MEDICATION ADHERENCE AND HEALTH RELATED QUALITY OF LIFE IN ADULT PATIENTS SUFFERING FROM DIABETES MELLITUS TYPE 2 AND ITS ASSOCIATION WITH GLYCOSYLATED HEMOGLOBIN AND LIPIDS – A PROSPECTIVE STUDY AT TERTIARY CARE HOSPITALAbstract
A prospective, cross sectional questionnaire-based study was carried out over a period of six months. All the diabetic patients aged 18 to 60 years in the Medicine department and diabetes clinic who are eligible for study were enrolled. In addition to a questionnaire on demography, exercise, and smoking status, we used a structured case record form to capture diabetes-related complications, duration of diabetes, glycemic status and lipid control, along with number and types of medication used. Also, their glycosylated hemoglobin, lipid profile was recorded. The Quality of life (QOL) was assessed by WHOQOL-BREF questionnaire and adherence to treatment was measured by using Modified Morisky Medication Adherence Scale (MMAS-8). Association between QOL and glycosylated hemoglobin, and lipids was established using pearson correlation coefficient. About 50% patients had poor glycemic control with the HbA1c value of 7.1-9.0. A Total of 215 drugs were given to total 100 patients with the average of 2.17 ± 0.682 per prescription. The mean score for questions related to the physical domain was 19.86 ± 11.61 and psychological domain was 44.73±13.26. As far as medication adherence was concerned, 84% showed medium adherence to medications. In the study, it was noted that increase in number of drugs decreases medication adherence which directly affects quality of life of the patients, the Pearson’s correlation with drugs and adherence value of R is: 0.3998. QOL in type 2 diabetes was affected in physical domain. Medication adherence correlated with QOL (P <0.05). There was an association between QOL and glycosylated hemoglobin and total cholesterol.
H. Rajgadhi, V. Patel, B. Sabu and S. Malhotra *
Department of Pharmacology, Smt. NHL Municipal Medical College, Kocharab, Paldi, Ahmadabad, Gujarat, India.
24 November, 2017
29 January, 2018
06 February, 2018
01 August, 2018