FORMULATION AND EVALUATION OF MICROSPHERES BASED ORO-DISPERSIBLE ROXITHROMYCIN TABLETS USING CENTRAL COMPOSITE DESIGNAbstract
The aim of this study was to develop microspheres based orodispersible tablets of roxithromycin using the solvent evaporation technique. The microspheres were formulated in to orodispersible tablets using direct compression technique by central composite design. The objective of the study was to analyze the effect of concentration of eudragit RS100 (X1) and concentration of polyvinyl alcohol (X2), on the entrapment efficiency of the drug. Tablets were evaluated for physical characteristics viz. weight variation, hardness, friability, disintegration time and in-vitro dissolution study. The hardness and weight variation of the tablet were found 4.7 ± 0.24 kg/cm2 and 346.74 ± 3.74 mg, respectively. Friability of tablets was found 0.54 ± 0.04 which is less than 1% or in the acceptable limit. Disintegration time and drug release were found 45 ± 0.51 seconds and 96.45 ± 2.24% in one hour, respectively. The drug release data were subjected to drug release kinetics study.
Reena, M. Dahiya, V. Kumar and H. Dureja *
Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, India.
05 March, 2018
13 May, 2018
26 June, 2018
01 November, 2018