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ANTI-PROLIFERATIVE AND APOPTOSIS INDUCING EFFECT OF NARAVELIA ZEYLANICA L. AGAINST LUNG CANCER CELL LINE A549
Cancer is one of the most dangerous diseases globally, and it appears due to extreme free radical damage, some chemicals, and a lack of physical activity which dispute causes damage to the cellular DNA, protein, and lipids. A number of treatment methods are available, but they cause unwanted side effects. The use of plant-derived products in the treatment of cancer prominently reduces adverse and ...
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SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF NOVEL QUINAZOLINONE DERIVATIVES AS ANTI-INFLAMMATORY AGENTS
A series of quinazolinone derivatives were synthesized and screened for anti-inflammatory activity. 5-chloro anthranilic acid undergoes acetylation in the presence of acetic anhydride and anhydrous sodium acetate to give 5-chloro-N-acetyl anthranilic acid as intermediate-I which upon cyclization in the presence of phosphorous pentaoxide, glacial acetic acid, and para aminobenzoic acid to yield 4-[...
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SALVIA HISPANICA (CHIA) SEEDS – A REVIEW ON PHARMACOLOGICAL BENEFITS, NUTRACEUTICAL PROPERTIES, EXTRACTION METHOD AND APPLICATIONS
The plant Salvia hispanica belongs to the family Lamiaceae, a highly valued medicinally important seed, commonly known as chia seeds. About 75% of the fats in chia seeds consist of omega-3 alpha-linolenic acid (ALA), while about 20% consist of omega-6 fatty acid. Omega-3s play an important role in sharpening memory and improving mood. Chia seeds also contain polyunsaturated fatty acids, dietary fi...
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DEVELOPMENT OF BIOSIMILARS: AN OVERVIEW OF THE REGULATORY FRAMEWORK IN INDIA, USA, EU; MAJOR CHALLENGES AND RELATED CASE STUDIES
A similar biologic product also called biosimilar, follow-on biologic, is highly similar in terms of quality, safety, efficacy with that of the reference product. These are the pharmaceutical products used as the prime treatment options in many chronic diseases and as substitutes for the primary treatment. For development and approval, each nation has adopted its own regulations, and some countrie...
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ANTITUMORIGENIC EFFECT OF VARIOUS PARTS OF FICUS RACEMOSA IN DALTON LYMPHOMA ASCITES TUMOR INDUCED SWISS ALBINO MICE
Medicinal plants play an important role in the development of potent therapeutic agents. In recent years there has been an increased interest in using of herbal medicines. To assess the antioxidative and antitumorigenic efficacy of methanolic extract of bark, fruits, and leaves of Ficus racemosa in Dalton Lymphoma Ascites tumors transplanted Swiss albino mice. The results showed that the cytotoxic...
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IN-VITRO EVALUATION OF PLEIOTROPIC PROPERTIES OF ROSUVASTATIN
Rosuvastatin, a selective and competitive inhibitor of enzyme 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, is marked as a first-choice drug amongst lipid-lowering agents because of its unique pharmacological and pharmacokinetic properties. An additional advantage of rosuvastatin administration is its specific, non-lipid pleiotropic properties, which are considered promising new fields of rese...
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SOLID STATE MANIPULATION OF TELMISARTAN VIA MECHANOCHEMICAL ACTIVATION WITH KAOLIN: AN ASSESSMENT OF BIOPHARMACEUTICAL PROPERTIES OF AMORPHOUS PHASE AND ITS PHYSICAL STABILITY
The objective behind this study is to investigate the affinity between a carboxylic model drug telmisartan and kaolin. Telmisartan was comilled in solid state with kaolin in different weight ratios and characterized by Fourier transform infrared spectroscopy, Differential scanning calorimetry, X-ray powder diffractometry, scanning electron microscopy to examine the extent of transformation from cr...
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CYTOTOXICITY OF EXTRACTS FROM THE PHILIPPINE MARINE SPONGES: PARATETILLA SP., STYLISSA SP. AND PETROSIA (STRONGYLOPHORA) NIGRICANS
This paper reports the cytotoxic activities of the hexane, dichloromethane, ethyl acetate, and methanol fractions of the marine sponges: Paratetilla sp., Stylissa sp., and Petrosia (strongylophora) nigricans, collected from the Island waters of Lipata, Surigao del Norte, Philippines, using the enzymatic reduction of a yellow tetrazolium salt, 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl-tetrazolium...
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A COMPREHENSIVE REVIEW OF PHARMACOLOGICAL PROPERTIES OF LITSEA POLYANTHA
Litsea, an outsized genus comprising 400 species of evergreen trees or shrubs, distributed chiefly in tropical and subtropical Asia, Australia, and therefore the Pacific Islands, belongs to the Lauraceae. Litsea polyantha is found throughout North, East, and Central India at an altitude of 1,200 m. It is often planted as an ornamental plant. It is mostly grown as an honest source of fodder for the...
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DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF LAMIVUDINE AND TENOFOVIR DISOPROXIL FUMARATE IN COMBINED DOSAGE FORM USING QUALITY BY DESIGN APPROACH
A new, simple, rapid, accurate, and economical method has been developed for the simultaneous estimation of Lamivudine and Tenofovir Disoproxil Fumarate in formulation by using a quality by design approach. Design expert software was used for QbD analysis. 03 level factorial quadratic design models were used to analyze the response. The model generated was found to be significant. The optimized co...
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