1.
COVID19 outbreak, originated from Wuhan, china is now declared as pandemic by WHO. HCQ has got special attention after various advisories are being issued by health authorities to utilize it for the prophylaxis of SARS COV2. Therefore, drug safety evaluation based on its pharmacokinetic & pharmacodynamics parameters & literature rationale for Evidence Based Medicine is required for its jus...
A. Singh, J. Kumaravel, D. Mahendru, M. Yadav, H. Kumar, A. Prakash and B. Medhi *
Department of Pharmacology, Postgraduate Institute of Medical Education & Research (PGIMER) Chandigarh, India.
DOI: 10.13040/IJPSR.0975-8232.11(8).3535-43
3535-3543
2.
NSAIDs (Non-steroidal anti-inflammatory drugs) show its effect by preventing prostaglandin synthesis, which reasons ulcer complications and mucosal damage all over the gastrointestinal tract. The world’s most accepted drug was aspirin for treatment of pain and inflammation without knowing that it has the ability to inhibit prostaglandin production by inhibiting the cyclooxygenase enzyme for the ...
R. K. Vishwakarma and D. S. Negi *
Department of Chemistry, H. N. B. Garhwal University (A Central University), Srinagar Garhwal, Uttarakhand, India.
DOI: 10.13040/IJPSR.0975-8232.11(8).3544-55
3544-3555
3.
Chronic hepatitis C (CHC) is a big cause of liver-related fibrosis and cirrhosis. The level of fibrosis is usually in the past (established by histology). The prognosis is estimated using fibrosis progression rates (FPRs; the annual probability of progressing across histological stages). However, new non-invasive options are quickly replacing biopsy. As the rates of HCV cirrhosis go on increasing ...
S. D. Labhade *, Y. B. Zambare, S. S. Chitlange, R. B. Saudagar, S. Mahadevan and S. Tiwari
Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, Maharashtra, India.
DOI: 10.13040/IJPSR.0975-8232.11(8).3556-63
3556-3563
4.
Viruses are like hijackers. They invade living, normal cells, and replicate and create other viruses like themselves using those cells. This can destroy, harm, or change the cells and cause sickness. Various viruses in the human body invade other cells, such as the liver, respiratory system, or blood. Viruses are too small germs. Inside a protein matrix, they are made of genetic material inside of...
S. Sivakrishnan * and J. Kavitha
Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu, India.
DOI: 10.13040/IJPSR.0975-8232.11(8).3564-73
3564-3573
5.
Birth defects induced by maternal exposure to exogenous agents during pregnancy are preventable if the agents themselves can be identified and avoided. This might be the causative effect in mechanical fetal diseases and retarded in the development of embryo and fetus. Often, the safety of a drug in the mother’s fetuses and nursing infants cannot be determined until it has been widely used. This ...
A. D. Paul *, V. M. Prathap and A. Chandrakala
Department of Pharmaceutics, SVU College of Pharmaceutical Sciences, SV University, Tirupati, Andhra Pradesh, India.
DOI: 10.13040/IJPSR.0975-8232.11(8).3574-86
3574-3586
