A CRITICAL ANALYSIS OF ELECTROPORATION IN MEDICAL TECHNOLOGYAbstract
When a high amplitude nanosecond electric field applied to a biological cell it disrupts the equilibrium of the phospholipid bilayer resulting in the permeability of the cell membrane to increase. This results in movement of extracellular material into the cell which otherwise cannot move inside the cell. This phenomenon is known as electroporation. In the initial years of research people concentrated on to find out the process which leads to the above phenomenon, but till now it is not proved theoretically / mathematically the complete theoretical background about the process. In recent years with the help of new fundamental knowledge and the latest experimental electroporation researchers can shift the technologies based on electroporation for clinical validations. In this paper, we have discussed regarding the theories of electroporation and also regarding the usages of electroporation in medical technologies. We have also discussed the challenges to be faced and the research barriers to make this technology on the market.
D. Ghosh, N. Saluja and T. G. Singh *
Chitkara College of Pharmacy, Chitkara University, Rajpura, Patiala, Punjab, India.
12 April 2018
22 November 2018
24 November 2018
01 January 2019