HEPATOPROTECTIVE ACTIVITY OF BERRY EXTRACTS OF DIOSPYROS KAKI LINN. AGAINST CARBON TETRACHLORIDE INDUCED LIVER DAMAGE MODELAbstract
Currently, nutrition and health linkages focused on the emerging strategy of diet based regimen to combat various physiological threats including cardiovascular disorders, oxidative stress, diabetes mellitus, etc. Berry / Fruit part of Diospyros kaki Linn. was extracted using petroleum ether, chloroform, ethanol consecutively and the obtained extracts were screened for hepatoprotective activity using CCl4 induced liver damage model. The activity was assessed by comparing the serum enzyme levels such as serum glutamate pyruvate transaminase, serum glutamate oxalate transaminase, total bilirubin, alkaline phosphatase of fruit extracts treated group with carbon tetrachloride treated animals and results showed dose-dependent activity, ethanolic extract treated group showed highly significant activity, whereas chloroform extract treated group has shown the significant action but less compare to ethanolic extract, petroleum ether treated group showed moderate action and petroleum ether extract at a dose of 100 mg/kg b.w showed least significant action. The results were further supported by histopathological studies.
S. N. V. L. Sirisha *, K. Prabhu and A. S. Rao
JNTU Institute of Science and Technology, Centre for Pharmaceutical Sciences, Hyderabad, Telangana, India.
29 April 2018
14 July 2018
18 July 2018
01 January 2019