RELATIONSHIP BETWEEN SMOKING AND HISTOLOGY OF LUNG CANCER IN MALAPPURAM DISTRICT OF KERALA, SOUTH INDIA
Background: Lung Cancer is the commonly diagnosed neoplasm in males in India. The main histological types of lung cancer are squamous cell carcinoma, adenocarcinoma, small cell carcinoma and large cell carcinoma. However, histological types may vary with the changes in geographical region, smoking status and other social factors. This study aimed to find out the relationship of smoking and histolo...
ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF SALBUTAMOL SULPHATE, GUAIFENESIN, AND AMBROXOL HYDROCHLORIDE BY RP-HPLC METHOD IN COMMERCIAL ORAL LIQUID DOSAGE FORM
Salbutamol is a bronchodilator, Guaifenesin is an expectorant and Ambroxol is a mucolytic. Combination of these drugs is used in the formulation of cough syrups. In the literature, there is no method reported for the simultaneous estimation of the drugs in oral liquid dosage form. Hence, the present work is aimed to develop reverse phase HPLC method for the simultaneous determination of Salbutamol...
HIGH FRUCTOSE INDUCED ADIPOGENESIS AND INHIBITORY POTENTIAL OF TRIGONELLINE ON MURINE MESENCHYMAL STEM CELLS: A MORPHOLOGICAL STUDY
Regular intake of carbohydrate diet containing high fructose or sucrose increases adipogenesis resulting in conditions like weight gain, high blood pressure, elevated blood glucose levels, insulin resistance, raised triglycerides, low HDL cholesterol, with metabolic syndrome as a leading consequence. Since intricacies of adipogenesis are of major relevance to human health; present study aimed to e...
STANDARDIZATION OF SIDDHA POLYHERBAL FORMULATION PANCHABAKIYA CHOORANAM THROUGH ICPOES AND FTIR TECHNIQUES
Siddha system of medicine is a traditional medicinal system being followed mainly in South India. It is better known as one among the AYUSH medicinal system. The present study aims to standardize the Siddha poly-herbal formulation Panchabakiya chooranam (PBC), which is mentioned in the Siddha classical text Anuboga vaidya Brahma ragasyam indicated for stomach burn, burning sensation in anus and di...
FLAXSEED OIL AMELIORATES METHOTREXATE-INDUCED OXIDATIVE STRESS AND HEPTO-RENAL TOXICITY IN MALE RATS
This study aimed to investigate the protective effect of flaxseed oil against hepato-renal toxicity induced by methotrexate. Rats treated with methotrexate exhibited elevations in the levels of AST, ALT, ALP, γGT, LDH, urea, creatinine, uric acid, and bilirubin. Furthermore, the levels of MDA, NO and the relative ratio of the gene expression of COX-2 and iNOS were significantly increased, accompa...
In this study, we developed a cheap and precise analytic method to measure Etodolac concentration in bulk and pharmaceutical formula. The modified, updated method depends on the reaction between ferric ion and Etodolac to yield ferrous ion. Then the former ion reacted with potassium ferric cyanide to form colored compound has a maximum absorbance at 700 nm. The method was validated by calculating ...
After more than a century, tuberculosis (TB) is still a formidable public health challenge as it contributes considerably to illness and death worldwide, irrespective of continuous advancement in technology and in depth understanding of molecular biology concepts. Mycobacterium tuberculosis persist for longer period in human and animal host in latent state without causing active disease and may re...
Preservatives are added to pharmaceuticals to ensure safety and shelf life. A number of Essential oil components are identified as effective antimicrobials. The antimicrobial activity is assessed of pure oils. Oils were evaluated based on Refractive index, Specific gravity and Antimicrobial activity. In present study Syrups were prepared using Peppermint, Rose and Orange oils in different concentr...
Background: Due to the rise of diabetes as the primary health issue nowadays, there is a need for a sweetener, which apart from fulfilling the role of a sweetener, also complies with the normal body metabolism. Objectives: To review the literature available on the different sugar alternates present globally. Methods: A literature search has been done on the various substitutes of sugar present, be...
The World Health Organization (WHO) defines traditional medicine as “the health practices, approaches, knowledge and beliefs incorporating plants, animals and mineral-based medicines, spiritual therapies, manual techniques and exercises, applied singularly or in combination to treat, diagnose and prevent illness or maintain wellbeing. Various compounds have been isolated from Bridelia micrantha ...