FORMULATION DEVELOPMENT AND IN-VIVO RADIOGRAPHIC STUDIES OF DILTIAZEM HYDROCHLORIDE LOADED FLOATING CAPSULES PREPARED BY MODIFIED PULSINCAP TECHNOLOGYAbstract
Oral extended release formulation with site-specific drug delivery formulations has been of greater importance in the field of drug delivery system to achieve adequate therapeutic results. The concept of novel gastro-retentive drug delivery system aroused due to site specificity behavior of the drug concerning drug absorption and solubility. The objective of the research work is to develop and evaluate gastro-retentive diltiazem hydrochloride modified pulisincap floating capsules. Diltiazem hydrochloride modified pulsincap floating capsules were formulated by filling the drug-polymer and diluents mixture in cross-linked hard gelatin capsules. Total of 15 formulations was developed and evaluated for pre capsule filling and post capsule filling parameters. Before development of formulation with different polymers, the cross-linked hard gelatin capsules were filled with only pure drug to carry out the diffusion studies of the drug through the cross-linked hard gelatin capsules among the developed, formulation containing carbopol 934p, i.e. F12 formulation was considered to be optimized based on its in-vitro drug release data and have shown the in-vitro drug release of 97.64 ± 3.45% at the end of 12th h, in-vitro drug release data were fitted into different kinetic models, optimized formulation has shown the zero order drug release with a mechanism of non-fickian diffusion, radiographic studies confirmed that optimized formulation with BaSO4 administered to the healthy volunteer with food have shown more gastric residence time than that of the optimized formulation with BaSO4 administered to the healthy volunteer in fasting condition.
P. Srikanth *, S. Hemalatha and V. S. Suggala
Jawaharlal Nehru Technological University Anantapur (JNTUA), Ananthapuramu, Andhra Pradesh, India.
19 February 2019
17 April 2019
20 April 2019
01 May 2019