COMPARATIVE STUDY OF PHARMACOGNOSTIC PARAMETERS, ANTIOXIDANT AND ANTICHOLINESTERASE POTENTIAL OF BRASSICA NAPUS AND BRASSICA OLERACEA VAR. ACEPHALA
Introduction: Green leafy vegetables are known for their anti-alzheimer potential. There are many leafy vegetables, however, that have not been examined scientifically for this activity. The present study was designed to evaluate antioxidant and antiacetylcholinesterase activities of two Brassica species namely B. napus and B. oleracea var. acephala, along with the comparison of their pharmacognos...
Quinolones are the organic compounds that act against the DNA-gyrase enzyme, a type II topoisomerase. Norfloxacin is one such quinolone which is characterized by a piperazinemoiety at C-7 position. This moiety plays a significant role in determining the antibacterial spectrum and potency and serves as a site amenable to significant modification. N-Mannich bases have proved to be potential prodrug ...
AQUA DISTILLATION ENHANCES THE ANALGESIC AND ANTI-INFLAMMATORY PROPERTIES OF ROSA DAMASCENA MILL.; A PILOT STUDY
Rosa damascena Mill. also known as Damask rose, Persian rose or Gul-e-Muhammadi of Rosaceae family is an aromatic small plant cultivated all over the world for its visual beauty, fragrances and therapeutic potential. The plant is rich in tannins, flavonoids, glycosides, carboxylic acids and ascorbic acid. In addition to its aromatic properties, the plant possesses laxative, anti-oxidant, anti-bact...
HEPATOPROTECTIVE ACTIVITY OF FUNGAL ENDOPHYTIC FRACTIONS OF ANDROGRAPHIS PANICULATA (BURM. F.) WALL NEES. LEAVES IN PARACETAMOL AND ETHANOL INDUCED HEPATOTOXICITY
The most widely used drug for analgesic and antipyretic is Paracetamol, but a change in dose at high-level yields to adverse reactions such as the toxic liver. The psychoactive compound present in alcoholic drinks is ethanol. Chronic alcohol consumption and various pathological conditions vary from basic intoxication to life-threatening pathological states. Endophytes are the microorganisms presen...
ANTI-MICROBIAL AND ANTI-CANCER ACTIVITY OF AEGLE MARMELOS AND GAS CHROMATOGRAPHY COUPLED SPECTROMETRY ANALYSIS OF THEIR CHEMICAL CONSTITUENTS
In this study, we investigated anti-cancer and antimicrobial activity of Aegle marmelos leaf extracts and their chemical profile characterized by gas chromatography coupled mass spectrometry (GC-MS). A. marmelos leaves were extracted with acetone, methanol, ethanol, and chloroform. Presence of phenolic compounds was identified in these extracts by qualitative analysis. All the extracts were subjec...
A NOVEL STABILITY INDICATING RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF ANTI-VIRAL CLASS OF ELBASVIR AND GRAZOPREVIR IN BULK AND PHARMACEUTICAL DOSAGE FORM
Objective: To develop accurate, precise stability indicating a method for simultaneous estimation of Elbasvir and Grazoprevir in bulk and pharmaceutical dosage form. Materials and Methods: Simple, rapid, precise, sensitive and reproducible validated stability-indicating Reverse-Phase High-Performance Liquid Chromatography (RP-HPLC) method for the quantitative analysis of Elbasvir and Grazoprevir i...
EVALUATION OF THE CHARACTERISTICS OF DIABETES INDUCED BY THE ADMINISTRATION OF ALLOXAN TO FRUCTOSE FED WISTAR RAT
Several type II diabetic models have been developed to evaluate the effects of potential antidiabetic agents. However, there seems to be a paucity of literature evaluating the characteristics of diabetes-induced with fructose and alloxan. Therefore, this study was conducted to characterize fructose-alloxan diabetes. Thirty rats were grouped equally into Control, Fructose and Fructose plus 150 mg/k...
AN EFFICIENT SYNTHESIS OF SOME NOVEL BIOACTIVE AZETIDINONE DERIVATIVES INCLUDING 5-(BENZOFURAN-2-YL) AND 1-PHENYL-1H-PYRAZOLE-3-CARBOXAMIDE MOIETY
In continuation of our efforts in the development of novel drugs, in the present article we have described synthesis of a series of novel azetidinones derivatives (4a-i) containing 5-(benzofuran-2-yl) and 1-phenyl-1H-pyrazole-3-carboxamide moiety, with excellent yields and without formation of undesirable side products from cyclo condensation reaction of N'- (benzylidene) -5- (benzofuran- 2- yl) -...
COMPARATIVE ANTIANXIETY POTENTIAL OF EUPHORBIA NERIIFOLIA LINN. LEAVES AND EUPHORBIA HIRTA LINN. AERIAL PARTS
Euphorbia neriifolia and Euphorbia hirta have been traditionally used for relieving anxiety and other nervous disorders. The present study was designed to evaluate and compare the antianxiety activity of E. nerrifolia leaves and E. hirta aerial parts using elevated plus maze model. Petroleum ether (60-80°C), chloroform, ethanol and aqueous extracts of both the plants were prepared and evaluated f...
The stem and root barks, leaves and seeds of Millettia pachycarpa Benth. are used for various medicinal purposes in Chinese and Mizo traditional practices. The plant extract reportedly showed potent vermicidal activity on cestodes. The ethanol extract of the root bark was tested against the poultry nematode, Heterakis gallinarum Schrank. In vitro treatment at 37±1°C revealed that a serial dose o...