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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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19.

DEVELOPMENT AND CHARACTERIZATION OF MICROPARTICLES OF SUMATRIPTAN SUCCINATE CARRIER SYSTEM VIA NASAL ROUTE

Sumatriptan succinate is the 5H1 receptor agonist and used in the treatment of migraine, cluster headache. The main objective is to develop ideal anti-migraine nasal mucoadhesive microparticles as local and systemic drug delivery system. An attempt was made to formulate the nasal mucoadhesive microparticle of Sumatriptan succinate with excipients like mucoadhesive polymers i.e., HPMC, ethyl cellul...

S. T. Galatage *, S. G. Killedar, A. B. Patil, A. A. Alman and S. S. Harale

Sant Gajanan Maharaj College of Pharmacy, Shivaji University, Mahagoan, Kolhapur, Maharastra, India.

DOI: 10.13040/IJPSR.0975-8232.10(9).4194-00

4194-4200

1782

876

47.

THE EVALUATION OF VITAMIN C SUPPLEMENTATION ON NUTRITIONAL STATUS OF PATIENTS WITH ACUTE MYELOID LEUKEMIA UNDERGOING CHEMOTHERAPY

Background: Leukemia is the seventh common cancer in Iran, and AML is considered as the most common type. Malnutrition is common among patients with cancer. Vitamin C deficiency has a high prevalence among patients with cancer, which may influence a patient's survival chance. This study was aimed to evaluate the effect of vitamin C supplementation on nutritional status and serum albumin in patient...

A. Hosseini, S. M. Jalali, M. Ajami *, M. Abdollahi, H. Ranjbar and M. Badeli

Department of Food and Nutrition Policy and Planning Research, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

DOI: 10.13040/IJPSR.0975-8232.11(1).394-00

394-400

1782

688

22.

ATTENUATION OF QUORUM SENSING ASSOCIATED VIRULENCE FACTORS AND BIOFILM FORMATION IN PSEUDOMONAS AERUGINOSA PAO1 BY PHOMA MULTI-ROSTRATA PUTY3, A SAPROPHYTIC FUNGUS, ISOLATED FROM CARICA PAPAYA

Pseudomonas aeruginosa is one of the most emerging multidrug-resistant opportunistic pathogens, which poses a threat to immunocompromised patients. Treatment of P. aeruginosa in the affected patients has become difficult because of its ability to develop resistant strains against most of the conventional therapeutic antibiotics. Quorum sensing plays a crucial role in the virulence nature of P. aer...

T. Ahmed and V. V. Sarma *

Department of Biotechnology, School of Life Sciences, Pondicherry University, Kalapet, Puducherry, India.

DOI: 10.13040/IJPSR.0975-8232.11(7).3268-84

3268-3284

1782

708

35.

ISOLATION AND QUANTIFICATION OF GALLIC ACID FROM EULOPHIA OCHREATA LINDL. BY HPTLC

In the healthcare system, the development and modernization of phytomedicine in phytochemistry play a central and important role in drug development. Isolation and purification of bioactive compounds from naturally occurring substance are of prime importance. A sensitive and reliable high-performance thin-layer chromatography method has been developed for the estimation of gallic acid in the alcoh...

A. A. Koparde *, R. C. Doijad, A. Patil and C. S. Magdum

KIMSDTU’s, Krishna Institute of Pharmacy, Krishna hospital Campus, Malkapur, Karad, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).3859-66

3859-3866

1782

861

14.

ANTI-DIABETIC ACTIVITY OF HYDROALCOHOLIC EXTRACTS OF ANACARDIUM OCCIDENTALE, AEGLE MARMELOS AND ACHYRANTHES ASPERA IN ALLOXAN-INDUCED DIABETIC RATS

Diabetes mellitus is a major endocrine metabolic disorder of multiple etiologies characterized by chronic hyperglycemia; with disturbances of carbohydrate, protein, and fat metabolism. It is caused by the deficiency or ineffective production of insulin by pancreas, which results in increase or decrease in concentrations of glucose in the blood. There is number of chemical agents available to contr...

Brijyog *, L. P. Singh, S. Kumar and S. Verma

Institute of Pharmacy, Harish Chandra P.G. College, Varanasi, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(11).4932-36

4932-4936

1781

792

22.

IN-VITRO ANTI-CANCER ACTIVITY OF TWO BRITTLE STAR SPECIES: OPHIOCOMA ERINACEUS AND OPHIOMASTRIX ANNULOSA

Marine organisms are excellent sources of structurally diverse molecules that are potentially valuable as drugs. The brittle starfish was shown to contain the bioactive components which exhibit various biological activities including cytotoxicity effects. Hence, the present study was carried out to determine the cytotoxicity of the extracts of two different starfish species like Ophiocoma erinaceu...

S. Senthilkumari and K. Revathi *

Department of Zoology, Ethiraj College for Women, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2272-79

2272-2279

1777

699

27.

FORMULATION AND IN-VITRO CHARACTERIZATION OF 5-FLUOROURACIL AND FLAVONOID DUAL LIPID DRUG CONJUGATES LOADED SELF NANOMULSIFYING DRUG DELIVERY SYSTEM FOR CANCER TARGETING

Objective: The Failure in chemotherapy is mainly because of the resistance of the chemotherapeutic drugs towards the neoplastic cells. The main reason behind this study was to develop a novel combination of 5-Fluorouracil (5-FU) lipid curcumin conjugates for the treatment of cancer. Methods: In this study, the lipid group stearic acid and oleic acid was conjugated with the parent drug moiety 5-Flu...

C. Karthika and R. Sureshkumar *

Department of Pharmaceutics, JSS College of Pharmacy, Ootacamund, (Affiliated to JSS Academy of Higher Education and Research, Mysuru, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(8).3746-54

3746-3754

1777

718

14.

MOLECULAR VERSUS CONVENTIONAL TECHNIQUES FOR THE DETECTION OF STAPHYLOCOCCUS AUREUS, PSEUDOMONAS AERUGINOSA AND CANDIDA ALBICANS IN NON-STERILE PHARMACEUTICAL PREPARATIONS

Notable progress has been made in methods that encourage the use of PCR as a rapid and accurate tool in quality evaluation of pharmaceuticals. In this study, monoplex and multiplex PCR based assays were developed and compared with standard conventional methods for rapid detection of three specified topical indicator pathogens, Pseudomonas aeruginosa, Staphylococcus aureus and Candida albicans, in ...

R. S. El-Houssieny, M. M. Aboulwafa *, W. F. Elkhatib and N. A. Hassouna

Department of Microbiology and Immunology, Faculty of Pharmacy, Ain Shams University, Al Khalifa Al Maamoun St., Abbassia, Cairo, Egypt.

DOI: 10.13040/IJPSR.0975-8232.11(8).3664-78

3664-3678

1777

745

23.

SOLID DISPERSIONS OF FENOFIBRATE BY DROPPING METHOD

The main objective of the study was to enhance the dissolution of fenofibrate (BCS class II), poorly soluble drug. To improve the solubility of the drug, solid dispersions were prepared by dropping method with PEG 4000 and PEG 6000 in the ratios of 1:1 and 1:2. The formulations were filled into capsules and evaluated for solubility, assay, FTIR, X-ray diffractions, DSC, and in-vitro dissolution. T...

D. Prasanthi *, C. Prakash and K. L. Aishwarya

G. Pulla Reddy College of Pharmacy, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.10(11).4995-01

4995-5001

1776

726

2.

HYDROXYCHLOROQUINE (HCQ) AS AN EMERGING AND PROMISING DRUG CANDIDATE IN COVID-19 PANDEMIC – A SYSTEMATIC REVIEW

Hydroxychloroquine (HCQ) belongs to the class of 4-aminoquinolines. It is a hydroxylated version of chloroquine with a similar mechanism of action but rather a safe profile. It is primarily an antimalarial drug but has been extensively used for treating rheumatoid arthritis, porphyria, discoid and systemic lupus erythematosus as well. Most recently, this drug has found a place in the treatment of...

S. Saini *, P. Chauhan and Babita

Abhilashi College of Pharmacy, Nerchowk, Himachal Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5290-97

5290-5297

1776

1179