Most Cited
| Year | 2020 | 2021 | 2022 | Total |
|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 548 | 2053 |
| Citations | 699 | 263 | 21 | 983 |
| Projected Impact Factor | 3.76 | 2 | 0.64 |
AN OVERVIEW ON MICROBIAL FIBRINOLYTIC PROTEASES
Microbial fibrinolytic proteases are of considerable interest in view of their specific activity and stability at biological pH. This review describes different isolation methods which enable the screening and selection of promising organisms for industrial production. Further, strain improvement using mutagenesis and/or recombinant DNA technology can be applied to augment the efficiency of the pr...
2596
945
BUCCAL MIDAZOLAM: COULD IT BE AN ALTERNATIVE FOR I/V DIAZEPAM FOR ACUTE SEIZURES IN MALNOURISHED CHILDREN
Acute convulsive disorders are the most frequent neurological disorders in children which require emergency drug treatment. Immediate management of a convulsive episode is must as, delay can lead to status epilepticus, which is a significant cause of neurological morbidity and mortality among children. Benzodiazepines especially diazepam is often used as first line and routinely administered intra...
3119
1297
ANATOMICAL CHARACTERIZATION AND MICROCHEMISTRY OF PEPEROMIA PELLUCIDA (L.) H.B.K. (PIPERACEAE)
Peperomia pellucida L. (H.B.K.)is an arboreal species occurring in the secondary vegetation in Amazonia. This study aims to perform anatomy analysis by light microscopy and microchemistry analysis of leaves and petiole of P. pellucida. It was observed that the cells, on the adaxial surface, are juxtaposed with irregular shape and heterodimensional and straight walls and, the abaxial surface is for...
4845
1710
IMPACT OF ALCOHOL ON RAT HEART AND AORTIC TISSUE ACETYLCHOLINE CONTENT LEVELS IN VITRO AND IN VIVO
Acetylcholine satisfies all criteria for a transmitter substance. Its most widely recognized action sites are the endings of vertebrate motor nerves, the endings of the automatic pre ganglionics and the parasympathetic post ganglionics. It appears also to be the transmitter of motor nerves in all advanced invertebrate animals except the arthropods where it seems to separate at the endings of senso...
3348
936
SIMULTANEOUS ESTIMATION OF ESOMEPRAZOLE MAGNESIUM TRIHYDRATE, ITOPRIDE HYDROCHLORIDE AND MOSAPRIDE CITRATE BY RP-HPLC METHOD: OPTIMIZATION, DEVELOPMENT, VALIDATION AND APPLICATION TO LABORATORY SAMPLE.
A simple, rapid, accurate, precise and economical RP- HPLC method with UV detection was optimized, developed and validated as per ICH-Q2 guideline for the simultaneous estimation of Esomeprazole magnesium trihydrate (ESO), Itopride hydrochloride (ITO) and Mosapride citrate (MOSA) in laboratory sample. An optimum condition of separation and detection was developed on a reverse-phase Supelco 516 C18...
3633
1409
INFLUENCE OF INCREASING CONCENTRATIONS OF MAGNESIUM STEARATE AND TALCUM ON DISSOLUTION PROFILE AND PHYSICAL PARAMETERS OF METOPROLOL TARTRATE EXTENDED RELEASE MATRIX TABLETS
Metoprolol tartrate (MT) is cardio-selective β1 receptor antagonist used primarily in the management of chronic heart diseases like in the management of hypertension, angina pectoris, cardiac arrhythmias, myocardial infarction and heart failure. It is only available as prescription drug. The objective of this study was to prepare sustained release matrix tablets of MT using hydrophilic polymer an...
4597
1047
DIURETIC ACTIVITY OF METHANOLIC RHIZOME EXTRACT OF PICRORRHIZA KURROA ROYLE EX. BENTH.
Kidneys are the excretory organs of our body that serves the important functions such as elimination of waste products, regulation of fluid volume and electrolyte content of the extracellular fluid. Picrorrhiza kurroa (Scrophulariaceae) is a small perennial herb growing in the hilly parts of the north-Western Himalayas region in India and Nepal. The objective of the present study was to evaluate a...
2727
937
ROLE OF SERUM BILIRUBIN IN CLINICALLY ADMITTED PATIENTS TO PREVENT THE RISK OF CARDIAC DISEASES
ABSTRACT: Background: Coronary artery disease /coronary vascular disease (CAD/CVD) remains the first killer and common silent disease in the world. The lipid profile plays the essential role in CAD development with lipid oxidation. Lipid oxidation, which accepted as an important element of arterial plaque formation and atherosclerosis, is involved in the patho physiology of CVD. Bilirubin...
2569
1207
ROLE OF N-ACETYLCYSTEINE IN RESCUE OF MICE HEART
An imbalance between oxidants and antioxidants generates the oxidative stress. Oxidative stress is the major cause of many diseases like cardiovascular, respiratory disease, renal diseases, neurological diseases, cancer, and aging. Cardiovascular complications are the leading cause of mortality in patients so the purpose of this review is to evaluate the effectiveness of N-acetylcysteine (NAC) in ...
3080
1145
ENHANCEMENT OF DISSOLUTION OF CLOPIDOGREL MINI-TABLETS IN INTESTINAL FLUIDS WITH THE AID OF IN-SITU ACIDIFYING AGENT
The main objective of the present study is to enhance the dissolution of clopidogrel bisulphate in intestinal fluids by formulating into mini-tablets with in-situ acidifying agent mini-tablets. The solubility data reveals, Clopidogrel bisulphate is freely soluble in pH 2.0 and the solubility decreases with increase in pH. Whereas, with weak acid, the solubility of clopidogrel is increased at pH 5....
4691
3535