IN-VITRO ALPHA- AMYLASE INHIBITORY ACTIVITY, ANTIOXIDANT POTENTIAL, AND GC-MS ANALYSIS OF CREPE GINGER (COSTUS SPECIOSUS (J. KOENIG.) SM) LEAVES
The leaves of crepe ginger (Costus speciosus (J. Koeng.) Sm. are utilized by the Subanen tribe of Lapuyan, Zamboanga del Norte, Philippines to treat diabetes. However, the hypoglycemic potential of this plant is not yet well-established. Thus, the present study investigated the in-vitro alpha-amylase inhibitory and antioxidant activities of the leaves of C. speciosus. The evaluation of the alpha-a...
The macro and micro nutrients content estimation was carried out for leaves of indigenous medicinal plant Murraya koenigii (L.) Sprenge collected from different places of North Karnataka region viz. Bidar, Kalaburagi, Shahapur, Sandur and Kappathgudda. About few kg of leaves of Murraya koenigii (L.) Sprenge plant material was collected and then they were washed in deionized water to eliminate cont...
SYNTHESIS, CHARACTERIZATION, INDUSTRIAL APPLICATION AND ANTICANCER ACTIVITY OF NEW N-MUSTARD SUBSTITUTED COUMARIN DERIVATIVES
A series of N-mustard substituted coumarin have been synthesized characterized and evaluated for their in-vitro cytotoxicity and anticancer activity against PC-3 human cancer cell lines. The methodology involves nucleophilic substitution of readily accessible 3-cyano-4-chloro coumarin with ethanol amine further on chlorination gives substituted 4-(bis(2-chloroethyl)amino)-2-oxo-2H-chromene-3-carbo...
Objective: There is rapidly growing interest in the development of nanoparticles drug delivery mainly for anticancer drugs as it promises to solve problems to several related to anticancer drugs. The aim of present work was to formulate erlotinib loaded chitosan nanoparticles using probe sonication technique. The objective of the study was to investigate the effect of surface stabilizers and sonic...
The objective of the study was to investigate the effect of microemulsion on in-vitro skin permeation, percutaneous absorption of Irbesartan and to postulate probable mechanism of skin permeation. Microemulsion was prepared by aqueous phase titration method. Pseudoternary phase diagrams were constructed for the microemulsions. Thermodynamic stability study was carried out on selected microemulsion...
PREPARATION AND CHARACTERIZATION OF pH BASED CARBOPOL 934P IN-SITU HYDROGELS FOR THE TREATMENT OF HARMFUL BACTERIAL INFECTIONS
The purpose of the present study describes the preparation of pH based in-situ gel formulations were applied for the harmful bacterial infections by using carbopol 934P and HPMC derivatives. The simple procedure was adopted for preparing these formulations. To eliminate or reduced adverse systemic effects produce from bacterial conjunctivitis, topical route of administration, such as eye drops was...
Plants are an important source for the discovery of new products of medicinal value for drug development and plants secondary metabolites are unique sources for pharmaceuticals food additives, flavors, and other industrial values. The commercial importance of these secondary metabolites has resulted in a great interest in its production and in exploring possibilities of enhancing its production us...
Aspirin became a cornerstone in the treatment of coronary artery disease and widely used in the secondary prevention of vascular events. Aspirin resistance remains a poorly defined term though clinical definition is failure of the drug to prevent an atherothrombotic event despite the regular intake of appropriate doses is a relatively common problem. Various laboratory parameters assessing its eff...
NON ENZYMATIC AND ENZYMATIC ANTIOXIDANT STATUS OF WISTAR RAT ERYTHROCYTE AFTER DIETARY ZINC DEFICIENCY
Zinc deficiency is prevalent worldwide. The present study deals with the effect of dietary zinc deficiency on erythrocytes of Wistar rats. Male Wistar rats (40-50 g) were divided into 3 groups: control (ZC) fed 100 μg/g zinc; pair fed (PF) fed 100 μg/g zinc but the diet given was based on the diet consumed the previous day and zinc deficient (ZD) fed 1 μg/g zinc. The experiment was carried out ...
A REVIEW ON THE PHARMACOGNOSTICAL, ECOLOGY AND PHARMACOLOGICAL STUDIES ON MARINE RED ALGAE – HYPNEA VALENTIAE
Seaweeds are the potential marine living resources in the world. More than 20,000 seaweeds are distributed throughout the world, of which only 221 (1.1%) are commercially utilized, which includes 145 species for food and 110 species for phycocolloid production. The biodiversity of the marine environment and the associated chemical diversity constitute a practically unlimited resource of new active...