EFFECT OF BISPHENOL-A ON THE CARDIOVASCULAR SYSTEM IN PREGNANT RATSAbstract
Bisphenol-A (BPA) is a chemical produced in large volumes worldwide and has large market diffusion in many consumer products. BPA is used mainly as a monomer in the production of polycarbonate plastics and as a precursor of epoxy resins. So the present study was undertaken to examine the toxic effect of BPA on heart function in pregnant rat models. BPA (50 mg/kg.b.wt/day and 500 mg/kg.b.wt/day) was administered for 8th to 15th day by oral-gavage. The rats were sacrificed by cervical dislocation after last treatment. Paraffin embedded heart tissue sections were stained with hematoxylin-eosin. Significant degenerative changes were observed in H&E stained heart tissue sections of test rats. The activities of antioxidant enzymes like- superoxide dismutase, catalase and glutathione peroxidase were seen to be decreased significantly in treated rats; while, the level of malondialdehyde, a biomarker of lipid peroxidation, was increased than treated rats. Up-regulation of proapoptotic protein has been reported in heart failure and myocardial infarction, to determine whether caspase-3 protein can affect cardiac function in treated pregnant rats. In conclusion, BPA inhibits ventricular function in rat presumably by producing oxidative stress induced apoptosis and causes potential cardio toxicity.
T. Geetharathan and K. Peera *
Department of Zoology, Sri Venkateswara University, Tirupati, Andhra Pradesh, India.
18 March, 2018
31 July, 2018
03 August, 2018
01 November, 2018