EVALUATION OF IN-VIVO ANALGESIC ACTIVITY OF ARGYREIA CYMOSA (ROXB.) SWEETAbstract
The current research was accomplished to assess the analgesic activity of Argyreia cymosa (A. cymosa) methanolic extracts (MEAC) at 200 and 400 mg/kg. The entire herb was extracted with the methanol (MEAC). Acute oral toxicity of the extract was according to OECD-423 recommendations. Analgesic activity was explored by utilizing hot plate, tail immersion and acetic acid-evoked writhing models. In acute toxicity study, no mortality was observed when each extract was orally administered with 2000 mg/kg. At the doses (200 and 400 mg/kg) methanolic extract of Argyreia cymosa demonstrated considerable and dosed reliant analgesic effect. The conclusions from the present investigation confirmed the folkloric usage of Argyreia cymosa as an analgesic agent. This significant analgesic impact might be because of the presence of steroids, flavonoids, and glycosides within the extract. But, further phytochemical, as well as biological tests, are needed to determine the additional active chemical constituents responsible for the antinociceptive activity.
V. Gunji * and G. Seru
Department of Pharmacognosy and Phytochemistry, A. M. Reddy Memorial College of Pharmacy, Uppalapadu, Andhra Pradesh, India.
10 April 2019
11 May 2019
18 May 2019
01 June 2019