Man has been dependent on plants for the treatment and cure of different diseases since time immemorial. Plants have served not only as a source of food and shelter but also as a very important source of different “portions” used for the treatment and cure of diseases. These portions are herbal or plant based mixtures made by traditional healers; who are individuals having a knowledge of medic...
Aim: To compare the immunomodulatory effect of Ocimum sanctum and Ocimum basilicum in mice. Methods: Acute oral toxicity test was performed as per OECD -23 guidelines. Maximum dose level of 2000 mg/kg was selected for toxicological evaluation. Delayed type hypersensitivity reaction were carried out for assessment of cell mediated immune functions Result: Administration of Ocimum sanctum and ...
Zika virus infection is caused by the bite of an infected Aedes mosquito, usually causing rash, mild fever, conjunctivitis, and muscle pain. First time the virus was isolated in 1947 in the Zika forest in Uganda. It is transmitted to people through the bite of an infected Aedes mosquito. Symptoms are similar to those of dengue and chikungunya, which are transmitted by the same type of mosquito. Au...
ADHATODA VASICA: EFFECT OF ADMINISTERING ETHANOLIC EXTRACT OF ADHATODA VASICA ON BLOOD COUNT AND SOD ENZYME ACTIVITY AGAINST EXPOSURE TO γ – RADIATIONS
In the present studies, antibacterial studies and medicinal effects of the ethanolic extract of Adhatoda vasica on the physiological variations including blood countvariations w.r.t. RBC, WBC, Hb and enzyme SOD activity of the subjects under study, Swiss Albino mice, on exposure to gamma radiations, have been evaluated. Phyto-chemical analysis of A. vasica showed the presence of alkaloids, sapon...
IDENTIFICATION, METHOD DEVELOPMENT AND METHOD VALIDATION FOR THE PROCESS AND DEGRADATION IMPURITIES OF VARDENAFIL HCl BY RP-UPLC AND UPLC-TOF
This present work is on method development of assay and related substances of Vardenafil HCl and degradation of drug substance under acid, base hydrolysis and oxidation conditions. Identification of the impurities were done by the UPLC-TOF. Waters LCT Premier time of flight HRMS instrument with 5 ppm accuracy employed for degradation impurity identification. The validation of the method for its im...
THE NON-ENZYMATIC ANTIOXIDANT ACTIVITIES OF FICUS CARICA L. SUBSP. CARICA LEAVES AND ITS ANTIMICROBIAL ACTIVITIES AGAINST FOOD PATHOGENS
The aim of this work was to investigate of the antimicrobial and antioxidant potentials of methanol extracts from Ficus carica. Methanol extracts were screened for antimicrobial activity against different species of Gram positive andGram negative bacteria and one yeast. The methanol extract of Ficus carica showed maximum inhibition zone of 10 mm against Listeria monocytogenes. In addition to, the ...
Depression is a well-defined mood disorder which is characterized by state of disposition of mind and dislike or antipathy to activity that can affect an individual’s thoughts, demeanor, sense of emotional touch and physical well- being. Depressed people may feel mournful, troubled, uneasy in mind, meaningless, helpless and unworthy, experiencing as if having committed an offence. They are easil...
Resolvins and lipoxins endue a novel way of approaching aspirin mechanism of action by developing models. Recent advances in research of aspirin from starting point Willow bark (Salix alba) to resolvins and lipoxins along with their repurposing network. Therefore, aspirin have a big impact on most interesting areas of research. Aspirin and there interaction with several targets molecules (Magic sh...
Suddhi is a unique process of detoxification which is employed topotentiate as well as enhance therapeutic properties the effect of raw drugs. Nabhi (Aconitum ferox), a herbal poisonous rhizome commonly known as aconitum is used extensively in various Siddha formulations, with great therapeutic significance. Siddha system recommends the administration of Nabhi only after suddhi (purification) in...
β-CYFLUTHRIN-INDUCED IMPAIRMENT IN NEUROTRANSMITTERS, TESTICULAR FUNCTION AND GENE EXPERISSIONS OF MALE RATS: THE PROTECTIVE ROLE OF OMEGA-3
The present study was designed to evaluate the protective effect of omega-3 against β-cyfluthrin (β-cyf)-induced neurotransmitters’ impairment, oxidative damage, testicular toxicity and genotoxicity. Adult male Wistar rats were divided equally into four groups: Group (I): Control, Group (II): β-cyf (5 mg/kg body weight/day), Group (III): omega-3 (400 mg/kg body weight/da y) + β-cyf (5 mg/kg ...