SYNTHESIS NEW MOLECULARLY IMPRINTED POLYMERS FOR THE SELECTIVE ELECTRODES OF ISOPROPAMIDE FROM PHARMACEUTICAL SAMPLESAbstract
Liquid electrodes of polymers imprinted with Isopropamide (ISP) were synthesized based on precipitation polymerization mechanism. The molecularly imprinted polymer (MIP) and non-imprinted polymers (NIP) were synthesized using (ISP) as a template. In the polymerization process, 2-Hydroxyethyl meth acrylate (2-HEMA) and 2-Vinyl pyridine (2-VP) were used as monomers. Di-vinylbanzene (DVB) was used as cross-linkers and benzoyl peroxide (BPO) as an initiator. The molecularly imprinted membranes and the molecularly non-imprinted membranes were synthesized using dibutyl sebacate (DBS) and nitrobenzene (NB) as plasticizers in PVC matrix. Slopes and detection limit of the liquid electrodes are ranged at (52.23-58.94) mV/decade and (1.2 × 10-6 – 2.0 × 10-5) M, respectively. Response time was 60 sec. Liquid electrodes were filled with 10-1 M standard solution of drug and observed stable response for a pH ranged from 1.5 to 12 and with good selectivity for over several species. The new synthesis electrodes were successfully used for the analyte estimated in preparation pharmaceutical sample without any time-consuming pre-treatment steps.
A. M. Dhari * and Y. K. Al-Bayati
Department of Chemistry, College of Science, University of Baghdad, Al-Jadryia, Baghdad, Iraq.
22 September 2018
10 December 2018
17 December 2018
01 June 2019