice Basheer Ahmed Sayeed College for Women, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).836-45

836-845

2663

991

50.

BENEFICIAL EXPLORATION OF NATURAL PESTICIDES FROM HIGHER PLANT

The methanolic extract (MeOH) of the bark of Holoptelea integrifolia (Roxb.) Planch and its partitions namely n-hexane (Hx), ethyl acetate (EtOAC), butanol (BuOH) and water (H2O) was screened for various in vitro biological activities including general cytotoxicity (brine shrimp lethality assay), phytotoxicity (lemna minor bioassay), nematicidal and insecticidal (Tribolium castaneum H., Rhyzoperth...

Maryam Ahmed*, Ghazala H. Rizwani , Shahina Fayyaz, Firoza Qazi and Shaukat Mahmud

Department of Pharmacognosy, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).1221-26

1221-1226

2662

1131