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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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34.

ANTI-PROLIFERATIVE AND APOPTOSIS INDUCING EFFECT OF NARAVELIA ZEYLANICA L. AGAINST LUNG CANCER CELL LINE A549

Cancer is one of the most dangerous diseases globally, and it appears due to extreme free radical damage, some chemicals, and a lack of physical activity which dispute causes damage to the cellular DNA, protein, and lipids. A number of treatment methods are available, but they cause unwanted side effects. The use of plant-derived products in the treatment of cancer prominently reduces adverse and ...

B. Umarani * and K. Saravanan

PG & Research Department of Zoology, Nehru Memorial College, Puthanampatti, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).5053-58

5053-5058

951

387

48.

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF NOVEL QUINAZOLINONE DERIVATIVES AS ANTI-INFLAMMATORY AGENTS

A series of quinazolinone derivatives were synthesized and screened for anti-inflammatory activity. 5-chloro anthranilic acid undergoes acetylation in the presence of acetic anhydride and anhydrous sodium acetate to give 5-chloro-N-acetyl anthranilic acid as intermediate-I which upon cyclization in the presence of phosphorous pentaoxide, glacial acetic acid, and para aminobenzoic acid to yield 4-[...

R. Patel *, R. Saraswat and S. Pillai

Department of Pharmaceutical Chemistry, Indore Institute of Pharmacy, Indore, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2296-05

2296-2305

949

564

6.

SALVIA HISPANICA (CHIA) SEEDS – A REVIEW ON PHARMACOLOGICAL BENEFITS, NUTRACEUTICAL PROPERTIES, EXTRACTION METHOD AND APPLICATIONS

The plant Salvia hispanica belongs to the family Lamiaceae, a highly valued medicinally important seed, commonly known as chia seeds. About 75% of the fats in chia seeds consist of omega-3 alpha-linolenic acid (ALA), while about 20% consist of omega-6 fatty acid. Omega-3s play an important role in sharpening memory and improving mood. Chia seeds also contain polyunsaturated fatty acids, dietary fi...

V. G. Kanase *, S. M. Dani and P. M. Pandagale

Department of Pharmacology, Oriental College of Pharmacy, Sector 2, Behind Sanpada Railway Station, Sanpada West, Navi Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(6).2263-73

2263-2273

949

469

21.

DEVELOPMENT OF BIOSIMILARS: AN OVERVIEW OF THE REGULATORY FRAMEWORK IN INDIA, USA, EU; MAJOR CHALLENGES AND RELATED CASE STUDIES

A similar biologic product also called biosimilar, follow-on biologic, is highly similar in terms of quality, safety, efficacy with that of the reference product. These are the pharmaceutical products used as the prime treatment options in many chronic diseases and as substitutes for the primary treatment. For development and approval, each nation has adopted its own regulations, and some countrie...

V. L. D. Sai Swetha Penugonda *, Vishnu Priya Cherukuri, Naga Sowjanya Vaka and Ravi Kumar Reddy Juturi

Department of Pharmaceutical Regulatory Affairs, Shri Vishnu College of Pharmacy (Autonomous), Vishnupur, affiliated to Andhra University, Visakhapatnam, Bhimavaram, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6341-52

6341-6352

948

481

17.

ANTITUMORIGENIC EFFECT OF VARIOUS PARTS OF FICUS RACEMOSA IN DALTON LYMPHOMA ASCITES TUMOR INDUCED SWISS ALBINO MICE

Medicinal plants play an important role in the development of potent therapeutic agents. In recent years there has been an increased interest in using of herbal medicines. To assess the antioxidative and antitumorigenic efficacy of methanolic extract of bark, fruits, and leaves of Ficus racemosa in Dalton Lymphoma Ascites tumors transplanted Swiss albino mice. The results showed that the cytotoxic...

A. Poongothai * and S. Annapoorani

Department of Biochemistry, Sacred Heart College (Autonomous), Tirupattur, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1495-03

1495-1503

948

472

61.

IN-VITRO EVALUATION OF PLEIOTROPIC PROPERTIES OF ROSUVASTATIN

Rosuvastatin, a selective and competitive inhibitor of enzyme 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, is marked as a first-choice drug amongst lipid-lowering agents because of its unique pharmacological and pharmacokinetic properties. An additional advantage of rosuvastatin administration is its specific, non-lipid pleiotropic properties, which are considered promising new fields of rese...

B. Pehlivanović *, K. Čaklovica, D. Lagumdžija, N. Ž. Smajić and F. Bečić

Department of Clinical Pharmacy, Faculty of Pharmacy, University of Sarajevo, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia and Herzegovina.

DOI: 10.13040/IJPSR.0975-8232.12(2).1201-06

1201-1206

947

449

51.

SOLID STATE MANIPULATION OF TELMISARTAN VIA MECHANOCHEMICAL ACTIVATION WITH KAOLIN: AN ASSESSMENT OF BIOPHARMACEUTICAL PROPERTIES OF AMORPHOUS PHASE AND ITS PHYSICAL STABILITY

The objective behind this study is to investigate the affinity between a carboxylic model drug telmisartan and kaolin. Telmisartan was comilled in solid state with kaolin in different weight ratios and characterized by Fourier transform infrared spectroscopy, Differential scanning calorimetry, X-ray powder diffractometry, scanning electron microscopy to examine the extent of transformation from cr...

Manami Dhibar, Santanu Chakraborty and Madhusmruti Khandai

Formulation Development Research Unit, Department of Pharmaceutics, Dr. B. C. Roy College of Pharmacy & AHS., Durgapur, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).5030-39

5030-5039

947

460

50.

CYTOTOXICITY OF EXTRACTS FROM THE PHILIPPINE MARINE SPONGES: PARATETILLA SP., STYLISSA SP. AND PETROSIA (STRONGYLOPHORA) NIGRICANS

This paper reports the cytotoxic activities of the hexane, dichloromethane, ethyl acetate, and methanol fractions of the marine sponges: Paratetilla sp., Stylissa sp., and Petrosia (strongylophora) nigricans, collected from the Island waters of Lipata, Surigao del Norte, Philippines, using the enzymatic reduction of a yellow tetrazolium salt, 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl-tetrazolium...

H. Luyao * and M. Uy

Department of Chemistry, Mindanao State University-Iligan Institute of Technology, Iligan City, Philippines.

DOI: 10.13040/IJPSR.0975-8232.12(10).5613-17

5613-5617

947

414

5.

A COMPREHENSIVE REVIEW OF PHARMACOLOGICAL PROPERTIES OF LITSEA POLYANTHA

Litsea, an outsized genus comprising 400 species of evergreen trees or shrubs, distributed chiefly in tropical and subtropical Asia, Australia, and therefore the Pacific Islands, belongs to the Lauraceae. Litsea polyantha is found throughout North, East, and Central India at an altitude of 1,200 m. It is often planted as an ornamental plant. It is mostly grown as an honest source of fodder for the...

Waseem Khan *, Jaya Sharma, Sanjay Singh, Pankaj Sharma and Ritu Sanwal

School of Pharmaceutical Sciences, Apex University, Sector-5, V. T Road, Mansarovar, Jaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.13(9).3425-32

3425-3432

947

264

36.

DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF LAMIVUDINE AND TENOFOVIR DISOPROXIL FUMARATE IN COMBINED DOSAGE FORM USING QUALITY BY DESIGN APPROACH

A new, simple, rapid, accurate, and economical method has been developed for the simultaneous estimation of Lamivudine and Tenofovir Disoproxil Fumarate in formulation by using a quality by design approach. Design expert software was used for QbD analysis. 03 level factorial quadratic design models were used to analyze the response. The model generated was found to be significant. The optimized co...

A. J. Asnani *, S. M. Mohurle and K. Pratyush

Priyadarshini J. L. College of Pharmacy Electronic Zone M. I. D. C., Nagpur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3306-15

3306-3315

946

503