FORMULATION, OPTIMIZATION AND IN-VITRO EVALUATION OF DICLOFENAC SODIUM LOADED SUSTAINED RELEASE MATRIX TABLET CONTAINING BOTH NATURAL AND SEMI-SYNTHETIC POLYMERSAbstract
Objective: The persistence of this effort was to frame, evaluate and examine the impact of natural and semi-synthetic polymer in changing the release rates of matrix tablet loaded with diclofenac sodium. Materials and method: Matrix tablets of diclofenac sodium were made-up by varying the concentrations of both natural polymer i.e Guar gum and semi-synthetic polymer i.e HPMC K4M via straight compression method. Optimization of the tablet was completed by taking quantity of Guar gum and HPMC K4M in percentage as self-governing variable and cumulative percent of drug release at 2 hr, 6 hr and 12 hr as faithful variable using design expert Software. Optimized tablet was assessed for various pre and post compression limitations equated with marketed formulation. Drug release kinetics of the optimized tablet was evaluated by various representations of drug release kinetics. Result: The verdict of present investigation evidently designates that by using both natural and semi-synthetic polymer in a same tablet was given a noteworthy sustained release. The dissimilarity with the optimized formulation in software data and actual result is not diverge too much. Optimized formulation also screening talented result when linked with marketed formulation. Optimized tablet obeys zero order drug release kinetics. Conclusion: It was settled that blend of these natural and semi-synthetic polymer having auspicious effects on sustained release outline of drug from the matrix tablet laden with diclofenac sodium.
U. Borah *, B. Dash, J. Chakraborty and B. Das
Girijananda Chowdhury Institute of Pharmaceutical Science, Azara, Guwahati, Assam, India.
21 September, 2017
07 December, 2017
25 December, 2017
01 July, 2018