LOCALIZATION OF CONNEXIN 36 AND CALCITONIN GENE RELATED PEPTIDE AS A DETERMINANT OF NEUROPATHIC PAIN IN THE TRIGEMINAL GANGLIONAbstract
The trigeminal ganglion consists of pseudounipolar neurons surrounded by satellite glial cells and processes innervating craniofacial region. The trigeminal ganglion consists of neurons which are of first order pseudounipolar carrying sensory pathway from the receptors from face, mouth, scalp and duramater. The gap junctions are trans-membrane proteins formed between the cell membranes of adjacent cells and calcitonin gene related peptide are neuro-peptides secreted by sensory neurons. In present study the immune histochemical localization for connexin 36 gap junctions and CGRP was done in the trigeminal ganglion of male Wistar rats. The result showed connexin 36 was present between the satellite glial cells, between satellite glial cell and neuron and in the schwann cells. CGRP was localized densely in the cytoplasm of small neurons. The excited neuron can influence the surrounding satellite glial cells and neurons through gap junctions and by paracrine actions altering its environment leading to pathological role in inducing painful conditions like migraine.
P. K. Sankaran *, R. Gunapriya, M. Kumaresan and G. Karthikeyan
Saveetha Medical College and Hospital, Chennai, Tamil Nadu, India.
07 February, 2017
10 April, 2017
26 April, 2017
01 September, 2017