Arsenic (As) is a metalloid. It occurs in almost every fraction of the environment. It is moving in each and every corner of our environment. Levels of arsenic (As) in the environment have become a global concern due to its toxicity and adverse effects on human health and other living beings. It is highly toxic even at low concentrations. It is also carcinogenic. Although, its natural sources are...
Functionality of Ion Exchange Resin (IER) mainly depends on solubility and degree of ionization and molecular weight of drug. For this reason the application of IER is limited to only strong acidic and basic drugs or drug existing as salt; not for weak acidic and weak basic drugs due to their low ionization properties. If we increase the ionization of weak acid and bases, then application of IER w...
The epidermal growth factor receptor (EGFR) pathway has emerged as a key target in non-small-cell lung cancer. EGFR inhibition in non-small-cell lung cancer is achieved via small molecular tyrosine kinase inhibitors, such as erlotinib or Iressa (gefitinib), or monoclonal antibodies such as cetuximab. The EGFR is under investigation as a therapeutic target for cancers. Lung cancer cell lines are va...
EVALUATION OF THE POSSIBLE ANTIOXIDANT EFFECTS OF PEGANUM HARMALA AND GINKGO BILOBA IN AMELIORATING ALZHEIMER’S DISEASE IN RAT MODEL
Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disorder leading to dementia in the elderly inhabitants. Increasing evidence advises that oxidative stress that is normally associated with aging is an obvious and early feature of AD and plays a role in its pathogenesis. The present study was designed to evaluate the possible neuroprotective activity of Ginkgo biloba (Gb...
Chronic Obstructive Pulmonary Diseases (COPD) refers to multiple lung diseases, is the occurrence of chronic bronchitis and emphysema, a pair of commonly co-existing diseases of the lungs in which the airways become narrowed because of inflammatory cells like neutrophils, CD8 cells and macrophages. These cells produce the Matrix metalloproteinases (MMPs), cathapsins and other proteinase enzymes. I...
Background: Triphala is exclusively used in more than 200 drug formulations in Indian system of Medicine. The formulation process of polyherbal drugs changes the physiochemical properties of the whole drug which need to be studied and understood. Objective: The present work aims to perform the organoleptic features (color, odor, taste), and physicochemical parameters such as pH, loss on drying, as...
The rhizome of Tectaria cicutaria has been used in Indian traditional medicine for the treatment of various disorders. Different extracts of the rhizomes of Tectaria cicutaria were subjected to phytochemical analysis, anti-microbial activity and in-vitro anticancer activity. The in-vitro anticancer activity was performed using Sulforhodamine B (SRB) assay against various cancer cell lines namely H...
Infective diarrhoea is a common cause of malnutrition in children <5 years of age. The aetiological agents may be bacteria, viruses or parasites. The bacterial agents cause diarrhoea by either secretion of toxins which act on the small intestine to cause outpouring of fluids into the lumen as seen in Vibrio cholerae, enterotoxigenic Escherichia coli, Clostridium perfringens, Staphylococcus aure...
IN-SILICO DESIGN, SYNTHESIS AND IN-VITRO ANTI-TUBERCULAR AND ANTI-MICROBIAL SCREENING OF NOVEL BENZIMIDAZOLE DERIVATIVES
The present work aims to design, synthesize some novel benzimidazole derivatives and to perform in-vitro evaluation of their antitubercular and antimicrobial activity. In-silico modelling of benzimidazole derivatives was carried out using various softwares such as, ACD Labs Chemsketch, Molinspiration, PASS (Prediction of activity spectra for substances) and Schrodinger Glide XP (Grid based ligan...
DEVELOPMENT AND VALIDATION OF STABILITY INDICATING UPLC METHOD FOR SIMULTANEOUS ESTIMATION OF SOFOSBUVIR AND VELPATASVIR IN TABLET DOSAGE FORM
The objective of the method was to develop a simple, rapid, sensitive, precise, accurate and validated Ultra Performance Liquid Chromatographic (UPLC) method for the simultaneous estimation of Sofosbuvir and Velpatasvir in tablet dosage form. Chromatographic separation was achieved on an acquity UPLC HSS C18, 2.1 × 100 mm, 1.8µ column with a mobile phase composed of orthophosphoric acid buffer a...