SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL QUINOLINE / CHALCONE HYBRID AS POTENTIAL ANTIBACTERIAL AGENTSAbstract
A series of new quinoline/chalcone hybrids 3a-e and 4a-e were designed and synthesized. The structures of all new target molecules 3a-e and 4a-e have been confirmed by various spectral techniques and elemental analyses. The newly synthesized compounds were screened for their antibacterial activity using agar disc diffusion method. Results showed that most of the newly synthesized compounds showed good antibacterial activity comparable with that of the standard drug Gatifloxacin against all tested strains (B. cereus, E. coli, and S. marcescens) except for P. aeroginosa where it does not respond to most of the newly synthesized compounds, and that compounds 3c, 4c, 4d, and 4e showed good antibacterial activity (53-78% that of Gatifloxacin) towards some bacterial strains (Bacillus cereus, Escherichia coli, and Serratia marcescens) when compared to standard drug Gatifloxacin. Amongst all the tested compounds, 4e exhibited excellent activity against S. marcescens (88% that of Gatifloxacin).
B. G. M. Youssif
Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Aljouf, Sakaka, Saudi Arabia.
11 September 2018
04 November 2018
09 November 2018
01 May 2019