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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

A Web of Science - ESCI Indexed Journal
Projected Impact Factor (2019): 1.230 , CiteScore (2017): 0.27

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Volume 11 (2020) - Issue 9, September

Review Articles

 
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1.

CONVALESCENT PLASMA THERAPY: A PROMISING APPROACH IN THE TREATMENT OF COVID-19

At present, the whole world fronting a very challenging situation of the pandemic, severe acute respiratory syndrome due to coronavirus (COVID-19). Today, COVID-19 is spreading rapidly in every part of the world; these pandemic affected billions of people. This virus is found as a new human pathogen. However, currently, there is no hasty therapy available, which will provide fruitful results in th...

D. E. Ahire *, N. V. Sonawane, R. K. Surana, R. K. Jadhav, D. D. Sonawane and A. A. Shah

Department of Pharmaceutics, SSS’s, Divine College of Pharmacy, Satana, Nashik, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4078-86

4078-4086

576

377

2.

POTENTIAL DRUG CANDIDATES FOR TREATMENT OF COVID-19

The late December of 2019 witnessed an outbreak of viral pneumonia of unknown etiology (VPUE) in the Wuhan city of Hubei province, China. Later it was identified as a novel strain of β-genus Coronavirus, which is similar to the Severe Acute Respiratory Syndrome (SARS) virus, which was a global pandemic during 2002-03. This novel coronavirus is rapidly spreading with an R0 of 2 and has an incubati...

B. Kumudhaveni *, S. Kathirvel, S. D. Muthu, A. Jeradsuresh and R. Radha

Department of Pharmacognosy, College of Pharmacy, Madras Medical College, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4087-94

4087-4094

413

197

3.

INHALATION OF ESSENTIAL OILS: COULD BE ADJUVANT THERAPEUTIC STRATEGY FOR COVID-19

The current pandemic of the novel coronavirus (SARS-CoV-2) termed as COVID-19 is the third recorded blowback of an animal coronavirus to a human being in the last twenty years. The pandemic is originated from China and currently impacted more than 205 countries worldwide (as on dated 2nd April 2020). This pandemic is not only affecting human life but also has questioned the worldwide status of hea...

T. Patne, J. Mahore * and P. Tokmurke

Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4095-03

4095-4103

425

171

4.

THE NOVEL CORONA VIRUS (nCoV2) SEEMS TO DEFY ALL LAWS OF VIROLOGY

Amongst the known coronaviruses, many were responsible for causing disease in humans knowingly from the common cold to acute severe respiratory syndrome. The novel coronavirus, nCoV-2 has been implied to cause increasingly severe damage to public health besides demolishing the global economy with a staggering figure of continuous rise in mortality within the afflicted cases in almost every country...

P. V. Dhadse, K. Sethiya *, C. Subhadarsanee and K. Durge

Department of Periodontics, Sharad Pawar Dental College, Datta Meghe Institute of Medical Sciences (Deemed to be University), Sawangi (Meghe), Wardha, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4104-13

4104-4113

325

156

5.

MANAGEMENT AGAINST COVID-19 THROUGH NUTRITIONAL SUPPLEMENTATION TO BUILD ADAPTIVE IMMUNITY – A SYSTEMATIC REVIEW

As humanity is progressing, many new borne infections are borne, and the stability and efficiency of the human body are being tested. Today the World is fighting with a deadly Novel infection named Corona Virus Disease. The aim of this systematic review is to find out the efficacy of Nutritional Interventions against the infections caused in the body due to pathogens. Further, the recommendations ...

L. Sharma

Dietetics and Applied Nutrition, Gurugram, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4114-22

4114-4122

263

150

6.

CHIA SEED IN HEALTH AND DISEASE PREVENTION: PRESENT USAGE AND FUTURE PERSPECTIVES

Salvia hispanica L. Well known as chia is gaining popularity day by day due to its nutritional value. This plant is native to Mexico, belonging to family Labiatae / Laminacea, and it was used as a superfood from ancient times. Chia is valued more due to its oil content as it consists of omega -3-alpha linolenic acid in higher amount along with various types of other nutrients, e.g., proteins, diet...

D. Pal * and K. Raj

Department of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur, Chhattisgarh, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4123-33

4123-4133

112

69

7.

ENDOPHYTIC FUNGI FROM MANGROVES – REVIEW

Mangrove plants are used in medicines, and extracts from mangrove species have proven inhibitory activity against human, animal, and plant pathogens. Endophytic fungi are an important component, are universal, and occur within all know plants, including a broad range of hosts in various ecosystems, and therefore play an important role in the natural environment. Numerous species of mangrove produc...

K. Kuzhalvaymani, L. Elizabethjacquline and T. S. Subha *

PG & Research Department of Botany, Bharathi Women’s College, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4134-43

4134-4143

117

69

8.

EMPAGLIFLOZIN: A REVIEW ON ANALYTICAL AND BIO-ANALYTICAL METHODS

Diabetes mellitus is a metabolic disorder that causes high levels of blood glucose level in that 90% of the diabetic population accounts for type 2 diabetes mellitus it also has secondary complications like Cardiovascular disorder, Renal impairment, and susceptibility to infections. Empagliflozin is a potentially highly selective Sodium-glucose co-transportace-2 (SGLT-2) inhibitor used for the tre...

S. Rahul *, B. P. Kumar and H. R. Avinash

Department of Pharmaceutical Analysis, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, Mandya, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4144-51

4144-4151

100

60

9.

VERSATILITY OF BENZIMIDAZOLE AND ITS DERIVATIVES; AN INSIGHT

Benzimidazole, a fused heterocyclic moiety containing benzene and imidazole, has gained considerable attention in the field of medicinal chemistry due to its wide array of pharmacological activities. Be it as a antifungal, anticancer agent, proton pump inhibitors, anthelmintic, anti-microbial, analgesic, it has become an intrinsic part of the pharmaceutical world. The presence of Nitrogen in its h...

A. Saxena, V. Hegde, S. Mutalikdesai and M. Maste *

Department of Pharmaceutical Chemistry, KLE College of Pharmacy, KLE Academy of Higher Education and Research, Belagavi, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4152-73

4152-4173

106

62

10.

MEDICATED TATTOOS: A RECENT DRUG DELIVERY APPROACH IN MEDICAL SCIENCE

Trandermal drug delivery systems are potential sources of administrating drugs through and have certain advantages as delivering a therapeutically effective amount of drug across a patient's skin. Medicated Tattoos is one of the upcoming approaches in transdermal drug delivery. Researches reveal that humans from the generations have used tattoos for various reasons like symbol of rank, religious/s...

S. Bahadur and P. Kumar *

Doon Valley Institute of Pharmacy and Medicine, Karnal, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4174-79

4174-4179

157

70

11.

A BRIEF REVIEW ON RECENT ADVANCEMENTS AND BIOLOGICAL ACTIVITIES OF ARYL PROPIONIC ACID DERIVATIVES

Arylpropionic acid derivatives are an important class of NSAIDs. Ibuprofen, 2- (4-isobutylphenyl) propionic acid, is known as NSAIDs. Arylpropionic acid derivatives have a broad biological activity, including antibacterial, anticonvulsant and anticancer activity, analgesic, and anti-inflammatory. In addition to the most powerful ingredients used in analgesic and antipyretic fields, such as ibuprof...

P. Kumar *, Sangam and M. I. Ahmad

Department of Pharmaceutical Chemistry, Shri Gopichand College of Pharmacy, Baghpat, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4180-88

4180-4188

123

58

12.

PRESENT SCENARIO OF HEPATOPROTECTIVE POTENTIAL OF MEDICINAL PLANTS: AN UPDATED REVIEW

The liver is the principal site for metabolism and excretion in the body. The human liver metabolizes substances by various biochemical pathways, including oxidation, reduction, hydration, condensation, hydrolysis, conjugation or isomerization. Disorder of any of therefore mentioned process may lead to liver cell injury, what we call as hepatotoxicity, which in turn leads to many diseases. Such di...

P. Saiju *, P. Jain and D. P. Chatterjee

Faculty of Pharmacy, SAGE University, Indore, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4189-00

4189-4200

155

68

13.

EFFICACY AND MECHANISM OF ACTION OF MORINGA OLEIFERA IN DIABETES

Diabetes mellitus (DM) is a globally spreading metabolic disorder with a high incidence rate. About 425 million cases took place in 2017 and expected to rise up to 693 million by 2045. In diabetes, the patient elevation of blood glucose level occurs due to the deformation of insulin receptor action/secretion or both. Long term increases in blood glucose level causes chronic effects such as dysfunc...

Sneha, M. Kaurav and S. Kumar *

Department of Pharmaceutical Sciences, Indira Gandhi University, Meerpur, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4201-13

4201-4213

204

70

14.

GARLIC (ALLIUM SATIVUM): PHARMACEUTICAL USES FOR HUMAN HEALTH

The medicinal properties of Garlic are well known for a long time. Garlic is recommended as a nutritive element in the treatment of various health problems and the prolongation of human life. The present review article on garlic is to explore ancient phytomedicinal uses with modern scientific knowledge. Garlic cloves contain a colorless, odorless, soluble compound called alliin, water, and vascula...

R. N. Singh *, P. Kumar, N. Kumar and D. K. Singh

Department of Zoology, Maharana Pratap P. G. College Jungle Dhusan, Gorakhpur, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4214-28

4214-4228

133

66

15.

BIOELECTRONIC MEDICINES: INNOVATION IN DISEASE TREATMENT

Innovation in technology is required to change the world. Bioelectronic medicine is the consolidation of molecular medicine, neuroscience, engineering, and computing to develop a device to diagnose and treat diseases. The mechanisms of Bioelectronic medicine for neural control of a biological process that underlie disease and the development of devices to modulate these specific neural circuits a...

D. A. Patel * and S. Chaudhary

Arihant School of Pharmacy and BRI, Adalaj, Gandhinagar, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4229-37

4229-4237

124

59

16.

SUSTAINABLE USE OF HIGH ALTITUDE MEDICINAL AND AROMATIC PLANT FOR SOCIO-ECONOMIC DEVELOPMENT IN UTTARAKHAND: A REVIEW

The present paper reveals the socio-economic benefits for the peoples of the Uttarakhand state. The demand for medicinal and aromatic plants of Uttarakhand is quite inflated, and many of these plants grow only in the Himalayan states. The State has diverse agro-geo climate conditions, which is most suitable for Medicinal and aromatic plant cultivation. Uttarakhand is blessed with a variety of soil...

P. Nainwal * and N. Singh

School of Pharmacy, Graphic Era Hill University, Clement Town, Dehradun, Uttarakhand, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4238-43

4238-4243

112

52

17.

A STATE OF THE ART REVIEW ON SELF EMULSIFYING DRUG DELIVERY SYSTEM

Solubility plays a vital role in achieving the therapeutic efficacy of a drug from a dosage form. Advances in molecular screening techniques for identification of potential drug molecules investigated an increased number of new pharmacologically active lipophilic compounds that are poorly water-soluble about 40% of new chemical entities have been discovered as poorly water-soluble. Numbers of tech...

A. Prameelarani, M. Desavathu * and L. S. Reddy

Department of Pharmaceutics, University College of Pharmaceutical Sciences, Acharya Nagarjuna University, Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4244-60

4244-4260

118

55

Research Articles

 
Title
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18.

MOLECULAR DOCKING STUDY REVEALS THE POTENTIAL REPURPOSING OF HISTONE DEACETYLASE INHIBITORS AGAINST COVID-19

The outburst of new coronavirus (COVID-19) infections, firstly appeared in Wuhan in 2019, has massively expanded to the whole world. At the end of March 2020, the rapid spread of the infection happened in about 206 countries around the globe. At the moment, the statistics of WHO on coronavirus pandemic revealed total infected cases of 21,770,000 and more than 77,000 deaths all over the world, with...

M. F. A. Mohamed *, G. E. A. Abuo-Rahma, A. M. Hayallah, M. A. Aziz, A. Nafady and E. Samir

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag University, Sohag, Egypt.

DOI: 10.13040/IJPSR.0975-8232.11(9).4261-70

4261-4270

545

155

19.

C-PHYCOCYANIN OF SPIRULINA PLANTESIS INHIBITS NSP12 REQUIRED FOR REPLICATION OF SARS-COV-2: A NOVEL FINDING IN-SILICO

SARS-CoV-2 or COVID-19 is one of the deadly pandemics faced by the world population, which has infected 7 million and claimed the lives of 0.4 million people. In spite of a few drugs available to control the pandemics, a formal vaccine is the least that the world expects under the current scenario. However, the release of a vaccine is expected to come at the cost of its own time. SARS-CoV-2 replic...

T. K. Raj, R. Ranjithkumar, B. M. Kanthesh and T. S. Gopenath *

Division of Biotechnology & Bioinformatics, School of Life Sciences, JSS Academy of Higher Education & Research, Mysuru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4271-78

4271-4278

440

143

20.

MOLECULAR VERSUS CONVENTIONAL TECHNIQUES FOR THE DETECTION OF STAPHYLOCOCCUS AUREUS, PSEUDOMONAS AERUGINOSA AND CANDIDA ALBICANS IN NON-STERILE PHARMACEUTICAL PREPARATIONS

Notable progress has been made in methods that encourage the use of PCR as a rapid and accurate tool in quality evaluation of pharmaceuticals. In this study, monoplex and multiplex PCR based assays were developed and compared with standard conventional methods for rapid detection of three specified topical indicator pathogens, Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans, in...

R. S. El-Houssieny, M. M. Aboulwafa *, W. F. Elkhatib and N. A. Hassouna

Department of Microbiology and Immunology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.

DOI: 10.13040/IJPSR.0975-8232.11(9).4279-92

4279-4292

357

110

21.

PHYTOCHEMICAL SCREENING AND EVALUATION OF ANALGESIC AND THROMBOLYTIC ACTIVITY OF THE CRUDE METHANOLIC EXTRACT OF CALAMUS ROTANG L. LEAVES (ARECACEAE)

Medicinal plants abound with many phytochemicals that are effective in representing lots of pharmacological activities. The current study aimed at investigating the phytochemical and pharmaco-logical activity of crude methanol extract of Calamus rotang L. (CRME) leaves. The analgesic activity and thrombolytic activity were examined by the acetic acid-induced writhing method, while the clot lysis e...

S. R. Afrin, S. Mitra, B. H. Khanam, M. R. Islam, N. M. Proma and M. K. Hossain *

Department of Pharmacy, University of Chittagong, Chittagong, Bangladesh.

DOI: 10.13040/IJPSR.0975-8232.11(9).4293-99

4293-4299

322

153

22.

THE EFFECT OF KEREHAU LEAF EXTRACT (CALLICARPA LONGIFOLIA LAMK.) ON LIPID RATIOS AND AORTA HISTOPATHOLOGY OF MALE RATS OF WISTAR STRAIN

Ethanol extract of kerehau leaves is known to have anti-inflammatory and antioxidant activities with the potential to prevent atherosclerosis. This study aims to determine the ability of kerehau ethanol extract in reducing the lipid levels, the lipid ratios, and the number of foam cells in the blood vessel walls. This study employed in-vivo and ex-vivo experiments on male rats of Wistar strain ind...

E. Susilawati *, Yeni and W. Aligita

Faculty of Pharmacy, Bhakti Kencana University, Jalan Soekarno Hatta No. 754 Bandung, Indonesia.

DOI: 10.13040/IJPSR.0975-8232.11(9).4300-06

4300-4306

292

131

23.

BIOLOGICALLY SYNTHESIZED SILVER NANOPARTICLES OF CURCUMA CAESIA ROXB. RHIZOME EXTRACT AND EVALUATION OF THEIR ANTIBACTERIAL ACTIVITY AGAINST MDR BACTERIA

Multidrug-resistant (MDR) bacterial infection is severe health concerns in the field of medicine. The researcher used green synthesized silver nanoparticles to overcome from MDR bacterial infection. Present study revealed successful synthesis of nanoparticles from Curcuma caesia aqueous rhizome extract by use of silver metal as a capping agent. Synthesized silver nanoparticles were identified by v...

M. Chaturvedi, A. Sharma, R. Rani, D. Sharma and J. P. Yadav *

Department of Genetics, Maharshi Dayanand University, Rohtak, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4307-15

4307-4315

136

56

24.

IN-SILICO MODELING AND VALIDATION OF L-GLUTAMINASE ENZYME, AN ANTICANCER DRUG USING WEB-BASED COMPUTATIONAL TOOLS

The L-Glutaminase enzyme is a therapeutic agent that can be employed for the treatment of human cancer, specifically lymphocytic leukemia. Microbes are exploited commercially to produce L-Glutaminase on a large scale. The L-Glutaminase is an economic anti-cancer drug and can be easily administered into patients. The L-Glutaminase is also employed in food industries in the processing of fermented f...

P. P. Reddy

Department of Microbiology, Vivekananda Degree and PG College, Karimnagar, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4316-20

4316-4320

121

57

25.

ANTIDYSLIPIDEMIC AND ANTI-OXIDANT ACTIVITIES OF NIGELLA SATIVA SEEDS EXTRACT IN HYPERLIPIDEMIC RATS

This experimental study had approved by animal ethics of Central Drug Research Institute, Lucknow, and had undertaken to evaluate the antidyslipidemic and anti-oxidant activities of Nigella Sativa (N. Sativa), Hindi name Kalonji seeds extract in two models of hyperlipidemia. 1- triton and 2- cholesterol-rich high-fat diet (HFD) induced hyperlipidemia. N. Sativa and Gemfibrogil were macerated with ...

S. Saxena, P. T. Pandey, V. Kumar * and J. K. Saxena

Department of Biochemistry, SRMS Institute of Medical Sciences, Bareilly, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4321-28

4321-4328

94

49

26.

DESIGN AND DEVELOPMENT OF SUPERPOROUS HYDROGEL OF AN ANTIHYPER-TENSIVE DRUG FOR GASTRORETENTIVE DRUG DELIVERY

Superporous hydrogels (SPHs) is originally developed as a novel drug delivery system to retain drugs in the gastric medium by instant swelling on water absorption through open porous structure and maintain their integrity in that harsh environment. Atenolol, an antihypertensive drug with a short half-life, limited bioavailability, unstable nature at basic pH potentiated the need for developing a g...

G. R. Biswas *, S. Shaw, S. B. Majee

Division of Pharmaceutics, NSHM College of Pharmaceutical Technology, NSHM Knowledge Campus, Kolkata-Group of Institutions, Kolkata, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4329-37

4329-4337

123

56

27.

COMMUNITY PHARMACISTS’ PERCEPTION AND EXPERIENCE IN PROVIDING LIFESTYLE ASSISTANCE TO PATIENTS WITH CARDIOVASCULAR DISEASE

Background: Cardiovascular disease (CVD) is the leading cause of death worldwide. Management of behavioral risk factors is recommended for primary and secondary prevention of CVDs. There is evidence that the involvement of community pharmacies in health promotion activities is successful. Objectives: This study was conducted to assess community pharmacists’ perception and current practice in pro...

H. P. Sia, T. M. Khan and A. M. Redzuan *

Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur, Malaysia.

DOI: 10.13040/IJPSR.0975-8232.11(9).4338-48

4338-4348

122

46

28.

A STRATEGY TO TREAT THE BREAST CANCER THROUGH INHIBITING THE OVER EXPRESSION OF PROTEIN ESTROGEN VIA SCHIFF BASE FUSED COUMARIN: AN IN-SILICO BASED SYNTHETIC APPROACH

Coumarin and its analogs have a wide range of attention in the treatment of hormone-dependent breast cancer by blocking the formation of estrogen through the inhibition of estrogen receptor. However, the Schiff bases are an important class of compounds with structural similarities of natural biological substances and also due to their presence of imine (-N=CH-), which have an impact on a biologica...

S. Jubie, T. Prabha *, S. Palanisamy, S. Latha and S. Ayyamperumal

Nandha College of Pharmacy, Erode, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4349-58

4349-4358

126

47

29.

SUSTAINED RELEASE MULTI-PARTICULATES FORMULATION OF STEREO-SELECTIVE MOLECULE OF KETOPROFEN BY FLUID BED PROCESSOR

The aim is to prepare sustained release multi-particulates dosage form of Dexketoprofen trometamol, which is the active isomer of ketoprofen. Utilization of active moiety with minimum drug dose and administration frequency sustained-release multi-particulates dosage form is explored. Sustained release pellets of the dexketoprofen trometamol were developed by the fluidized bed technology, in which ...

B. G. Prajapati * and A. Patel

Department of Pharmaceutics, Shree S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Mehsana, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4359-69

4359-4369

147

52

30.

ANTICHOLINESTERASE ACTIVITY OF PLANT EXTRACTS OF SMILAX ZEYLANICA AND SMILAX CHINA

Alzheimer’s disease is the most common neurodegenerative disease, which initially causes oxidative stresses and leads to neuronal death. It characterized by notable memory loss, cognitive impairment, and personality disorders accompanied by diffuse structural abnormalities in the brain of the aged population. The present work focused on anticholinesterase inhibiting activity Smilax zeylanica and...

A. Yokeshwaran *, V. V. Venkatachalam, B. Sabarisenthil and V. K. Kalaichelvan

Department of Pharmacy, FEAT, Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4370-74

4370-4374

131

43

31.

FORMULATION AND PHYSICAL EVALUATION OF GLUCOCORTICOID LOADED TEA TREE OIL NANOEMULSION: A SUMMARIZED TECHNICAL NOTE

Clobetasol propionate (CP) has anti-inflammatory, immunomodulatory, and anti-proliferative activity. The current work aimed to prepare and evaluate the nanoemulsions of CP loaded tea tree oil (TTO) would be stable nanoemulsion. Clinical use of CP is restricted to some extent due to its poor permeability across the skin. So, to increase its permeation across the skin, microemulsion based formulatio...

M. S. Alam *, M. S. Ansari, R. Saraswat and P. Sharma

School of Pharmacy, OPJS University, Churu, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4375-87

4375-4387

105

51

32.

QSAR STUDIES, SYNTHESIS AND BIOLOGICAL EVALUATION OF PYRAZOLE DERIVATIVES CONTAINING THIOUREA AS TYROSINE KINASE INHIBITORS: AN APPROACH TO DESIGN ANTICANCER AGENTS

A series of pyrazole derivatives designing for potential EGFR kinase inhibitors have been discovered. Some of them exhibited significant EGFR inhibitory activity. Compound 3-(4-Amino-phenyl)-5-(3-nitro-phenyl)-4, 5-dihydro-pyrazole-1-carbothioic acid amide (AP-2) displayed the most potent EGFR inhibitory activity. The QSAR analysis of a set of these compounds tested for growth inhibitory activity ...

A. Singh * and P. K. Singour

Computational & Synthetic Chemistry Division, Department of Pharmaceutical Chemistry, VNS Faculty of Pharmacy, Bhopal, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4388-94

4388-4394

157

44

33.

PHYSICOCHEMICAL STUDY AND DEVELOPMENT OF SOPs OF A POLYHERBAL UNANI FORMULATION: SAFŪF-I MU’ALLIF

In the Unani system of medicine, different dosage forms of the drug are used; out of them powder dosage form is known as Safūf, which is an important dosage form and has been used frequently since long. There are many Unani preparations used in the form of Safūf to treat various diseases. Safūf –I Mu’allif (SM) is a polyherbal Unani formulation that is known to be used as Spermatogenic agen...

A. Alam *, J. I. Siddiqui and M. H. Kazmi

Department of Ilmul Advia (Pharmacology), Central Research Institute of Unani Medicine, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4395-02

4395-4402

112

46

34.

ISOLATION OF CADMIUM DEGRADING MICROORGANISMS FROM ELECTROPLATING, STEEL AND BATTERY INDUSTRY

Increase in industrialization has raised the levels of heavy metal pollution in the country. In order to combat with this problem, many strategies were developed till date, and among them, the use of microorganisms is the most successful technique. The present study was undertaken for isolation, identification, and characterization of heavy metal (Cd) tolerant bacteria from industrial effluents of...

S. Lata, S. Kaur and T. Mishra *

University Institute of Biotechnology, Chandigarh University, Gharuan, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4403-10

4403-4410

224

42

35.

DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR ESTIMATION OF FLUTICASONE PROPIONATE AND MUPIROCIN IN A COMBINED TOPICAL DOSAGE FORM

The objective of the present study was to develop and validate a precise and accurate reversed-phase high-performance liquid chromate-graphy for simultaneous estimation of for Fluticasone Propionate (FUP) and Mupirocin (MUP) in combined topical dosage form as per ICH guidelines. Chromatographic separation was achieved using HPLC Shimadzu, Japan, with column syncronis C18 (250 × 4.6 mm, 5 μm). Th...

A. Khristi * and N. Prajapati

Parul Institute of Pharmacy, Limda, Waghodiya, Vadodara, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4411-19

4411-4419

114

44

36.

EFFECT OF CHROMIUM ON IN-VITRO GROWTH AND ANTIOXIDANT POTENTIAL OF DIANTHUS CARYOPHYLLUS L.

Catalase, guaiacol peroxidase and polyphenol oxidase are antioxidant enzymes that are important in the metabolism of reactive oxygen species and can be induced by environmental stresses including chromium (Cr), heavy metal toxic to living organisms. In-vitro regenerated shoots of carnation (Dianthus caryophyllus L.) were exposed to K2Cr2O7, and the activities of these antioxidant enzymes were anal...

S. Purohit *, S. Gupta and R. Jain

Department of Botany, The IIS University, Jaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4420-25

4420-4425

103

43

37.

STRUCTURE ELUCIDATION OF OXIDATIVE DEGRADATION PRODUCT OF DROSPIRENONE

Stressed degradation study of Drospirenone in H2O2 and characterization of degradants by IR, NMR, LC-MS was done. Stressed degradation study of Drospirenone in H2O2 and characterization of degradants by IR, NMR, and LC-MS was done. To evaluate the stability of Drospirenone under stress conditions, it was subjected to oxidative degradation, according to ICH guideline Q1A (R2). The analysis was carr...

S. V. Sutar *, V. C. Yeligar and S. S. Patil

Ashokrao Mane College of Pharmacy, Peth - Vadgaon, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4426-32

4426-4432

99

41

38.

ETHNOBOTANICAL SURVEY OF MEDICINAL PLANTS USED FOR DISINFECTION OF PREMISES AND SURFACES IN THE FEZ-MEKNES CITIES (CENTRE OF MOROCCO)

The irrational and repetitive use of synthetic chemical disinfectants can contribute to the emergence of resistant strains and represent a risk to health and the environment. The aim of this ethnobotanical survey, a first innovative study, is exploring for plants with disinfecting power. An ethnobotanical study was conducted among herbalists in Fez and Meknes cities located in the center of Morocc...

S. Jaouhar, K. Bekhti *, J. E. Oualidi, J. Bouzid and A. E. Ouali Lalami

Laboratory of Microbial Biotechnology, Faculty of Science and Technology, Sidi Mohammed Ben Abdellah University, Fez, Morocco.

DOI: 10.13040/IJPSR.0975-8232.11(9).4433-41

4433-4441

123

47

39.

EFFECTS OF ALLIUM SATIVUM ON BODY WEIGHT AND BIOCHEMICAL PARAMETERS IN HEALTHY RATS

This case-control study had undertaken to evaluate effect of Allium sativum in normal rats. In this study ethanol extract of Allium sativum had macerated with aqueous gum acacia (2%, w/v) suspension and fed orally (500 mg/kg b w p. o.) to male adult normal rats of charles foster strain for 15 days. Results of this study showing that alcoholic extracts caused no any significant reduction in blood g...

S. Bhatt, K. Malik and V. Kumar *

Department of Biochemistry, Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4442-48

4442-4448

113

46

40.

PHYTO-PHARMACOGNOSTICAL EVALUATION AND HPTLC FINGER-PRINTING PROFILE OF LEAVES OF SAPTAPARNA [ALSTONIA SCHOLARIS (L.) R. BR.]

Objective: We report the phyto-pharmacognostic evaluation and HPTLC finger-printing profile of the methanolic extract of Saptaparṇa [Alstonia scholaris (L.) R. Br.] leaves – unaffected and gall-affected, collected in January 2019. Materials and Methods: Physicochemical parameters and phytochemical screening were done by standard procedures. HPTLC finger-printing profile of the methanolic extra...

M. Das *, R. Bolleddu, A. Banerji and J. Hazra

Department of Chemistry, Central Ayurveda Research Institute for Drug Development, Kolkata, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4449-57

4449-4457

101

52

41.

PHYTOCHEMICAL SCREENING AND EVALUATION OF ANTI-DIARRHEAL POTENTIALITY OF PLUMERIA ALBA LINN. LEAVES

Plumeria alba Linn. belonging to the family Apocynaceae (Dogbane family) is the flowering plant. P. alba is used as a purgative, rubefacient in rheumatism, asthma, piles, gonorrhea, blood disorders and tumors, mentioned in the traditional system of medicine. The present study was carried out to establish the pharmacognostic studies, physicochemical parameters along with a preliminary phytochemical...

S. Kumari *, A. Mazumder and S. Bhattacharya

Noida Institute of Engineering and Technology (Pharmacy Institute), Greater Noida, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4458-62

4458-4462

111

48

42.

DEVELOPMENT AND EVALUATION OF PEPTIDE LOADED MUCOADHESIVE MICROSPHERES: IN AN EFFORT TO IMPROVE NASAL BIOAVAILABILITY OF PEPTIDE

The nasal drug delivery system has been a promising route for delivery of proteins and peptides as it can avoid degradation in the gastrointestinal tract and metabolism by liver enzymes. However, due to the rapid mucociliary clearance, the bioavailability of proteins and peptides is still low. Hence, mucoadhesive microspheres may prolong the residence time of peptide drugs in nasal cavity and impr...

S. Pande * and J. R. Parikh

Department of Pharmaceutics and Pharmaceutical Technology, A. R. College of Pharmacy and G. H. Patel Institute of Pharmacy, Anand, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4463-69

4463-4469

91

45

43.

ANTI-DIABETIC AND ANTI-OBESITY EFFECT OF FUNCTIONALLY ACTIVE PROTEINS OBTAINED FROM SEVEN EDIBLE INSECTS

The bioactive peptides derived from food have increased consideration for their function in averting numerous chronic diseases, comprising, diabetes and obesity. Edible insects are the feasible composition of bioactive peptides owing to their high protein content and viable production. The present study was aimed to evaluate the antidiabetic and anti-obesity effects of seven edible insects’ prot...

P. Matheswaran, L. Raja and S. B. Gani *

PG and Research Department of Zoology, NKR Government Arts College for Women, Namakkal, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4470-78

4470-4478

97

44

44.

SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL EVALUATION OF SOME ARYL PIPERAZINE COMPOUNDS

In this planed research work, aryl piperazine derivatives will be synthesized because aryl piperazine currently the most important constructive block in drug discovery with positive pharmacological evaluation. A series N- (4- (benzo[d]thiazol-2-yl) phenyl)-2-[4-(aryl-substituted) piperazines-1-yl]acetamide, N-(4-(benzo[d]oxazol-2-yl)phenyl)-2-[4-(arylsubstituted)piperazines-1-yl]acetamide and Synt...

D. G. Bari *, K. Saravanan and R. Ahmad

Bhagwant University, Ajmer, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4479-86

4479-4486

101

45

45.

SPECTROPHOTOMETRIC DETERMINATION OF DRUGS & PHARMACEUTICALS USING N-BROMOSUCCINIMIDE AND RHODAMINE-B COUPLE

Simple, sensitive, and accurate spectrophotometry method one each for estimation of five drugs viz., chloroquine phosphate (CHP), granisetron hydrochloride (GRA), rizatriptan benzoate (RIZ), zoledronic acid (ZOL) and zolmitriptan (ZOT),  have been developed. The method depends upon oxidation of each drug by excess N-Bromo succinimide (NS), and subsequent determination of UN reacted NBS by Rhodami...

D. Mallesh and G. Venkateshwarlu *

Department of Chemistry, University College of Science, Osmania University, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4487-94

4487-4494

97

39

46.

RP-HPLC METHOD QUANTITATIVE ESTIMATION OF TAPENTADOL HYDROCHLORIDE AND ITS TABLETS

The objective was to develop and validate an easy, economical, fast, reliable, reproducible, precise and accurate reversed-phase high-performance liquid chromatography (RP-HPLC) method for the estimation of tapentadol hydrochloride (TAP, a mu opioid-receptor agonist, and noradrenaline reuptake inhibitor) in the bulk and pharmaceutical dosage form. The chromatographic separation was achieved by u...

M. Bishnoi, Y. P. Singla, A. Jain * and B. Shrivastava

DBT-Postdoctoral Research Associate, Department of Materials Engineering, Indian Institute of Science, Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4495-00

4495-4500

97

42

47.

IN-VITRO ANTI-INFLAMMATORY ACTIVITY, ACUTE TOXICITY TO ZEBRAFISH EMBRYOS AND NUTRITIONAL ANALYSIS OF BOHADSCHIA VITIENSIS WATER EXTRACT

Anti-inflammatory activity and the toxicity of Bohadschia vitiensis water extract were investigated by in-vitro models to evaluate the consumption of the extract by the local community to reduce arthritic-related pain. Specimens of B. vitiensis were collected from Mannar, Sri Lanka, and the water extract (WE) was prepared by removing visceral organs and incubating diced samples in distilled water,...

J. M. N. J. Jayathilake and K. V. K. Gunathilake *

Department of Zoology, University of Sri Jayewardenepura, Gangodawila, Nugegoda, Sri Lanka.

DOI: 10.13040/IJPSR.0975-8232.11(9).4501-08

4501-4508

100

47

48.

EFFECT OF OLANZAPINE ON HYPERTHERMIA IN SEROTONIN SYNDROME MODEL

The serotonin syndrome is a life-threatening adverse drug reaction caused by a significant increase in the concentration of 5-hydroxytryptamine (serotonin) in the central nervous system. The aim of this study was to establish the effects of olanzapine, an antipsychotic drug, on the hyperthermic response in rat experimental serotonin syndrome. In this study, we used an animal model of the serotonin...

R. Nikolov * and G. Bogdanov

Department of Pharmacology and Toxicology, Faculty of Medicine, Medical University, 2 “Zdrave” Sofia, Bulgaria.

DOI: 10.13040/IJPSR.0975-8232.11(9).4509-12

4509-4512

92

49

49.

SYNTHESIS, SPECTRAL ELUCIDATION, ANTIBACTERIAL, ANTIOXIDANT AND DNA STUDIES OF ONNO TETRADENTATE SCHIFF BASE METAL(II) COMPLEXES DERIVED FROM 2-AMINOPHENOL DERIVATIVES

The new asymmetrical tetradentate (ONNO) Schiff base (L) 4-chloro- 2- ((E)- (4- ((E)-((2-hydroxy-5-nitrophenyl)imino)methyl)benzylidene) amino)phenol was prepared by the condensation of terephthalaldehyde with 2-amino 4-chlorophenol and 2-amino 4-nitrophenol in 1:1:1 molar ratio in methanol. The homo binuclear metal(II) complexes were synthesized in ligand to metal ratio 2:2 from the template meth...

K. Savitha and S. Vedanayaki *

Department of Chemistry, Kandaswami Kandar’s College, Namakkal, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4513-23

4513-4523

99

49

50.

PLANT MEDIATED GREEN SYNTHESIS OF SILVER NANOPARTICLES USING RUMEX OBTUSIFOLIUS LEAF EXTRACT AND THEIR ANTIBACTERIAL ACTIVITY

Rumex obtusifolius, belonging to the Polygonaceae family, commonly known as ‘broad-leaf-dock’ is one of the most important medicinal plants. It is common wayside weeds and uses as an antidote to nettle, depurative, astringent, laxative, and tonic and in the treatment of sores, blisters, jaundice, burns, cancer, and tumors. In this study, we design to synthesize silver nanoparticles from silver...

M. C. Purohit, M. Singh *, G. Kumar and N. Singh

Department of Chemistry, B. G. R. Campus Pauri (H.N.B. Garhwal University (A Central University), Srinagar, Garhwal, Uttarakhand, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4524-29

4524-4529

97

46

51.

DEVELOPMENT OF RP-HPLC METHOD FOR THE ESTIMATION OF ACOTIAMIDE HYDROCHLORIDE HYDRATE USING AQbD APPROACH

The current studies details QbD enable the development of a simple, rapid, and cost-effective reverse phase high performance liquid chromatographic method for estimation of Acotiamide hydrochloride hydrate. The simple analytical RP-HPLC method was developed using Box-Behnken Design (BBD). In the present work, three independent factors were used, such as org phase (A), aqueous phase (B), and flow ...

S. S. Gawande, A. T. Hemke *, K. R. Gupta and M. J. Umekar

Department of Pharmaceutical Chemistry, Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4530-39

4530-4539

104

50

52.

PHYTONUTRIENTS AND ANTIMICROBIAL ASSAY OF CAT’S TAIL

Herbal medicine plays an important role in rural areas, and various locally produced drugs are still being used as household remedies for different ailments. Acalypha hispida (Euphorbiaceae) is a plant popularly used in pharmaceutical used and as a commercial product. Hence, the need to explore the potential of this plant, especially in the area of traditional medicine and pharmaceutical industrie...

D. Saikia * and B. Parasar

Department of Biotechnology, Kaliabor College, Kuwaritol, Assam, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4540-49

4540-4549

99

43

53.

IN-VIVO AND STABILITY STUDIES OF DRY POWDER INSUFFLATION CONTAINING TERBUTALINE SULPHATE AND ITRACONAZOLE NANOPARTICLES FOR THE TREATMENT OF ASTHMA

The present research was envisaged on the development of dry powder to treat asthma. Terbutaline sulphate (a bronchodilator) and Itraconazole (an antifungal) were used in the present study for bronchodilation and allergy to Aspergillus fumigatus (fungi) using lactose and trehalose as excipients. Dry powder insufflations were prepared by physical mixing (milling) and spray drying, out of which spra...

V. Penabaka, B. Kumar * and N. B. L. Prasad

Department of Pharmaceutics, Ratnam Institute of Pharmacy, Pidathapolur, Muthukur, SPSR Nellore, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4550-57

4550-4557

93

38

54.

BIOSYNTHESIS, CHARACTERIZATION AND BIOLOGICAL STUDIES OF SILVER NANOPARTICLES USING METHANOLIC EXTRACT OF BULB OF ZEPHYRANTHES CITRINA

In the present study, an eco-friendly, cost-efficient, rapid and simple approach was applied to the synthesis of silver nanoparticles by using a methanolic extract of bulb of Zephyranthes citrina. The metal salt was reduced to ions by metabolites present in bulb extracts. The plant extracts acts both as a reducing agent as well as a capping agent. The synthesized silver nanoparticles were characte...

J. Prakash and S. Vedanayaki *

Department of Chemistry, Kandaswami Kandar’s College, Namakkal, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4558-66

4558-4566

86

45

55.

A VALIDATED LCMS METHOD FOR THE ANALYSIS OF ISOPROTERENOL – A β ADRENORECEPTOR AGONIST IN SPIKED HUMAN PLASMA

A simple, sensitive, and rapid Liquid Chromatography-Mass Spectroscopy method was developed and validated for the quantification of Isoproterenol in human plasma using Dobutamine as an internal standard. The method utilized simple liquid-liquid extraction using a mixture of diethyl ether and dichloromethane for the sample preparation involved prior to LCMS analysis. The analytes were chromatograph...

V. S. S. Gaddala *, R. S. R. Dachuru and E. D. Tella

Department of Chemistry, SRR & CVR Government Degree College (A), Vijayawada, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4567-74

4567-4574

103

51

56.

EXPLORATION OF THE UNIQUE FUNGAL ASSOCIATION AND PROTEIN PROFILE OF BODA FROM BASTAR, CHHATTISGARH, INDIA

Bastar is endowed with a unique blend of traditional knowledge and rich floral diversity. The region is known as the island of Shorea robusta, which is a key source for white and black truffle called Boda. It is also known as the black gold of the sal forest. It sets underground with the onset of early monsoon and is an edible mushroom with high protein, vitamin, and fiber with the low calorific v...

B. Acharya *, D. Pandey and S. Nema

School of Studies in Biotechnology, Bastar Vishwavidyalaya, Dharampura, Jagdalpur, Chhattisgarh, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4575-84

4575-4584

92

44

57.

DEVELOPMENT AND EVALUATION OF TRANSDERMAL DRUG DELIVERY OF SALBUTAMOL SULPHATE VIA ETHOSOMES

Asthma is a chronic disease; there is a need for a drug delivery system that maintains adequate therapeutic concentrations for a longer duration of action to improve better clinical efficacy. Salbutamol sulphate (SS) is a widely prescribed drug to treat asthma though it has short plasma half-life and undergoes extensive first-pass metabolism. Thus, it necessitates frequent administration by oral r...

S. K. M. Lokamatha * and M. P. Ahmed

Department of Pharmaceutics, V. L. College of Pharmacy, Raichur, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4585-97

4585-4597

98

45

58.

IDENTIFICATION OF BIOACTIVE COMPOUNDS FROM RHIZOPHORA MUCRONATA METHANOLIC LEAF EXTRACT BY GC-MS ANALYSIS

Herbal medicines play an important role in cancer prevention. Mangroves have been used worldwide due to the presence of various bioactive metabolites in it. The specific medicinal properties of Rhizophora mucronata have been an interest in preventing breast cancer. Mangroves Rhizophora mucronata belongs to family Rhizophoraceae. The leaf extract reveals various roles in folk remedies to treat vari...

X. A. Mary *, M. S. Ali, V. Anuradha and M. Moorthi

Post Graduate & Research Department of Biotechnology, Mohamed Sathak College of Arts & Science, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4598-02

4598-4602

90

42

59.

HYDROPHILIC AND HYDROPHOBIC MATRIX SYSTEM ENGINEERED DEVELOPMENT OF EXTENDED-RELEASE TABLETS OF OXYBUTYNIN CHLORIDE

The present aim study is the formulation development and evaluation of extended-release matrix tablets of oxybutynin chloride by using hydrophilic and hydrophobic matrix systems. The pilot-scale batches of nine formulations were prepared using Eudragit RSPO, Eudragit RLPO, Carbopol 971NF, ethylcellulose individually, and in the combination of above polymer and Avicel PH102 by adopting direct compr...

P. S. Gangane *, S. V. Pusala, D. K. Mahapatra and N. M. Mahajan

Department of Pharmaceutics, Dadasaheb Balpande College of Pharmacy, Nagpur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4603-11

4603-4611

144

48

60.

EFFECT OF ABIOTIC STRESSES ON THE MARKER CONTENT AND THE ACTIVITY OF CENTELLA ASIATICA

Centella asiatica (CA; family Apiaceae) is extensively used in traditional medicine. A regular supply of this plant is required by the herbal drug industry. Hence, the cultivation of this plant is required. The emphasis of the available cultivation practices is on biomass yield. The activity of the plant, however, depends on the amount of bioactive constituents. The production of these secondary m...

Hurmat, P. Singh, G. Bansal and R. Shri *

Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4612-21

4612-4621

100

43

61.

DEVELOPMENT AND VALIDATION OF A CHROMATOGRAPHIC ASSAY METHOD FOR THE DETERMINATION OF LULICONAZOLE IN CREAMS

A simple and rapid reverse-phase high-performance liquid chromatographic technique was developed and validated for the determination of Luliconazole in the presence of its excipients. Chromatographic elution was performed on a binary gradient HPLC equipped with PDA detector using a Luna-5µ C8(2) 100 Å column (250 × 4.6 mm, 5 µm) with orthophosphoric acid (0.1%) and methanol (20:80% w/v) as mob...

S. Gummadi * and M. Kommoju

Department of Pharmaceutical Analysis, GITAM Institute of Pharmacy, GITAM (Deemed to be University), Visakhapatnam, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4622-28

4622-4628

122

43

62.

UTILITY AND EFFECTIVENESS OF GENEXPERT OVER CONVENTIONAL METHODS FOR DIAGNOSIS OF PULMONARY TUBERCULOSIS

Background: Tuberculosis (TB) is a global health burden and can cause potential infection in any system of the body. Pulmonary tuberculosis (PTB) is most common presentation, but the diagnosis of TB remains elusive because of none of biochemical or serological test is invalid. During the development of END TB strategy, the gene expert (CBNAAT) test was first endorsed by WHO. Materials and Methods:...

V. Gaur, A. K. Singh *, A. Kumar and A. K. Mishra

Department of Microbiology, Baba Raghav Das Medical College, Gorakhpur, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4629-36

4629-4636

110

40

63.

PREFORMULATION, FORMULATION DEVELOPMENT AND DRUG RELEASE STUDIES OF DIPYRIDAMOLE FLOATING MICROBALLOONS

For the drugs possessing stomach and upper intestine as the absorption window, it has become high practical importance to improve their gastric residence time. The in vitro performance of the drug delivery being highly variable is ascertaining as gastric emptying is one of the complex mechanisms. Intense researches are being carried out for the development of multiparticulate systems, which are of...

S. R. Krishna *, A. Ramu and S. Vidyadhara

Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Acharya Nagarjuna University, Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4637-47

4637-4647

109

42

64.

A COMPARATIVE STUDY ON PROXIMATE AND MINERAL COMPOSITION OF UNPROCESSED AND PROCESSED UNDERUTILIZED JERUSALEM ARTICHOKE TUBER FLOUR

Jerusalem artichoke is one of the underutilized tuber crops distributed worldwide in temperate areas. It is considered healthy and functional food due to its chemical composition as it contains proteins, mono or poly-unsaturated fatty acids, dietary fibers, vitamins, and minerals. In this present research work, the effect of processing on the proximate and mineral composition of Jerusalem artichok...

D. Gupta * and N. Chaturvedi

Department of Food Science and Nutrition, Banasthali Vidyapith, Tonk, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4648-54

4648-4654

92

42

65.

DEVELOPMENT, CHARACTERIZATION AND OPTIMIZATION OF KUTKI PHOSPHOLIPID COMPLEX USING CENTRAL COMPOSITE DESIGN AND RESPONSE SURFACE METHODOLOGY

Kutki (Picrorrhiza kurroa) is a medicinal herb with remarkable pharmacological properties. However, poor solubility of the active principles limits its medicinal value. This study sought to prepare kutki phospholipid complex in phospholipids such as phosphatidyl choline in order to improve its solubility and permeability. Kutki phospholipid complex (phytosome) was prepared by solvent evaporation m...

P. P. Udapurkar * and O. G. Bhusnure

Channabasweshwar Pharmacy College, Latur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4655-66

4655-4666

87

38

66.

DEVELOPMENT, OPTIMISATION, AND CHARACTERISATION OF SNEDDS OF ANTI-LIPASE INHIBITOR

Background: Self-Nanoemulsifying Drug Delivery System (SNEDDS) has been employed extensively by the formulation of scientists to tackle the low solubility issues of various drugs and lift the bioavailability profile. But the potential of SNEDDS is not limited to augment the dissolution profile only. Objective: The objective of the study was to develop, optimization, and characterization of SNEDDS ...

A. Vyas *, A. Diwan and R. Sharma

School of Pharmaceutical Sciences, Apeejay Stya University, Gurgaon, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4667-75

4667-4675

88

46

67.

FORMULATION AND EVALUATION OF BILAYER FLOATING TABLETS OF ATORVASTATIN AND CAPTOPRIL

The aim of the present research work was to develop a bilayer floating dosage form of immediate-release Atorvastatin (ATR) and sustained release Captopril (CPT) in matrix form for the treatment of hyperlipidaemia and hypertension to reduce multiple dosing frequencies and enhance patient compliance. ATR belongs to the BCS Class II category having poor aqueous solubility, which was enhanced by using...

K. Hari *, C. Bhavani, P. Rajeswari, S. Rajeswari and G. Vasavi

Department of Pharmaceutical Technology, Maharajah’s College of Pharmacy, Vizianagaram, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4676-90

4676-4690

121

50

68.

DEVELOPMENT AND CHARACTERIZATION OF CARBOXYMETHYLCELLULOSE BASED EMULGEL FOR DRY EYE SYNDROME

Dry Eye Syndrome is a common disorder of the normal tear film that results from one of the following: decreased tear production, excessive tear evaporation, an abnormality in the production of mucus or lipids normally found in the tear layer. Carboxymethylcellulose (CMC) is a highly viscous derivative of cellulose that is used as an eye lubricant. CMC moistens the eye to prevent or relieve dry eye...

M. K. Singh *, H. P. Singh, A. Verma and B. Kumar

Department of Pharmacy, Bhupal Nobels University, Udaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.12(9).4691-99

4691-4699

103

52

69.

MOLECULAR DOCKING STUDY OF ACYCLOVIR AND ITS DERIVATIVES AS POTENT INHIBITORS IN NOVEL COVID-19

Novel coronavirus (nCovid-19) is a recent emerging, dangerous pathogen that has shaken the whole world. Present therapeutic strategies to deals with this infectious disease are only supportive. The discovery of a new drug within a short period of time is a great task. Structure predictions of several proteins associated with SARS-CoV-2, the virus that causes COVID-19, was made possible by Genomics...

B. Arunkumar, A. Fernandez *, S. P. Laila and A. S. Nair

Department of Chemistry, College of Engineering Trivandrum, Thiruvananthapuram, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.11(9).4700-05

4700-4705

89

45

70.

ASSOCIATION BETWEEN HYPERURICEMIA, SERUM IRON LEVEL AND POSSIBILITY OF GOUT AMONG SAUDI PATIENTS: A RETROSPECTIVE STUDY

The present study has been undertaken to evaluate the association between serum uric acid levels as a marker of iron overload in Saudi people. A retrospective cohort study was carried out at King Fahad Medical City in the Riyadh-central region of the Kingdom of Saudi Arabia for four months from 1st November 2018 to the end of February 2019 on the random sample of 117 medical files for Saudi patien...

S. A. T. Alenezi, H. B. Khaled *, M. A. Almansour, Z. A. Asiri, Z. H. Alshehry and V. R. Chidrawar

Department of Basic Health Science, Faculty of Pharmacy, Northern Border University, Rafha, The Kingdom of Saudi Arabia.

DOI: 10.13040/IJPSR.0975-8232.11(9).4706-11

4706-4711

80

58