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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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Volume 12 (2021) - Issue 9, September

Review Articles

 
Title
Views
PDF
Cited
1.

A REVIEW ON MECHANISTIC ASSESSMENT OF HEPATOTOXICITY AND MEDICINAL PLANTS WITH HEPATOPROTECTIVE POTENTIAL

The liver is the most important organ in the body that plays a central role in the detoxification and excretion of many exogenous and endogenous compounds. Due to these functions, hepatic diseases continue to be among the main threats to public health, and that challenges health care professionals. Many liver diseases are chronic, meaning they last for years and may never go away. But even chronic...

Krishn Kumar Agrawal and Yogesh Murti *

Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.12(9).4549-79

4549-4579

376

420

2.

RADIOTHERAPY AGAINST SARS-COV-2: RISK OR BENEFIT

The noble coronavirus SARS-CoV-2 results in a devastating, multisystem disease among which COVID-19 pneumonia creates serious complications and most of COVID-19 related deaths. COVID-19 patients develop a systemic inflammatory response through interleukin (IL) and tumor necrosis factors. In COVID-19 patients, cytokine storm controlling is the key step for treatment because cytokine attacks own bod...

N. P. Neupane, A. Adhikari, S. Alok, A. K. Singh and A. Verma *

Bioorganic and Medicinal Chemistry Research Laboratory, Department of Pharmaceutical Sciences, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj, U. P, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).4580-87

4580-4587

255

121

3.

A REVIEW ON EVIDENCE-BASED CLINICAL RESEARCH IN TRADITIONAL MEDICINE FOR COMBAT COVID-19

Covid-19, caused by Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) is a life-threatening disease that has been declared a global pandemic. Even with the intervention of numerous medical systems to combat Covid-19, an effective remedy is not yet in sight rather than supportive therapies accompanied with anti-viral drugs and vaccines. The usage of these medicines has caused for unexpe...

J. I. D. Diddeniya and P. K. Perera *

Institute of Indigenous Medicine, University of Colombo, Colombo, Sri Lanka.

DOI: 10.13040/IJPSR.0975-8232.12(9).4588-99

4588-4599

577

120

4.

AN UPDATED REVIEW ON THE THERAPEUTIC POTENTIAL OF PRUNUS ARMENIACA

Excessive  drug  therapy,  environmental  pollutants,  hepatic  cancer  and  alcoholic  intoxicants  are  the  main  causes  of  liver  disorders. The hepatic disorders/toxicity can occur by several mechanisms like cytochrome P450 activation, lipid peroxidation, induction of nitric acid synthase, mitochondrial dysfunction, activation of pro-inflammatory mediators and bile acid-indu...

Varsha Raj *, Prevesh Kumar, Munish Mani and Navneet Verma

Department of Pharmacy, I. F. T. M. University, Moradabad, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).4600-15

4600-4615

219

117

5.

LOCAL DRUG DELIVERY IN PERIODONTITIS: AN INNOVATIVE TREATMENT MODALITY

Periodontitis is a destructive inflammatory disease of the periodontium induced by specific microorganisms and requires more specific treatment. The traditional mechanical therapy alone is not sufficient for the treatment of moderate to severe periodontitis because of in accessibility in the deep periodontal pocket and depth of penetration of microorganisms into the periodontal connective tissues....

Raju Anarthe *, Preeti Kale, Amit Mani and Shriram Kendre

Department of Periodontology, Rural Dental College of Pravara Institute of Medical Sciences- DU Ahmednagar Loni , Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).4616-25

4616-4625

222

102

6.

A REVIEW ON DIVERSITY AND ANTIMICROBIAL METABOLITES FROM HALOPHILIC BACTERIA

Microorganisms that live their life in places with high salt concentrations are known as Halophiles. Halophilic bacteria play a majority role in hypersaline environments than other microorganisms. These Halophiles are having intense strategies of adaptation and tolerate them to sustain their survival in the saline extreme, such adaptation in hypersaline environments makes them to give unique atten...

C. Ramprasath, K. M. Sucharitha and G. Abirami *

Department of Biotechnology, School of Life Science, Vels Institute of Science, Technology and Advanced Studies, Pallavaram, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).4626-34

4626-4634

105

45

7.

EXPLORING THE PATH OF NIRYASA (EXUDATES): AN OVERVIEW

Ayurveda (Indian system of medicine) chikitsapaddhati treats the patient with herbal, animal, and mineral drugs. Among the three, plant-based products acquire prime importance because of their wide utility and negligible side effects. Various parts of the plant are used solely or in different formulations. Niryasaor exudate broadly includes all types of secretory products like gum, resins and some...

Daneshwari S. Kanashetti, Lalit Nagar * and Kamal Nayan Dwivedi

Department of Dravyaguna, I. M. S, B. H. U, Varanasi, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).4635-46

4635-4646

99

49

8.

ZEA MAYS LINN AND CORN SILK: A PHYTO-PHARMACOLOGICAL REVIEW AND ITS UTILIZATION IN UNANI MEDICINE

Herbal medicine is the source of primary health care due to its cultural acceptability and better compatibility with the human body and lesser side effects. Resha-e-Makka (Zea mays) is an important medicinal plant in the Unani system of medicine (USM) due to its multiple therapeutic properties. The review has been reviewed, compiled, and analyzed using references from major databases like classica...

M. Siraj, Hamiduddin, M. Naquibuddin and S. Nagori

Department of Ilmul Saidla (Unani Pharmacy), NIUM, Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).4647-54

4647-4654

110

59

9.

A REVIEW ON DIFFERENT PROPERTIES AND TYPES OF A NOVEL PROMISING APPROACH FOR ENHANCING THE BIOAVAILABILITY OF POORLY WATER-SOLUBLE DRUGS

Poor aqueous solubility has been one of the major challenges in modern drug delivery as it hinders the absorption process leading in the decrease of bioavailability. As a consequence of low water solubility of drugs, low oral bioavailability is a growing challenge to the development of new pharmaceutical products. There has been a consistent increase in the number of new pharmacologically active l...

Violina Kalita * and Rupjyoti Kalita

NEF College of Pharmacy, Guwahati Royal School of Pharmacy, Betkuchi, Guwahati, Assam, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).4655-65

4655-4665

110

42

10.

A SYSTEMIC REVIEW ON BIOMEDICAL APPLICATIONS AND SYNTHESIS OF METALLIC NANOPARTICLES

 ...

Santosh S. Bhujbal * and Rakesh M. Pawara

Department of Pharmacognosy, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Sant Tukaram Nagar Pimpri, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).4666-75

4666-4675

112

39

11.

PERCEPTION OF THE TREATMENT VACCINES FOR COVID-19 (CORONAVIRUS DISEASE-2019) – REVIEW ON CURRENT STATUS

A Novel virus, coronavirus 2 (SARS-CoV-2), in 2019 from Wuhan, China which is globally expanded, causing the severe acute respiratory syndrome. Coronavirus is transmitted human to animal or human to human through airborne droplets. Coronavirus causes respiratory infections like pneumonia, cold, sneezing and coughing, while in animals, it causes diarrhoea and upper respiratory diseases. The virus o...

Saritha Surapaneni

Department of Pharmacology, R. R. College of Pharmacy, Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).4676-83

4676-4683

113

52

12.

THE FUTURE OF NON-INVASIVE WAYS TO TREAT CANCER

The non-invasive technique in which a variety of nanoparticles are used to deliver the chemotherapy drug to the location of metastatic cancer has fewer side effects, high bio-availability, and high bio-stability of a drug. The anti-proliferative activity of EGCG is very efficient against a variety of cancer, but the problem is that it can’t withstand the environment of an intestine. One of the n...

Syed Saif Imam

Department of Pharmaceutical Sciences, HIMT College of Pharmacy, 8, Institutional Area, Knowledge Park-1, Greater Noida, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).4684-96

4684-4696

117

61

13.

MICROSPONGES DRUG DELIVERY SYSTEM

Microsponges are novel drug delivery systems made up of cross-linked spongy, polymeric, porous, spherical microspheres particles which vary in size from 5-300 μm. This delivery system as the advantage of producing controlled release formulations of poorly soluble drugs. It increases drug stability, reduces side effects and modifies drug release profiles making it a versatile drug delivery vehicle...

M. Tomar and S. Pahwa *

Lloyd Institute of Management and Technology, 11, Knowledge Park-II, Greater Noida, UP, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).4697-07

4697-4707

98

49

Research Articles

 
Title
Views
PDF
Cited
14.

THE CYTOTOXIC ACTIVITIES OF PHILIPPINE MARINE SPONGES STELODORYX PROCERA TOPSENT 1904 AND RHABDASTRELLA SP. AGAINST COLORECTAL CANCER CELL LINE HCT116

Marine sponges have become a promising source of secondary metabolites with diverse structures and have been shown to have a wide range of biological activities. In search of bioactive compounds, a preliminary cytotoxic assessment of marine sponge extracts was conducted. The cytotoxic activities of the hexane, dichloromethane (DCM), ethyl acetate, and aqueous extracts of the marine sponges, Stelod...

Y. C. Manalundong II * and M. M. Uy

Department of Chemistry, College of Natural Sciences and Mathematics, Mindanao State University, MSU Campus – 9700, Marawi City, Philippines.

DOI: 10.13040/IJPSR.0975-8232.12(9).4708-13

4708-4713

248

131

15.

CHEMOPREVENTIVE EFFICACY OF ZINGERONE ON MASTOCYTE INFLAMMATION, CELL PRO-LIFERATION AND APOPTOSIS AGAINST DMBA-INCITED MAMMARY CARCINOGENESIS IN FEMALE SPRAGUE-DAWLEY RATS

Zingerone is an active phenolic acid and the least pungent component of Zingiber officinale. It is known to exhibit different pharmacological properties which include anti-inflammatory, antioxidant, anticancer and antimicrobial activities. But, so far there has been no information available on the role of zingerone in experimental breast carcinogenesis. The objective of this experiment is to untwi...

Ayyanar Rajagopal, Ravi Sriragavi and Namasivayam Nalini *

Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).4714-29

4714-4729

200

107

16.

BACTERIAL LIPOPOLYSACCHARIDE INDUCES A ‘DOUBLE HIT’ WITH DIFFERENTIAL EFFECTS CENTRALLY AND PERIPHERALLY IN A DIETHYLNITROSAMINE-TREATED WISTAR RAT MODEL OF HEPATIC CANCER

Bio behavioural aspects, immunity, and disease course are interlinked in a majority of conditions, particularly cancer. Peripheral stressors or their products regulate immunity by various ways. When there is added insult in an already compromised immune state such as cancer, as is done here using lipopolysaccharide (LPS), the system is said to be ‘double-hit. Behavioural and brain tissue-associa...

Hariprasad Shetty * and Monika Sadananda

Brain Research Laboratory, Department of Zoology, St. Aloysius College (Autonomous) 2, Mangaluru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).4730-44

4730-4744

203

95

17.

DEVELOPMENT AND EVALUATION OF HERBO SYNTHETICGEL: A NOVEL TREATMENT FOR PSORIASIS

Background: Psoriasis is an immune-mediated inflammatory disease characterized by excessive growth and abnormal differentiation of keratinocytes. Objective: In the present research work, an attempt has been made to formulate and evaluate gel containing cyclosporine, aloe vera and tree tea oil. Methods: The gel was prepared by a conventional method and evaluated for various parameters viz., physica...

Vinay Pandit * , Anurag Kumar, Tarun Kumar Sharma, CPS Verma and Shiv Kumar Kushawaha

Department of Pharmaceutics, Kathog, Distt, Kangra, Himachal Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).4745-52

4745-4752

213

96

18.

FLASH RELEASE ORAL FILM OF CANDESARTAN CILEXETIL FORMULATION AND IN-VITRO EVALUATION

In the present study, to develop a novel flash release fast dissolving oral film of candesartan cilexetil to achieve rapid dissolution and further improve the bioavailability of the drug. Also, to resolve the swallowing problems in pediatrics, geriatric patients by rapid dissolution in saliva and improve the patient compliance. Fast dissolving flash release oral flim of candesartan cilexetil was f...

Chandrasekar G, Abdual Hasan Sathali A *, Umamaheswari D and Prabhu R

Department of Pharmaceutics, College of Pharmacy (COP), Madurai Medical College, Madurai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).4753-63

4753-4763

186

99

19.

EVALUATION OF PHYTOCHEMICAL, ANTIOXIDANT AND ANTIMICROBIAL ACTIVITIES OF CURCUMA LEUCORRHIZA (ZINGIBERACEAE) ROXB. RHIZOME

The aim of the present study was to characterize the petroleum ether, chloroform, and ethanol extracts of rhizomes of Curcuma leucorrhiza Roxb and to evaluate their biological activities such as anti-oxidant, anti-bacterial, and anti-fungal activities. Sequential solvent extraction was performed by Soxhlet apparatus using petroleum ether, chloroform, and ethanol, and respective extracts were named...

Rameshor Singh Atom, Warjeet Singh Laitonjam *, Rakhi Khunjamayum, Shaukat Ali M. Shaikh, Raghumani Singh Ningthoujam and Amit Kunwar

Department of Chemistry, Manipur University, Imphal, Manipur, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).4764-73

4764-4773

99

55

20.

ANTIMICROBIAL ACTION OF MANGROVE PLANT EXTRACTS AGAINST SALMONELLA TYPHI AND CANDIDA PARAPSILOSIS CHARACTERISED BY THEIR ANTIOXIDANT POTENTIALS AND BIOACTIVE COMPOUNDS

Plants present in the mangrove ecosystem are underexplored for their natural bioactive agents, including a neglected scope of inventing newer antimicrobials, to combat global crisis mediated by MDR microorganisms. In this study, we investigated four plants-Excoecaria agallocha, Bruguiera gymnorhiza, Avicennia alba and Aegialitis rotundifolia of the Sundarbans, world’s largest mangrove ecosystem ...

Tamanna Sultana, Arup Kumar Mitra and Satadal Das *

Department of Microbiology, St. Xavier’s College (Autonomous), 30, Mother Teresa Sarani, Kolkata, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).4774-89

4774-4789

96

42

21.

DEVELOPMENT OF HYDROGEL BEAD NANOCOMPOSITE USING TEA DUST FOR THE AQUEOUS BIOMEDICAL WASTE MANAGEMENT

Most of the Bio-medical wastes got dumped in highly eminent aquatic sources. To control this pollution due to biomedical wastes, the current study focused on the development of hydrogel bead nanocomposite incorporated with the adsorbent and nanoparticles along with biopolymer. The formed hydrogel bead nanocomposite acts as an effective adsorbent of infectious microbes, heavy metals and pollution c...

Thiruvengadasamy Rajendran Poorani, Shazia Begum, G. Sandhiyadevi and B. Velmanikandan

Department of Biotechnology, Karpagam Academy of Higher Education, Coimbatore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).4790-98

4790-4798

118

40

22.

A GEL CASTING TOOL FOR FABRICATION OF THREE DIMENSIONAL SANDWICH IN-VITRO CULTURE SYSTEM FOR CYTOCOMPATIBILITY EVALUATION OF HYDROGELS

Two-dimensional (2D) culture systems are indispensably used as in-vitro tools to improve our perception and understanding of cell biology, tissue engineering, tissue morphology, mechanisms of diseases, and drug action. However, the conventional 2D culture systems suffer from limitations such as alterations in cell morphology and lack of interactions between extracellular and cellular environments....

Shiny Velayudhan, Shilpa Ajit, Roopesh R. Pai, Ramesh Babu V, Sabareeswaran A and Anil Kumar PR *

Division of Tissue Culture, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).4799-06

4799-4706

90

39

23.

SYNTHESIS OF SILVER NANOPARTICLES USING LEAVES AND STEM BARK OF PTEROCARPUS INDICUS AND ITS ACTIVITY ON HUMAN BREAST CANCER CELL LINE (MCF-7)

In the present study, synthesis of silver nanoparticles (AgNPs) using leaves and stem bark of Pterocarpus indicus were tested against human breast cancer cell line (MCF-7) separately. The synthesized AgNPs were characterized using UV-visible spectroscopy, X-ray powder diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), Scanning Electron Microscope (SEM) and zeta potential. The synth...

Vithya Dharmaraj * and Joseph Sebastin Raj

P.G and Research Department of Biotechnology, Jamal Mohamed College (Autonomous), Affiliated to Bharathidasan University, Tiruchirappalli, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).4807-16

4807-4816

97

60

24.

DENSITY FUNCTIONAL THEORY STUDY ON IMIDAZOLINONE DERIVATIVES

Theoretical studies on two previously synthesized 3-((2, 4-dinitrophenyl) amino)-5-methyl-2-phenylimidazolidin-4- one (1) and 3-((2,4-dinitrophenyl) amino)-2-phenylimidazolidin-4- one (2) were carried out using the Density Functional Theory method. The geometrical parameters of the molecules in the ground state was optimized at the DFT-B3LYP level of theory and ab initio method using 6-31G (d,p) b...

R. Namitha * and E. Vidya

Department of Chemistry, RSM SNDP Yogam Arts and Science College, Kozhikode, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).4817-23

4817-4823

82

38

25.

TOXIC IMPACT OF λ- CYHALOTHRIN ON DNA AND RNA CONTENTS OF THE FISH CTENOPHARYNGODON IDELLA

The synthetic pyrethroids used in agriculture also absorb rapidly via different routes and slowly accumulate into various vital tissues and cause adverse effects on the health status of animals.  It leads to produce a number of biochemical changes at the level of nucleic acids. The freshwater fish Ctenopharyn godonidella was exposed to sublethal concentrations (1/10th of LC50 value) of λ- cyhalo...

G. Rajeswari * and V. V. Rathnamma

Department of Zoology, SDM Siddhartha Mahila Kalasala, Vijayawada, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).4824-31

4824-4831

102

35

26.

DETERMINATION OF INORGANIC TOXICANTS IN NUTRACEUTICALS BY INDUCTIVELY COUPLED PLASMA MASS SPECTROSCOPY

Moringa oleifera and chywanprash are two main nutraceuticals used worldwide because of their large medicinal application. The quality of these nutraceutical products is in question, especially due to the inorganic contaminants like heavy metals. In the present study, six Moringa herbal powder and five chywanprash samples were collected in India and further analyzed for As, Cd, Hg, and Pb. All samp...

Ashwini Satpute and Astha Pandey *

School of Forensic Science, National Forensic Sciences University, Gandhinagar, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).4832-42

4832-4842

84

45

27.

IDENTIFICATION OF BIOMARKERS OF OXIDATIVE STRESS IN FRESHWATER FISH (CIRRHINUSREBA) AFTER EXPOSURE TO INDUSTRIAL WASTE IN KANPUR

Exposure to heavy metals may modify fish behavior, metabolism, physiology, growth, and reproduction. They are also responsible for introducing genetic and teratogenic effects in fish. Now a day’s in many regions; fish production is decreased due to the occurrence of diseases caused by different pathogens in aquaculture. The increasing level of trace elements is dangerous for fish growth and repr...

Shashwat Katiyar *, Ajay Kumar Gupta, Praveen Katiyar and Kuman Sharma

Institute of Biosciences & Biotechnology, Chhatrapati Shahu Ji Maharaj University, Kanpur, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).4843-50

4843-4850

80

48

28.

DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF MONTELUKAST SODIUM, LEVOCETIRIZINE DIHYDROCHLORIDE AND ACEBROPHYLLINE IN FIXED-DOSE COMBINATION TABLETS

A fixed-dose combination of montelukast sodium, levocetirizine dihydrochloride, and acebrophyl line is used in the treatment of asthma, COPD, allergic rhinitis and other conditions where patients feel difficulty in breathing. The present study was designed to develop and validate a simple, sensitive, precise and accurate isocratic reverse-phase high-performance liquid chromatography (HPLC) method ...

S. Butala and T. Khan *

Department of Pharmaceutical Chemistry and Quality Assurance, SVKM’s Dr. Bhanuben Nanavati College of Pharmacy, Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).4851-57

4851-4857

94

36

29.

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF SOME NOVEL TRIAZOLE DERIVATIVES

Triazole is a diunsaturated heterocyclic compound that contains two nitrogen groups as heteroatoms. In the present study, an attempt was made to synthesize various derivatives of substituted 1, 2, 4-triazol-3-yl) benzene-1-ol and assess their antimicrobial efficiency. The synthesized compounds were subjected to physical characterization and spectral analysis by IR and NMR for structure elucidation...

Khushboo Arora *, Sumeet Prachand, Hemant Khambete and Sanjay Jain

Faculty of Pharmacy, Medicaps University Indore, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).4858-63

4858-4863

94

37

30.

STRUCTURAL AND FUNCTIONAL ABNORMALITIES ASSOCIATED WITH HIGH FRUCTOSE DIET-INDUCED METABOLIC SYNDROME IN WISTAR ALBINO RATS

Purpose of the study: To assess Structural and functional abnormalities associated with High fructose diet-induced Metabolic syndrome in wistar albino rats. Materials and Methods: Metabolic syndrome is induced in adult male Wistar albino rats by feeding a combination of High Fructose Diet (55%) and Fructose enriched water (15%) for 75 days and kept as group 2 or HFrD Group. Normal male Wistar albi...

V. Sreekala, R. Rajesh and Kamal Nayan Dwivedi

Department of Anatomy, World College of Medical Sciences and Research, Jhajjar, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).4864-69

4864-4869

80

43

31.

STABILITY INDICATING METHOD DEVELOPMENT AND VALIDATION OF REVERSE PHASE ULTRA-FAST LIQUID CHROMATOGRAPHY METHOD FOR SIMULTANEOUS ESTIMATION OF SITAGLIPTIN PHOSPHATE AND METFORMIN HCL IN BULK AND TABLET DOSAGE FORM

A RP-UFLC method was developed &validated for simultaneous estimation of Sitagliptin Phosphate and Metformin HCl in bulk and tablet dosage form. Separation was achieved by using Phenomenex Luna C18 (150 × 4.6mm, 5µm) column. The mobile phase comprises MeOH: Phosphate Buffer of pH 7 using Triethylamine in the ratio (60:40v/v). The flow rate was 0.6ml/min at temperature 300C. The instrument us...

Majukar Suryamala Maruti, Palled Mahesh Shivabasappa *, Mahendra Kumar Chouhan, Tirodkar Chaitali Uday, Shailendra Suryawanshi Sanjay and Sunil Satyappa Jalalpure

Department of Pharmaceutical Chemistry, K. L. E College of Pharmacy, Belagavi , Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).4870-76

4870-4876

76

34

32.

PHYTOCHEMICAL SCREENING AND IN-VITRO ANTIUROLITHIATIC ACTIVITY OF PUNICA GRANATUM AQUEOUS LEAF EXTRACT

Pashanabheda is used as antiurolithiatic in Ayurveda. In the present study, Punica granatum is used for screening in-vitro antiurolithiatic potentials. Screening of in-vitro antiurolithiatic potentials of aqueous leaf extract of Punica granatum. The extract was subjected to Preliminary phytochemical analysis. In-vitro anti-urolithiatic activity was screened by nucleation and aggregation assay in w...

Keerthana Arra *, P. Rajeshwari and Sive Prasad Panda

Koneru Lakshmaiah Educational Foundation, Vaddeswaram, Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).4877-82

4877-4882

85

38

33.

STABILITY INDICATING METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF FEXOFENADINE AND MONTELUKAST BY USING RP-UPLC

A simple, reliable, accurate and precise method was developed for the simultaneous estimation of Fexofenadine and Montelukast in pharmaceutical dosage form. The chromatogram was run through Standard HSS C18 (2.1 × 100 mm, 1.8 µm). Mobile phase employed was 0.1% OPA Buffer and Acetonitrile taken in the ratio of 65:35 was pumped through column at a flow rate of 0.2 ml/min. The temperature was main...

Christina Emette Jaldi and Mangamma Kuna *

School of Pharmaceutical Sciences, Jawaharlal Nehru Technological University, Kakinada, East Godavari District, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).4883-04

4883-4904

73

29

34.

IMPACT OF LEVOTHYROXINE SUPPLEMENT ON TRIGLYCERIDES AND VERY LOW-DENSITY LIPOPROTEINS IN HYPOTHYROID PATIENTS

Our aim is to observe the impact of Levothyroxine supplement on Triglycerides and Very- low-density lipoproteins in Hypothyroid patients. This study is to observe the incidence of Dyslipidemia condition (elevated TG’s, VLDL levels) and the impact of levothyroxine supplement on TG's and VLDL in hypothyroidism patients. Our current study is an observational study, which involves observation of hyp...

A. Laxmi Sowjanya, N. Divya, P. Madhu Varma and Kumaraswamy Barla *

Department of Pharmacology and Pharmacy Practice, Sir C. R. Reddy College of Pharmaceutical Sciences, Eluru, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).4905-10

4905-4910

155

62

35.

A NEW VALIDATED RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF ESOMEPRAZOLE IN BULK AND PHARMACEUTICAL DOSAGE FORM

Reverse Phase High-Performance Liquid chromatography is a widely and commonly used analytical method for qualitative and quantitative analysis. A simple, accurate, economical, rapid, and precise RP-HPLC process has been proposed and validated for the determination of esomeprazole in immense bulk and dispensed pharmaceutical drug form. The RP-HPLC separation was achieved on Symmetry ODS RP C18, 5 ...

Nellore Dharani Sai Sreekanth, Nenavath Adilakshmi, Doddi Anusha, Gurram Sowmya and Pogaku Surya Teja

Department of Pharmaceutical Analysis, Ibrahimpatnam, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).4911-19

4911-4919

95

32

36.

DEVELOPMENT AND VALIDATION OF A NEW ISOCRATIC RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF DEXTROMETHORPHAN HYDROBROMIDE, PHENYLEPHRINE HYDROCHLORIDE AND TRIPROLIDINE HYDROCHLORIDE IN THEIR COMBINED LIQUID DOSAGE FORM

A new isocratic HPLC method based on reverse phase separation has been developed for simultaneous estimation of Dextromethorphan hydrobromide (DMP), Triprolidine hydrochloride (TPN), and Phenylephrine hydrochloride (PHE) in their mixed liquid dosage form. The chromatographic separation was accomplished on Agilent TC-C18 (250 x 4.6 mm, 5× m) column with a flow rate of 1 ml/min, UV detection (271 n...

Vivek Kumar Pandey, Gulzar Alam * and Jai Narayan Mishra

Kailash Institute of Pharmacy & Management, GIDA, Gorakhpur, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).4920-26

4920-4926

92

37

37.

PHYTOCHEMICAL ANALYSIS AND ISOLATION OF FLAVONOID COMPOUND FROM METHANOL EXTRACT OF THE LEAVES OF SCURRULA PARASITICA L.

Scurrula parasitica L. is a parasitic plant, traditionally used by the people of Mizoram for the treatment of various diseases, and locally called Vatesawi. The bioassay-guided purification of the methanol extract of the leaves of Scurrula parasitica L. led to the isolation of 2-(3, 4-dihydroxy phenyl)-3,5,7-trihydroxy-4H-Chromen-4-one. Quercetin is a flavonol that belongs to one of the subclasses...

Laldingngheta Jerry *, Lalnundanga 1 and Vabeiryureilai M

Department of Forestry, Mizoram University, Aizawl, Mizoram, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).4927-32

4927-4932

91

45

38.

PHYTOCHEMICAL ANALYSIS AND PHARMACOLOGICAL EVALUATION OF ETHANOL EXTRACT OF FRUITS OF GREWIA TILIAEFOLIA FOR NEPHROPROTECTIVE ACTIVITY

Aim: The present study was undertaken to screen the phytochemicals present in fruits of Grewia tiliaefolia and to evaluate the potential role of these fruits in the amelioration of cisplatin-induced nephrotoxicity in male Albino rats. Materials and methods: Ethanol extract of Fruits of Grewia tiliaefolia was prepared by hot extraction method. The prepared ethanol extract was subjected to prelimina...

Adikay Sreedevi *, Pravallika BV and Kaveripakam Sai Sruthi

Division of Pharmaceutical Chemistry, Institute of Pharmaceutical Technology, Sri Padmavathi Mahila Visvavidyalayam, Tirupati, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).4933-41

4933-4941

94

54

39.

EVALUATION OF ANTI-ARTHRITIC ACTIVITY OF MICROSPONGE FORMULATION IN FREUND’S COMPLETE ADJUVANT-INDUCED ARTHRITIC RAT MODEL

The aim of the present study was to improve the release rate of herbal drugs by microsponges prepared through quasi-emulsion solvent diffusion technique using ethyl cellulose and PVA as carriers. The microsponges were characterized by FTIR, DSC and SEM studies followed by the determination of total drug content and entrapment efficiency. Anti-arthritic activity was evaluated by Freund’s Complete...

Pallavi Shelke * and Pradnya Jagtap

Department of Pharmacology, Savitribai Phule Pune University, Saswad, Pune, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).4942-53

4942-4953

87

97

40.

DEVELOPMENT AND VALIDATION OF STABILITY INDICATING RP-HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF DOLUTEGRAVIR AND RILPIVIRINE BY FORCED DEGRADATION STUDIES

Background: Dolutegravir and Rilpivirine are two antiretroviral drugs that have been approved for the treatment of HIV Infection. An error-free, accurate, precise and valid reverse-phase liquid chromatography method was developed for the quantitation of Dolutegravir and Rilpivirine in its bulk form as well as in combined dosage form by forced degradation studies. Methods: Chromatographic separatio...

M. Niranjan Babu * and R. Chandrasekar

Department of Pharmacognosy, Seven Hills College of Pharmacy, Tirupati, Chittoor, AP. India.

DOI: 10.13040/IJPSR.0975-8232.12(9).4954-63

4954-4963

142

101

41.

AN ASSESSMENT OF ANTI-OXIDANT ACTIVITY OF MARINE ALGAL POLYPHENOLS RETRIEVED FROM SARGASSUM WIGHTII, TURBINARIA ORNATA, GRACILARIA CORTICATA AND GELIDIELLA ACEROSA

Objective: To assess the anti-oxidant activity of different seaweed extract. Methods: Different seaweeds as Sargassum wightii, Turbinaria ornata, Gracilaria corticata and Gelidiella acerosa were collected from Mandapam, Ramanathapuram District, Tamil Nadu, India and assessed for their suitability as anti-oxidant compounds. Seaweeds were cleaned from epiphytes, washed, dried in shade and powdered. ...

M. A. Salunke *, P. S. Wakte and B. S. Wakure

University Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).4964-71

4964-4971

95

71

42.

ANTI-INFLAMMATORY, ANTI-CANDIDAL ACTIVITY AND IN-SILICO PREDICTION OF PHARMACOKINETIC PROPERTIES OF NARDOSTACHYS JATAMANSI

The earlier reports on Nardostachys jatamansi show contain a various class of chemical constituents that have influenced the anti-inflammatory and anti-candidal activities. The present study reports the evaluation of anti-inflammatory and anti-candidal activities of N. jatamansi and also studies pharmacokinetic properties using in-silico model. In ongoing research work, we used individual extracts...

B. B. Rachotimath, M. S. Gavimath, V. K. Uppar, A. I. Basarikatti and B. Padmashali *

Department of Chemistry *, School of Basic Sciences, Rani Channamma University, Belagavi, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).4972-78

4972-4978

80

47

43.

ANTIOXIDANT AND ANTIMICROBIAL POTENTIALS OF THE EXTRACTS OBTAINED FROM THE FIVE MARINE SPONGES COLLECTED OFF THE COASTS OF AGUSAN DEL NORTE, PHILIPPINES: AXINYSSA SP, PLOCAMIONIDA SP, FORCEPIA SP, PACHYMATISMA SP AND PLACOSPONGIA SP

Five marine sponges were collected off Carmen, Agusan del Norte, Philippines and taxonomically identified as Axinyssa sp., Plocamionida sp., Forcepia sp., Pachymatisma sp and Placospongia sp. The “non-polar” (EtOAc-MeOH) and “pola”r (EtOH-H2O) extracts of the marine sponges were prepared and subjected to 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay, a total antioxidant ca...

S. R. S. Murcia and M. M. Uy *

Department of Chemistry, College of Science and Mathematics, Mindanao State University-Iligan Institute of Technology, A. Bonifacio Ave, Iligan City, Philippines.

DOI: 10.13040/IJPSR.0975-8232.12(9).4979-84

4979-4984

96

37

44.

THERAPEUTIC POTENTIAL AND CHARACTERIZATION OF SENNA ALATA: AN ETHANO-MEDICINAL PLANT

Senna alata is an effective novel pharmaceutical medicinal plant. The hot extraction method was used to prepare methanol and ethanol extracts of leaves. The extracts were further evaluated to study Antimicrobial potential, phytochemical analysis, FTIR, and Antioxidant activity. The FTIR analysis showed various functional groups that served as secondary metabolites and responsible for antimicrobial...

Prajakta Y. Pachorkar * and Sunita H. Patil

Department of Microbiology, K. R. T. Arts, B. H. Commerce and A. M. Science College, Gangapur Road, Nashik, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).4985-92

4985-4992

99

45

45.

STATISTICAL ANALYSIS ON EFFECT OF SITAGLIPTIN AND GLIMEPIRIDE ON PANCREATIC BETA-CELLS DURING THE TREATMENT OF TYPE-2 DIABETIC MELLITUS

The study aimed to analyze the treatment of Sitagliptin with Glimepiride to improve pancreatic beta-cells in T2DM patients. Beta cells are a type of cell found in the pancreatic islet and also synthesize, secrete insulin and amylin. Sitagliptin is found to be maintaining the beta-cells function and glycemic control in T2DM patients. Randomly diabetes mellitus type-2 (T2DM) patients’ data is coll...

Praveen Yadav, Bhaskar Joshi and A. Geetha Bhavani *

Department of Chemistry, Noida International University Research Innovation Centre, Noida International University, Gautama Buddha Nagar, Greater Noida, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).4993-98

4993-4998

83

52

46.

IN-VITRO ANTHELMINTIC EVALUATION OF HIBISCUS ROSA-SINESIS (L) AND AZADIRACHTA INDICA (L) LEAVES AGAINST HELMINTH PARASITE OF THE GOAT: A COMPARATIVE STUDY

The comparative study designed to evaluate the anthelmintic potential of the methanolic extracts of Hibiscus rosa-sinesis (L) and Azadirachta indica (L) leaves against  helminth: Haemonchus spp., an abomasal parasite For this study various concentrations (1, 2.5, 5.0, 10.0 mg/ml) of both the extracts were screened. 1 mg/ml concentration of Albendazole (ABZ) was used as a positive control (referen...

K. Jaiswal, S. Mishra and J. Pandey *

Department of Zoology, Babasaheb Bhimrao Ambedkar University, Lucknow, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).4999-04

4999-5004

87

38

47.

SPECTRAL ANALYSIS AND HYPOGLYCEMIC EFFECT OF CRUDE SAPONIN EXTRACTED FROM PHOENIX PUSILLA ROOT

In this present study, the objective was to extract crude saponins from the root of Phoenix pusilla (PP) and to check its inhibitory potential of α- amylase and α- glucosidase enzyme. Saponins were isolated by partitioning between butanol and water. Further, the presence of saponin was confirmed by the foam test. Then the crude saponins were analyzed by UV- spectroscopy in the range of 200-400 n...

S. Vijaya Bharathi and V. Anuradha *

Department of Biochemistry, Mohammed Sathak college of Arts & Science, Shollinganallur, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).5005-09

5005-5009

80

39

48.

PHYTOCHEMICAL EVALUATION AND STANDARDIZATION OF POLYHERBAL ETHYL ACETATE EXTRACT AND ITS GEL-BASED FORMULATION OBTAINED FROM BERRIES AND FLAXSEED (EAPEG-BF)

Berries, fruits, and flaxseed have nowadays have increased in research studies. The berries such as Rubus idaeus (Red raspberry), Vaccinium macrocarpon (cranberry), Vaccinium angustifolium (blueberry) and Fragaria x ananassa Duch. (strawberry) have health beneficial compounds like anthocyanins, ellagitannins, ellagic acids, polyphenolic compounds and whereas in flaxseed the polyunsaturated fatty a...

Tamsheel Fatima Roohi

Department of Pharmacology, Institute of Pharmacy, Pranveer Singh Institute of Technology, Bhauti, Kanpur, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).5010-17

5010-5017

89

42

49.

GC-MS ANALYSIS OF METHANOL EXTRACT OF CLEOME BURMANNI W. & A. (CLEOMACEAE)

Plants are rich sources of chemical compounds of high therapeutic value and screening plants for such bioactive compounds is the order of the day. First and foremost, it appears sensible to probe into the chemical reserves of abundantly available but rarely studied plants. The present study was carried out to determine the presence of phytochemicals in a common roadside weed, Cleome burmanni using...

Lakshmi S. Pillai * and Bindu R. Nair

Department of Botany, NSS College, Pandalam, Pathanamthitta, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).5018-21

5018-5021

86

41

50.

SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME N’-(SUBSTITUTED BENZYLIDENE)-2-(7-BROMO-PHENYLQUINAZOLIN-4-YLOXY) ACETOHYDRAZIDE DERIVATIVES

Quinoline or 1-aza-naphthalene or benzo [b] pyridine is a weak tertiary base. In the study, the synthesis of compounds and their antimicrobial activity which is not done earlier and is quite significant. An attempt has been made for the synthesis of N'-(substituted benzylidene)-2-(7-bromo-2-phenylquinazolin-4-yloxy) acetohydrazide (5-15). The titled compounds were prepared by the reaction of bromo...

Shalini Shah * and Anju Goyal

Department of Pharmaceutical Chemistry, Khyati College of Pharmacy, Ahmedabad, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).5022-29

5022-5029

80

42

51.

SOLID STATE MANIPULATION OF TELMISARTAN VIA MECHANOCHEMICAL ACTIVATION WITH KAOLIN: AN ASSESSMENT OF BIOPHARMACEUTICAL PROPERTIES OF AMORPHOUS PHASE AND ITS PHYSICAL STABILITY

The objective behind this study is to investigate the affinity between a carboxylic model drug telmisartan and kaolin. Telmisartan was comilled in solid state with kaolin in different weight ratios and characterized by Fourier transform infrared spectroscopy, Differential scanning calorimetry, X-ray powder diffractometry, scanning electron microscopy to examine the extent of transformation from cr...

Manami Dhibar, Santanu Chakraborty and Madhusmruti Khandai

Formulation Development Research Unit, Department of Pharmaceutics, Dr. B. C. Roy College of Pharmacy & AHS., Durgapur, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).5030-39

5030-5039

89

33

52.

IN-VITRO CULTURE CHARACTERISTICS OF YOUNG AND OLD RAT MESENCHYMAL STEM CELLS

Mesenchymal stem cells are a small number of undifferentiated cells located in various tissues of the body. They have the ability to self-renew and differentiate into lineages of mesenchymal origin. They serve as most promising candidates for various regenerative medicine and tissue engineering applications. Their use in various clinical applications depend on their proliferative capacity to expan...

G. A. Patil and A. S. Moghe *

Department of Pharmacology, JSS Medical College, JSS Academy of Higher Education and Research (JSS AHER) Mysuru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).5040-50

5040-5050

91

38

53.

EVALUATION OF ANTI-DEPRESSANT ACTIVITY OF ROFLUMILAST IN ALBINO MICE

Depression is a collective term used for the mental condition characterized by loss of interest, inability to concentrate, eat or sleep, reduced energy levels, together with reduced self-esteem. To date, the medicines available are often associated with several adverse conditions and fail to treat comorbidities it entails. Phosphodiesterase (especially its inhibitors) are recently gaining attent...

V. H. Pushpa *, M. K. Jayanthi and Ramith Ramu

Department of Pharmacology, JSS Medical College, JSS Academy of Higher Education and Research (JSS AHER) Mysuru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).5051-56

5051-5056

81

42

54.

SOLUBILITY ENHANCEMENT OF BCS CLASS II DRUGS

One of the major barriers in the development of oral dosage form is poor solubility. Poor water solubility obstructs drug bioavailability and decreases its pharmaceutical development. Many drugs are in the pipeline to enhance solubility to formulate dosage form to be taken by the most preferred route of administration that is the oral route. Etodolac is nonsteroidal anti-inflammatory drug having a...

V. G. Bhamare *, R. R. Joshi and R. D. Amrutkar

Bhupal Nobles’ University 1, Udaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).5057-64

5057-5064

130

87

55.

ANTI-INFLAMMATORY ACTIVITY POTENTIAL OF ARECA CATECHU LEAF EXTRACTS-AN IN-VITRO STUDY

Areca catechu L. (Arecaceae) is a species of palm mainly grown in Asian countries for seed crop. Areca nut leaves are commonly used in traditional systems of medicine against various ailments. There is a need for identifying native natural plant sources to acquire their recognized medicinal properties, which may widen them to use as new therapeutics for various diseases. Phytochemical investigatio...

N. G. D’ Souza, J. Fernandes * and S. D’ Souza

Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, Nitte (Deemed to be University), Paneer, Deralakatte, Mangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).5065-71

5065-5071

87

56

56.

SYNTHESIS, CHARACTERIZATION AND ANTI-MICROBIAL ACTIVITIES OF SOME METAL COMPLEXES WITH SCHIFF BASE DERIVED FROM SUBSTITUTED SALICYLALDEHYDE AND AMINO ACIDS

The development of anti-microbial agents, microorganisms that have acquired resistance to drugs through a variety of mechanisms, have emerged and continue to plague human beings. Since, the use of anti-microbial drugs has selected drug-resistant bacteria, the proper use of currently available anti-microbial drugs and efforts to minimize the transmission and spread of resistant bacteria through app...

Munusamy Jambulingam, Subramaniam Ananda Thangadurai * and Manickam Vijayabaskaran

Department of Pharmaceutical Chemistry, J. K. K. Nattraja College of Pharmacy, Komarapalayam Salem, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).5072-78

5072-5078

88

92

57.

EVALUATION OF ANTI-DIABETIC AND HEPATOPROTECTIVE ACTIVITIES OF AQUEOUS AND ETHANOLIC EXTRACTS OF ANISOMELES MALABARICA ROOTS

Anisomeles species are traditionally used for treating aliments like hysteria, amentia, dyspepsia, epilepsy, anorexia, diarrhoea etc. the present work, we aimed to evaluate the anti-diabetic activity and hepatoprotective activities of aqueous and ethanolic extracts of Anisomeles malabarica roots. Anti-diabetic activity was studied at three dose levels 100, 200, 400 mg/kg of aqueous and ethanolic e...

Palli Subha Rani *, P. Rajeswara Rao

Government Polytechnic for Women, Kakinada, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12 (9). 5079-86

5079-5086

75

41

58.

ISOLATION, CHARACTERIZATION AND PHYTOCHEMICAL EVALUATION OF ACTIVE COMPOUND THYMOL FROM CYCLEA PELTATA LAM

Cyclea peltata (Lam), belonging to the family Menispermaceae, is a common plant in South India. It is mentioned in Ayurvedic classics by Rajapatha and is one of the important drugs used in Ayurveda therapeutics and is used widely in different formulations in medical practice. The quality control of crude herbal drugs and their bio constituents is paramount in justifying their acceptability. The cr...

Sonja Jose * and B. Jayakar

Department of Pharmaceutical Analysis, Vinayaka Mission College of Pharmacy, Ariyalur, Salem, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).5087-92

5087-5092

86

47

59.

POTENTIAL AND ACTUAL DRUG-DRUG INTERACTIONS AMONG PATIENTS WITH CARDIOVASCULAR DISEASE: A COMPREHENSIVE ANALYSIS OF DATA FROM A TERTIARY CARE HOSPITAL IN SOUTH INDIA

Context: Drug-drug interactions (DDIs) are frequently observed in hospitalized cardiac patients and associated with alteration in the effectiveness of cardiovascular therapy. Aim: The study was conducted to identify the incidence and nature of DDIs and their associated risk factors among patients with cardiovascular disease (CVD). Materials and Method: A prospective interventional study was conduc...

Asmita Priyadarshini Khatiwada *, Krishna Undela, S Sunil Kumar and Sunil Shrestha

Department of Pharmaceutical and Health Service Research, Nepal Health Research and Innovation Foundation, Lalitpur, Nepal.

DOI: 10.13040/IJPSR.0975-8232.12(9).5093-01

5093-5101

82

50

60.

ESTIMATION OF PHYTOCHEMICAL CONSTITUENTS IN THREE PLANTS WIDELY USED FOR TRADITIONAL TREATMENT OF ASTHMA IN MYANMAR

The crude drug powder extracts from three plants Datura metel L., (Solanaceae), Leucas cephalotes (Roth.). Spreng, Piper betel L., (Piperaceae) were screened for estimating phytochemical constituents. Phytochemical analysis of the extracts revealed that glycoside; tannin, saponin, carbohydrate and phenolic compounds are present in Piper and Leucas species. Besides glycoside, tannin, saponin, carbo...

Za Khai Tuang

Department of Botany, University of Kalay, Kalay, Sagaing District, Myanmar.

DOI: 10.13040/IJPSR.0975-8232.12(9).5102-09

5102-5109

87

42

61.

VALIDATED RP-HPLC STABILITY-INDICATING METHOD OF ANTICOAGULANT ACTIVE PHARMACEUTICAL INGREDIENT; APIXABAN

A simple and precise stability-indicating reversed-phase (RP-HPLC) method was developed and validated for the determination of Apixaban active pharmaceutical ingredient. The chromatographic condition was carried out on Phenomenex Luna 5 µm C18 100 Å (150 × 4.6 mm) HPLC column with prepared buffer solution 1.0 ml of Orthophosphoric acid mixed with 0.2% of potassium dihydrogen phosphate solution,...

Mitali Manjrawala *, Srinivasarao VN Divvela and Rakesh Kumar

Department of chemistry, Shri Jagdishprasad Jhabarmal Tibrewal University, Jhunjhunu, Churela, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).5110-16

5110-5116

89

38

62.

COMPLETENESS ASSESSMENT OF HANDWRITTEN MEDICAL PRESCRIPTIONS IN SOUTHEAST KINSHASA COMMUNITY PHARMACIES

Medical prescription carefully conceived is essential to provide effective health care to the patient. It is a medicolegal document that should be legible, clear and complete. However, several studies have shown that prescription errors remain common worldwide, particularly in low-income countries the such Democratic Republic of Congo. This study aimed to explore the completeness of medical prescr...

D. K. Mana *, P. M. Kapepula and N. K. Ngombe

Laboratory of Drug Analysis, Faculty of Pharmaceutical Sciences, University of Kinshasa, Kinshasa, Democratic Republic of Congo.

DOI: 10.13040/IJPSR.0975-8232.12(9).5117-24

5117-5124

105

50

63.

ANTI-DIABETIC ACTIVITIES OF ISOLATED COMPOUND BETA-SITOSTEROL FROM THE ETHANOLIC EXTRACT OF STEM OF ANDROGRAPHIS ECHIOIDES

To study the anti-oxidant and anti-diabetic activities of isolated compound beta-sitosterol from the ethanolic extract of stem of Andrographis echioides under the in-vitro model. The isolation was done using column chromatography using gradient elution with different mobile phases. Structural elucidation was carried out on the basis of spectral analysis. Anti-oxidant activity was determined by 2,2...

G. Manigandan * and V. Subramaniyan

PG and Research Department of Biotechnology, J.J. College of Arts and Science, J.J Nagar, Sivapuram Post, Pudukkottai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).5125-33

5125-5133

88

54