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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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Volume 13 (2022) - Issue 12, December

Review Articles

 
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1.

THE POTENTIAL APPLICATIONS OF PLANT-BASED ANTI-CANCER COMPOUNDS AND THEIR CHEMICAL DERIVATIVES

Cancer has evolved as a detrimental disorder alongside cardiovascular diseases. Plant-derived natural products have been the most successful source of potential anti-cancer drugs and for the isolation and characterization of novel compounds. Till now, only about 10% of the world’s biodiversity has been assessed for biological activity and numerous useful natural lead compounds are expected to be...

A. Shirolkar, S. Chougule, A. Ranade, A. Pawase, S. Gaidhani and S. Pawar *

Department of Pharmacology, National Research Institute of Basic Ayurvedic Sciences (NRIBAS), Kothrud, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(12).4794-04

4794-4804

263

150

2.

ADVANCEMENTS AND FUTURE PERSPECTIVES OF 1, 2, 3 TRIAZOLE SCAFFOLD AS PROMISING ANTIVIRAL AGENT IN DRUG DISCOVERY

Severe viral infections like Covid-19 are emerging now a day and are the common causes of human illness and death. Presently, we have a limited availability of antiviral chemotherapeutic agents to prevent and treat these infections, so it is the need of an hour to develop potential antiviral drugs against various harmful and fatal viral infections. A large quantity of research has been performed o...

Pavan Kumar D. Chopade * and Anwar Rafique Shaikh

M. C. E. Society's Allana College of Pharmacy, Azam Campus, Camp, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(12).4805-18

4805-4818

95

72

3.

CRITICAL INSIGHT INTO THE GLOBAL EPIDEMIOLOGY OF VIRAL HEPATITIS ALONG WITH METHODS OF PREVENTION

Even though viral hepatitis is a major public health concern around the world. It now has the attention and financial support of global health decision-makers. Every year, over 1.4 million individuals die due to viral hepatitis-related cirrhosis and liver cancer, with the majority of the population being unaware of their illness. This demographic has numerous challenges, including a profound ignor...

Kiranjeet Kaur and Puneet Sudan *

Chandigarh College of Pharmacy, Chandigarh Group of Colleges, Landran, Mohali-Punjab, Chandigarh, India.

DOI: 10.13040/IJPSR.0975-8232.13(12).4819-29

4819-4829

74

55

4.

A CONCISE REVIEW ON NOVEL APPROACH FOR CHALLENGING PHARMACEUTICALS THROUGH SELF – MICRO EMULSIFYING DRUG DELIVERY SYSTEM (SMEDDS)

SMEDDS are formulated to improve the oral bioavailability of lipophilic drugs. It is an isotropic mixture of compounds like oil, surfactant, co-surfactant, and drug having the unique ability to form fine o/w micro-emulsion by agitation and diluted with GI fluid. Its liquid formulation technique enhanced the absorption and bioavailability of poorly water-soluble drugs but also had a few drawbacks l...

Renu Tushir *, Bharti Gupta, Rahul Sharma and Ajesh Chauhan

Hindu College of Pharmacy, Sonipat, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.13(12).4830-47

4830-4847

96

48

5.

PHARMACEUTICAL POTENTIAL OF A RESOURCEFUL NITROGEN-CONTAINING HETEROCYCLE: PYRAZOLINE-A REVIEW

Heterocyclic chemistry has grown very rapidly, particularly in evaluating synthetic methods and investigating synthesized materials' bioactive properties. Heterocycle compounds are important in many facets of life's pharmacological activities. In their structure, many biologically active compounds such as amino acids, vitamins, hormones, nucleic acids, alkaloids, dyes, and drugs (natural and synth...

Alka Pradhan * and Pratibha Dwivedi

Department Chemistry, Government M. V. M. College, Bhopal, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(12).4848-56

4848-4856

80

47

6.

VALIDATED SPECTROSCOPIC AND CHROMATOGRAPHIC TECHNIQUES FOR QUALITY CONTROL ANALYSIS OF APIGENIN IN HERBAL MEDICINES

The herbal medicines have been largely used since form several thousands of years in all developing and developed countries in the primary health care of community and society. Flavonoids are the class of polyphenolic secondary metabolites, which are mainly found in plants. Apigenin is a flavonoid which shows several pharmacological activities and used effectively for the management and treatment ...

Shweta B. Chougule, Arati B. Jivaje, V. S. Mannur and Shailendra S. Suryawanshi *

Department of Pharmaceutical Chemistry, KLE College of Pharmacy Belagavi, KLE Academy of Higher Education and Research, Belagavi, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.13(12).4857-64

4857-4864

44

28

7.

PLANT MOLECULAR PHARMING: THE FUTURE OF PHARMACEUTICAL BIOTECHNOLOGY

Plants are the natural sources of a vast diversity of molecules, exploited for the benefit of human health. They are the factories synthesizing proteins, carbohydrates, secondary metabolites, and biopolymers. Further, converting these molecules into antioxidants, pharmaceuticals, food, and biofuels is a major industrial process. Plants are becoming significant sources for producing pharmaceuticall...

A. Venkata Sai Sanat and K. V. Chaitanya *

Department of Microbiology and Food Science Technology, GITAM Institute of Technology, GITAM University, Visakhapatnam, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(12).4865-70

4865-4870

46

43

8.

A REVIEW OF ANALYTICAL METHODS FOR ESTIMATION OF LEVOCETIRIZINE AND MONTELUKAST SODIUM IN COMBINED PHARMACEUTICAL DOSAGE FORMS

Beginning from simple analytical methods to the recent development of advanced hyphenated techniques stages, various analytical methods have been designed for the multicomponent analysis of drugs. Simultaneous estimation of drugs in the combined dosage form is vital in the pharmaceutical analysis since it is cost-effective and time-saving. Levocetirizine, the R-enantiomer of Cetirizine, is a perip...

Y. D. Bhutia, N. R. Bhuyan, B. Shrestha and V. R. Baraily *

Department of Pharmaceutical Analysis, Himalayan Pharmacy Institute, Majhitar, East Sikkim, India.

DOI: 10.13040/IJPSR.0975-8232.13(12).4871-84

4871-4884

41

26

9.

THE PATHOLOGICAL ASPECTS OF ERECTILE DYSFUNCTION: A TABOO OF SEXUAL HEALTH

Normally, there are two major sexual grievances in men; Erectile dysfunction or impotence and premature ejaculation. Premature ejaculation (PE) is a condition where the orgasm or the emission of semen occurs sooner during sexual intercourse. Erectile dysfunction (ED) is a sexual dysfunction mainly characterized by the inability to either develop an erection or maintain an erection of the penis dur...

Pallab Kalita *, Gaurav Kumar Bhargav, Sudarshana Borah, Deepak Kumar, Aditya Borah and Quri Kiron Hazarika

School of Pharmaceutical Sciences, University of Science and Technology, Baridua, Meghalaya, India.

DOI: 10.13040/IJPSR.0975-8232.13(12).4885-89

4885-4889

46

30

10.

EPIDEMIOLOGY, MUTATIONS AND IMPACT OF NEW OMICRON VARIANT (B.1.1.529): A REAL GLOBAL THREAT OF COVID-19 PANDEMIC

The recent emergence of the Omicron variant (B.1.1.529) of SARS‐CoV‐2 has added alarm to the eternal flame of the global COVID‐19 pandemic. Omicron was first identified in Botswana in November 2021. The omicron is thought to be at least three times more infectious than the previous variants. Omicron can cause diseases varying from asymptomatic, mild, and severe infection and people have died...

Amresh Kumar Singh * and Indra P. Adhikari

Department of Microbiology, B. R. D. Medical College Gorakhpur, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(12).4890-00

4890-4900

41

23

11.

COMPREHENSIVE STUDY OF VANDA ROXBURGHII: TRADITIONAL USES, PHYTOCHEMISTRY, AND PHARMACOLOGICAL SIGNIFICANCE

In order to discover new treatments for a wide range of ailments, ethnopharmacological research has investigated different leads from plants. In nature, the Orchidaceae family's Vanda roxburghii is found in Bangladesh and India. As a remedy for dyspepsia, bronchitis, and inflammations, as well as for rheumatoid arthritis and bronchitis, various portions of the plant are employed. A number of the p...

Nagendra Bhuwane, Ragni Mishra, Sanjay Nagdev *, Shashi Alok, Pradeep Golani, Devendra Sigh Lodhi and Gaurav Mude

Department of Pharmacy, Gyan Ganga Institute of Technology and Sciences, Jabalpur, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(12).4901-08

4901-4908

59

35

Research Articles

 
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12.

CYTOTOXICITY EVALUATION OF MORINGA OLEIFERA (M. OLEIFERA) LAM. FLOWERS ON HUMAN LIVER CANCER CELL LINE AND A. SALINA (BRINE SHRIMP) MODELS

Moringa oleifera Lam is a fast-growing deciduous tree widely cultivated in tropical and sub-tropical regions. All parts of the plant have widely acclaimed nutrition and health-promoting values, but little has been done regarding the toxicity. This study evaluated the safety of different extracts from Moringa flowers using brine shrimp and cell line models. The effect of different concentrations (0...

Sandisiwe Maposa, Gloria Aderonke Otunola * and Anthony Jide Afolayan

Medicinal Plants and Economic Development (MPED) Research Centre, Department of Botany, University of Fort Hare, Alice 5700, South Africa.

DOI: 10.13040/IJPSR.0975-8232.13(12).4909-17

4909-4917

101

62

13.

DIVALENT METAL COMPLEX OF COUMARIN: SYNTHESIS & CYTOTOXIC EVALUATION

Introduction: Coumarins are secondary metabolites widely spread in nature. Due to their broad pharmacological activities, many natural and synthetic coumarins and more complex related derivatives are of interest. The coumarin is extremely variable in structure due to the various types of substitutions in their basic structure, influencing their biological activity. Metal complexes of coumarins obt...

Akshata S. Menasinakai, Pradeep Kumar M. Ronad * and Pratibha M. Huded

Department of Pharmaceutical Chemistry, KLE College of Pharmacy, Vidyanagar, Hubballi, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.13 (12). 4918-27

4918-4927

82

73

14.

HEPATOPROTECTIVE ACTIVITY OF RUNGIA PARVIFLORA AGAINST THIOACETAMIDE INDUCED HEPATOTOXICITY IN WISTAR RATS

Rungia parviflora belongs to the family Acanthaceae (Linn.). The dried and powdered leaves were extracted with ethanol in Soxhlet’s apparatus for 12 hrs. The extract was subjected to toxicity studies at the doses of 5, 50, 300, and 2000 mg/kg under the observation of 24 hrs. An acute toxicity study of ethanolic extract was found to be toxic (1/2 of rats died) at a dose of 2000 mg/kg, orally. Hen...

Santosh Kirtane, Vijendra Fulzele *, Vaibhav Uplanchiwar and Sachin Hiradeve

School of Pharmacy, GH Raisoni University, Dhoda Borgaon, Tah. Saunsar, Chhindawara , Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(12).4928-33

4928-4933

82

57

15.

NICKEL OXIDE NANOPARTICLES SYNTHESIS BY CHEMICAL REDUCTION TECHNIQUE AND IT’S APPLICATION AS ANTIMICROBIAL AND DYE DEGRADING AGENT

Nanoparticles are fascinating materials that find many applications in basic and applied research. The chemical reduction technique is one of the easiest methods for synthesizing Nickel Oxide Nanoparticles (NiO NPs) in low-temperature ranges. Nickel Nitrate Hexahydrate (Ni(NO3)2.6H2O), Ascorbic acid, NaOH, and NaBH4 were applied as starting reagents to synthesize NiO NPs. Noble metal oxide nanopar...

Jayaram Mari Selvi, Mariappan Murugalakshmi * and Mariappan Gnanaprakash

Department of Chemistry, The Standard Fireworks Rajaratnam College for Women (Autonomous), Sivakasi, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.13(12).4934-41

4934-4941

74

51

16.

HISTOPATHOLOGICAL PROTOCOL TO FIND OUT THE MODE OF ACTION OF FUNGUS BEAUVERIA BASSIANA (BALSAMO) PREPARATION ON MIDGUT OF FOURTH IN STAR LARVAE OF ANOPHELES STEPHENSI (L.)

The effect of many plant extracts and microbial biopesticides on insects' different developmental stages and physiology have been widely studied from time to time, but the effect of microbial biopesticides on the mosquito tissues, especially mid gut tissues, is very few. Since the malaria vector is one of the most important inclusions in human health and mosquito-borne diseases represent a great h...

Bharati Veerwal, Arti Prasad and Anjana Intodia *

Department of Zoology, Government Meera Girls’ College, Udaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.13(12).4942-51

4942-4951

75

56

17.

CUTANEOUS WOUND HEALING BY VERNONIA ARBOREA EXTRACTS IN ADULT ZEBRAFISH MODEL

Cutaneous wound healing starts with an acute inflammatory phase marked by secretion of pro-inflammatory mediators that enhance infiltration of leukocytes with a peak in the first 24 to 48 h. This resolves to enable the continuation of other phases in series, namely, the proliferative, re-epithelialization, vascularisation, and tissue remodelling phases. The study uses a mechanical device, for the ...

Lalitha Vaidyanathan * and Lokeswari T. Sivaswamy

Department of Biomedical Sciences, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.13(12).4952-62

4952-4962

43

31

18.

A NEW RP-UPLC METHOD DEVELOPED FOR THE SIMULTANEOUS DETERMINATION OF TELMISARTAN AND AZELNIDIPINE IN DOSAGE FORMS

A new, precise, and sensitive ultra-performance liquid chromatography method for simultaneous estimating Telmisartan and Azelnidipine in bulk and tablet dosage form was developed and validated. The chromatographic separation was achieved by using the HSS C18 (100 x 2.1 mm, 1.8m) column. A mixture of buffer and ACN (70:30 v/v) was pumped through the column at a flow rate 0.3 mL/min. The temperature...

Kunala Anusha * and G. Sowjanya

Department of Pharmaceutical Analysis and Quality Assurance, GITAM Institute of Pharmacy, GITAM University, Visakhapatnam, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(12).4963-72

4963-4972

41

29

19.

COMPARISON OF FUNCTIONAL AND RADIOLOGICAL OUTCOMES BETWEEN CANNULATED CANCELLOUS SCREW FIXATION AND TENSION BAND WIRING IN CLOSED MEDIAL MALLEOLUS FRACTURES

Introduction: Medial malleolus fractures are among the most common fractures encountered around the ankle joint. This study was performed to assess the functional outcome between cannulated cancellous screw fixations versus tension band wiring in managing these fractures. Method: A total of 30 patients were selected and were randomly segregated into two groups, Group A and Group B. Group A patient...

V. Aakash, N. Adhishwarkumaran, Arun Vignesh and Vignesh

Department of Orthopedics, Saveetha Medical College and Hospital, Thandalam, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.13(12).4973-78

4973-4978

34

22

20.

EVALUATION OF FUNCTIONAL OUTCOME OF MINIMALLY INVASIVE PLATE OSTEOSYNTHESIS (MIPO) IN PROXIMAL TIBIA FRACTURES

Introduction: Proximal tibia is a weight-bearing area, and treating these fractures is challenging. Various treatment options will be closed reduction and casting, Open reduction and internal fixation with plate osteosynthesis, and minimally invasive plate osteosynthesis (MIPO). The advantage of MIPO in this type of fracture is that it requires only minimal exposure for stable fixation and will gi...

P. Krishna Sandeep, M. S. Deiv Ramkumar, Alagurswamy Ravi, Arun Kumar and Yeshwanth Subash*

Department of Orthopaedics, Saveetha Medical College and Hospital, Thandalam, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.13(12).4979-84

4979-4984

41

30

21.

COMPARISON OF FUNCTIONAL OUTCOME AND PAIN RELIEF BETWEEN STEROID INJECTION AND PLATELET RICH PLASMA INJECTION IN EARLY OSTEO ARTHRITIS KNEE

Introduction: Osteoarthritis Knee (OA) is the most common form of joint disability in elderly individuals. Various treatment modalities have been established for OA. This study is to compare the functional outcome and pain relief following IA (intraarticular) steroid versus PRP (platelet-rich plasma) injection. Methods: In this study 30, patients were selected and segregated into two groups 15 eac...

V. Aakash, N. Adhishwar Kumaran, Arun Vignesh and Vignesh

Department of Orthopedics, Saveetha Medical College and Hospital, Thandalam, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.13(12).4985-90

4985-4990

41

31

22.

HPLC METHOD DEVELOPMENT AND VALIDATION OF SPIRONOLACTONE IN TABLET DOSAGE FORMS IN PRESENCE OF IMPURITIES AND DEGRADANTS

An isocratic reversed-phase HPLC method was developed and validated to estimate and separate spironolactone and its related substances in its tablet dosage forms. Estimation and separation were achieved on Symmetry C-8 analytical column (150X3.9) mm, 5µm, using Water, Tetrahydrofuran (THF), and Acetonitrile (ACN) in the ratio of 77:21:2 v/v as mobile phase at the flow rate of 20 µl. UV photodiod...

Rini Singhal *, Chhaya Cauhan, Preeti Sharma and Monika Sachdeva

Raj Kumar Goel Institute of Technology, Ghaziabad, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(12).4991-00

4991-5000

42

31

23.

PATTERN, CAUSALITY ASSESSMENT AND SEVERITY OF SUSPECTED ADVERSE DRUG REACTIONS REPORTED AT TERTIARY CARE TEACHING HOSPITAL

Background: Present study was conducted to evaluate pattern, causal association and severity of suspected Adverse Drug Reactions (ADRs) at a tertiary care teaching hospital in western India. Materials & Method: Spontaneous collection of suspected ADRs was done over a period of one year. Demographic data, suspected drug group/s, causal association, severity & preventability scale from the r...

A. Shukla, P. Barot * and D. J. Dave

Department of Pharmacology, GMERS Medical College, Himmatnagar, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.13(12).5001-06

5001-5006

43

29

24.

COMPARISON OF POVIDONE-IODINE VS CHLOROHEXIDINE IN PRE-OPERATIVE SKIN PREPARATION IN ELECTIVE ORTHOPEDIC SURGERY CASES

Introduction: SSI (Surgical site infection) is the dreaded complication following orthopaedic surgery. The main source of surgical site infection is the patient's own skin flora. So skin preparation plays a major role in preventing the SSI. This study aims to compare povidone-iodine and 2% chlorohexidine alcohol in pre-operative skin preparation in elective orthopedic surgery and followed uo for 4...

N. Adhishwar Kumaran, G. Vignesh, Arun Vignesh and Aakash Vishwanathan

Department of Orthopaedics, Saveetha Medical College and Hospital, Thandalam, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.13(12).5007-11

5007-5011

42

24

25.

COMPARISON OF FUNCTIONAL OUTCOME BETWEEN COMPRESSION SCREWS WITH BUTTRESS PLATE AND COMPRESSION SCREWS FOR HOFFA FRACTURE – A PROSPECTIVE STUDY

Background: Hoffa fracture management is almost always surgical since it involves the intraarticular part of the femur. It can be managed either with cannulated cancellous screw alone or with the addition of a buttress plate. The study aimed to evaluate and compare the functional outcome of fracture fixation between the CC screw &CC screw with a buttress plate. Method: This was a prospective s...

P. S. Arun Vignesh *, V. Aakash, Adhishwaran Kumaran and G. Vignesh

Department of Orthopaedics, Saveetha Medical College & Hospital, Thandalam, Kancheepuram, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.13(12).5012-17

5012-5017

36

28

26.

EFFICACY OF PLATELET-RICH PLASMA (PRP) VS CORTICOSTEROID INJECTION IN PLANTAR FASCIITIS

Introduction: Plantar fasciitis is one of the more common causes of pain in the heel, as seen in non-traumatic patients. When the conservative treatments fail, Corticosteroid injection and Autologous Platelet Rich Plasma (PRP) injection will provide good pain relief. The study was performed to compare the functional outcomes following PRP and steroid injection and to identify which modality provid...

P. Krishna Sandeep, M. Sai Deiv Ramkumar, Alagurswamy Ravi and Arun Kumar

Department of Orthopaedic Surgery, Saveetha Medical College and Hospital, Thandalam, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.13(12).5018-23

5018-5023

38

21

27.

EVIDENCE FOR THE ROLE OF NOR-ADRENERGIC AND SEROTONERGIC SYSTEMS BUT NOT THE OPIOID SYSTEM IN THE ANTIDEPRESSANT ACTIVITY OF AQUEOUS EXTRACT OF ABELMOSCHUS ESCULENTUS SEEDS IN THE MOUSE FORCED SWIM TEST

Background: Depression is a state of mental illness characterized by long-lasting moods of desolation. Typical to atypical antidepressants are available in modern medicine for depression therapy, but the side effects are still questionable. Aqueous extract of Abelmoschus esculentus seeds (AEAES) from the Okra has been chosen for the study. AEAES has already been shown to exhibit an antidepressant-...

P. Santhanalakshmi *, M. C. Alwar, B. Aravinda Kumar and Shweta Oommen

Department of Pharmacology, Mahatma Gandhi Medical College and Research Institute, Pillayarkuppam, Puducherry, India.

DOI: 10.13040/IJPSR.0975-8232.13(12).5024-31

5024-5031

36

27

28.

VALIDATION OF TRADITIONAL SIDDHA ANTHROPOMETRIC DIAGNOSTIC METHODOLOGY MAṆIKKAṬAI-NŪL- AN OBSERVATIONAL FIELD STUDY

Maṇikkaṭai-nūl (MK) is an exclusive diagnostic method particular to Siddha Medicine, where the subject's Finger breadths (FB) calculated from the Antebrachial circumference (ABC) is accessed for predicting the symptom, disease, or the pathological sequence. The present observational field studies (Study 1 & 2) aim to validate the clinical significance of MK as a reliable diagnostic tool....

S. Vinayak *, N. P. Vinod, M. S. Shreedevi, R. Gayatri, B. K. Priya and P. Sathyarajeswaran

Siddha Central Research Institute (Central Council for Research in Siddha), Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.13(12).5032-44

5032-5044

51

28

29.

ANTIFUNGAL ACTIVITY OF PLAGIOCHASMA APPENDICULATUM AND PELLIA ENDIVIIIFOLIA

Bryophytes are the closest modern relatives of the predecessors to the earliest terrestrial plants and have shown to be brilliant chemists since they have long been a favorite treatment among tribal peoples all over the world, who use its pharmacological characteristics to treat a wide range of ailments. As bryophytes' Phytochemistry contains a diverse range of biologically active compounds such a...

Shweta Pandey * and Mahendra Rana

Department of Pharmaceutical Sciences, Bhimtal Campus, Kumaun University, Nainital, Uttarakhand, India.

DOI: 10.13040/IJPSR.0975-8232.13(12).5045-49

5045-5049

37

27

30.

COMPARISON OF SARS CoV-2 RT-PCR TEST WITH RAPID ANTIGEN DETECTION KIT AND OTHER NON SPECIFIC TEST

Background: Severe Acute Respiratory Syndrome Corona Virus Disease 2019 (COVID-19) is responsible for the COVID-19 pandemic causing respiratory illness worldwide. Hence there is an urgent need for simple, rapid, and accurate tests for diagnosis. Performance characteristic of Rapid Antigen detection test for identifying sensitivity and specificity with gold standard Real-Time Polymerase Chain React...

Ria Murugesan, Bhuvaneshwari Gunasekar * and Neelusree Prabhakaran

Saveetha Institute of Medical and Technical Sciences, Thandalam, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.13(12).5050-56

5050-5056

50

25

31.

DEVELOPMENT AND VALIDATION OF UV SPECTROMETRIC METHOD OF ECONAZOLE NITRATE CO-CRYSTAL LOADED IN GEL FORMULATION

A simple, fast, inexpensive, and reliable UV spectrometric method was developed and validated to quantify Econazole Nitrate incorporated in topical gel in the form of co-crystal. This article presents the development and validation of different methods for quantification of Econazole nitrate co-crystal loaded in the topical gel as per ICH [Q2(R1)] guidelines. In method-A, the standard and sample s...

Priyanka S. Gala *, Mohammad Wais and Ojaswi Ghadge

Department of Pharmaceutics, HK College of Pharmacy, Oshiwara, Jogeshwari [W] Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(12).5057-67

5057-5067

47

27

32.

EVALUATION OF ACUTE AND SUBCHRONIC TOXICITY OF POLYHERBAL FORMULATIONS OF SHREE DHANWANTRI HERBALS IN WISTAR RATS

Plants have been utilized as medicine since the ancient period, and they are at the basis of much of modern medicine. Plants provide the basis for many conventional medications and the majority of the few successful drugs. Herbal formulations are becoming increasingly popular nowadays. But in some cases, side effects of the herbal formulations have been reported. So, according to the AYUSH ministr...

Balbir Singh, Palvi Sharma, Ankita Rajput, Gurmeet Singh and Saroj Arora *

Department of Botanical and Environmental Sciences, Guru Nanak Dev University, Amritsar, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.13(12).5068-79

5068-5079

41

30

33.

SOLUBILITY ENHANCEMENT OF LABETALOL HYDROCHLORIDE BY USING LIQUISOLID TECHNIQUE FOR MANAGEMENT OF HYPERTENSION

Background: Hypertension is the most common disorder affecting different age groups of people. The increased blood pressure creates discomfort in the patients; these cardiovascular diseases are risky which can lead to “mortality and morbidity”. Labetalol hydrochloride is an anti-hypertensive drug used to treat high blood pressure and Angina. These compounds possess less water solubility and lo...

Vinayak Mastiholimath *, Nisha S. Shirkoli, Rachana Sambargi and Pallavi Chiprikar

Department of Pharmaceutical Quality Assurance, KLE College of Pharmacy, Belagavi, Belagavi, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.13(12).5080-89

5080-5089

42

27

34.

DEVELOPMENT AND EVALUATION OF TASTE-MASKED ORALLY DISINTEGRATING TABLETS OF LEVOCETIRIZINE DIHYDROCHLORIDE

Purpose: The goal of this study was to develop taste-masked orally disintegrating tablets of the bitter-tasting levocetirizine dihydrochloride (LCDH) to improve the accessibility and adherence of pediatric, elderly, non-cooperative and paraplegic patients. Methods: In the present study, orally disintegrating Levocetirizine dihydrochloride tablets were formulated by direct compression. Taste maskin...

P. Thakker, T. Mehta, A. Kuchekar, V. Shetty, R. Aware and J. Shah *

Department of Pharmacology, Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.13(12).5090-07

5090-5107

46

27

35.

FORMULATION AND DEVELOPMENT OF SOLID SELF-EMULSIFYING DRUG DELIVERY SYSTEM FOR CIPROFLOXACIN

The purpose is to formulate the solid self emulsifying drug delivery system (S-SEDDS) to improve poor aqueous solubility and dissolution of ciprofloxacin. A solubility study was carried out, and then Soyabean oil (as oil phase), Tween 20 (as surfactant), and Span 80 (as co-surfactant) were selected for preparation of emulsion by titration method. Adsorption to solid carrier technique was used for ...

P. S. Gawade *, H. A. Joshi and R. N. Patil

Department of Pharmaceutics, Shivnagar Vidya Prasarak Mandal’s College of Pharmacy, Malegaon (BK), Baramati, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(12).5108-19

5108-5119

47

30

36.

STUDIES ON FORMULATION AND EVALUATION OF IBUPROFEN MATRIX DRUG DELIVERY SYSTEM BY USING “BEE PROPOLIS” (APIS MELLIFERA L.)

Ibuprofen is a Non-steroidal anti-inflammatory (NSAID) class drug and is used to treat pain, minor aches, fever, inflammation, and arthritis. Ibuprofen has an oral dose of 300 mg minimum and 3200 mg maximum in a day and is the main reason for the increase in its dosing frequency; many of the Ibuprofen formulations are of three times a day dosing and is the main reason for the development of such a...

Jayesh M. Rajput

Department of Pharmaceutics, Jiiu’s Ali-Allana College of Pharmacy, Akkalkuwa, Nandurbar, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(12).5120-28

5120-5128

36

25

37.

PHYTOCHEMICAL ASSESSMENT AND SYNERGISTIC BIOEFFICACY OF CURCUMA CAESIA (ROXB.) FROM BASTAR AGAINST MULTI-DRUG RESISTANT HUMAN PATHOGENS

The current research is an attempt to investigate the antibacterial and synergistic bioefficacy of Curcuma caesia (Roxb.) versus human pathogenic bacteria viz., Bacillus cereus, Bacillus subtilis, Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Klebsiella pneumonia, Pseudomonas aeruginosa and Proteus vulgaris procured from IMTECH, Chandigarh, India. Agar well diffusion assay w...

Dhananjay Pandey * and A. K. Gupta

Department of Botany, Government Naveen Girls College, Surajpur, Chhattisgarh, India.

DOI: 10.13040/IJPSR.0975-8232.13(12).5129-38

5129-5138

37

28

38.

COMPARISON BETWEEN STEROID AND PRP INJECTIONS IN MEDIAL EPICONDYLITIS (GOLFER’S ELBOW) PATIENTS

Background: Golfer's elbow, commonly known as medial epicondylitis, is an overuse syndrome caused by an eccentric overload of flexor-pronator mass on the medial epicondyle. This is produced by repetitive actions causing micro-trauma to insert the flexor-pronator mass, which affects the pronator teres more than the flexor carpi radialis. This study evaluates the efficacy of platelet-rich plasma and...

Nissanth Chandrasekaran, Shri Vishnu Manokaran, Harish Babu Jayakaran and Gandhamsetty Sai Ganesh,

Department of Orthopaedics, Saveetha Medical College and Hospital, Thandalam, Kancheepuram, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.13(12).5139-44

5139-5144

45

34

39.

EVALUATION OF POLYHERBAL FORMULATION FOR ANTIPYRETIC ACTIVITY ON SMALL ANIMAL MODEL

Background: Fever is a part of a complex biological response due to pathogens, bacterial infection, damaged cells, drugs, toxins, etc. Fever is currently treated by NSAIDs. Unfortunately, NSAIDs damage the liver and kidney, inhibit COX-1, which affects the digestive system, and increase the risk of a blood clot. Therefore, the developments of potent antipyretic drugs from medicinal herbal plants a...

Renu Pandey *, Amit Kishor Srivastava, Kalyani Srivastava and Amresh Gupta

Department of Pharmacy, Goel Institute of Pharmacy and Sciences, Lucknow, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(12).5145-51

5145-5151

41

27

40.

IN-SILICO IDENTIFICATION OF NEWER POTENTIAL PROPROTEIN CONVERTASE SUBSTILSIN/KEXIN TYPE 9 INHIBITORS AS POTENT ANTI-HYPERLIPIDEMIC AGENTS

Hyperlipidemia is a term that encompasses various genetic and acquired disorders that describe elevated lipid levels within the human body. The present study aims to design newer potent PCSK9 Inhibitors to treat hyperlipidemia. In the current study, pharmacophoric features like one hydrogen bond acceptor, one hydrogen bond donor, and one aromatic ring were used to construct a virtual library of li...

R. Priyadarsini * and V. Dinesh Kumar

Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Park Town, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.13(12).5152-68

5152-5168

36

24

41.

COMPARISON OF QUALITATIVE AND QUANTITATIVE APPROACHES TO SOIL QUALITY ASSESSMENT FOR AGRICULTURAL PURPOSES IN JAIPUR DISTRICT, RAJASTHAN

The nutritional quality of soil plays a key role in the growth of plants as soil minerals act as a source and sink for providing the essential nutrients to plants. The fertility of the soil and nutritional management are the two important factors that directly influence plants' productivity and quality. Soil management is an important tool for agriculture to provide nutritious food. Soil managemen...

Shobhana Sharma and Anupama Singh *

Department of Chemistry, S. S. Jain Subodh P. G. College, Jaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.13(12).5169-77

5169-5177

45

25

42.

EFFECT OF PH & TEMPERATURE VARIATIONS ON PHAGE STABILITY – A CRUCIAL PREREQUISITE FOR SUCCESSFUL PHAGE THERAPY

Phage therapy has become a successful alternative to conventional antibiotic therapy due to the increasing number of multidrug-resistant bacteria in most clinical settings. Various factors like phage adsorption to the host site and phage neutralization by the host determine the efficacy of phage treatment. However, external factors like temperature and pH are critical in deciding the success of us...

A. N. Pradeep, S. Ramasamy, J. K. Veniemilda and C. S. Vinod Kumar *

Department of Microbiology, S. S. Institute of Medical Sciences & Research Centre, Davangere, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.13(12).5178-82

5178-5182

42

31

43.

FOLKLORE MEDICINAL KNOWLEDGE OF THE PEOPLES IN PATHINETTAMKOTTAI VILLAGE, SIVAGANGAI DISTRICT, TAMIL NADU, INDIA

Since ancient times, man has been looking for plants to rescue from diseases and improve immunity. He may find the right choice of plants by trial and error, observing nature and following theories, and passing that information to the next generation by word of mouth. Folklore medicine combines traditional healing practices, spirituality, and therapies to diagnose and prevent ailments. In the pres...

T. Ganeshmoorthy, M. Rama Prabha * and R. Karthiyayini

Department of Botany, Thiagarajar College, Madurai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.13(12).5183-89

5183-5189

44

28

44.

ANTI-NEOPLASTIC TRANSDERMAL PATCH: A NOVEL APPROACH IN BREAST CANCER THERAPY

Background: In the present investigation Antineoplastic loaded transdermal patch was formulated using Liposomes, eudragit-RL, hydroxypropyl methyl cellulose K-50, and ethyl cellulose. Materials and Methods: Liposomes were formulated by solvent evaporation method using poly (sebacic acid-co-ricinoleic acid) in varying ratios and evaluated for particle size, drug loading, entrapment efficiency, tr...

Chandra Shekhar Sharma *, Subas Chandra Dinda and Anurag Verma

Department of Pharmaceutics, Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(12).5190-99

5190-5199

56

43

45.

MICHELIA CHAMPACA LEAF EXTRACTS EXHIBIT HYPOGLYCEMIC EFFECT AND HYPOLIPIDEMIC ACTIVITY IN STREPTOZOTOCIN-NICOTINAMIDE-INDUCED DIABETIC RATS

A metabolic disease called diabetes mellitus in which blood glucose levels are abnormally high. It could be due to tissue glucose intolerance and impaired insulin production. In a Type II diabetes model generated by Streptozotocin and nicotinamide, the antidiabetic potential of ethanolic and aqueous leaf extracts of Michelia champaca (Magnoliaceae) was compared to a control group of diabetes. Th...

Jyoti Nanda *, Munesh Mani , Shanti Bhushan Mishra and Neeraj Verma

School of Pharmaceutical Sciences, CSJM University, Kanpur, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(12).5200-06

5200-5206

50

54

46.

ARSENIC-INDUCED ALTERATIONS IN GLYCOGEN AND LIPID DURING THE OVARIAN CYCLE OF A FRESHWATER SILUROID, MYSTUS (M.) VITTATUS (BL.)

Heavy metals get their way into the environment through a wide spectrum of natural and anthropogenic sources. Arsenic (As) has been reported to be present in main too different oxidation states (As3+ and As5+). Trivalent arsenic (As3+) has been reported to be more toxic than the pentavalent (As5+) one. Mystus (M.) vittatus, a siluroid fish, were exposed to Sublethal concentration (SLC) of As3+ to ...

Anuradha Shukla, Yogendra Kumar Payasi * and J. P. Shukla

Department of Zoology, Indira Gandhi National Tribal University, Amarkantak - 484886, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(12).5207-10

5207-5210

36

25