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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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Volume 12 (2021) - Issue 4, April

Review Articles

 
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1.

OVERVIEW OF FAVIPIRAVIR AND REMDESIVIR TREATMENT FOR COVID-19

The current coronavirus disease 2019 (COVID-19) outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in the wholesale market in Wuhan, China in the last months of 2019 and spread to almost all countries of the world. Although several vaccines have already been developed in different countries of the world, there is currently no specific treatment for COVID-19. So...

E. Eroglu * and C. Toprak

Department of Pharmacology, Faculty of Pharmacy, Lokman Hekim University, Ankara, Turkey.

DOI: 10.13040/IJPSR.0975-8232.12(4).1950-57

1950-1957

252

176

2.

CLINICAL FEATURES, TREATMENT APPROACHES AND PROMISING CONTRIBUTIONS OF NANOMEDICINES TOWARDS COVID-19

The World Health Organization (WHO) declared COVID -19 a pandemic on March 11 2020.  As of today, there have been 122 million COVID -19-update cases worldwide, and the counting goes on. Unfortunately, strategic measures such as total lockdown, social and self-isolation, and gradual lifting of some of these restrictions both pose economic, social, and psychological distress and are thought to hav...

I. A. Shehu *, M. K. Musa, S. Alok and A. Verma

School of Pharmacy, Sharda University, Greater Noida, Uttar Pradesh India.

DOI: 10.13040/IJPSR.0975-8232.12(4).1958-65

1958-1965

330

107

3.

PRECLINICAL EXPERIMENTAL SCREENING MODELS FOR THE ASSESSMENT OF ANTI-CANCER DRUGS

Cancer, according to WHO, is a generic terminology for a group of diseases that are characterized by abnormal growth of cells. This uncontrolled, abnormal growth is beyond the natural boundaries of normal cell growth, which can then metastasize to adjoining or distant sites of the body and/or to the organs. Cancer is the second most leading cause of mortality and has resulted in 9.8 million deaths...

C. Singh, S. Khan, F. Bamne and I. Ansari *

Department of Pharmacology, Oriental College of Pharmacy, Navi Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).1966-77

1966-1977

146

82

4.

NANOEMULSION: A SNAPSHOT ON DEVELOPMENT, CHARACTERIZATION, APPLICATIONS, PATENTS AND CLINICAL TRIALS

Nanoemulsionis a special case of emulsion. It is nano-sized emulsion used as a carrier. It has the ability to deliver the drug to the target site. It is a good vehicle for the controlled delivery of the drug. It is prepared by the high energy and low energy emulsification method. Emulsifier plays an important role in stabilizing the nanoemulsion. It is anisotropic and thermo-dynamically stable sys...

R. Deshmukh, B. Sharma, R. K. Harwansh and B. Dewangan *

Shri Shankaracharya Institute of Medical Sciences, Bhilai, Chhattisgarh, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).1978-88

1978-1988

143

65

5.

BIOAVAILABILITY AND BIOEQUIVALENCE OF BIOSIMILARS

Biosimilars are the most promising medicines for treating complex diseases. The first biosimilar was approved in India in 2000, and since then, there is no looking back. CDSCO in collaboration with DBT has developed new guidelines in 2012, which were revised in 2016 for pre and post-marketing approval of biosimilars in India. India is one of the leading manufacturers of biosimilars catering to dom...

A. Arora * and A. Parle

Department of Quality Assurance, Delhi Institute of Pharmaceutical Sciences and Research, New Delhi, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).1989-00

1989-2000

156

67

6.

MEDICINALLY IMPORTANT COLEUS SPECIES, COLEUS MALABARICUS BENTH. AND MANY OTHERS OF FAMILY LAMIACEAE FROM THE WESTERN GHATS, INDIA – A REVIEW

India is renowned for its rich biodiversity and the Western Ghats, because of its varied topography and ecological conditions support a very rich flora including medicinally valuable aromatic and non-aromatic plant species. The Western Ghats are additionally documented for diversity within the ethnic communities; they have been utilizing the plant wealth for medicinal purposes and have proven succ...

B. S. Kamal * and B. R. Balakrishnan

Govt. T. D. Medical College, Vandanam, Alappuzha, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2001-11

2001-2011

93

39

7.

SCOPE FOR HARMONISATION OF HERBAL MEDICINE REGULATIONS

Herbal Medicinal Products are gaining acceptance among people across the world due to rising awareness of lifestyle diseases and improper food habits. During the latter part of the twentieth century, increasing interest in self-care resulted in enormous growth in the popularity of traditional healing modalities, including the use of Herbal remedies. Side effects caused by the use of modern medicin...

A. Metta *, N. L. N. Kingumahanthi, V. R. Kalidindi, R. K. R. Juturi and V. Boddu

Shri Vishnu College of Pharmacy (Autonomous), Bhimavaram, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2012-20

2012-2020

74

34

8.

ASYSTASIA GANGETICA: A BIBLIOMETRIC ASSESSMENT OF GLOBAL PUBLICATIONS OUTPUT DURING 1960-2020

There has been an exponential growth in plant-based products during the last few decades for the treatment of various ailments. According to literature, about 25% of prescribed drugs are of plant origin globally. One such important plant is Asystasia gangetica, also known as ‘Chinese violet’ or ‘Ganges primrose’ is an ornamental, scattering, groundcover herb. The plant is about 0.30 to 0.6...

H. Kumar *, Ishu and H. Singh

School of Pharmacy, Om Sterling Global University Hisar, Juglan, Hisar, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2021-35

2021-2035

72

41

9.

LYMPHATIC TARGETING SYSTEM USING NANO-FORMULATION: CHALLENGES AND APPROACHES

The lymphatic system is the subpart of the systemic circulation for maintaining immune function; this system is mainly known as a drainage system to removes foreign bodies. This system consists of various lymphoid organs and tissues. The lymphatic system based on physiological function as absorption and micro-particulate uptake by these routes the bioavailability and efficacy were enhanced and und...

J. Desai * and T. Patel

Ramanbhai Patel College of Pharmacy, Charusat University, Charusat Campus, Anand, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2036-48

2036-2048

95

42

10.

COLON DRUG DELIVERY SYSTEM, ADVANCE DEVELOPMENT AND EVALUATION: A REVIEW

Colon targeted drug delivery system is a significant part of the pharmaceutical dosage form. Because the colon targeted formulation system only responds to the colon-specific physiological conditions, a triggering mechanism is required. Site of colon provides local and systemic drug delivery. Inflammatory bowel disease can be treated by localized delivery of drugs. The systemic side effect can be ...

A. Jain *, A. Mittal and D. Ghosh

Meerut Institute of Engineering and Technology, Meerut, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2049-64

2049-2064

88

35

Research Articles

 
Title
Views
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Cited
11.

IN-VITRO MUTAGENIC, GENOTOXIC AND ANEUGENIC POTENTIAL OF OMEPRAZOLE

The aim of this investigation was to re-evaluate the in-vitro mutagenic, genotoxic, and aneugenic potential of omeprazole through the Ames test, comet (SCGE), and cytokinesis-block micronucleus assays (CBMN), as previous reports on the mutagenic and genotoxic effects of omeprazole are scarce and inconclusive. The results of this study indicated a negative mutagenic effect through the Ames test. Co...

V. Kutsar, S. LaFolette, J. Ringenberg, R. Dudley and A. Vaglenov *

Department of Pharmaceutical Science, University of Findlay, 1000 North Main Street, Findlay, Ohio, USA.

DOI: 10.13040/IJPSR.0975-8232.12(4).2065-75

2065-2075

143

99

12.

FORMULATION AND EVALUATION OF GASTRORETENTIVE METRONIDAZOLE TABLETS USING BRACHYSTEGIA EURYCOMA GUM

This study was conducted to evaluate gastroretentive metronidazole tablets formulated using Brachystegia eurycoma gum as a matrix. The gum was isolated from powdered dried Brachystegia eurycoma seeds. Gastroretentive metronidazole tablets were produced by direct compression technique using Brachystegia eurycoma gum, sodium carboxymethylcellulose, or their combination as the matrix. Sodium bicarbon...

S. E. Okafo *, C. A. Alalor and J. I. Ordu

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Delta State University, Abraka, Nigeria.

DOI: 10.13040/IJPSR.0975-8232.12(4).2076-84

2076-2084

136

74

13.

EVALUATION OF PLASMA GLUCOSE AND SERUM LIPID PROFILE LEVELS AMONG STUDENTS IN NNEWI CONSUMING GLYCINE MAX (SOYA BEAN)

Medicinal plants are becoming globally recognized because of their acclaimed therapeutic potentials. This study evaluated the plasma glucose and serum lipid profile levels among university students consuming Glycine max (Soya bean) in Nnewi, Nigeria. A total of thirty (30) apparently healthy male subjects aged between 18 and 30 years were randomly recruited from medical students to serve as both t...

I. C. Maduka, R. A. Analike, S. N. Chiwetalu, E. C. Ogbodo *, C. E. Onah, C. M. Njoku, J. C. Nnamdi, A. K. Amah and U. N. Agada

Department of Medical Laboratory Science, Faculty of Health Sciences and Technology, Nnamdi Azikiwe University, Awka, Nigeria.

DOI: 10.13040/IJPSR.0975-8232.12(4).2085-92

2085-2092

134

54

14.

PREPARATION AND EVALUATION OF NON-IONIC SURFACTANT VESICLE USING STATISTICAL OPTIMIZATION: OLMESARTAN USED AS MODEL DRUG

The purpose of the present work was to prepare and evaluate olmesartan-loaded non-ionic surfactant vesicles (niosomes) to get sustained release by increasing the solubility and bioavailability. Ether injection and thin-film hydration methods were used for the preparation of all formulations as per the factorial design to study the effect of the three independent variables X1 (amounts of span 60), ...

N. Akter, S. Delwar, S. M. A. Islam, M. M. Al Hasan and I. Dewan *

Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.

DOI: 10.13040/IJPSR.0975-8232.12(4).2093-07

2093-2107

127

62

15.

EVALUATION OF THE SERUM LEVELS OF SOME TRACE ELEMENTS AND ANTIOXIDANT LEVELS IN APPARENTLY HEALTHY INDIVIDUALS WITH FAMILY HISTORY OF TYPE 2 DIABETES IN NNEWI, NIGERIA

There is a paucity of data on studies evaluating trace elements and antioxidant levels and susceptibility of offspring of diabetic parents to type 2 diabetes in Nigerian population. This study evaluated the serum level of some trace elements and antioxidants among apparently healthy individuals with a family history of type2 diabetes mellitus (FH-T2DM). This was a cross-sectional study involving 1...

J. E. Okwara, C. C. Agudi, E. C. Ogbodo *, C. M. Njoku, R. A. Analike, A. K. Amah, O. O. Eze and S. C. Meludu

Department of Medical Laboratory Science, Faculty of Health Sciences and Technology, Nnamdi Azikiwe University, Awka, Nigeria.

DOI: 10.13040/IJPSR.0975-8232.12(4).2108-16

2108-2116

123

58

16.

GENOMIC STRUCTURAL IDENTIFICATION AND IMMUNOINFORMATICS STUDIES FOR SARS‐COV‐2

Coronaviruses are a group of viruses that belongs to the Coronaviridae family. These viruses have helical symmetry, enveloped, positive-sense, single-stranded RNA genome with nucleocapsid that causes diseases in birds and mammals. SARS-CoV 2 complete genome has genome size of 29,903 bp, having nine genes identified as Orf1a Polyprotein, Orf1ab Polyprotein, ORF3a Protein, ORF7a Protein, ORF8 Protei...

D. S. V. G. K. Kaladhar

Department of Microbiology and Bioinformatics, UTD, Atal Bihari Vajpayee University, Bilaspur, Chhattisgarh, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2117-25

2117-2125

89

36

17.

SYNTHESIS AND CHARACTERIZATION OF 6 – HYDROXY – 3, 4 -DIHYDROQUINOLINONE CILOSTAZOL IMPURITY-A AS PER INDIAN PHARMACOPOEIA

Impurity profile study is critical for getting market approval of finished dosage forms from regulatory authorities. There are many manufacturing firms (small and medium scale) in India that they cannot afford the high priced USP reference standards for analysis. So, the availability of cheaper affordable IP reference standards will help them adhere to quality guidelines for active pharmaceutical ...

K. Sankhe, S. Trikha, P. L. Sahu and T. Khan *

Department of Pharmaceutical Chemistry & QA, SVKM’s Dr. Bhanuben Nanavati College of Pharmacy, Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2126-31

2126-2131

82

39

18.

FORMULATION AND CHARACTERIZATION OF CLOZAPINE ADHESIVE PATCHES USING VARIOUS PRESSURE SENSITIVE ADHESIVES AND PERMEATION ENHANCERS

The present research work was intended to develop and characterize the transdermal adhesive patch of clozapine using different types of acrylate, polyisobutylene and silicon adhesives. Various permeation enhancers such as 1, 8 – cineole, D-limonene, Azone, IPM and Oleic acid were also evaluated to achieve desired permeation rate and hence to attain the improved bioavailability as compared to ora...

M. B. Agrawal * and M. M. Patel

Department of Pharmaceutics, Institute of Pharmacy, Nirma University, Chharodi, Ahmedabad, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2132-39

2132-2139

67

37

19.

ANALYSIS OF BIOLOGICALLY ACTIVE COMPOUNDS IN JIMSON WEED LEAFS

Jimson weed (Datura stramonium) members of the Solanaceae plant family; serve as major folklore medicinal herbs. The biologically active compounds spectrum in leaves of Datura stramonium L. was investigated by GC-MS with NMR & FTIR analysis. Steroids, terpenoids, anticholinergic alkaloids, atropine, and scopolamine, are detected. Twenty of them are new constitutions for the species, and eight ...

A. Ananth *, S. Rajan and A. U. Devi

Department of Microbiology, Srinivasan College of Arts & Science, Perambalur, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2140-46

2140-2146

76

43

20.

ANTIDIABETIC EFFECT OF MIXTURE OF CYATHEA NILGIRIENSIS (HOLTTUM) AND PTEROCARPUS MARSUPIUM ROXB. IN STREPTOZOTOCIN INDUCED DIABETIC RAT MODEL

Diabetes mellitus is a metabolic disorder of the endocrine system and becoming a serious threat to mankind's health in all parts of the world. Herbal remedies are considered convenient for management of diabetes due to their traditional acceptability, availability, and less side effects than oral hypoglycaemic agents. Thus, the present study aims to test the toxic and antidiabetic effect of a trad...

S. Elavarasi *, G. Revathi, K. Saravanan and H. I. Averal

PG & Research Department of Zoology, Holy Cross College (Autonomous), Tiruchirappalli, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2147-57

2147-2157

75

33

21.

DEVELOPMENT, OPTIMIZATION AND IN-VITRO CHARACTERIZATION OF GLICLAZIDE NANOSPONGE TABLETS FOR ORAL ADMINISTRATION

Poor bioavailability by the oral route is noticeable with the majority of new active pharmaceutical ingredients due to its dissolution rate-limited absorption. Gliclazide is an oral anti-hyperglycemic drug, though it is a class II drug, results in poor oral bioavailability. The present investigation was undertaken to prepare polymeric nanosponges of an oral anti-hyperglycemic drug Gliclazide to ac...

S. S. Gedam * and G. D. Basarkar

SNJBS Shriman Sureshdada Jain College of Pharmacy, Chandwad, Nashik, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2158-74

2158-2174

67

32

22.

GC-MS ANALYSIS AND IN-VITRO CYTOTOXICITY STUDY OF DENDROPHTHOE FALCATA AND TRIDAX PROCUMBENS EXTRACTS AGAINST HACAT CELLS LINE

The present study shows the cytotoxic effect of Dendrophthoe falcata (L. f) and Tridax procumbens Linn. extracts against HaCat (Skin cancer) cell line by MTT and SRB assay method. The phytochemical screening of extracts dichloromethane: methanol (DM), methanol: water (MW), and ethanol: water (EW) revealed the presence of secondary metabolites such as alkaloids, flavonoids, saponins, tannins, stero...

V. C. A. Bhagat * and M. S. Kondawara

Department of Quality Assurance, Appasaheb Birnale College of Pharmacy, Sangli, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2175-84

2175-2184

72

39

23.

DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF SAXAGLIPTIN AND DAPAGLIFLOZIN IN BULK AND DOSAGE FORM

Objective: In the present work, A Simple, rapid, sensitive, precise, and reproducible, specific UV spectrophotometric method for the determination of Saxagliptin (SAXA) and Dapagliflozin (DAPI) in bulk drug and pharmaceutical dosage form were developed and validated. Methods: A simple double beam UV spectrophotometric method has been developed and validated with different parameters such as linear...

S. Ahmad *, M. R. Usman, T. Shaikh, M. Imran and R. Akhtar

Department of Quality Assurance and Pharmacognosy, Gangamai College of Pharmacy, Nagaon, Dhule, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2185-92

2185-2192

78

45

24.

STRUCTURE BASED VIRTUAL SCREENING IN SEARCH OF POTENTIAL INHIBITORS AGAINST HGPRT AS TARGET FOR PLASMODIUM FALCIPARUM

Malaria is a parasitic infectious disease transmitted through the bite of female Anopheles mosquitos. Every year, approximately 210 million Peoples are suffering from this dangerous disease, and around 440,000 individuals pass from this infectious disease. Recently, the Indonesia Ministry of Health declared that the malaria pre-elimination stage should be reached by 2020 and be free of malaria tra...

P. Verma *, B. Chauhan, A. K. Gupta and Peeyush

Adarsh Vijendra Institute of Pharmaceutical Sciences, Shobhit University Gangoh, Saharanpur, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2193-02

2193-2202

74

38

25.

FABRICATION, OPTIMIZATION AND EVALUATION OF CHRONOTROPIC DRUG DELI-VERY SYSTEM OF CAPTOPRIL

The present investigation was based on the development and evaluation of chronotropic capsules for hypertension treatment. Captopril has ACE inhibitor action to prevent the circadian rhythm related to hypertension. The solubility of captopril in the GI tract was pH-dependent i.e., captopril soluble only at 1.2 pH, show better stability, and absorbed in the upper part of the gastrointestinal tract....

P. Sharma *, V. Jain and S. Jain

Department of Pharmaceutics, Shri Ram College of Pharmacy, Morena, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2203-10

2203-2210

81

34

26.

IN-VITRO SEED GERMINATION AND EFFECT OF TDZ AND AgNO3 ON HIGH FRE-QUENCY SHOOT REGENERATION FROM RUELLIA TUBEROSA L., USING COTYLE-DANARY NODE EXPLANTS

Ruellia tuberosa, commonly called Minnie root, has plenty of applications in herbal medicine due to the presence of several bioactive compounds. A simple, efficient, and reproducible in-vitro plant regeneration protocol was developed for Ruellia tuberosa. The cotyledonary nodal explants were excised from seedlings were inoculated on Murashige and Skoog (MS) medium supplemented with various concent...

P. V. C. Lakshmi, C. M. N. Reddy, P. Rathinapriya, M. Ramesh and B. Srinivas *

Department of Biotechnology, Dravidian University, Kuppam, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2211-24

2211-2224

77

32

27.

IN-SILICO ANALYSIS OF POTENTIAL ANTIMYCOBACTERIAL COMPOUNDS PRESENT IN CYNODON DACTYLON

Tuberculosis is one of the major contagious diseases and a leading cause of death in humans. Current treatment methods suffer from a multitude of problems like long duration of treatment, lack of patient compliance, presence of drug-resistant bacteria, etc. To combat the disease effectively, there is an urgent need for the development of new drugs effective against both drug-sensitive and drug-res...

S. B. Alex and M. S. Latha *

Sree Narayana College, Chathannur, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2225-31

2225-2231

66

32

28.

EFFECT OF INCENSE SMOKE ON THE BEAS-2B AND EB-3 CELLS

Usage of incense smoke has aesthetic importance. But, studies have shown that incense smoke has oxides of carbon, nitrogen, sulphur, which has ill effects on human health. Polyphenol analysis showed the presence of phenol-like compounds in the water extracts of the incense. This study was conducted to understand the impact of exposure of cells to these types of smokes by performing viability test ...

R. R. Hegdekatte *, N. R. Kumari, A. P. Uppar and P. G. Anantharaju

Department of Biochemistry, Pooja Bhagavat Memorial Mahajana Education Centre, Post Graduate Wing of SBRR Mahajana First Grade College, Mysuru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2232-36

2232-2236

87

37

29.

IMPROVED BIOAVAILABILITY OF LINAGLIPTIN BY RESVERATROL IN RATS- INVOLVEMENT OF PERMEABILITY GLYCOPROTEIN (P-gp) INHIBITION

The maintenance of an appropriate serum concentration of a drug is important to ensure therapeutic efficacy. Functional alterations of drug transporters may influence the serum concentration of drugs through changes in its pharmacokinetics and pharmacodynamics (PK/PD). In this study, we have focused on the influence of functional alterations in the intestinal P-glycoprotein (P-gp) on the PK of lin...

P. Neerati * and B. L. Athukuri

DMPK & Clinical Pharmacology Division, Department of Pharmacology, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2237-46

2237-2246

67

28

30.

SYNTHESIS AND 2D-QSAR STUDY OF SOME NOVEL SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS ANTITUBERCULAR AGENTS

In the present work, a series of some novel substituted benzimidazole derivatives were efficiently synthesized, and a thin layer chromatography study confirmed the completion of the reaction on silica gel-G plates. The characterization was done through recording spectra of FTIR using Jasco FTIR-460 plus spectrophotometer, recording spectra of 1HNMR with the help of spectrometer, specifically BRUKE...

D. P. Kardile * and M. K. Shirsat

Department of Pharmaceutical Sciences, Madhav University, Pindwara, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2247-56

2247-2256

64

34

31.

LC-MS METHOD DEVELOPMENT AND VALIDATION FOR THE LOW-LEVEL DETERMINATION OF GENOTOXIC IMPURITY, ETHYL P-TOLUENE SULFONATE IN PERIN-DOPRIL TERT-BUTYLAMINE

Objective: Ethyl para toluene sulfonate is a genotoxic impurity and the current work’s primary objective is to develop a hyphenated and highly sensitive LC-MS method for the determination (EPTS) in Perindopril tert-butylamine. Method: EPTS was determined by LC-MS method in selective ion monitoring mode (SIM) using Atlantis T3 (150×4.6mm) 3.0 µm column. 0.01M ammonium acetate is utilized as buf...

S. K. Susarla *, S. Duvvuri and B. M. Rao

Gandhi Institute of Technology and Management, Visakhapatnam, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2257-62

2257-2262

69

35

32.

HPTLC METHOD DEVELOPMENT AND VALIDATION FOR THE IN-VITRO INTERACTION STUDY OF MEBENDAZOLE WITH ATORVASTATIN

By the HPTLC method, a mobile phase system comprising of Ethyl acetate: Toluene: Methanol (5:4:1v/v/v) was selected, and the detection was carried out at 280 nm. The Rf values were found to be 0.65 ± 0.03 and 0.27 ± 0.03 for Mebendazole and Atorvastatin, respectively, which showed a good separation. The method was validated as per ICH guidelines. The percentage RSD values of repeatability, intra...

T. Thomas *, A. Manohari and T. K. Ravi

Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2263-69

2263-2269

71

27

33.

AMELIORATIVE ROLE OF SELENIUM AND ZINC AGAINST REPRODUCTIVE TOXICITY DUE TO EXPOSURE TO A MIXTURE OF HEAVY METALS LEAD, CADMIUM AND ARSENIC IN MALE ALBINO RATS

Introduction: Reproductive organs are the major target of heavy metal toxicity; oxidative stress plays a vital role in induction of such toxicity. Toxicity due to chronic exposure to a low dose mixture of three heavy metal lead (Pb), cadmium (Cd) and arsenic (As) and ameliorative potentials of two antioxidant micronutrients selenium (Se) and zinc (Zn) were evaluated in male albino rats. Materials ...

S. Choudhuri, B. Sutradhar, S. Das and D. Choudhuri *

Department of Human Physiology, Tripura University, A Central University, Suryamaninagar, Agartala, Tripura, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2270-78

2270-2278

73

35

34.

IN-VITRO ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITY OF SALIX ALBA L. ALONG WITH SIMULTANEOUS HPTLC ANALYSIS OF SALICIN AND FERULIC ACID

Now a day’s interest towards natural and has been growing due to the unhealthy consequences of chemicals in the health industry; though, herbal substances possess several quality control and confirm pharmacological action issues. This present study was designed to determine the effects of Salix alba L. methanolic extract (MESAL) for its antioxidant and anti-inflammatory activity in rat models. F...

R. S. Shivatare *, S. M. Kewatkar, R. Musale, P. Lohakare, D. Patil, D. Choudhary, G. Ganu, D. H. Nagore and S. Chitlange

Department of Pharmaceutical Sciences, Shri Jagdishprasad Jhabarmal Tibrewala University, Jhunjhunu, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2279-87

2279-2287

65

31

35.

PHYTOCHEMICAL AND ANTIOXIDANT ASSAY OF ECLIPTA ALBA (L.) LEAF EXTRACT

Currently, pharmacological activities of Eclipta alba (L.) plant extracts and individual phytoconstituents have revealed anticancer, hepatoprotective, snake venom neutralizing, anti-inflammatory and antimicrobial properties. The role of antioxidants is increasing day by day due to their multiple roles to reduce the harmful effects of oxidative stress. Phytoconstituents like wedelolactone and ursol...

K. S. Tripathi, S. Jha, A. Dikshit and R. Kumar *

Department of Botany, Mahatama Gandhi Govt. Arts College, Mahe, Puducherry, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2288-95

2288-2295

89

46

36.

DEVELOPMENT AND VALIDATION OF FIRST ORDER DERIVATIVE SPECTRO-PHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF TACROLIMUS AND BERBERINE HYDROCHLORIDE

A simple UV spectrophotometric method using the first order derivative technique was developed for the simultaneous estimation of tacrolimus and berberine hydrochloride in nanoparticles. The tacrolimus and berberine hydrochloride stock solutions were prepared methanol and scanned in UV- region for first-order derivative spectrum. The zero-crossing point for tacrolimus and berberine hydrochloride w...

S. Patel *, C. Aundhia, A. K. Sen, A. Zanwar and K. Pandya

Department of Pharmacy, Sumandeep Vidyapeeth, Vadodara, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2296-00

2296-2300

70

34

37.

APPLICATION OF VALIDATED LC-MS/MS METHOD FOR THE QUANTIFICATION OF LENVATINIB IN BIOLOGICAL MATRICES: SUPPORTING IN-VIVO BIOAVAILABILITY STUDIES IN HEALTHY RABBITS

A sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) technique was developed and validated for the quantification of lenvatinib in plasma samples. Plasma samples were presented by selecting the Liquid-Liquid extraction (LLE) method with ethyl acetate. The technique was developed and validated with respect to the parameters specificity, sensitivity, carry-over, recovery, precision,...

M. L. Kanth * and B. R. Kamal

Mewar University, Chittorgarh, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2301-09

2301-2309

71

35

38.

APPRAISEMENT OF DRUG UTILIZATION PATTERN OF ANTIMICROBIALS IN THE GENERAL MEDICINE DEPARTMENT OF A TERTIARY CARE TEACHING HOSPITAL – A PROSPECTIVE OBSERVATIONAL ANALYTICAL STUDY

AIM: To see the appraisement of drug utilization pattern of antimicrobials in the general medicine department of a tertiary care teaching hospital. Methodology: A prospective observational, analytical study was done on patients admitted in general medicine of Maharaja Institute of Medical Sciences, Vizianagaram, Andhra Pradesh, India information regarding age, gender, diagnosis, patients present/p...

K. M. Pavan, V. Upajna, G. Kusuma, V. J. Lakshmi and U. S. Viriti *

Department of Pharmacy Practice, Avanthi Institute of Pharmaceutical Sciences, Cherukupally, Bhogapuram, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2310-22

2310-2322

85

34

39.

MICROWAVE ASSISTED SYNTHESIS AND EVALUATION OF ANTICONVULSANT ACTIVITY OF SOME 1, 4-DIHYDROPYRIDINE DERIVATIVES

In the view of an extensive literature survey that revealed the anticonvulsant profile of 1,4-dihydropyridines and 1,3,4-Thiadiazole, we have coupled these two moieties with the aim of achieving an enhanced anticonvulsant effect. In present investigation some of ethyl-1-((5-amino-1, 3, 4-thiadiazol-2-yl) methyl)-5-ethyl-2, 6-dimethyl-4-substituted phenyl-1, 4-dihydro-pyridine-3-carboxylate derivat...

D. D. Rishipathak * and K. V. Patil

Department of Pharmaceutical Chemistry, MET’s Institute of Pharmacy, (Savitribai Phule Pune University, Pune), Adgaon, Nashik, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2323-29

2323-2329

78

32

40.

FORMULATION AND EVALUATION OF MUCOADHESIVE VAGINAL TABLET FOR THE TREATMENT OF BACTERIAL VAGINOSIS

The primary purpose of this study was to formulate a mucoadhesive vaginal tablet of clindamycin phosphate. It developed to achieve an excellent therapeutic effect and patient compliance in the treatment of bacterial vaginosis. The formulation has a sustained-release effect with good mucoadhesion due to mucoadhesive polymers like Polycarbophil and Carbopol 971P NF, which decreases dose frequency. T...

D. Kanojia and D. Patel *

Department of Pharmaceutics, Parul Institute of Pharmacy and Research, Faculty of Pharmacy, Parul University, Vadodara, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2330-37

2330-2337

79

42

41.

ANTIOXIDANT ACTIVITY OF LEAVES SOLVENT EXTRACT OF MIMUSOPS ELENGI LINN.

The present study was to estimate the total phenolic content, flavonoids content and evaluate the in vitro antioxidant activity of alcoholic and aqueous extract of the leaves of plant Mimusops elengi Linn. Total phenolic content was determined calorimetrically using Folin ciocalteu reagent, and Total flavonoid content was determined by aluminum chloride method. The total phenolic content of methan...

A. Asif *, S. Ahmad, M. R. M. Usman, T. Shaikh, M. Husain and Z. Shaikh

Department of Pharmacognosy, Gangamai College of Pharmacy, Nagaon, Dhule, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2238-46

2238-2246

72

35

42.

SIMULTANEOUS ESTIMATION OF CIPROFLOXACIN AND METRONIDAZOLE IN BULK AND TABLET FORMULATION BY UV SPECTROPHOTOMETRY

Three simple and economical UV-spectrophotometric methods have been developed and validated for simultaneous estimation of ciprofloxacin (CIP) and metronidazole (MET) in a tablet dosage form using distilled water as a green solvent. The proposed methods were; simultaneous equation method (method A), Q-absorbance ratio method (method B), and area under curve method (method C). λmax of CIP & ME...

A. Veeshma, S. Priyanka, K. P. Kumar and K. Sirisha *

Department of Pharmaceutical Analysis, Vaagdevi College of Pharmacy, Ramnagar, Hanmakonda, Warangal, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2247-56

2247-2256

77

36

43.

IN-SILICO SCREENING AND MODELING OF DELETERIOUS nsSNPs IN HUMAN GENE FBN1 FOR MARFAN SYNDROME

Marfan syndrome (MFS) is a common dominant inherited disorder that affects connective tissue, which is associated with mutation of the gene FBN1. The protein encoded by this gene contributes to the final structure of microfibrils. Single nucleotide polymorphisms (SNPs) of this gene links to variations in gene expression phenotypically among patients. Therefore SNPs would be the main target for ide...

M. Radha *, S. M. Devi and J. Suganya

Department of Bioinformatics, School of Life Sciences, Vels Institute of Science Technology and Advanced Studies, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2257-64

2257-2264

149

57

44.

EFFECT OF ALFUZOSIN ON ETHYLENE GLYCOL AND AMMONIUM CHLORIDE INDUCED UROLITHIASIS IN MALE RATS

Urolithiasis is the most prevalent urinary tract disorder in males. Alfuzosin is a selective antagonist of post-synaptic α1a adrenoceptor, causing relaxation of smooth muscle in the bladder and prostate, which results in an improvement of urine flow and prevents ureter stones. The present study was aimed to evaluate the effectiveness of Alfuzosin on rats as a preventive and curative agent against...

C. H. S. Bindu *, A. R. N. Reddy, K. T. Reddy and P. K. Raju

Department of Pharmacology, Jyothismathi Institute of Pharmaceutical Sciences, Thimmapur, Karimnagar, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2265-70

2265-2270

68

35

45.

EVALUATION OF PESTICIDE CHLORPYRIFOS TOXICITY ON DROSOPHILA MELANOGASTER

Chlorpyrifos is one of the commonly detected pesticides found in food and water. Extensive use of it in agriculture and its persistence in the environment have raised public concern to overcome the pollution and toxicity problems. Exposure to chlorpyrifos poses several harmful effects to animal and human health. And the pathology in neurodegenerative diseases is mainly because of mitochondrial dys...

H. N. N. Kumar, M. Raveesh, A. K. Shettar and P. Niranjana *

Post-graduate Studies and Research in Biochemistry, Kuvempu University, Shankaraghatta, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2271-81

2271-2281

73

31

46.

HYPOGLYCEMIC EFFECTS OF LUFFA ACUTANGULA (L.) ROXB. FRUIT EXTRACT IN NORMAL AND STREPTOZOTOCIN-INDUCED DIABETIC RATS

Luffa acutangula (L.) Roxb. (Family: Cucurbitaceae) has been used in the folkloric Indian medicinal system to treat numerous health conditions. The fruits of the plant have been used in dysentery, jaundice, diabetes, hemorrhoids, leprosy, and ringworm infection. The present study aimed to establish the hypoglycemic effect of the aqueous fruit extracts of Luffa acutangula was investigated in normal...

R. Thatchinamoorthi *, K. Ganesan and M. R. Pandian

PG Research Department of Biotechnology & Microbiology, National College (Autonomous), Tiruchirappalli, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2282-88

2282-2288

71

37

47.

NEW STABILITY INDICATING UFLC METHOD FOR SIMULTANEOUS ESTIMATION OF METFORMIN HCL AND VILDAGLIPTIN IN BULK AND SOLID DOSAGE FORM

A new stability indicating Ultra-Fast Liquid Chromatography (UFLC) method was validated for the simultaneous estimation of Metformin hydrochloride (MET) and Vildagliptin (VILDA) in bulk and tablet dosage form as per the International Council for Harmonization guidelines. Chromatography developed on Shimatzu UPLC, X-Bridge C18 column equipped with PDA detector. Mobile phase composed of phosphate bu...

R. B. Mendhule *, A. S. Warokar, U. N. Mahajan, N. M. Mahajan and L. N. Barde

Dadasaheb Balpande College of Pharmacy, Besa, Nagpur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2289-95

2289-2295

66

31

48.

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF NOVEL QUINAZOLINONE DERIVATIVES AS ANTI-INFLAMMATORY AGENTS

A series of quinazolinone derivatives were synthesized and screened for anti-inflammatory activity. 5-chloro anthranilic acid undergoes acetylation in the presence of acetic anhydride and anhydrous sodium acetate to give 5-chloro-N-acetyl anthranilic acid as intermediate-I which upon cyclization in the presence of phosphorous pentaoxide, glacial acetic acid, and para aminobenzoic acid to yield 4-[...

R. Patel *, R. Saraswat and S. Pillai

Institute of Pharmacy, Indore, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2296-05

2296-2305

73

38

49.

EVALUATION OF THE GENETIC DIVERGENCE OF VARIOUS ACCESSIONS OF THE SPECIES CARISSA CARANDAS USING INTER SIMPLE SEQUENCE REPEAT PRIMERS

Carissa carandas Linn. belonging to the family Apocynaceae, is an underutilized fruit plant. C. carandas has been used in many ethno medicines 6, 40, 30. Genetic diversity is a ubiquitous feature of all species in nature. ISSR markers are useful in areas of genetic diversity, phylogenetic studies, gene tagging, genome mapping, and evolutionary biology in a wide range of plant species 4, 12. In thi...

D. Saikia * and P. J. Handique

Department of Biotechnology, Gauhati University, Gopinath Bardoloi Nagar, Guwahati, Assam, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2306-16

2306-2316

70

37

50.

DEVELOPMENT AND VALIDATION OF NOVEL UV SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF MEBENDAZOLE IN PHARMACEUTICAL FORMULATION

Mebendazole is a broad-spectrum anthelmintic drug that is widely used in the treatment of helminthic infections. A simple, accurate, and precise UV-visible spectrophotometric method has been developed and validated for the determination of Mebendazole in tablet formulation. The solvent used for the development of the proposed method was Phosphate buffer 6.8 at 278.6 nm. The Beers' law was obeyed i...

S. Shrivastava * and C. D. Kaur

Shri Rawatpura Sarkar Institute of Pharmacy, Kumhari, Durg, Chhattisgarh, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2317-22

2317-2322

71

36

51.

EVALUATION OF ANTICONVULSANT, ANTIANXIETY ACTIVITY OF IPOMOEA PES-TIGRIDIS EXTRACTS IN MICE

Ipomoea pes-tigridis (IP) is a twinning hairy herb grown in India. Based on the ethnopharmacological information of the plant, the ethanolic extract of the whole plant of Ipomoea pes-tigridis was evaluated for its anticonvulsant, antianxiety activity in mice. The Antiepileptic activity was assessed by using MES (maximal electroshock) model (200 and 400 mg/kg), and antianxiety activity was assessed...

V. I. Anaha * and R. N. Manohar

Department of Pharmacology, Sreekrishna College of Pharmacy and Research Centre, Parassala, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2323-30

2323-2330

68

34

52.

A STUDY TO ASSESS EFFECT OF MA-UL-SHA’EER (BARLEY WATER) IN INTERMEDIATE HYPERGLYCEMIC (PRE-DIABETIC) SUBJECTS ATTENDING HOSPITALS IN DELHI

Objective: To assess the efficacy of Ma-ul-Sha’eer (Barley water) as a dietary intervention in Intermediate Hyperglycemic subjects. Methods: A hospital-based prospective, pre and post interventional studies, conducted on 40 diagnosed cases of Intermediate Hyperglycemia (Pre-diabetes) as per WHO and ADA criteria at OPD of Majeedia Unani Hospital and A & U Tibbia College and Hospital, Delhi. R...

G. Fatma *, M. J. Siddiqui, P. Wani, A. Habib, S. Nikhat and A. Nasir

Department of Tahaffuzi wa Samaji Tibb (Preventive and Social Medicine), School of Unani Medical Education & Research, Jamia Hamdard, New Delhi, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2331-43

2331-2343

71

34

53.

MICELLAR SPECTROPHOTOMETRIC DETERMINATION OF COPPER IN THE VARIOUS SAMPLES OF MILK

Milk is a complex system where analysis of metal ions is a difficult task due to the presence of interfering materials. The formation of a coloured complex between the metal and a coloured or colourless ligand is the basis for the development of spectro-photometric methods. The aim of this study is to analyze and estimate copper present in various samples of milk (i.e., cow, buffalo, goat, camel, ...

N. Gakkhar * and N. Bhojak

Department of Chemistry, S. S. Jain Subodh P. G. College, Jaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2344-48

2344-2348

74

33

54.

EFFECT OF PIPER BETLE LEAF EXTRACT AND SYZYGIUM AROMATICUM FLOWER EXTRACT AND THEIR ACTIVE COMPONENT EUGENOL ON THE SURVIVAL OF LUNG ADENOCARCINOMA CELLS (A549)

Medicinal plants are one of the most important resources for developing new lead therapeutic compounds used in various traditional medicines worldwide for thousands of years due to the presence of natural bioactive components, which help in preventing various human diseases. Piper betle Linn belongs to the Piperaceae family, commonly known as Betel and Paan. Betel leaves possess several bioactivit...

C. Azhagumeena, P. R. Padma and S. Sumathi *

Department of Biochemistry, Biotechnology and Bioinformatics, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2349-60

2349-2360

72

38

55.

IN-VIVO ANTI-ARTHRITIC EFFECT OF ETHANOL EXTRACT OF SESBANIA GRANDIFLORA SEEDS ON COMPLETE FREUND’S ADJUVANT (CFA)-INDUCED ARTHRITIS IN RATS

Herbal medicines are in substantial demand in the developed country for primary healthcare because of their high efficacy, safety, and few side effects. Sesbania grandiflora is an ancient plant that belongs to the family Fabaceae. Traditionally, it is used for the treatment of various disorders such as diabetes, anxiety, hepatotoxicity, ulcer, and anti-inflammatory activity. Therefore the present ...

S. N. Pandey and B. C. Semwal *

Department of Pharmacology, Institute of Pharmaceutical Research GLA University, Mathura, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2361-69

2361-2369

70

40

56.

STUDIES ON IN-VITRO ANTICANCER AND ANTIOXIDANT PROPERTIES FROM MARINE BACTERIAL PIGMENT ISOLATED FROM THE COASTAL AREA OF MARAKANAM (TN)

Marine bacteria have the potentiality to produce diverse bioactive molecules such as pigment. Therefore, it needs to exploit and identifying a novel type of pigment from marine bacteria for Industrial applications. This study aimed to investigate the marine bacterial pigment against antioxidant and anti-cancer properties; the marine bacteria producing pigment were isolated from water samples colle...

S. Aroumougame

Department of Microbiology, School of Life Sciences, Pondicherry University, Puducherry, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2370-79

2370-2379

67

35

57.

REVISITING THE ROLE OF LOW DOSE RADIATION THERAPY AGAINST COVID-19 PNEUMONIA

Background: The entire world is battling the coronavirus disease (COVID-19) that potentially leads to pneumonia, Acute Respiratory Distress Syndrome (ARDS), multi-organ failure, often resulting in death. Therefore, the utmost challenge from a medical perspective is to improve lung function before the patient requires intubation and critical care. In the same light, the use of low dose radiation th...

J. Sati, S. Bhat and V. D. Chadha *

Centre for Nuclear Medicine, Panjab University, Chandigarh, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2380-84

2380-2384

87

54

58.

PREPARATION AND CHARACTERIZATION OF Fe3O4@SiO2@L-VALINE NANOPARTICLES AS AN EFFECTIVE AND NOVEL NANOCATALYST FOR THE SYNTHESIS OF PERIMIDINE DERIVATIVE UNDER MILD CONDITIONS

We presented an eco-friendly procedure for effective and fast preparation of biologically active substituted pyrimidine ligand through a condensation reaction of 1,8-diaminonaphthalene and 2-methoxy-benzaldehyde with Fe3O4@SiO2@L-valine magnetic nanoparticles (MNPs) as a new recyclable catalyst. In this experiment, we aim to increase reaction efficiency for the synthesis of 2-(2-methoxyphenyl)-2,3...

S. Siabi, H. Pasdar *, N. Foroughifar, M. Davallo and R. Fazaeli

Department of Chemistry, North Tehran Branch, Islamic Azad University, Tehran, Iran.

DOI: 10.13040/IJPSR.0975-8232.12(4).2385-93

2385-2393

69

27

59.

DETERMINATION OF LETHAL CONCENTRATION FIFTY (LC50) OF WHOLE PLANT ETHANOLIC EXTRACT OF AMARANTHUS VIRIDIS, CYNODON DACTYLON & AERVA SANGUINOLENTA ON ZEBRAFISH (DANIO RERIO) EMBRYOS

Introduction: Most potent toxic elements are derived from nature only. So safety and toxicological evaluation of plant extracts which are otherwise thought to be very safe, are mandatory. The zebrafish embryo has become an important model organism for toxicological research due to its small size, genetic similarity to humans, etc. The Objective: The objective of the present study is to determine a...

S. Zahir *, T. K. Pal, A. Sengupta, S. Biswas, S. Bar and S. Bose

Department of Pedodontics and Preventive Dentistry Gurunanak Institute of Dental Science & Research, Kolkata, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2394-04

2394-2404

66

31

60.

AN OBSERVATIONAL STUDY REGARDING PRESCRIPTION EVENT MONITORING OF ANTI-HYPERTENSIVE MEDICATIONS AMONGST PATIENTS COMING TO A TERTIARY CARE CENTRE OF NORTHERN INDIA

Hypertension is now defined on the basis of systolic (SBP) and diastolic (DBP) blood pressure levels and classified into stages on the basis of the degree of elevation. The generally recognized cut point for hypertension is an average office BP of 140/90 mmHg or greater, which has been obtained by a recommended standard technique with an accurate manometer and has been confirmed on at least one ot...

S. Mishra *, N. Nigam, S. S. Ahmad, P. Shankar, S. Kumar, V. Kumar and S. Gupta

Department of Pharmacology, Rama Medical College Hospital & Research Centre, Kanpur, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2405-10

2405-2410

67

31

61.

GEOGRAPHICAL BASED GENOMIC AND PATHOGENIC STUDY OF THE SARS-COV-2

The current pandemic COVID 19 caused by SARS-CoV-2 is very contagious and causes respiratory disease outbreaks. In a various genomic analysis, different strains of SARS-CoV-2 was found to infect different geographical locations of the world (India, USA, and Brazil) and also in different parts of India (Kerala, Surat, and Ahmedabad). Different genome sequences of SARS-CoV-2 isolated from different ...

G. Dhanalakshmi * and Anadi

Department of Biochemistry, Padmashree Institute of Management and Sciences, Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2411-16

2411-2416

75

40

62.

VALIDATED UV SPECTROPHOTOMETRIC METHOD FOR IN-VITRO DISSOLUTION STUDIES IN PHOSPHATE BUFFER pH 7.4

A simple, accurate, and economical, least time-consuming method has been developed for Losartan potassium (LP) by using UV spectrophotometer. This method was developed using phosphate buffer solution pH 7.4 (PBS) for quantifying the amount of LP released from the colon-specific formulations. The wavelength maximum (λmax) of LP in phosphate buffer pH 7.4 was found to be 228.5 nm. The developed UV ...

S. Chaturvedi *, S. Ayaz and K. Shah

Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2417-21

2417-2421

84

36

63.

SARS COV, MERS COV, SARS COV-2 AND TREATMENTS: A BIBLIOMETRIC ANALYSIS

As the incidences of Coronavirus (SARS CoV-2) infections have been increasing at a rapid pace, the need for its containment and treatment has taken center stage for numerous research institutions. The similarity of SARS CoV-2 with that of SARS CoV has led to a jumpstart in the research activities on corona-virus on the same. The number of research articles appearing since the time SARS CoV-2 was d...

R. Parveen, M. Wahid, P. Chudhury, S. A. Dar, S. Haque, E. Arya and A. Jawed *

Research and Scientific Studies Unit, College of Nursing and Allied Health Sciences, Jazan University, Jazan, Saudi Arabia.

DOI: 10.13040/IJPSR.0975-8232.12(4).2422-27

2422-2427

71

36

64.

ANTI-DIABETIC EFFECT OF LEAF AND STEM EXTRACT OF MACROTYLOMA UNIFLORUM (LAM.) VERDC IN ALLOXAN INDUCED DIABETIC RATS

Diabetes mellitus (DM) is a metabolic disorder in the endocrine system resulting from a defect in insulin secretion, insulin action or both of them. Adverse side effects of chemical drugs for the treatment of diabetes persuaded the use of medical plants. Macrotyloma uniflorum is a traditionally used plant for the treatment of diabetes is packed with powerful plant constituents with polyphenols, fl...

G. Vasantha *, A. Venkatesham and C. H. Dayakar

Vignan Institute of Pharmaceutical Technology, Visakhapatnam, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2428-37

2428-2437

65

33

65.

THERAPEUTIC DRUG MONITORING OF SERUM PHENYTOIN FOR EARLY POST TRAUMATIC SEIZURE PROPHYLAXIS IN TRAUMATIC BRAIN INJURY PATIENTS USING EMIT ASSAY IN A TERTIARY CARE HOSPITAL

Aims & Objective: To monitor therapeutic drug level of serum phenytoin for early posttraumatic seizure prophylaxis in traumatic brain injury (TBI) patients using enzyme multiplied immunoassay technique (EMIT) in a tertiary care hospital. Materials and Method: In this observational, open-label, non-interventional, prospective study, 90 patients of mild to moderate TBI patients were recruited, a...

L. Majhee, A. Chandra *, A. Prakash and M. Gari

Department of Pharmacology, MMCH, Ranchi, Jharkhand, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2438-43

2438-2443

70

36

66.

FORMULATION AND EVALUATION OF VINPOCETINE ORODISPERSIBLE TABLETS: IN-VITRO CHARACTERIZATION AND IN-VIVO PHARMACOKINETIC STUDY

Objective: This research article aims to formulate and evaluate orodispersible tablets (ODTs) for Vinpocetine, a nootropic drug used for improving brain functions and cerebral blood flow. This will provide a convenient way for taking medication for dysphagia patients and therefore improve compliance. Methods: Vinpocetine ODTs were prepared by using superdisintegrants. A full mixed 31×41 factorial...

E. S. G. Sidhom *, S. M. Salah and D. M. M. Ghorab

Medical Research Centre, Heliopolis University for Sustainable Development, Cairo, Egypt.

DOI: 10.13040/IJPSR.0975-8232.12(4).2444-57

2444-2457

79

34

67.

DESIGN CHARACTERIZATION AND FORMULATION OF IN-SITU GELLING OPHTHAL-MIC DRUG DELIVERY SYSTEM CONTAINING PLANT DERIVED PHENOLS

The objective of the present investigation was to formulate and evaluate ion-activated in-situ gel using the herbal drug catechin, a potential natural antioxidant for the treatment of glaucoma by lowering oxidative stress. A total of eight formulations were prepared and evaluated for parameters, namely physical appearance, gelling capacity, pH measurement, rheological studies, the effect of steril...

P. Akki *, F. S. Dasanakoppa and K. S. Akki

Department of Pharmaceutics, KLE College of Pharmacy, Vidyanagar Hubli, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2458-65

2458-2465

75

37

68.

NOVEL SULFONAMIDE SCHIFF’S BASES AND THEIR ANTIMICROBIAL ACTIVITY

In the vision of chemistry, Schiff bases are excellent ligands and play a very important role in drug discovery and development. The Schiff bases and their complexes have been reported in the literature possessing wide applications in biological, clinical, and analytical fields. In outlook of this, new Schiff bases of Sulfonamide drug were synthesized by a very simple reaction and in good yield. T...

H. V. Shahare *, G. S. Lodha, S. R. Jain and A. R. Patni

Department of Pharmaceutical Chemistry, SNJBs Shriman Sureshdada Jain College of Pharmacy Chandwad, Nashik, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2466-69

2466-2469

66

31

69.

ANTICOAGULANT AND FIBRINO(GENO)LYTIC PROTEASE FROM LEUCAS ASPERA

Leucas aspera is the medicinal plant commonly known as ‘Thumbai’ found all over India. It is being used in traditional medicine to treat cough, cold, diarrhea, inflammatory diseases, and paste of the plant that has been used to treat the wound to enhance the wound healing process. The plant is reported to have anti-inflammatory, analgesic, antidiarrheal, antimicrobial, antioxidant, and insecti...

V. Gubbiveeranna, C. G. Kusuma, C. K. Sumachirayu, S. Bhavana, H. Ravikumar and S. Nagaraju *

Department of Studies and Research in Biochemistry, Tumkur University, Tumakuru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2470-76

2470-2476

45

19

70.

FORMULATION AND EVALUATION OF BIOADHESIVE BUCCAL TABLETS OF ENALAPRIL MALEATE

Enalapril maleate competitively inhibits the ACE to hinder the production of angiotensin II, a key component of the rennin angiotensin aldosterone system that promotes vasoconstriction and reabsorption of sodium ion in the kidney, overall decrease in blood pressure. The study's main objective was to formulate and evaluate bioadhesive buccal tablets to avoid the first-pass metabolism in the liver a...

V. R. Joan, S. N. Santha and K. Balamurugan *

Department of Pharmay, FEAT, Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2477-84

2477-2484

45

17

71.

SIMULTANEOUS QUANTIFICATION OF ROSUVASTATIN AND TELMISARTAN IN BULK AND TABLET – A VALIDATED UV-SPECTROPHOTOMETRIC TECHNIQUE

Rosuvastatin and Telmisartan are used together as a fixed dosage combination to treat hypertension associated with dyslipidemia. Objective: To develop and validate a simple, sensitive, precise, ecofriendly and cost-effective method for the determination of Rosu-vastatin and Telmisartan in bulk and pharmaceutical formulation as per ICH Guidelines. Methods: an effort has been made to develop a simpl...

N. Patil and B. Sharannavar *

K. L. E. College of Pharmacy, Belagavi, K. L. E. Academy of Higher Education and Research, JNMC Campus, Belagavi, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2485-91

2485-2491

40

18

72.

DEVELOPMENT AND EVALUATION OF LAPATINIB DITOSYLATE SELF-NANO-EMULSIFYING DRUG DELIVERY SYSTEMS

The main objective of the study is to develop gelucire 44/14 based lapatinib ditosylate (LPT) SNEDDS for the improvement of solubility and drug release. Pseudo tertiary phase diagram constructed for varying oil, surfactant, and co-surfactant combinations. Fifteen LPT SNEDDS formulations were prepared with anticipated component ratios (gelucire 44/14, peceol, and capmul MCM) based on monophasic reg...

A. Khan *, S. Roshan, K. Anandarajagopal and B. Tazneem

School of Pharmacy, KPJ Healthcare University College, Nilai, Negeri Sembilan, Malaysia.

DOI: 10.13040/IJPSR.0975-8232.12(4).2492-99

2492-2499

42

22