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PREFORMULATION, FORMULATION DEVELOPMENT AND DRUG RELEASE STUDIES OF DIPYRIDAMOLE FLOATING MICROBALLOONS
For the drugs possessing stomach and upper intestine as the absorption window, it has become high practical importance to improve their gastric residence time. The in vitro performance of the drug delivery being highly variable is ascertaining as gastric emptying is one of the complex mechanisms. Intense researches are being carried out for the development of multiparticulate systems, which are of...
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ISOLATION OF CADMIUM DEGRADING MICROORGANISMS FROM ELECTROPLATING, STEEL AND BATTERY INDUSTRY
Increase in industrialization has raised the levels of heavy metal pollution in the country. In order to combat with this problem, many strategies were developed till date, and among them, the use of microorganisms is the most successful technique. The present study was undertaken for isolation, identification, and characterization of heavy metal (Cd) tolerant bacteria from industrial effluents of...
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THE EVALUATION OF VITAMIN C SUPPLEMENTATION ON NUTRITIONAL STATUS OF PATIENTS WITH ACUTE MYELOID LEUKEMIA UNDERGOING CHEMOTHERAPY
Background: Leukemia is the seventh common cancer in Iran, and AML is considered as the most common type. Malnutrition is common among patients with cancer. Vitamin C deficiency has a high prevalence among patients with cancer, which may influence a patient's survival chance. This study was aimed to evaluate the effect of vitamin C supplementation on nutritional status and serum albumin in patient...
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EFFECT OF OLANZAPINE ON HYPERTHERMIA IN SEROTONIN SYNDROME MODEL
The serotonin syndrome is a life-threatening adverse drug reaction caused by a significant increase in the concentration of 5-hydroxytryptamine (serotonin) in the central nervous system. The aim of this study was to establish the effects of olanzapine, an antipsychotic drug, on the hyperthermic response in rat experimental serotonin syndrome. In this study, we used an animal model of the serotonin...
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ENVIRONMENTAL WELLNESS WITH SPECIAL REFERENCE TO HAEMATOZOAN INFECTION IN REPTILIAN HOSTS
Environment provides a solid platform for good health. An unhealthy environment makes place unsafe for wild animals. One of the effects is a parasitic load on these animals, as a high degree of parasitization may cause harm to the health of these animals. In the present research work, blood parasitic infestation in two species of lizards, Hemidactylus flaviviridis and Calotes versicolor were inves...
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EVALUATION OF FIELD AND LABORATORY RESPONSES OF MALE XANTHOPIMPLA PREDATOR TO SYNTHETIC PHEROMONE LURES
Mating disruption by an artificial release of synthetic female pheromone components like Tetradecyl acetate (A), Ethyl (Z)-9-hexadecenoate (B) and a mixture of these two at different concentrations is a feasible method to control Xanthopimpla predator. Male Xanthopimpla predator was evaluated for responses to these synthetic pheromone components in a laboratory wind tunnel and in Terminalia arjuna...
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SENSITIVE AND RAPID SIMULTANEOUS QUANTITATION OF RALOXIFENE AND ITS TWO MAJOR ACTIVE METABOLITES 4-GLUCURONIDE RALOXIFENE AND 6-GLUCURONIDE RALOXIFENE IN HEALTHY VOLUNTEERS USING A LIQUID CHROMATOGRAPHY COUPLED WITH TRIPLE QUADRUPLE MASS SPECTROMETER
Simultaneous estimation of parent and its metabolite(s) in a single method poses a threat when one has to monitor one mass transition while running the other compound on liquid chromatography-mass spectrometer. This would again become critical once interference is observed at the retention time of compound of interest in-spite of its absence in the sample. In this paper, a selective and sensitive ...
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USE OF ELECTRON MICROSCOPY IN STUDY OF STEROIDOGENIC CELLS OF NORMAL, REGRESSING AND PREGNANT CAPRINE CORPORA LUTEA
Electron microscopic studies revealed variations in different cell organelles in steroidogenic cells of normal, regressing and pregnant caprine corpora lutea. Corpus luteum was comprised of two types of steroidogenic cells viz. small theca luteal cells and large granulosa luteal cells. In granulosa luteal cells, rough endoplasmic reticulum was most abundant in corpus luteum of pregnancy. The numbe...
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CHEMICAL CONSTITUENTS OF ANDROGRAPHIS PANICULATA (BURM.F) NEES: A REVIEW
Andrographis paniculata Nees is a valuable medicinal herb of Acanthaceae family, is used for centuries to treat several diseases including viral hepatitis, cirrhosis, malaria and diabetes. This medicinal plant has hepato-protective, immunological, anti-bacterial, anti-inflammatory, anti-oxidant and antithrombotic qualities. It has many important bioactive compounds such as diterpenoids, flavonoids...
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SCREENING OF 4-([1,3,4]OXADIAZINO[6,5-b] INDOLE-3-YL)ANILINE DERIVATIVES FOR ANTI-BACTERIAL ACTIVITY BY IN-SILICO AND IN-VITRO METHODS
Schiff bases of isatin are investigated overtime for their pharmaceutical properties and have been found to have various activities such as anti-viral, anti-bacterial, anti-inflammatory, analgesic, anti-HIV, anti-depressant, anti-convulsant, fungicidal, etc. Isatins are treated with hydrazine derivatives and cyclized by sulfuric acid. These compounds are alkylated by di alkyl aminoalkyl halides in...
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