EVALUATION OF ANTI-INFLAMMATORY EFFECTS OF LOSARTAN IN EXPERIMENTALLY INDUCED RHEUMATOID ARTHRITISAbstract
Aim: To evaluate anti-inflammatory effects of losartan in experimentally induced rheumatoid arthritis (RA).
Materials and Methods: Adjuvant induced arthritis model is used in this study. Albino-Wistar rats of either sex were used. Arthritis was induced by single intra-plantar injection of Freund’s complete adjuvant (FCA) suspended in oil in right hind paw. Rats were divided in to three groups (n=8) namely disease control, standard and test group. Drug treatment was carried out for 21 days. Effect of test drug on acute inflammatory phase was evaluated on day 5 by assessing right hind paw edema. After 21 days animals were sacrificed and evaluated for left hind paw edema, weight changes, histo-pathological synovitis grading in left hind limbs and secondary lesion score.
Results: Results showed that losartan significantly reduced right hind paw edema on day 5 (p<0.05) and showed significant weight gain (p<0.05). Losartan though reduced the histo-pathological synovitis grade and secondary lesion score was not statistically significant (p>0.05).
Conclusion: Our study suggests that losartan could be a potential candidate for treatment of RA. It is therefore recommended that studies using different doses and routes of administration of losartan needed to be conducted in future.
G.Y. Munde and P.R. Pandit
Department of Pharmacology, Topiwala National Medical College, Mumbai Central, Mumbai-400 008, Maharashtra, India
11 January, 2013
12 February, 2013
30 April, 2013
01 May, 2013