ANTITUMOR ACTIVITY OF METHANOLIC EXTRACT OF ROOT OF DECALEPIS HAMILTONII IN DALTON’S LYMPHOMA ASCITES (DLA) BEARING MICEAbstract
The antitumor activity of methanolic extract of Decalepis hamiltonii was evaluated using Dalton’s Lymphoma Ascites (DLA) tumor model in Swiss albino mice. Methanolic extract of Decalepis hamiltonii was administered at a dose of 200mg and 400mg/kg b.wt once daily for 14 days after 24h of tumor inoculation. Cyclophosphamide was used as a standard drug at a dose of 25mg/kg b.wt. The result showed that methanolic extract of Decalepis hamiltonii root increased the mean survival time and percentage increase in life span and also decreased the body weight of the DLA tumor bearing mice. Hematological studies reveal that increase in hemoglobin content and RBC count and decrease in WBC count was observed in methanolic extract of root of Decalepis hamiltonii and cyclophosphamide treated mice. Administration of methanolic extract of root of Decalepis hamiltonii and standard control significantly decrease the serum marker enzymes (aspartate transaminase, alanine transaminase) and protein level to nearly normal levels in DLA tumor bearing mice. The methanolic extract of root of Decalepis hamiltonii at a dose of 400mg shows potent antitumor activity.
M. Devi*and P. Latha
Ph. D Scholar, Department of Biochemistry, Muthayammal College of Arts and Science, Rasipuram - 637408, Namakkal, Tamil Nadu, India
04 January, 2013
23 February, 2013
21 April, 2013
01 May, 2013