GASTROPROTECTIVE EFFECTS OF FRUITS OF TRIBULUS TERRESTRIS L. IN PYLORUS-LIGATED WISTAR RAT MODELAbstract
Tribulus terrestris L. (TT; Zygophyllaceae) is employed in the folk medicine against sexual impotence, oedemas, abdominal distention and cardiovascular diseases. Gastroprotective (i.e. antiulcer and anti-secretory) potential of methanolic extract of TT fruits was evaluated in pylorus-ligated rat model of Wistar rat. The methanolic extract of TT was tested orally at the doses of 150, 300 & 600 mg/kg, on gastric ulcerations experimentally induced by pylorus ligation. Preliminary phytochemical screening of the methanol extract of TT showed the presence of alkaloids, carbohydrates, cardiac glycosides, flavonoids, saponins, tannins and proteins. The methanolic extract at the doses of 300 & 600 mg/kg produced more significant inhibition when gastric ulcerations were induced by pylorus ligation respectively. The methanol extract of the fruits of Tribulus terrestris L. possess gastroprotective i.e. antiulcer and anti-secretory effect.
Javed Akhtar Ansari*, Md Faruque Ahmad and Fakhruddin Ali Ahmad
Assistant Professor, Department of Pharmacology, MESCO College of Pharmacy, 13-5-741, MEC, Mustaeedpura, Karwan Road, Hyderabad-500 006, India.
22 September, 2012
17 October, 2012
17 December, 2012
01 January, 2013