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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

A Web of Science - ESCI Indexed Journal
Projected Impact Factor (2019): 1.230 , CiteScore (2017): 0.27

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Volume 11 (2020) - Issue 8, August

Review Articles

 
Title
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1.

HYDROXYCHLOROQUINE DRUG SAFETY REVIEW FOR THE PROPHYLAXIS OF SARS COV 2 PANDEMIC

COVID19 outbreak, originated from Wuhan, china is now declared as pandemic by WHO. HCQ has got special attention after various advisories are being issued by health authorities to utilize it for the prophylaxis of SARS COV2. Therefore, drug safety evaluation based on its pharmacokinetic & pharmacodynamics parameters & literature rationale for Evidence Based Medicine is required for its jus...

A. Singh, J. Kumaravel, D. Mahendru, M. Yadav, H. Kumar, A. Prakash and B. Medhi *

Department of Pharmacology, Postgraduate Institute of Medical Education & Research (PGIMER) Chandigarh, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).3535-43

3535-3543

412

200

2.

THE DEVELOPMENT OF COX-1 AND COX-2 INHIBITORS: A REVIEW

NSAIDs (Non-steroidal anti-inflammatory drugs) show its effect by preventing prostaglandin synthesis, which reasons ulcer complications and mucosal damage all over the gastrointestinal tract. The world’s most accepted drug was aspirin for treatment of pain and inflammation without knowing that it has the ability to inhibit prostaglandin production by inhibiting the cyclooxygenase enzyme for the ...

R. K. Vishwakarma and D. S. Negi *

Department of Chemistry, H. N. B. Garhwal University (A Central University), Srinagar Garhwal, Uttarakhand, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).3544-55

3544-3555

261

106

3.

HEPATITIS C VIRUS: AN OUTLINED REVIEW

Chronic hepatitis C (CHC) is a big cause of liver-related fibrosis and cirrhosis. The level of fibrosis is usually in the past (established by histology). The prognosis is estimated using fibrosis progression rates (FPRs; the annual probability of progressing across histological stages). However, new non-invasive options are quickly replacing biopsy. As the rates of HCV cirrhosis go on increasing ...

S. D. Labhade *, Y. B. Zambare, S. S. Chitlange, R. B. Saudagar, S. Mahadevan and S. Tiwari

Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).3556-63

3556-3563

187

90

4.

VIRUSES AS HIJACKERS

Viruses are like hijackers. They invade living, normal cells, and replicate and create other viruses like themselves using those cells. This can destroy, harm, or change the cells and cause sickness. Various viruses in the human body invade other cells, such as the liver, respiratory system, or blood. Viruses are too small germs. Inside a protein matrix, they are made of genetic material inside of...

S. Sivakrishnan * and J. Kavitha

Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).3564-73

3564-3573

190

90

5.

EVOLVING KNOWLEDGE IN FRAMING OF TERATOGENIC ACTIVITY TOWARDS RISK PERCEPTION

Birth defects induced by maternal exposure to exogenous agents during pregnancy are preventable if the agents themselves can be identified and avoided. This might be the causative effect in mechanical fetal diseases and retarded in the development of embryo and fetus. Often, the safety of a drug in the mother’s fetuses and nursing infants cannot be determined until it has been widely used. This ...

A. D. Paul *, V. M. Prathap and A. Chandrakala

Department of Pharmaceutics, SVU College of Pharmaceutical Sciences, SV University, Tirupati, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).3574-86

3574-3586

161

61

6.

MECHANISM OF DRUG INDUCED RENAL FAILURE: A REVIEW

Acute renal failure (ARF) is characterized by a rapid, potentially reversible decline in renal function, including a rapid fall in glomerular filtration rate (GFR) and retention of nitrogenous waste products over a period of hours or days. The mortality rate of patients with ARF has remained 25–70% despite the use of various pharmacologic agents. Due to the multiple causes of renal failure, many...

S. Roy

Department of Biological Sciences, Midnapore City College, Kuturia, Bhadutala, Midnapore, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).3587-94

3587-3594

78

30

7.

IMPROVEMENT IN BIOAVAILABILITY OF POORLY SOLUBLE DRUG BY SELF MICRO EMULSIFYING DRUG DELIVERY

Solubility is the rate-limiting step for bioavailability of poorly water-soluble drugs. The solubility of poorly water-soluble drugs can be enhanced by incorporating active pharmaceutical ingredients into oral lipid-based drug delivery systems. Self micro emulsifying drug delivery system (SMEDDS) is a researcher’s choice amongst other oral lipid drug delivery systems because it offers advantages...

A. Shelar, J. Mahore *, S. Deshkar and R. Trivedi

Department of Pharmaceutics, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).3595-07

3595-3607

93

31

8.

GLUTATHIONE: INDUCTION OF APOPTOSIS AND AUTOPHAGY IN CANCER

Glutathione (GSH) is the most abundant non-protein thiol in eukaryotic cells capable of carrying out antioxidant defense mechanisms in the cell for its survivability, mostly against free radicals, i.e., Reactive Oxygen Species (ROS). GSH protects normal cells against carcinogenic transformation, but high GSH levels in cancer cells decrease sensitivity to chemo- and radiotherapy, producing resistan...

S. Gupta and A. N. Sahu *

Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).3608-18

3608-3618

92

27

9.

TARGET TREATMENT IN DIABETIC AND MICROVASCULAR COMPLICATIONS: AN UPDATED REVIEW

Diabetes Mellitus is the most common endocrine disorder, affecting a larger population of the world, which arises due to defective insulin secretion by beta cells in the pancreas or insulin resistance by peripheral tissues. As the disease progress, microvascular complications like nephropathy, neuropathy, retinopathy, and cardiovascular complications are observed, which the leading causes of death...

D. R. Kamalesh *, K. M. Geetha and M. Harish

Drug Testing Laboratory, Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).3619-25

3619-3625

77

30

10.

DESIGN OF EXPERIMENTS: A MANIFEST APPROACH IN DESIGNING OPTIMIZED DRUG PRODUCTS

The recent scenario of accomplishment with faultlessness indulges a bent towards the techniques that develop the final formulations with the precise use of experimental designs. Also, the application of computer-aided optimization techniques has proved to be favorable in the development of drug delivery systems with reliable results. The optimization techniques have a comprehensive range of design...

A. Hardenia *, S. Hardenia and S. Dwivedi

Sri Aurobindo Institute of Pharmacy, Indore, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).3626-35

3626-3635

82

26

11.

CARBON NANOTUBES AN ADVANCED DRUG DELIVERY SYSTEM – A REVIEW

In today’s 21st century, Carbon nanotubes (CNTs) are the most researched material by world investigation of the growing industry due to their various reasons properties for use in many applications either in medical or other potential applications. Carbon nanotubes become increasingly popular in various fields simply because of their small size and amazing optical, electric, and magnetic propert...

S. R. Divekar

Department of Pharmaceutics, Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).3636-44

3636-3644

63

28

12.

A COMPREHENSIVE PHARMACOGNOSTIC REVIEW: MANILKARA HEXANDRA (ROXB.) DUBARD

The aim of this review paper is to provide throughout the information of Manilkara hexandra (Roxb.) Dubard, used as a Khirni or Rayon in most of the tropical regions of India. It is native to India, mainly distributed as a wild tree in the southern part and North-central part of India. It is widely spread in Gujarat, Rajasthan, Madhya Pradesh, Andhra Pradesh, Kerala and Maharashtra our efforts are...

S. Singh * and M. K. Jha

Institute of Pharmaceutical Research, G. L. A. University, Mathura, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).3645-52

3645-3652

179

35

13.

SELF-EMULSIFYING SYSTEMS: A REVIEW

Effective delivery of drugs can be made through various routes of administration, and the oral route is considered to be the most convenient for the administration of drugs to patients. Poor aqueous solubility was acknowledged as the main reason for the poor oral absorption of chemical entities. Apart from the conventional solubilization approaches like co-solvency, salt formation, solid dispersio...

K. L. Prasad, G. Vasavi and K. Hari *

Department of Pharmaceutical Technology, Maharajah’s College of Pharmacy, Phool Baugh, Vizianagaram, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).3653-63

3653-3663

996

40

Research Articles

 
Title
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14.

MOLECULAR VERSUS CONVENTIONAL TECHNIQUES FOR THE DETECTION OF STAPHYLOCOCCUS AUREUS, PSEUDOMONAS AERUGINOSA AND CANDIDA ALBICANS IN NON-STERILE PHARMACEUTICAL PREPARATIONS

Notable progress has been made in methods that encourage the use of PCR as a rapid and accurate tool in quality evaluation of pharmaceuticals. In this study, monoplex and multiplex PCR based assays were developed and compared with standard conventional methods for rapid detection of three specified topical indicator pathogens, Pseudomonas aeruginosa, Staphylococcus aureus and Candida albicans, in ...

R. S. El-Houssieny, M. M. Aboulwafa *, W. F. Elkhatib and N. A. Hassouna

Department of Microbiology and Immunology, Faculty of Pharmacy, Ain Shams University, Al Khalifa Al Maamoun St., Abbassia, Cairo, Egypt.

DOI: 10.13040/IJPSR.0975-8232.11(8).3664-78

3664-3678

189

93

15.

ANTI-WRINKLE ACTIVITY AND UPLC-MS/MS METABOLIC PROFILING OF POMEGRANATE AND GRAPE SEEDS EXTRACTS

UV irradiation is one of the main causes of what is known as photoaging characterized by loss of skin elasticity and the appearance of wrinkles. In this study, the anti-wrinkle activity of grape seed extract (GSE) and Pomegranate seed extract (PSE) was studied through evaluation of their in-vitro antioxidant, anti-tyrosinase and in-vivo anti-wrinkle activity in UVB-irradiated mice through topical ...

S. M. Odah, M. M. Salama, W. M. Aziz, T. S. El-Alfy and S. M. Ezzat *

Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, Egypt.

DOI: 10.13040/IJPSR.0975-8232.11(8).3679-89

3679-3689

194

77

16.

BIOCHEMICAL ANALYSIS AND EVALUATION OF ANTIMICROBIAL PROPERTIES OF THEAFLAVINS AND FLAVONOIDS RICH EXTRACT (TFE) AND ITS SILVER NANOCONJUGATES: A COMPARATIVE STUDY

Black tea, the most widely consumed aromatic non-alcoholic beverage second to water, is prepared by boiling cured leaves of Camellia sinensis. It is reported that black tea contains plenty of bioactive constituents, including complex polyphenols like theaflavins (TF2A, TF2B, TF3) and thearubigins that exhibit a wide range of pharmacological properties and also contribute to its quality and bioacti...

C. Das, A. Dutta, A. Muhuri, S. Kothari, P. Ghosh, A. Roy, A. K. Hazra, S. K. Bandyopadhyay and S. Chatterjee *

Department of Biotechnology, Techno India University, Kolkata, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).3690-01

3690-3701

179

81

17.

NEUROPROTECTIVE EFFECT OF LEUCAS ASPERA IN STREPTOZOTOCIN INDUCED ALZHEIMER RAT MODEL

The present investigation deals with the assessment of neuroprotective effect Leucas aspera in streptozotocin (STZ) induced Alzheimer’s disease (AD) in rats. AD was induced by administering STZ (3 mg/kg, ICV) on day one and 3rd day after surgery. Surgery was performed on anesthetized rats with the help of the stereotaxic apparatus. STZ induced AD rats were treated with ethanolic extract of Leuca...

V. Ramachandran *, S. Umakanth and H. N. Ahamed

Department of Pharmacology, J. S. S. College of Pharmacy, (J. S. S. Academy of Higher Education & Research), Ootacamund, Nilgiris, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).3702-08

3702-3708

157

66

18.

FORMULATION DEVELOPMENT AND CHARACTERIZATION OF MICROEMULSION OF EXTRACT OF E. NUDA

The compounds that are derived from the natural sources have been used for the treatment of cancer since ancient times. The tubers of Eulophia nuda, belonging to family Orchidaceae, have been reported for its anti-cancer use in the literature. There are many disadvantages to the conventional herbal drug delivery system. These disadvantages could be overcome by formulating these herbs using novel d...

D. Bhatt *, D. Suthar, K. Jethva, S. Deshpande and M. Zaveri

Department of Pharmacognosy, K. B. Institute of Pharmaceutical Education and Research, Gandhinagar, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).3709-16

3709-3716

157

67

19.

MOLECULAR DOCKING STUDIES ON PHYTOCHEMICALS OF SOLANUM NIGRUM FRUITS FOR ITS HEPATOPROTECTIVE ACTIVITY

Liver fibrosis is a wound healing process that is initiated in response to chronic liver injury caused by viruses, toxins, and hepatotoxic drugs. This disease is characterized by inflammation, followed by the deposition of extracellular matrix proteins to form scar tissue. Ephrin receptor A2 (EphA2) is identified as a host cofactor for Hepatitis C Virus (HCV) entry. The fruits of Solanum nigrum po...

U. Mythily *, S. Subramaniam and S. Shyama

Department of Biochemistry, Regenix Super Speciality Laboratories, Choolaimedu, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).3717-24

3717-3724

99

32

20.

FORMULATION DEVELOPMENT AND EVALUATION OF BUCCAL DRUG DELIVERY OF DAPOXETINE HYDROCHLORIDE

The current study work is focused on Dapoxetine hydrochloride buccal films. In recent days, buccal drug delivery has aimed at importance in many aspects compared to conventional tablets. The addition of mucoadhesive polymers to the formulation enhances the therapeutic levels of drug. Dapoxetine hydrochloride, a choice of drug used in the therapy of premature ejaculation in men. Dapoxetine hydrochl...

M. S. Reddy * and N. Mounika

Centre for Pharmaceutical Sciences, Institute of Science and Technology, Jawaharlal Nehru Technological University, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).3725-33

3725-3733

73

23

21.

FORMULATION, CHARACTERIZATION AND EVALUATION OF SOLID LIPID NANOPARTICLES OF SELECTED ANTITUBERCULAR AGENT

The purpose of this work was to develop prolonged-release solid lipid nanoparticles (SLNs) of Rifampicin (RIF) for oral drug delivery and to improve the bioavailability of RIF. SLNs were designed by using Glycerol monostearate (GMS) and lipid core materials and polaxamer 188 as a stabilizer. SLNs were prepared by o/w microemulsion technique and characterized by particle size analysis, Fourier tran...

M. Hanumanaik *, K. V. Kumar, G. Kiran and G. S. Rao

Vishwabharti College of Pharmaceutical Sciences, Perecherla, Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).3734-44

3734-3744

75

26

22.

FORMULATION AND IN-VITRO CHARACTERISATION OF CONTROLLED RELEASE LAFUTIDINE SUPER PORUS HYDROGEL TABLETS

The aim is to design, develop & characterize a desired gastro retentive super porous hydrogel (SPH) formulations containing lafutidine is histamine H2-receptor antagonist that may be used alone or with other agents to treat inhibits stomach acid production. SPH‘s synthesized employing various composite agents viz., sodium alginate, pectin, Carbopol, and chitosan were subjected to density and...

M. G. Ramya *, R. Akki and S. Kathirvel

University College of Pharmaceutical Sciences, Faculty of Pharmacy, Acharya Nagarjuna University, Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).3745-62

3745-3762

66

26

23.

ANALYSIS OF MULTIPLE ANTIBIOTICS RESISTANT AND MOLECULAR EPIDEMIOLOGY OF ESCHERICHIA COLI AND PSEUDOMONAS AERUGINOSA

The present investigation aimed at the study of resistant plasmid patterns of multidrug-resistant Escherichia coli and Pseudomonas aeruginosa isolated from hospital-acquired infection in urinary tract site are causes serious public health hazard throughout the world. A total of 100 urine samples were collected from patient admitted to the hospital. The antibiotic sensitivity of isolated uropathoge...

M. M. M. Raja * and N. Reehana

PG and Research Department of Microbiology, Jamal Mohamed College (Autonomous), Tiruchirappalli, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).3763-71

3763-3771

53

24

24.

DESIGNING A FORMULATION SYSTEM TO ENHANCE AQUEOUS SOLUBILITY AND DISSOLUTION OF POORLY SOLUBLE DRUG

The main purpose of this investigation study is to enhance the solubility and dissolution rate of poorly water-soluble drug Fluconazole. Fluconazole was selected as the choice of drug as it belongs to BCS class II i.e., drugs having low solubility and high permeability, which hinders in-vivo efficacy of drugs giving poor pharmacokinetic profile and low absorption. Solid dispersions are formed to i...

Z. Nasikkar * and N. Khutle

Department of Pharmaceutics, Dr. L. H. Hiranandani College of Pharmacy, Ulhasnagar, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).3772-81

3772-3781

53

44

25.

EVALUATION OF DIURETIC ACTIVITY OF CRUDE EXTRACTS OF LEAVES OF FILICIUM DECIPIENS AND ANALYSIS OF BIOMOLECULES PRESENT IN FRACTION OF METHANOLIC EXTRACT USING GC-MS TECHNIQUE

Filicium decipiens belongs to the Sapindaceae family, which is commonly known as fern tree, is found in the Western Ghats of southern India, small highland areas of East Africa and Sri Lanka and it is a medium to a large evergreen tree. It is commonly cultivated in gardens and roadsides as ornamental, noise barriers and windbreak plant. Filicium decipiens traditionally used for the treatment of di...

A. I. Basarikatti, V. Uppar and B. Padmashali *

Department of Chemistry, Rani Channamma University, Belagavi, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).3782-87

3782-3787

67

28

26.

A NEW SERIES OF CHALCONES INCORPORATED WITH PYRIDINE MOIETY AS POTENTIAL ANTI-BACTERIAL AGENTS

A new series of chalcones have been designed and synthesized, which are incorporated with pyridine moiety chalcones possess heterocyclic rings like pyridine, pyrazole, indole, etc. These heterocycles are cyclic compounds in which one or more atoms of the ring are hetero atoms: O, N, S, P, etc. These are important components in many of the pharmaceuticals and therapeutic drugs. These are present in...

D. Vimala, P. Subashini and S. S. Shafi *

Department of Chemistry, Thiruvalluvar University, Serkkadu, Vellore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).3788-96

3788-3796

63

32

27.

PHARMACOLOGICAL EFFECT OF DIOSGENIN ON DIETHYLNITROSAMINE INDUCED HEPATOTOXICITY IN WISTAR RATS

Background: The liver is the major detoxification organ that deactivates and removes toxic chemicals. The oxidative stress-mediated toxicity of chemicals involves destruction primarily to liver tissue (Hepatotoxicity), which could lead to cancer. Diosgenin, a steroidal sapogenin, is reported to be an apoptosis inducer, antineoplastic and antioxidant. The present study is aimed to screen diosgenin ...

S. G. Jagdale, S. Arulmozhi *, S. Jamadagni and K. R. Mahadik

Department of Pharmacology, Poona College of Pharmacy, Bharati Vidyapeeth (Deemed to be University), Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).3797-05

3797-3805

68

23

28.

TERBINAFINE LOADED CHITOSAN SCAFFOLD FOR FUNGAL WOUND TREATMENT

Chitosan-based porous scaffolds are of great interest in biomedical applications especially in tissue engineering because of their excellent biocompatibility in vivo, good texture, surface contact, controllable degradation rate and tailorable mechanical properties. These days biomaterials scaffolds have contributed as an alternative choice of therapy mainly due to the increase failure rates in a...

R. P. Yadav * and M. K. Chauhan

Department of Pharmaceutics, Delhi Pharmaceutical Sciences and Research University, New Delhi, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).3806-18

3806-3818

147

29

29.

ANTI-INFLAMMATORY ACTIVITY OF CUCUMIS MELO L. SUBSP. AGRESTIS (NAUDIN) PANGALO

The present study was aimed to evaluate the in-vitro anti-inflammatory activity of fruits and leaves extract of Cucumis melo L. subsp. agrestis (Naudin) Pangalo (Family Cucurbitaceae). The ethanol and aqueous extracts of fruits and leaves of the plant were subjected to preliminary phytochemical screening and in-vitro anti-inflammatory activity. Extracts were incubated with bovine albumin under con...

S. Singh * and B. Devi

Department of Pharmaceutical Sciences Guru Jambheshwar University of Science and Technology, Hisar, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).3819-23

3819-3823

54

29

30.

FORMULATION CHARACTERIZATION AND OPTIMIZATION OF CEFIXIME TRI-HYDRATE HYDROGEL TABLET BY USING DESIGN EXPERT

The purpose of current research work has been made to formulate a gastro-retentive drug delivery system (GRDDS) of those drugs having a narrow absorption window or having good absorption at the proximal part of the gastrointestinal tract (GIT) to deliver at stomach site and to improve the bioavailability of a drug. Gastro-retentive hydrogel tablet of Cefixime trihydrate was prepared by the direct ...

L. Devi *, P. Gaba and N. Sharma

Department of Pharmaceutics, Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, Bela, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).3824-33

3824-3833

61

23

31.

IN-VITRO ANTIBACTERIAL POTENTIAL OF ALTERNANTHERA PHILOXEROIDES (MART) GRISEB AGAINST MULTI-DRUG RESISTANT UROPATHOGENS

Antimicrobial drug resistance is one of the major threats due to the wide usage of broad-spectrum antimicrobial drugs in the general population. The present study was undertaken to investigate the antibacterial potential of Alternanthera philoxeroides methanolic extract (APME) against multidrug-resistant UTI pathogens. The preliminary phytochemical screening of the extract showed the presence of c...

S. Pulipati * and P. S. Babu

Department of Pharmaceutical Biotechnology, Vignan Pharmacy College, Vadlamudi, Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).3834-40

3834-3840

66

25

32.

PHARMACOGNOSTICAL EVALUATION AND PRELIMINARY PHYTOCHEMICAL ANALYSIS OF DIFFERENT PARTS OF LAGERSTROEMIA SPECIOSA

The present study aimed to determine the pharmacognostical evaluation and phytochemical analysis of the plant part of Lagersreomia speciosa. In this study, a macroscopical, microscopical evaluation was done. Various quantitative parameters such as total ash, acid insoluble ash, water-soluble ash sulphated ash, extractive value with various solvent were done. In the preliminary phytochemical analys...

C. Majee *, R. Mazumder and A. N. Choudhary

Noida Institute of Engineering and Technology, Pharmacy Institute, Institutional Area Greater Noida, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).3841-47

3841-3847

55

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33.

PHARMACOLOGICAL EVALUATION OF POLYHERBAL SUSPENSION FOR ANTI-PARKINSONS ACTIVITY IN ALBINO RAT

The ethanolic extract of Terminalia chebula extract obtained from successive extraction of Rosa damascene by Methanol; n-hexane & n-butanol was subjected to various phytochemical tests. The antioxidant activity was accessed by DPPH method. The anti-Parkinson’s activity was tested in albino Rats. Thirty albino rats (180-250 g) of either sex were divided into five groups and each group consist...

A. Kumar and K. Mishra *

Hygia Institute of Pharmaceutical Education & Research, Lucknow, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).3848-53

3848-3853

61

22

34.

EVALUATION OF ANTI-MICROBIAL ACTIVITY OF DRYOPTERIS COLCHEATA RHIZOME

Herbal drugs have gained more importance and popularity in recent years because of their safety, efficacy, and low cost. The pteridophytes have an important role in folklore medicine, although neglected in modern days. These plants have been successfully used in different systems of medicines like Ayurvedic, Unani, Homeopathic, and other systems of medicines. Antimicrobial drugs are the greatest c...

S. Das * and D. N. Singh

Bengal College of Pharmaceutical Sciences and Research, Durgapur, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).3854-58

3854-3858

57

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35.

ISOLATION AND QUANTIFICATION OF GALLIC ACID FROM EULOPHIA OCHREATA LINDL. BY HPTLC

In the healthcare system, the development and modernization of phytomedicine in phytochemistry play a central and important role in drug development. Isolation and purification of bioactive compounds from naturally occurring substance are of prime importance. A sensitive and reliable high-performance thin-layer chromatography method has been developed for the estimation of gallic acid in the alcoh...

A. A. Koparde *, R. C. Doijad, A. Patil and C. S. Magdum

KIMSDTU’s, Krishna Institute of Pharmacy, Krishna hospital Campus, Malkapur, Karad, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).3859-66

3859-3866

70

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36.

QUALITY BY DESIGN (QbD) APPROACH FOR METHOD DEVELOPMENT FOR AZILSARTAN MEDOXOMIL USING UPLC: APPLICATION TO HYDROLYTIC, THERMAL AND OXIDATIVE DEGRADATION KINETICS

Quality by Design (QbD) is a systematic approach for the development of products and processes. Azilsartan Medoxomil is a competitive antagonist of the Angiotensin II Type 1 receptor. A precise and reproducible ultra-performance liquid chromatographic (UPLC) method was developed and validated for the estimation of Azilsartan Medoxomil from its marketed tablet dosage form applying Quality by Design...

L. Kothapalli *, P. Darekar, A. Thomas and A. Kanhere

Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).3867-75

3867-3875

61

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37.

EFFECT OF SATWA FROM THREE TINOSPORA SPECIES ON LIPID METABOLISM AND INFLAMMATORY MARKERS IN ACETAMINOPHEN AND ALCOHOL-INDUCED HEPATO-TOXICITY IN RATS

To investigate the possible protective effects of satwa from three Tinospora species against acetaminophen and alcohol-induced hepatotoxicity in rats. Male albino wistar rats were divided into six groups (n=6); healthy control, negative control (Acetaminophen 1000mg/kg b.w./day, p.o. or 30%; alcohol 1ml/100g b.w./day, p.o.), positive control (Silymarin; 100mg/kg b.w./day, p.o.), Treatment 1 (Tinos...

T. C. Chavan *, A. A. Ghadge and A. A. Kuvalekar

Nutrigenomics and Functional Foods Laboratory IRSHA, Bharati Vidyapeeth Deemed University, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).3876-90

3876-3890

76

28

38.

PHYTOCHEMICAL AND BIOLOGICAL SCREENING OF THREE SELECTED ETHNOMEDICINAL PLANTS FROM MIZORAM, INDIA

This research explores Achyranthes bidentata L., Adhatoda zeylanica and Aeginetia indica L's pharmacological potential. Antibacterial disc assay (20 mg/ml), antifungal disc assay (20 mg/ml) and antioxidant DPPH/reducing energy assay (50 μg/ml, 100 μg/ml and 200 μg/ml) were tested for biological operations of plant extracts (aqueous, methanol and acetone leaf extracts). Significant alkaloid cont...

P. Khandayataray, M. K. Murthy * and D. Samal

Department of Biotechnology, Academy of Management and Information Technology (AMIT), Khurda, Odisha, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).3891-01

3891-3901

59

27

39.

FORMULATION DEVELOPMENT OF ROSUVASTATIN CALCIUM DRUG IN ADHESIVE TRANSDERMAL SYSTEM

Current investigation was aimed at designing a Rosuvastatin calcium loaded drug- in- adhesive patch (DIAP) to overcome the problems associated with the daily oral administration of the drug. The patches were prepared by solvent casting method using acrylate emulsion polymers like Covinax 525-78, Mowinyl 461 and Novacryl PSR 32, which served as sustained release matrix polymer and adhesive. Methoce...

R. B. Geevarghese * and S. V. Shirolkar

Department of Pharmaceutics, Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).3902-11

3902-3911

79

28

40.

SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF SOME NOVEL 1, 2, 3, 4-TETRAHYDROQUINAZOLINONE DERIVATIVES

In the study, we have successfully synthesized N-3 substituted tetrahydroquinazolinone by the reaction of isotonic anhydride with aniline derivatives. Thereafter novel derivative would be subjected to synthesize (1, 2, 3, 4-tetrahydroquinazoline) by Mannich reaction with ciprofloxacin and norfloxacin. These synthesized compounds (2a, 2b, 2c, 2d, 2e, 2f, 2g, and 2h) were characterized by FT-IR, 1H ...

R. Rajput

Kanpur Institute of Technology & Pharmacy, Kanpur, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).3912-22

3912-3922

64

26

41.

STABILITY INDICATING RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR DETERMINATION OF RELATED SUBSTANCE IN VENLAFAXINE HYDROCHLORIDE TABLETS

Recently, several methods have been developed for the determination of drugs and their impurities products by Reverse Phase-High Performance Liquid chromatography (RP-HPLC). The present paper describes highly specific, linear, precise, rugged, accurate, robust, and stability, indicating the RP-HPLC method for the determination of related substances present in Venlafaxine tablets as per ICH guideli...

A. Ajitha * and G. S. Rani

Department of Pharmaceutical Analysis, CMR College of Pharmacy, Kandlakoya, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).3923-29

3923-3929

50

23

42.

FORMULATION AND EVALUATION OF DORZOLAMIDE SPANLASTICS

Dorzolamide is commonly used to treat glaucoma, damage in the eye often caused by abnormally high pressure in the eye. It is one of the carbonic anhydrase inhibitors which is effective in decreasing intraocular pressure by decreasing the production of the aqueous humor. The main objective of the study was to entrap dorzolamide in a novel nanovesicular carrier system (spanlastics) to ensure sustain...

A. Sharma, S. Pahwa *, S. Bhati and P. Kudeshia

Lloyd Institute of Management and Technology (Pharm.), Greater Noida, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).3930-35

3930-3935

56

24

43.

EVALUATION OF METHANOLIC EXTRACT OF MACROTYLOMA UNIFLORUM SEEDS ON INHIBITION OF CALCIUM OXALATE CRYSTALLIZATION- IN-VITRO

Seeds of Macrotyloma uniflorum Linn. (Fabaceae) are widely used for treatment in kidney stones in India. In This study evaluates the in-vitro effect of methanolic extract of Macrotyloma uniflorum (MEMU) on calcium oxalate crystallization. A methanolic extract of M. uniflorum seeds at different concentrations (250-1500 μg/ml) was subjected to in-vitro crystallization activity. The obtained results...

V. B. Patel and N. Acharya *

Department of Pharmacognosy, Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).3936-43

3936-3943

55

24

44.

SCREENING OF PHYTOCONSTITUENTS, HPTLC AND FT-IR ANALYSIS IN LUFFA CYLINDRICA (L.) M. ROEM FRUITS

The present investigation deals with the preliminary phytochemical, High Performance Thin Layer Chromatography and Fourier Transform Infrared Spectral analysis of Luffa cylidrica (L.) Roem (Cucurbitaceae) fruits. The results revealed that most of the phytochemicals evaluated were present in ethanolic extract as compared to the petroleum ether extract. Quantitative analysis revealed that the fruits...

K. V. N. Megha *, V. S. Babu and P. M. Radhamany

Department of Botany, University of Kerala, Kariavattom, Thiruvananthapuram, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).3944-52

3944-3952

62

23

45.

HPLC, FTIR AND GC-MS ANALYSIS OF ETHYL ACETATE EXTRACT OF RED SEAWEED HYPNEA FLAGELLIFORMIS GRAVILLE EX J. AGARDH 1851

The experiment was carried out to investigate the phytochemicals constituents of the red seaweed Hypnea flagelliformis (Greville ex J. Agardh. 1851) from Tuticorin coastal waters, Gulf of Mannar, southeast coast of India; by using HPLC, FTIR, and Gas Chromatography-Mass Spectrometry. The selected seaweed was extracted with ethyl acetate (by soxhlet extraction method), furthermore subjected to HPLC...

R. S. Raubbin *, R. L. Laju, P. Ambika and A. Pushparaj

Department of Zoology, Tirunelveli Dakshina Mara Nadar Sangam College, T. Kallikulam, Tirunelveli, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).3953-59

3953-3959

60

23

46.

FORMULATION AND EVALUATION OF SELF EMULSIFYING DRUG DELIVERY SYSTEM OF POORLY SOLUBLE ANALGESIC

In the present work, the aim was to prepare a self-emulsifying drug delivery system of poorly soluble analgesic, mefenamic acid to improve its solubility with a view to enhance its oral bioavailability. From the solubility studies the selected oil, surfactant and co-surfactant was soyabean oil; tween 80, span 20; glycerol. Blends of surfactant mixtures containing tween 80, span 20, and glycerol we...

S. Chouhan

Department of Pharmaceutical Sciences, Mohan Lal Sukhadia University, Udaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).3960-67

3960-3967

64

23

47.

PHARMACOLOGICAL EVALUATION OF POLYHERBAL SUSPENSION AS ANTI-DEPRESSANT IN RAT

The ethanolic extract of Moringa oleifera leaves & methanolic extract of rose hips of Rosa damascena were first subjected to various phytochemical tests and further assessed for their antioxidant activity by DPPH method. Different ratio of two drugs in the polyherbal formulation were based on antioxidant activity in albino Wistar rats. Thirty rats (180 -250 g) of either sex were randomly divid...

S. Gupta and K. Mishra *

Hygia Institute of Pharmaceutical Education & Research, Lucknow, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).3968-74

3968-3974

58

21

48.

PHARMACOLOGICAL EVALUATION OF SODIUM DIETHYLDITHIOCARBAMATE TRIHYDRATE AS NEPHROPROTECTIVE POTENTIAL IN RATS

Objective: The present study was carried out to evaluate the pharmacological evaluation of SDDCT as nephroprotective potential in rats. Material and Methods: The current study was designed to evaluate the pharmacological potential of SDDCT in Gentamicin induced nephrotoxicity in rats. The SDDCT found to be useful in suppression of nephrotoxicity. The pharmacological potential was evaluated in gent...

A. Sharma, H. Maurya, U. V. S. Sara and K. Mishra *

Hygia Institute of Pharmaceutical Education & Research, Lucknow, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).3975-83

3975-3983

59

22

49.

FORMULATION DEVELOPMENT AND COMPARATIVE EVALUATION OF TRANSDERMAL DELIVERY SYSTEM FOR EFFECTIVE ANTI-EMETIC THERAPY

Transdermal patch or skin patch is a medicated adhesive patch that is placed on the skin to deliver a specific dose of medication through the skin and into the bloodstream. Transdermal patches of dolasetron have prepared by the solvent evaporation method using eudragit RL-100: eudragit RS-100 and ethylcellulose: PVP, using different ratios (8:2, 6:4, 5:5), in solvents like ethanol and methanol (1....

S. Latha *, P. Selvamani and T. Prabha

Department of Pharmaceutical Technology, Centre for Excellence in Nanobio Translational Research, Anna University, Bharathidasan Institute of Technology Campus, Tiruchirappalli, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).3984-92

3984-3992

66

27

50.

SCREENING OF ANTI-BACTERIAL ACTIVITY OF BROWN SEAWEEDS FROM SOUTH EAST COAST OF INDIA

Three different species of seaweeds collected from south east coast of India such as Sargassum plagiophyllum, Padina gymnospora and Turbinaria conoides for evaluating anti-bacterial activity against selected gram-positive and gram-negative bacteria. Extracts prepared using solvents namely hexane, ethyl acetate, methanol, and water against human pathogenic strains of Proteus vulgaris, Staphylococcu...

K. K. Vennila *, P. S. Chitra, K. Hilda, S. Janarthanan and P. Martin

Department of Zoology, Quaid-e-millath College, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).3993-09

3993-4009

59

31

51.

EVALUATION AND COMPARISON OF HEPATOPROTECTIVE ACTIVITY OF LIVSPLIN SYRUP AND LI- VERVE TONIC FORMULATIONS AGAINST CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY IN RATS

Liver diseases are a worldwide problem. Conventional drugs used in the treatment of liver diseases are sometimes inadequate and can have serious adverse effects like mild digestive problem, headache, nausea etc. It is necessary to search for alternative drugs and for treatment of liver disease to replace currently used drugs of doubtful efficacy and safety. Herbal therapies are free from side effe...

N. M. Kagadi *, P. L. Ladda and N. S. Naikwade

Department of Pharmacology, Appasaheb Birnale College of Pharmacy, Sangli, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).4010-16

4010-4016

55

21

52.

CHARACTERIZATION AND PHARMACODYNAMIC EVALUATION OF DEVELOPED MICROEMULSION FOR NASAL DRUG DELIVERY

In the present study, we had developed Asenapine maleate (ASNM) loaded microemulsion (ME) to increase the solubility of Asenapine maleate by components of microemulsion including formulation concern, characterization, mucosal diffusion, stability and nasal ciliotoxicity of Asenapine maleate microemulsion (AME). For nasal delivery of Asenapine maleate, a challenge existing in formulation developmen...

B. Prajapati * and A. Dharamsi

Department of Pharmaceutics, Parul Institute of Pharmacy, Parul University, Vadodara, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).4017-28

4017-4028

60

36

53.

ANTHELMINTIC EFFECT OF CITRULLUS COLOCYNTHIS ON THE TEGUMENT OF COTYLOPHORON COTYLOPHORUM BY LIGHT MICROSCOPE

The anthelmintic effect of alcoholic Citrullus colocynthis fruit extract on the tegument of Cotylophoron cotylophorum was studied by light microscopy. Live amphistome Cotylophoron cotylophorum flukes were collected from the infected rumen of freshly slaughtered domestic buffaloes (Bubalus bubalis) at the local zoo abattoir in Udaipur. The control and anthelmintic treated C. cotylophorum with the a...

K. Menaria, G. Swarnakar * and A. Kumawat

Department of Zoology, Government P.G. Meera Girls College, M.L.S. University, Udaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).4029-38

4029-4038

75

26

54.

FORMULATION, DEVELOPMENT AND EVALUATION OF SUBLINGUAL ANTI-EMETIC TABLET BY MELT GRANULATION TECHNIQUE

Prochlorperazine maleate is used for the treatment of motion sickness and classified under BCS class II for treatment of emesis, the per-oral route is preferred route of administration but first-pass effect and poor bioavailability limits its application. To overcome these limitations, efforts were made to enhance the bioavailability of drugs via the development of a sublingual tablet by melt gran...

R. P. Chitlange * and V. A. Kilor

Department of Pharmaceutics, Gurunanak College of Pharmacy, Nagpur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).4039-52

4039-4052

75

48

55.

CURCUMIN LOADED SOLID LIPID NANOPARTICLES ENHANCED EFFICACY IN VASCULAR DEMENTIA AGAINST HOMOCYSTEINE INDUCED TOXICITY

Vascular dementia (VaD), a diverse group of brain disorders with cognitive decline is attributable to cerebrovascular pathologies. Recent studies have shown that mitochondrial dysfunctions and oxidative stress are involved in cognitive decline. The aim of the present study was designed to evaluate the effects of Curcumin loaded solid lipid nanoparticles (Cur-SLNP) in vascular dementia (VaD) agains...

B. Prathipati and P. Rohini *

Department of Pharmaceutics, University College of Pharmaceutical Sciences, Acharya Nagarjuna University, Guntur, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).4053-61

4053-4061

30

19

56.

METHODS OF EXTRACTION AND FRACTIONATION OF BIO-ACTIVE COMPONENTS OF MORINDA COREIA FOR ANTI-TUBERCULAR AND ANTICANCER ACTIVITIES

In Asian countries, roots, barks, stems, leaves, and fruits of plants belonging to the Morinda species are considered as valuable traditional herbs. They are used in folk medicine for the treatment of many diseases, including diabetes, high blood pressure, and cancer. Anti-tubercular and cytotoxic activities of Morinda citrifolia (noni) have been reported, but Morinda coreia has not been explored ...

A. S. Avasthi, M. Bhatnagar, A. Thirumoorthy, W. Selvamurthy, N. Sinha and S. Ghosal *

Center for Plant and Environmental Biotechnology, Amity Institute of Biotechnology, Amity University, Noida, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(8).4062-69

4062-4069

28

12