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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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Volume 15 (2024) - Issue 6, June

Review Articles

 
Title
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1.

EVOLUTION OF ANTICONVULSANT DRUGS: BIRD’S EYE VIEW

This review covers the research on the anticonvulsant properties of marketed drugs with their side effects and adverse drug reactions and the importance of medicinal plants and homeopathic medications in the treatment of epilepsy with the mechanism of actions with fewer side effects in comparison to allopathic medications that cause side effects which may be dangerous in some situations so to over...

Sangeeta Bhatt, Amita Joshi Rana *, Mahendra Rana and Shweta Singh

Department of Pharmaceutical Sciences, Sir J. C. Bose Technical Campus, Kumaun University Bhimtal, Nainital, Uttarakhand, India.

DOI: 10.13040/IJPSR.0975-8232.15(6).1546-57

1546-1557

242

256

2.

INITIATIVES AND CHALLENGES IN SCHEDULE Y REGULATION IN INDIA: STILL LONG WAY TO GO

Schedule Y has been established under Drugs and Cosmetic Act 1940 and rule 1945 for the conduction of clinical trials. It is referred to fundamentals and guidelines for import and manufacture of original drugs for trade or for clinical trials. Schedule Y provides guidance for conducting various clinical trials in different fields of clinical research, controlling and regulating any new drug prior ...

Yesh Kumar *, Mukesh Maithani and Raman Yadav

Glenmark Lifesciences Limited, Dahej, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.15(6).1558-71

1558-1571

185

124

3.

MYRICA ESCULENTA: A COMPREHENSIVE REVIEW ON PLANT PROFILE, PHYTOCHEMISTRY, ETHNOBOTANICAL AND PHARMACOLOGICAL USES

Medicinal plants usage has been continued since olden times for treatment of illness and various diseases internationally. They contain substances which have therapeutics activities and further study of these substances has led to discovery of new drugs. In present days, the medicinal plants play a significant role in the development of plant-based medicines. Myrica esculenta is a plant which belo...

Mayble Mary Lyngkhoi * and Arjina Mondal

Department of Pharmacology, School of Pharmaceutical Sciences, University of Sciences and Technology Meghalaya, Ri-Bhoi, Killing Road, Baridua, Meghalaya, India.

DOI: 10.13040/IJPSR.0975-8232.15(6).1572-80

1572-1580

188

124

4.

ANTI-TUBERCULAR DRUGS: A REVIEW ON CURRENT TRENDS AND NOVEL DRUGS

Tuberculosis remains a challenge globally affecting the health of several individuals globally. The emergence of drug resistant tuberculosis has further increased the threat. Despite having several drugs available the peril of the mycobacterium continues to loom. Across the globe several scientists are putting in efforts to come up with newer drugs with novel mechanism of action and belonging to s...

A. A. Ankalikar, A. S. Menasinkai, P. M. Ronad *, Anuradha, Rohan Kurbet and Honur Hussen

Department of Pharm-Chemistry, KLE College of Pharmacy, Vidyanagar, Hubli, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.15(6).1581-90

1581-1590

169

125

5.

β- SITOSTEROL: ANALYTICAL PROFILE AND COMPREHENSIVE REVIEW

Phytosterols, a subclass of steroids, have gained considerable attention in scientific research and nutrition due to their potential health benefits. This article presents an overview of phytosterols, encompassing their sources, chemistry, extraction methods, analytical techniques, and biological activities. Phytosterols, structurally resembling cholesterol, are found abundantly in plants, animals...

Sameer. R. Lode, Aditya R. Wadalkar, Samiksha S. Tammewar and Ujban Md. Hussain Hussain *

Department of Pharmaceutical Sciences, The Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.15(6).1591-01

1591-1601

174

102

6.

SYNTHESIS, ANTIMICROBIAL AND ANTIOXIDANT ACTIVITIES OF SULFUR QUANTUM DOTS: A REVIEW

Day by day it is challenging to prepare a chemical reagent against antimicrobial resistant pathogenic for pharmaceutical and food sector. There are several types of quantum dots are invented among them Sulfur Quantum Dots (SQDs) a new type of luminescent quantum dots which is prepared from unused sublimed sulfur can be replaced for these purposes. SQDs are highly water soluble, low toxicity and ha...

Suman Sarker *, Indira Mondal, Raptan Sonjit Kumar and Susmita Paul

School of Chemistry & Chemical Engineering, Shanxi University, Taiyuan, China.

DOI: 10.13040/IJPSR.0975-8232.15(6).1602-15

1602-1615

77

41

7.

AN OVERVIEW ON TREATMENT OF RHEUMATOID ARTHRITIS

Rheumatoid arthritis (RA) is an autoimmune disease associated with chronic inflammation of the joints. If it is untreated then it leads to destruction of joints, erosion of cartilage and bone and eventually leads to loss of physical function. Since, RA is not complete curable disease, the treatment goals are to reduce the pain and stop/slow further damage. With advancement in the field of molecula...

Drashti R. Mandlik * and Binal S. Patel

Department of Pharmacology, Bhagwan Mahavir College of Pharmacy, Vesu, Surat, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.15(6).1616-26

1616-1626

80

44

8.

HERBAL PLANTS USED IN VARICOSE VEINS

Varicose vein is a clinical class of Chronic Venous Disease also called the varicosites. Varicose veins are enlarged, swollen and twisting veins often appearing blue or dark purple. It is more common in women than men, superficial veins of the leg are under high pressure, hence this disorder is mostly seen in the leg. The pathophysiology includes genetic components, dysfunctional valves, and weak ...

Sunanda Dattatray Malode *, Komal P. Mahajan, Priyanka Suresh Pagar, Sulochana Sonya Gavit and Anjali Kantilal Raut

Department of Pharmacognosy, K. K. Wagh College of Pharmacy, Nashik, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.15(6).1627-38

1627-1638

80

45

9.

AN UPDATE ON THE THERAPEUTIC POTENTIAL OF HEMIDESMUS INDICUS (INDIAN SARSAPARILLA)

Hemidesmus indicus (H. indicus), also known as Indian Sarsaparilla or Anantmul, is a plant with diuretic, demulcent, and diphoretic properties. It treats various illnesses, detoxifies the blood, and reduces Vata, Pitta, and Kaphadoshas. It has been shown in pre-clinical trials to reduce illnesses in everyday clinical practice. In order to effectively promote this herbal medicine, clinical trials a...

Sangita Jogdand *, Raju Shinde and Smruti Besekar

Department of Pharmacology, Jawaharlal Nehru Medical College, Sawangi (Meghe), Wardha, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.15(6).1639-45

1639-1645

85

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10.

RECENT ADVANCEMENTS IN THE TREATMENT OF ONYCHOMYCOSIS: A COMPREHENSIVE REVIEW

The most prevalent condition affecting the nails is onychomycosis. It is a typical nail fungal infection that causes millions of individuals globally. Yeasts, non-dermatophyte moulds, and dermatophytes can all be the cause. It's not only results in physical discomfort but also has a major negative effect on the affected person's quality of life. This infection affects the nails of the toes and fin...

Abhishek Singh, Sapna Pandey * and Priyanka Gupta

College of Pharmacy, Shivalik Campus, Dehradun, Uttarakhand, India.

DOI: 10.13040/IJPSR.0975-8232.15(6).1646-53

1646-1653

80

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11.

A PERSPECTIVE OF TRADITIONAL MEDICINE (TM) IN REDUCING TRANSPLACENTAL GENOTOXICITY CAUSED BY MODERN MEDICINES

The contemporary generation utilizes specific pharmaceuticals to treat ailments, irrespective of their detrimental effects on genetic material. More specifically, the lifestyles of expectant mothers and the medications they come across during pregnancy, such as antiemetic, antacid, antihistamine, analgesic, antibacterial, diuretic, sedative, and other medications, exert a significant influence on ...

Camellia Roy, Suvarna Jayothi Kantipudi and V. Gayathri *

Department of Centre for Toxicology and Developmental Research (CEFTE), SRIHER (DU), Porur, Chennai, Tamil Nadu, India

DOI: 10.13040/IJPSR.0975-8232.15(6).1654-60

1654-1660

89

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12.

A REVIEW ARTICLES ON MUCOADHESIVE BUCCAL FILMS: A PROMISING APPROACH FOR ENHANCED DRUG DELIVERY

Mucoadhesive buccal films have gained significant attention as a promising drug delivery system for various therapeutic applications. This review article provides a comprehensive overview of the recent advancements in mucoadhesive buccal films, focusing on their formulation strategies, mucoadhesive mechanisms and potential applications. The article discusses the various polymers used in the formul...

Abdallah Abdalmalk *, S. Rajarajan, Beny Abin and Vasudeva Rao

Department of Industrial Pharmacy, Faculty of Pharmacy, Karnataka College of Pharmacy, Karnataka, Bangalore, India.

DOI: 10.13040/IJPSR.0975-8232.15(6).1661-72

1661-1672

79

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Research Articles

 
Title
Views
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13.

EFFECT OF CALCIUM PHOSPHATE COMPOSITE WITH DOXYCYCLINE AS A GRAFT FOR BONE DEFECT

The objective was to determine the effect of calcium phosphate composite with doxycycline molecularly included as a graft on bone defect after tooth extraction for slow delivery of drug. Methods: animal were distributed in to four groups: Group 1 (Blood Clot), Group 2 (TCP), Group 3 (TCP/PCL/PLGA), and Group 4 (TCP/PCL/ PLGA/ DOX/CD). An alveolar bone defect was created, and the analysis was condu...

Bruno S. B. Lopes, Larissa C. R. de Souza, Richard A. Fills-Cerchar, Guilherme L. Campos, Soraia Macari, Leonardo A. Lanza, Alfonso Gala-Garcia, Carlos A. Tagliati and Maria E. Cortés *

Department of Restorative Dentistry, Faculty of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

DOI: 10.13040/IJPSR.0975-8232.15(6).1673-81

1673-1681

152

115

14.

IDENTIFICATION OF NOVEL NCP7 INHIBITORS FOR HIV DRUG DISCOVERY USING LIGAND-BASED COMPUTATIONAL APPROACHES

Background: NCp7 is a nucleocapsid protein of HIV-1, a retrovirus causing AIDS in human beings. It is a small protein of 72 amino acids that plays an important role in being a chaperone protein involved in viral development. HIV has shown resistance to drugs engineered to treat its infections. Objectives: In this study, a Structure-Activity Relationship analysis of two distinct derivatives based o...

K. V. Lisina * and Shanmughavel Piramanayagam

DBT-Bioinformatics Centre, Computational Biology Laboratory, Department of Bioinformatics, Bharathiar University, Coimbatore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.15(6).1682-02

1682-1702

141

76

15.

ORAL GLUCOSE TOLERANCE, HEPATOPROTECTIVE AND NEPHROPROTECTIVE EFFECT OF COMBINATION THERAPY OF LINAGLIPTIN AND EMBLICA OFFICINALIS AND ITS AMELIORATING EFFECT ON STREPTOZOTOCIN INDUCED DIABETIC RATS

Background & Objectives: Emblica officinalis Gaertn is a widely used medicinal plant with antidiabetic activity. This study was aimed to improve oral glucose tolerance, hepatoprotective and nephroprotective effect of linagliptin by given combination of aqueous fruit extract of Emblica officinalis on streptozotocin induced diabetic rats. Materials & Methods: Diabetes was produced on Wister ...

Khadiza Khanam, A. H. M. Khurshid Alam, Farjana Sharmin, Ibrahim Hossain, Sarwar Jahan, Aziz Abdur Rahman and Mamunur Rashid *

Departments of Pharmacy, University of Rajshahi, Rajshahi, Bangladesh.

DOI: 10.13040/IJPSR.0975-8232.15(6).1703-10

1703-1710

154

77

16.

ALOE VERA EXTRACT STABILISED NANO SILVER- REDUCED GRAPHENE OXIDE NANO COMPOSITES AS VISIBLE LIGHT PHOTOCATALYST FOR OXIDATIVE DEGRADATIONS OF RANITIDINE HYDROCHLORIDE AND SODIUM DICLOFENAC IN AQUEOUS MEDIUM: A KINETIC STUDY

Nano composites of reduced graphene oxide (rGO) and silver nanoparticles (AgNps) were prepared in this work, adopting green reaction conditions. Aloe vera plant extract was used as the stabilizing agent in the AgNps system and graphite precursor has been chosen for rGO preparation adopting mild hydrothermal and sonication methods. AgNps and AgNp–rGO Nano composites are characterized using UV-VIS...

R. Vijayalakshmi *, J. Santhanalakshmi and J. Sangeetha

Department of Chemistry, Quaid E Millath Government College for Women, Annasalai, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.15(6).1711-18

1711-1718

145

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17.

DEVELOPMENT OF VALIDATED RP-HPLC METHOD FOR ESTIMATION OF CAPECITABINE BY QBD APPROACH

It belongs to the group of medications called as anti-metabolites and is a fluoropyrimidine carbonate with anti-cancer properties. The chemotherapy drug capecitabine is taken orally and is used to treat metastatic colorectal and breast cancers. A review of the literature reveals several analytical techniques have been developed for Capecitabinein single and combined with other drugs. No QbD-assist...

Ram S. Sakhare *, Rakhi M. Marashivane and Akanksha S. Waghmare

Department of Pharmaceutical Quality Assurance, Channabasweshwar Pharmacy College (Degree), Kava Road, Basweshwar Chowk, Latur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.15(6).1719-27

1719-1727

162

93

18.

ANTIDIABETIC AND ANTIOXIDANT PROPERTIES OF IMPORTANT TRADITIONAL MEDICINAL PLANTS FROM NORTHEASTERN INDIA

The antidiabetic and antioxidant efficacy of traditional medicinal plants from North-Eastern India remains largely unexplored. This study seeks to address this gap by examining the properties of 11 such plants. The plant samples were subjected to extraction using four different solvents. Their antidiabetic potential was evaluated through in-vitro α-glucosidase and α-amylase inhibition bioassays,...

K. Kennedy Singh *, S. Sureshkumar Singh and C. Lal Sharma

Department of Forestry, North Eastern Regional Institute of Science and Technology (Deemed to be University), Nirjuli, Itanagar, Arunachal Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.15(6).1728-36

1728-1736

96

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19.

PHARMACEUTICAL POTENTIAL OF FLEXIRUBIN PIGMENT FROM CHRYSEOBACTERIUM

The study was carried out to isolate and characterize pigment producing bacteria from rhizosphere soil. In our study, isolation and characterization of bacteria that produced pigments were performed using serial dilution, spread plating method followed by gram staining and various other biochemical tests (Oxidase, Catalase and IMViC tests). Our study concluded that bacteria isolated from rhizosphe...

Parvathy Prasad

Bioroot Exploration India Pvt Ltd, KNRA -15, Upper Meridian Road, Kuravankonam, Kowdiar, Thiruvananthapuram, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.15(6).1737-44

1737-1744

77

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20.

A NOVEL METHOD AND VALIDATION FOR THE QUANTIFICATION OF SACCHARINE AND ASPARTAME IN THE LOCAL MARKETED PRODUCTS

Artificial sweeteners are non-nutritive sugar substitutes designed to provide sweetness without the calorie content of sugar. Examples like Saccharin, Aspartame, Neotame Acesulfame K and they are used in producing a low- or no-calorie diet to lose weight. In the last few years, they have be used in most of the products. Now a days artificial sweeteners are used because they have no calories and po...

Khagga Bhavya Sri *, Samudrala Saileela and Mogili Sumakanth

Department of Pharmaceutical Analysis, RBVRR Women’s College of Pharmacy, Barkatpura, Hyderabad, India.

DOI: 10.13040/IJPSR.0975-8232.15(6).1745-54

1745-1754

72

34

21.

METHOD DEVELOPMENT AND VALIDATION OF AMOXICILLIN TRIHYDRATE BY HPTLC IN BULK AND PHARMACEUTICAL DOSAGE FORM

Amoxicillin Trihydrate is an extensively used antibiotic, and the accurate determination of its content in bulk and pharmaceutical dosage forms is of greatest importance. This thesis focuses on the development and validation of a High-Performance Thin-Layer Chromatography (HPTLC) method for the analysis of Amoxicillin Trihydrate. The study begins with an inclusive review of the existing analytical...

Kalyan Kumar Yadav, Jyoti Verma and Sanjay Kumar Kushwaha *

Bhavdiya Institute of Pharmaceutical Sciences and Research Sewar, Sohawal, Ayodhy, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.15(6).1755-65

1755-1765

76

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22.

FORMULATION DEVELOPMENT AND CHARACTERIZATION OF ION AND PH DUAL ACTIVATED NASAL IN-SITU GEL CONTAINING LEVODOPA AND CARBIDOPA FOR THE TREATMENT OF PARKINSON’S DISEASE

Levodopa suffers from low oral bioavailability and less than 1% of the drug reaches the brain because of its peripheral degradation. This study aimed to prepare a nasal in-situ gel of levodopa and carbidopa to provide prolonged drug release, improve bioavailability, and increase drug uptake by the brain. Preliminary studies were carried out using different polymers. The concentration of polymer to...

Sai Shivani Morthala *, P. J. Prasuna Sundari, Rajesh Vooturi, Veena Vithalapuram, Meena Sree Bukka, Putchakayala Purnachandar Rao, D. Vara Prasad Reddy and D. Shivaji

Sri Venkateshwara College of Pharmacy, Hitech City Rd, Sri Sai Nagar, Madhapur, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.15(6).1766-76

1766-1776

82

51

23.

AN EVALUATION OF BELIEFS/NOTIONS OFPHARMACY PROFESSIONALS TOWARD PSYCHOPATHS

Psychopathy is associate rising health issue in current times. In recent years, there has been increasing acknowledgement of mental state that plays a very important role in achieving international development goals. Several health conditions will be effectively treated at comparatively low price, however the gap between individuals needing care and people with access to worry stay substantial. Th...

Madhu Bala *, Sumit Takhi, Shweta Sharma and Neelam Sharma

Department of Pharmacology, Himachal Institute of Pharmaceutical Education & Research, Bela, Nadaun, Hamirpur, Himachal Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.15(6).1777-80

1777-1780

84

46

24.

SAFETY AND EFFICACY OF FORMOTEROL/TIOTROPIUM BROMIDE AND FORMOTEROL/GLYCOPYRRONIUM COMBINATION IN COPD WITH GOLD GRADE 3 PATIENTS

An increasing airflow limitation that is not entirely reversible is a hallmark of chronic obstructive pulmonary disease (COPD). In patients with COPD, the present study investigated the effectiveness and safety of formoterol/tiotropium bromide vs formoterol/glycopyrronium in fixed combinations. In conjunction with formoterol, the long-acting anti-muscarinic drug glycopyrrolate has recently receive...

Jameel Ahmad *, Siraj Ahmad, Farida Ahmad, Zuber Ahmad, Diwan Israr Khan and Vibhu Pandey

Department of Pharmacology, Jawaharlal Nehru Medical College and Hospital, AMU, Aligarh, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.15(6).1781-87

1781-1787

86

45

25.

ANTIMICROBIAL RESISTANCE PATTERN IN A TERTIARY CARE HOSPITAL: RETROSPECTIVE STUDY

Introduction: Antibiotics’ efficacy is declining over a period of time because of haphazard use in humans and animals. Empirical use of antibiotics and reduction in the new drug development strategies by pharmaceutical industry can lead to antibiotic resistance crisis in near future. Hence, identifying the common causative organism and their resistance pattern in the geographical region would be...

Hiren N. Hirapara *, Divyesh B. Sondarva, Prakash P. Malam and Anurag K. Pipalava

Department of Pharmacology, GMERS Medical College, Junagadh, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.15(6).1788-95

1788-1795

79

41

26.

SELF-MEDICATION PRACTICES AMONG DENTAL STUDENTS IN A PRIVATE DENTAL COLLEGE IN NORTH INDIA

Background: Self-medication is of particular concern as the trend is increasing now-a-days, especially during the post COVID-19 pandemic. Without adequate knowledge, self-medication may lead to adverse drug reactions, or in extreme cases, may require hospitalization for further management. Methods: A questionnaire-based cross-sectional study was undertaken involving the dental undergraduate studen...

Reena Doomra *, Anjana Goyal, Ankita Bhardwaj and Alishbazainab Khan

Department of Pharmacology, Manav Rachna Dental College, MRIIRS, Faridabad, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.15(6).1796-00

1796-1800

86

42

27.

QUALITATIVE AND QUANTITATIVE DETERMINATION OF TRACE ELEMENTS IN GLINUS OPPOSITIFOLIUS (L) USING ATOMIC ABSORPTION SPECTROSCOPY

Glinus oppositifolius (L) is a medicinal plant as well as edible leafy vegetables that has long been utilized for its therapeutic effects. The goal of this work is to use Atomic Absorption Spectroscopy to determine trace elements in Glinus oppositifolius (L). Acid digestion was used as a flexible method and all elements were determined using Atomic Absorption Spectroscopy. Calibration curves were ...

Tushar Adhikari * and Prerona Saha

Department of Pharmaceutical Chemistry, Guru Nanak Institute of Pharmaceutical Science and Technology, 157/F, Nilgunj Road, Kolkata, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.15(6).1801-04

1801-1804

84

50

28.

ASSESSMENT OF CAESAREAN SECTION TRENDS BY USING ROBSON’S TEN GROUP CLASSIFICATION SYSTEM IN A TERTIARY CARE HOSPITAL IN WEST BENGAL, INDIA: A RETROSPECTIVE ANALYSIS

Introduction: The increasing trends for caesarean section (CS) not only in India but also globally have been a cause of concern. With the aim of comparing and analyzing CS rates worldwide, the WHO suggests Robson’s ten group classification system (RTGCS). Aims and Objectives: To find the groups of women with high CS rate which will help policymakers to target that specific groups of women for th...

Hasibul Hasan Shirazee, Pritilata Show, Animesh Naskar, Suvasmita Saha * and Monimala Murmu

Department of Gynecology & Obstetrics, College of Medicine & JNM Hospital, Kalyani, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.15(6).1805-10

1805-1810

73

37

29.

PRODUCTION OF NUTRABEVERAGE THROUGH FERMENTATION OF POMEGRANATE, STRAWBERRY AND PINEAPPLE JUICES WITH KEFIR GRAINS

The term nutrabeverage was applied to the product of alcoholic fermentation made by using Kefir grains. In the present studies initially, the pH of the pomegranate juice sample was 3.7, 3.5 for strawberry and 3.8 pH for pineapple. The titrable acidity optimum was found in pineapple at 3.37 % while 16% TSS was found in pomegranate. The highest TSS content before fermentation was observed at 160brix...

Swati Chandak *, Vishal Dhundale and Vinayak Manekar

Department of Microbiology, Sinhgad College of Science Ambegaon, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.15(6).1811-18

1811-1818

78

42

30.

ACUTE AND SUBACUTE TOXICITY STUDIES OF LIVAMURTHA, TRADITIONAL FORMULATION

Livamurtha, traditional polyherbal formulation possess hepato-protective, antibacterial, and antihepatotoxic properties used for treating liver disorders. This exploratory study was designed to evaluate the acute and sub acute toxicity effects of traditional formulation in albino mice based on the OECD Guidelines. 10g of formulation ”Livamurtha” was boiled in 500ml of water for 1 hour. The dec...

R. Sri Kamatchi Priya *, S. Subramaniam, Shyama Subramaniam and M. Diwakar

Regenix Superspeciality Laboratories, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.15(6).1819-30

1819-1830

72

41

31.

PHARMACOTHERAPY AND DRUG INTERACTIONS IN PATIENTS WITH CHRONIC KIDNEY DISEASE AT A TERTIARY CARE CENTRE– A CROSS-SECTIONAL STUDY

Background: Chronic kidney disease (CKD) is defined as either kidney damage or a decreased glomerular filtration rate (GFR) of less than 60 mL/min/1.73m2 for 3 or more months. The prevalence of CKD in India is 17.2% and it is substantially higher in hypertension, Diabetes, and vascular disease patients. Polypharmacy potentiates the risk of medication-related problems, such as drug-drug interaction...

R. Yuvarani *, K. R. Mamatha, V. S. Purushotham, K. Mamatha, M. V. Raghav and D. Mohan Prasanth

Department of Pharmacology, Bangalore Medical College and Research Institute, Bengaluru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.15(6).1831-34

1831-1834

82

43

32.

PRODUCTION, CHARACTERIZATION, APPLICATION OF CHITOLOGIOSACCHARIDES HYDROLYSATE WITH PARTIALLY PURIFIED CHITOSANASE ENZYME FROM MARINE ISOLATE BREVIDOMONAS DIMINUTA

Microbial chitosanase has received greater attention for producing chitooligosaccharides. In this study, chitooligosaccharide hydrolysate was developed using the chitosanase enzyme, and its bioactivity was evaluated. Marine muddy samples proved to be a source of isolating novel chitosan-degrading bacteria when compared to the other samples collected. A chitosan-degrading marine bacterium was isola...

P. Vanathi

Department of Microbiology, Bharathidasan Arts and Science College, Ellispettai, Erode, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.15(6).1835-44

1835-1844

86

45

33.

EXPLORING AND INVESTIGATING THE POTENTIAL PHYTOCHEMICALS OF PSIDIUM GUAJAVA L. STEM EXTRACTS

Objective: This study aimed to carry out a phytochemical, pharmacognostic, qualitative, and quantitative evaluation of the medicinal plant Psidium guajava L., also known as guava, a member of the Mytaceae family. Methods: The present study provides pharmacognostic, phytochemical, and quantitative details of Psidium guajava L. Results: Plant-dried stem powder material was subjected to continuous ho...

Shagufta A. Farooqui *, S. S. Patil, Sayyed Javvad Ali and Dhanshri Chelmelwar

School of Pharmacy SRTMUN, Nanded-Waghala, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.15(6).1845-58

1845-1858

60

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34.

IN-VITRO EVALUATION OF ANTIOXIDANT AND HEPATOPROTECTIVE ACTIVITY OF AEGLE MARMELOS, LAWSONIA INNERMIS AND MURRAYA KOENGII

The present study was conducted with an objective to evaluate the in-vitro antioxidant and hepatoprotective activity of three different medicinal plants. Due to the adverse effects of therapeutic agent with better hepatoprotective activity in modern medicine several plants have been screened for the aforesaid activity during last few decades detailed literature survey revealed that leaves of Aegle...

Srikar Barik * and P. K. Panda

Department of Pharmacology, UDPS, Utkal University, Vanivihar, Bhubaneswar, Odisha, India.

DOI: 10.13040/IJPSR.0975-8232.15(6).1859-69

1859-1869

55

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