Coronaviruses wrapped with the layers of positive-sense RNA viruses specified by the club-like projections from their surface responsible for a variety of diseases in the animal kingdom. After the two historical episodes of coronaviruses i.e., severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002 and Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012, this time world strike...
Spices, nature's gift to mankind are the reservoir of secondary metabolites – alkaloids, flavonoids, saponins, tannins, glycerides, sulfides, and other oxygen/nitrogen compounds that can effectively treat viral infections, bacterial infections, and respiratory problems. Since ancient days they have been used for its anti-inflammatory, carminative, antioxidant, anti-clotting, anti-microbial, anti...
The important barrier in transdermal drug delivery (TDD) is the Stratum corneum (SC), the outermost layer of the skin, which acts as an excellent protective physiological barrier. To boost the penetration or permeation of drugs through SC, several tactics have been used including passive and active methods of permeation or both in combination. This unwraps the opportunity to broaden the range of d...
Today, Nanotechnology is widely used for leading new dosage forms. Vesicular drug delivery system is expanding as one of advanced nanotechnology. Delivery of drugs using colloidal particulate carriers and liquid crystalline compact niosomal hybrid such as niosome and proniosomes has peculiar advantages over conventional dosage forms. Proniosomes is a dry formulation using suitable carrier coated w...
Curcumin, chemically 1,7-bis (4-hydroxy-3-methoxyphenyl) hepta-1,6-diene-3,5-dione derived from Curcuma longa L. is an active chemical constituent used medicinally worldwide from ancient times. Though Curcumin enjoying the reputation of many pharmacological actions, it has certain setbacks with poor bioavailability. The poor water solubility is said to be the reason for poor bioavailability, rathe...
Background: Zinc (Zn) is the most common trace element in eukaryote cells and the second most abundant trace element in human tissues and secretions after iron. Zinc is required for normal growth and development from in uteri to puberty. There is a lack of evidence on Zn as a potential therapeutic agent to reduce weight and improve metabolic parameters in obese adults. Aim: to evaluate Zn suppleme...
Macro and microelements are integrally linked to hormones, vitamins, amino acids, and enzymes in the human body. They affect the normal course of physiological processes. Some medicinal plants contain substantial contents of micro-and macro-elements, which makes it possible to use them purposefully for the prevention and treatment of various diseases. The target of the research was samples of G. m...
Combretum mucronatum Schumach & Thonn is a scandent shrub whose leaves are widely used by Ghanaians and other West-African herbalists for the treatment of various infectious and non-infectious diseases. It is used to treat wounds, coughs, dysentery, worm infestation, neurological disorders and bacterial infections. Some coughs are as a result of mycobacterial infection. Despite the success gai...
A major genetic suspect for Alzheimer's disease is the pathological conformation assumed by Apolipoprotein E4(Apo E4) through intramolecular interaction. The aim of the current study is to synthesize newer potent Apo E4 inhibitors. In the present study, with specific pharmacophoric features of three Hydrogen bond donors and three hydrophobic spheres, a large library of ligands was constructed for ...
Drynaria quercifolia rhizome (DQR) ethnomedicinal information shows the traditional usage of this rhizome for the treatment of body and joint pain, diarrhoea, typhoid, cholera, and skin diseases. The fresh juice of rhizome is still being consumed as an energy drink by tribes and localities of Tamil Nadu and Kerala. However, no investigations have been carried out to claim the anti-arthritic activi...
