SYNTHESIS, CHARACTERIZATION AND COMPARATIVE STUDY OF CERTAIN METAL-1, 3-DIKETONATESAbstract
A substantial interest in rational design of novel transition metal complexes which bind and cleaves duplex DNA has been a motivation of the present investigation. This DNA adhesion of metal complex which targets bacterial DNA and cleaves it thereby results in an effective antibacterial agent. In the present work two series of metal diketonates were prepared by using diketones like acetyl acetone and benzoyl acetone. Metals like Cu2+, Ni2+, Co2+ were used for complexation. Bacterial cultures Staphylococus aureus, Bacillus subtilis, Escherichia coli and pseudomonas aeruginosa and fungal cultures Candida albicans, Aspergillus niger were used for screening anti-bacterial and anti-fungal activities respectively. Anti-microbial screening was carried out by using Kirby-Bauer disc plate method .It was found that metal complexes of benzoyl acetone shown more anti-microbial action. The presence of aryl ring in the molecular structure seems to augment the antimicrobial activity of the compound. Further Cu (II), Ni (II), Co (II) complexes of ML2 stoichiometry were characterized by UV, IR, mass and 1H NMR spectroscopies.
K.L. Krishnakumar* and R. Manju
Department of Chemistry, Nehru College of Pharmacy, Pampady-680597, Kerala, India
20 September, 2012
12 December, 2012
27 December, 2012
01 January, 2013