Most Cited
Year | 2020 | 2021 | 2022 | Total |
---|---|---|---|---|
No. of Published Articles | 745 | 760 | 548 | 2053 |
Citations | 699 | 263 | 21 | 983 |
Projected Impact Factor | 3.76 | 2 | 0.64 |
COLON TARGETED MATRIX TABLET OF BIODEGRADABLE SWELLABLE POLYMERS
The colon targeted drug delivery has a number of important implications in the field of pharmacotherapy. Oral colon targeted drug delivery systems have recently gained importance for delivering a variety of therapeutic agents for both local and systemic administration. Targeting of drugs to the colon via oral administration protect the drug from degradation or release in the stomach and small inte...
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EVALUATION OF PHYTOCHEMICAL AND ANTIMITOTIC POTENTIAL OF LAGENARIA SICERARIA FRUIT USING ONION ROOT MODEL
Cancer is one of the leading causes of mortality worldwide. Many of the cucurbitaceae plants traditionally reported to possess antitumor activity. The present study was carried out to evaluate the anticancer activity for different extracts of Lagenaria siceraria Fruit. The present research work had carried out on laboratory level assay to avoid the use of different animal models. Preliminary phyto...
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LIPID BASED PARENTERAL DRUG DELIVERY SYSTEM
Lipid-based drug delivery systems in the form of triglyceride emulsions, micellar systems and liposomes have been used for parenteral administration for the last few decades. Large number of new chemical entities (NCE) presents formulation and bioavailability problems because of the dose and poor solubility in solvent and co-solvent systems. In addition, high drug concentrations can lead to irrita...
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GENERIC DRUG USER FEE: AN OVERVIEW
The globalization of generic drug manufacturing, supply and testing, and a growing workload that has far outpaced USFDA’s resources has created new challenges. USFDA & Industry propose generic drug user fee to address the need for globalization of the inspection process, and to speed the timely review of generic product applications. The Generic Drug User Fee (GDUF) proposal is agreed by gen...
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ANGIOGENESIS IN CARDIOVASCULAR DISEASE: A REVIEW
Angiogenesis is process of new blood vessel formation that occurs under both normal and pathological conditions. In the normal state, two distinct processes can be seen. One utilizes endothelial progenitor cells (EPC) and the second utilizes existing vasculature to generate new vessels. The healthy body controls angiogenesis through a series of "on" (angiogenesis-stimulating growth factors) and "o...
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EFFECT OF METFORMIN AND ROSUVASTATIN ON ERYTHROCYTES OF PATIENTS WITH SICKLE CELL DISEASE: AN IN-VITRO STUDY
Objectives: Sickle cell disease (SCD) is a common hereditary blood disease with a progressive clinical course and multiple end organs damage. Due to its intercalated pathophysiology, several trials have been conducted targeting its pathophysiology in an attempt to modify the clinical course and minimize complications. Metformin and rosuvastatin are known to have pleiotropic effects such as antioxi...
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ROLE OF BISOPROLOL ADDING TO ANGIOTENSIN CONVERTING ENZYME (ACE) INHIBITOR AND FUROSEMIDE COMBINATION ON THE LEFT VENTRICULAR FUNCTION IN SYSTOLIC HEART FAILURE PATIENTS
Background: β-blocker is an established therapeutic strategy for stage C systolic heart failure based on the American Heart Association guideline, nonetheless limited studies analyzed the role of β-blocker primarily Bisoprolol adding to ACE inhibitor and furosemide combination on the left ventricular function in systolic heart failure patients. Objectives: This study was designed to analyze t...
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A VALIDATED LC METHOD FOR THE DETERMINATION OF CHIRAL PURITY OF (R)-3-((1-METHYLPYRROLIDIN-2-YL) METHYL)-5-(METHYLSULFONYLMETHYL)-1H-INDOLE: A KEY RAW MATERIAL OF ELITRIPTAN HYDROBROMIDE
A simple and accurate normal phase liquid chromatographic method was developed for the determination of chiral purity of (R)-3-((1-methylpyrrolidin-2-yl) methyl)-5-(methylsulfonylmethyl)-1H-indole, R-isomer used as key starting raw material in the manufacturing of Elitriptan hydrobromide bulk drug. Chromatographic separation between (R)-3-((1-methylpyrrolidin-2-yl) methyl)-5-(methylsulfonylmethyl)...
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IMPACT OF TRADE AND TRIPS ON AFFORDABILITY OF MEDICINE IN TANZANIA
To meet healthcare demands and costs, Tanzania depends largely on imports and financial aid from foreign countries. Current research analyses the impact of market competition on the cost and availability of medicine in Tanzania. Product approvals granted by Tanzanian drug regulatory authority were analyzed on the basis of exporting countries, molecules and therapeutic categories. The market compet...
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α-GLUCOSIDASE AND α -AMYLASE INHIBITORY ACTIVITIES OF RAPHANUS SATIVUS LINN.
Herbal medicine has been used for many years by different cultures around the world for the treatment of diabetes. There has been an enormous interest in the development of alternative medicines for type 2 diabetes, specifically screening for phytochemicals with the ability to delay or prevent glucose absorption. The goal of the present study is to evaluate the invitro antidiabetic activity of Rap...
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