STUDIES ON THE SYNTHESIS AND IN-VITRO ANTIMICROBIAL ACTIVITY EVALUATION OF SOME NOVEL β-LACTAMS CONTAINING SULFA DRUGSAbstract
The present study aims to synthesize 2-azetidinone derivatives; 4-(3-chloro-1-(4-substituted-phenyl)-4-oxoazetidin-2-yl)-2-methoxyphenyl-acetate (c1-c6) and 2-allyl-4-(3-chloro-1-(4-Substituted-phenyl)-4-oxoazetidin-2-yl)-6-methoxyphenyl4-methylbenzenesulfonate (d1-d6) by electrocyclisation of imines with chloroacetylchloride in the presence of triethyle – amine and 1, 4-dioxane. The synthesized compounds were characterized by FT-IR, 1H NMR spectra and elemental analysis and were screened in-vitro against three bacterial strains namely Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis and two fungal strains namely Aspergillus niger, Aspergillus flavus by disc diffusion method. The compounds exhibited good antimicrobial activity.
P. Deshmukh, P. K. Soni*, M. K. Ahirwar and A. K. Halve
School of Studies in Chemistry, Jiwaji University, Gwalior, Madhya Pradesh, India
02 January, 2017
12 July, 2017
19 July, 2017
01 August, 2017