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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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Volume 12 (2021) - Issue 12, December

Review Articles

 
Title
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Cited
01.

TRANSDERMAL DRUG DELIVERY SYSTEM: AN ATTRACTIVE APPROACH FOR TREATMENT OF NEUROLOGICAL DISORDERS

Neurodegenerative diseases are progressive degeneration of certain nerve cells causing ataxias and dementia affecting millions of people worldwide. Transdermal drug delivery systems – “patches” represent an attractive alternative to the conventional method and have made an important contribution to the management of the various medical conditions. A transdermal patch is a medicated adhesive ...

R. Bundele * and R. Mallya

Department of Quality Assurance, Mumbai University, Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6112-27

6112-6127

112

73

02.

NANO STRUCTURED LIPID CARRIER SYSTEM- A NOVEL TARGETING CARRIER

Oral administration of drugs is considered a convenient route; however, various drugs that are insoluble in water or cannot permeate across gastrointestinal tract membrane cannot be delivered by this route. To enhance the permeability through the physiological barriers, lipophilic drugs are introduced but, lipophilic drugs have low oral bioavailability. To enhance the bioavailability, a third-gene...

S. Satya Lakshmi and K. Persis Joni *

Department of Pharmaceutics, Vignan Institute of Pharmaceutical Technology, Duvvada, Visakhapatnam, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6128-38

6128-6138

77

33

03.

NATURAL GELLING AGENTS POLYMER IN PHARMACEUTICAL PREPARATION

Pharmaceutical preparation mostly contains active ingredients and excipients. The function of excipients to improve the physicochemical properties of pharmaceutical manufacturing products. In pharmaceutical preparation, polymer plays a key role act as excipients in any dosage formulation development. Polymers are derived from the source of natural and synthetic. The polymer should have basic prope...

Muhammad Masood Ahmad and Syed Nasir Abbas Bukhari

Department of Pharmaceutics, College of Pharmacy, Jouf University, Sakaka, Saudi Arabia.

DOI: 10.13040/IJPSR.0975-8232.12(12).6139-50

6139-6150

78

38

04.

MANNICHBASES: AN OVERVIEW OF HETEROCYCLIC COMPOUND WITH VARIOUS BIOLOGICAL ACTIVITIES

In Organic chemistry, largest families of organic compounds belong to heterocyclic compounds. In place of a carbon atom incorporation of an oxygen, a nitrogen, a sulfur, or an atom of a related element gives rise to a heterocyclic compound..Heterocyclic compounds are of very essential for our day-to-day life. It has a broad range of applications in medicinal chemistry as well as in agrochemicals p...

C. Geethapriya * and Karthikeyan Elumalaiim

Department of Pharmaceutical Chemistry, R. R. College of Pharmacy, Chikkabanavara, R. R. Layout, Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6151-65

6151-6165

76

29

05.

CLERODENDRUM INFORTUNATUM: AN UNHEEDED BOON OF NATURE

The excavation for new delegates into the chemotherapeutic family and modernization of existing candidates are evergreen goals of cancer researchers. It is quite interesting to make out that the plant kingdom has gifted us with an array of anti-cancer compounds, reporting over 60% of the drugs today coming out from natural sources such as plants, marine organisms, and micro-organisms. With the evo...

B. S. Akhil, Asha Lekshmi and K. Sujathan

Division of Cancer Research, Regional Cancer Centre, Thiruvananthapuram, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6166-74

6166-6174

69

26

06.

A CRITICAL REVIEW ON NIDIGDHIKADI LEHA IN THE MANAGEMENT OF RECURRENT UPPER RESPIRATORY TRACT INFECTION IN CHILDREN

Upper respiratory tract infections are the major cause of childhood morbidity leading to limit the day to day activities and school absenteeism. Diseases like tonsillitis, cough, and cold account for the maximum respiratory tract morbidities. Studies document that, in developing countries, on average, every child has five episodes of acute respiratory infections per year accounting for 30%-50% of ...

Amandeep and Nisha Kumari Ojha

P.G. Department of Kaumarbhritya-Balroga, National Institute of Ayurveda, Jaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6175-88

6175-6188

35

17

07.

EUPHORBIA HIRTA LINN – AN INVASIVE PLANT: A REVIEW OF ITS TRADITIONAL USES, PHYTOCHEMISTRY AND PHARMACOLOGICAL PROPERTIES

Euphorbia hirta Linn. (Euphorbiaceae), commonly known as ‘Dudhy’ is an annual medicinal herb of Kumaun Himalaya Uttarakhand. It is an invasive plant used in conventional medicine to treat various diseases such as gastrointestinal disorders, respiratory system disorders, and asthma. The present review is designed to compile updated information on E. hirta, including its medicinal uses, phytoche...

Amrendra Nath Tripathi *, Suresh Chandra Sati and Parikshit Kumar

Department of Botany, D. S. B. Campus, Kumaun University, Nainital, Uttarakhand, India.

DOI: 10.13040/IJPSR.0975-8232.12(2).6189-01

6189-6201

32

20

08.

ALZHEIMER’S DISEASE AND PATHOLOGICAL ANGIOGENESIS

In spite of huge investigations, the pathology of Alzheimer’ sdisease (AD) is uncertain. Vessels dysfunction is a critical mark of AD. Research has stated like beta-amyloid (Aβ) results augmented vascular development in brains, a pathway observed in AD patients. In AD, cerebral endothelium releases pro substances for β-amyloid plaque and neurotoxins that kill cortical neurons. Vascular vulnera...

Mrunalini Devi Kotagiri * and Abhisek Pal

Department of Pharmacology, GITAM Institute of Pharmacy, Gandhinagar, Rushikonda, Vishakapatnam, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6202-08

6202-6208

33

18

09.

EVIDENCE BASED STUDY OF EFFECT OF SWARNA YOGA (GOLD FORMULATIONS) IN CHILDREN: A SYSTEMATIC REVIEW

Background: In the field of pediatrics, a number of herbo-metallic preparations are available which tend to enhance immunity in children. Various Ayurveda texts have mentioned these preparations, especially gold formulations like Swarna Prashan, Suvarnabindu, Suvarna Vacha, Kumarabharana Rasa etc. in children, and many clinical studies have also been published to establish their safety and efficac...

Rashmi Pareek * and Nisha Ojha

P.G. Department of Kaumarbhritya, National Institute of Ayurveda, Jaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).1000-05

6209-6213

32

18

10.

AYURVEDIC ANTIVIRAL AGENTS: OVERVIEW OF MEDICINAL PLANTS PERSPECTIVE

In recent years, it has been reported that many herbal plants contain antiviral agents which combat a human disease that is caused by pathogenic viruses. The natural products which are obtained from plants as antiviral agents against viruses have gone through researches to check the efficacy and potentials of the herbal products in the prevention of viral disorders. On the basis of randomized cont...

Ranu Choudhary *, Laxmikant Borse and Anil Jadhav

Department of Quality Assurance, Sandip Institute of Pharmaceutical Sciences, Mahiravani, Nasik, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6214-20

6214-6220

36

19

11.

IVABRADINE AND METOPROLOL: A REVIEW OF ANALYTICAL METHODS FOR PHARMACEUTICAL QUALITY CONTROL AND MONITORING

Beta-blockers are widely used in combination with Ivabradine in people with coronary heart disease (CHD), one of the leading causes of death. Thus, monitoring of these drugs is important because it is accessible to manage heart failure amongst people with CHD. In addition, its quality control is fundamental to provide quality medicines. Method of analysis can be the first step in the rational use ...

N. K. Gandhi * and S. B. Ezhava

Department of Pharmaceutical Chemistry, L. M. College of Pharmacy, Ahmedabad, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6221-32

6221-6232

83

14

12.

HYDROGELS IN REGENERATIVE MEDICINE: A CONCISE REVIEW

Hydrogels were the primary biomaterials developed for human use. Hydrogels are playing an increasing role in regenerative medicine attributable to their growing functional sophistication. Polymer scaffolds have many diverse applications within the field of drug delivery, tissue engineering, and implantation. They are used as dispensing devices for bioactive molecules and as three-dimensional (3D) ...

Asish Dev *, Abdullah Khan, Bilal Khan, Jayesh Jain and Pravin Bangar

Department of Pharmaceutics, Oriental College of Pharmacy, University of Mumbai, Navi Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6233-44

6233-6244

32

16

13.

MALE INFERTILITY: A REVIEW ON SPERMATOZOA PROTEOMICS AND FERTILITY-ASSOCIATED BIOMARKERS IDENTIFICATION

Male infertility has remained a complex multi-factorial disease and needs advanced molecular studies. The development of effective diagnostic capabilities has resulted in the desire to create minimally invasive tests to help in the understanding of the etiology of male infertility. In recent times, research on human sperm proteomics has gained momentum and provides detailed information regarding s...

Binita Basnet Baruah

Mergen Biologics Training and Research Private Limited, Khanapara, Guwahati , Assam, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6245-52

6245-6252

31

15

14.

ORAL ULCERS –A REVIEW

Oral ulcers have been a source of diagnostic difficulty. This has been due to the overlap in their clinical appearances. The problem is complicated because a number of oral ulcers may be superimposed by infections due to their easy access to the oral cavity and the thin nature of the oral mucous membrane is an additional challenge to their diagnosis. While the diagnosis of some types of oral ulcer...

J. Manju *, Mutum Sangeeta Devi, Ravi Ranjan and S. Francyteena

Thai Moogambigai Dental College and Hospital, Dr. M. G. R Educational and Research Institute, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6253-59

6253-6259

30

15

15.

ANALYTICAL METHODS OF TICAGRELOR: A REVIEW

Ticagrelor is a platelet aggregation inhibitor. It is used for the prevention of stroke, heart attack, and other events in people with the acute coronary syndrome, meaning problems with the blood supply in the coronary arteries. It acts as a platelet aggregation inhibitor by antagonising the P2Y 12 receptor. Its half-life is up to 12 h with the hepatic type of metabolism and biliary excretion. Thi...

G. Nikitha and A. Ajitha *

Department of Pharmaceutical Analysis, Faculty of Pharmaceutical Analysis, CMR College of Pharmacy, Medchal, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6260-69

6260-6269

30

14

16.

MUCORMYCOSIS (THE BLACK FUNGUS) ASSOCIATED WITH COVID-19 PATIENTS- EPIDEMIOLOGY, PATHOGENESIS, DIAGNOSIS AND TREATMENT REGIMES

Mucormycosis is an opportunistic fungal infection caused by a member of the order Mucorales. It is an angio-invasive fungal infection because of its propensity to invade blood vessel walls, resulting in catastrophic tissue ischemia (restriction in blood supply to tissues, causing a shortage of oxygen that is needed for cellular metabolism), infarct (tissue death that is necrosis) due to inadequate...

Pranay Jain * and Ram Kumar Pundir

Department of Biotechnology, University Institute of Engineering and Technology, Kurukshetra University, Kurukshetra, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6270-80

6270-6280

38

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17.

SYNCHRONIZING CLINICAL DEVELOPMENT STRATEGY WITH TECHNOLOGY INNOVATIONS IN MEDICAL DEVICES

The earliest anecdotes of ‘medical device’ dates back thousands of years.  In 7000 BC, Neolithics used flint-tipped drills and bowstrings for dentistry. However, regulation of medical devices has only happened recently. Modern medical devices are used for the diagnosis, cure, mitigation, treatment, or prevention of disease. This industry is one of the most dynamic, disruptive, and fastest-gro...

Manish Narang *, Ramanpreet Walia, Upendra Kaul and Krishnakutty Sudhir

Medical Affairs-Asia Pacific & Japan, Department of Medical Affairs, Abbott Vascular, New Delhi, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6281-89

6281-6289

35

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18.

ANTIPSORIATIC ACTIVITY OF GENISTEIN: A REVIEW

Psoriasis is a chronic inflammatory skin disease characterized by red, scaly and raised patches, and it has affected nearly 2-3% of the population worldwide. This skin disorder occurs when the immune system sends faulty signals that result in the speeding up of the skin cell cycle. Psoriasis is histologically characterized by marked hyperproliferation of keratinocytes, neutrophils, and a dense inf...

J. M. Gandhi *, S. A. Jadhav, R. C. Doijad and U. I. Belgaumi

Department of Pharmacognosy, School of Dental Sciences, Krishna Institute of Pharmacy, Krishna Institute of Medical Sciences, Deemed to be University, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6290-97

6290-6297

31

15

19.

SCOPE OF AZETIDINONE HYBRIDS FOR DIVERSE PHARMACOLOGICAL ACTIVITIES; A REVIEW

Azetidinones (Azetidin-2-ones), more commonly known as β-lactams, are well-known heterocyclic moieties among the medicinal compounds mainly because of their diverse pharmacological activities such as antimicrobial, anti-inflammatory, anticonvulsant, anti-HIV, anti-parkinsonian, antidiabetic and antitubercular activities. Various com-parative studies of current azetidinone derivatives show an alar...

Praveen Prakali and Basavaraj M. Dinnimath *

Department of Pharmachemistry, KLES College of Pharmacy, KAHER, Hubballi, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6298-09

6298-6309

30

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20.

OPUNTIA FICUS-INDICA: ESCALATING FROM FARM TO PHARMACOLOGICAL ACTIONS

Medicinal plants are a reservoir of biologically active compounds with therapeutic properties, and in that context, Opuntia ficus indica and other Opuntia species are of immense importance because of their nutraceutical and pharmaceutical values along with their anti-inflammatory effects, hypoglycemic, anti-hyperlipidemic effects, anti-atherogenic and anti-spermatogenic potential. The cactus Opunt...

Aakriti Jain, Shivani Sharda and Anupama Sharma Avasthi *

Amity Institute of Biotechnology, Amity University, Noida, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6310-40

6310-6340

73

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21.

DEVELOPMENT OF BIOSIMILARS: AN OVERVIEW OF THE REGULATORY FRAMEWORK IN INDIA, USA, EU; MAJOR CHALLENGES AND RELATED CASE STUDIES

A similar biologic product also called biosimilar, follow-on biologic, is highly similar in terms of quality, safety, efficacy with that of the reference product. These are the pharmaceutical products used as the prime treatment options in many chronic diseases and as substitutes for the primary treatment. For development and approval, each nation has adopted its own regulations, and some countrie...

V. L. D. Sai Swetha Penugonda *, Vishnu Priya Cherukuri, Naga Sowjanya Vaka and Ravi Kumar Reddy Juturi

Department of Pharmaceutical Regulatory Affairs, Shri Vishnu College of Pharmacy (Autonomous), Vishnupur, affiliated to Andhra University, Visakhapatnam, Bhimavaram, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6341-52

6341-6352

44

21

Research Articles

 
Title
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Cited
22.

ANTITOXIC EFFECTS OF GUM ARABIC (ACACIA SENEGAL) AND GUAR GUM (CYAMOPSIS TETRAGONOLOBUS) AGAINST HEPATORENAL TOXICITY INDUCED BY MERCURIC CHLORIDE IN RATS

Heavy metal accumulates mostly in the liver and kidney as these organs involved in the detoxification and excretion of foreign materials. In the present study, we explored the effect of Gum Arabic (GA) and Guar Gum (GG) on mercuric chloride (HgCl2) induced hepatorenal toxicity. Twenty-eight adult male albino rats “Sprague Dawely” weighing 250-300 g were divided into four equal groups: the firs...

Amira Abd El-Rhman * and Nehad Naem Hamed Shosha

Department of Biochemistry and Nutrition, Faculty of Women for Arts, Science and Education Ain Shams University, Cairo, Egypt.

DOI: 10.13040/IJPSR.0975-8232.12(12).6353-61

6353-6361

78

45

23.

ISOLATION, CULTURE, AND ANTI-MRSA POTENTIAL OF A MARINE-ASSOCIATED BACTERIA ZOOSHIKELLA KANGWENSIS

Isolation, identification, culturing, and chemical screening of a marine-associated bacterial strain, S6.2, were performed in this study. Anti-MRSA analysis of its extract was also conducted. Strain S6.2 was isolated from an unidentified red marine sponge and identified as Zooshikella kangwensis by 16S rDNA sequencing and biochemical characterization. On marine agar, the colonies embedded in the m...

Rachow Khawchamnan, Monthon Lertcanawanichakul, Pharkphoom Panichayupakaranant, Wen Han Lin and Patchara Pedpradab *

Department of Marine Science, Faculty of Sciences and Fishery Technology, Rajamangala University of Technology Srivijaya, Sikao District, Trang Province, Thailand.

DOI: 10.13040/IJPSR.0975-8232.12(12).6362-69

6362-6369

70

24

24.

A CONCISE TWO-STEP METHOD FOR PREPARATION OF MEMANTINE HYDROCHLORIDE FROM 1, 3-DIMETHYLADAMANTANE

Memantine hydrochloride is a medicine used to medicate patients with moderately severe to severe Alzheimer's disease and other neurodegenerative disorders; because of mechanisms of neuroprotection, the efficiency of memantine have been delivered in preclinical and clinical experiments. Several approaches for preparing memantine hydrochloride have been announced. The process began with 1,3-dimethyl...

Thi Hong Tham Nguyen, Trong Diep Nguyen, Dinh Chau Phan and Binh Duong Vu *

Vietnam Military Medical University, No.160, Phung Hung str., Phuc La ward, Ha Dong district, Hanoi, Vietnam.

DOI: 10.13040/IJPSR.0975-8232.12(12).6370-83

6370-6383

75

29

25.

HEPATOPROTECTIVE ACTIVITY OF DORSTENIA BRASILIENSIS AGAINST ACUTE HEPATITIS INDUCED BY ACETAMINOPHEN AND CARBON TETRACHLORIDE IN MICE

The aim of this study was to assess the influence of extract of D. brasiliensis (CEDb) on acute liver injuries induced by both acetaminophen, and carbon tetrachloride in mice as an initial step to validate its popular use. A liquid-chromatography method coupled to Mass Spectrometry showed the presence of coumarins dorstenin, bergapten, and psoralene in CEDb. Swiss albino male mice were pre-treated...

A. M. Velázquez, E. M. G. Diarte, A. K. Galeano, A. J. Burgos-Edwards, N. L. Alvarenga, O. Y. Heinichen, Y. Montalbetti, M. A. Campuzano-Bublitz, M. L. Kennedy, M. C. Hellión-Ibarrola and D. A. Ibarrola *

Departamento de Farmacología, Facultad de Ciencias Químicas, Universidad Nacional de Asunción, Campus UNA, San Lorenzo, Paraguay.

DOI: 10.13040/IJPSR.0975-8232.12(12).6384-92

6384-6392

72

33

26.

ANTAGONISTIC MECHANISM OF ANTI-FUNGAL COMPOUNDS FROM ASPERGILLUS GIGANTEUS ON HUMAN FUNGAL PATHOGENS

Cryptococcus neoformans and Candida albicans are the major causative agents for infections, cryptococcosis, and candidiasis in human. Anti-fungal drugs for the treatment of fungal infections may show less effective activity on the pathogens due to the poor absorption or inadequate drug distribution, and some pathogens may evolve anti-fungal drug resistance. The development of anti-fungal drugs fro...

R. Ramya and D. Kavitha *

Department of Biochemistry, Biotechnology and Bioinformatics, School of Biosciences, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore - 641043, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(12). ).6393-02

6393-6402

64

30

27.

EVALUATION OF PHYTOCHEMICAL ANALYSIS OF CALLUS TISSUE FROM INTERNODE EXPLANTS OF TRADITIONAL MEDICINAL PLANTS OF JATROPHA GOSSYPIIFOLIA LINN.

Jatropha gossypiifolia Linn. (Euphorbiaceae) is an ornamental shrub extensively used in traditional medicine for various ailments. In view of its potential medicinal properties, an attempt has been undertaken to devise an efficient protocol for in-vitro propagation from the internodes explants of J. gossypiifolia for a rapid and large-scale production as well as to study the phytochemical composit...

A. Kalaiyarasan and N. Hariram *

Department of Biotechnology, Kalasalingam Academy of Research Education, Krishnankoil, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6403-15

6403-6415

30

13

28.

ESTABLISHMENT OF QUALITY STANDARDS FOR SHYONAK: AN IMPORTANT INGREDIENT OF THE DASHMOOLA GROUP OF DRUGS

Shyonak is botanically equated to Oroxylum indicum (L.) Kurz. of family Bignoniaceae. It is extensively used in the Indian system of medicine as an important ingredient of ‘Dashmoola and also one of the important constituents of a reputed Ayurvedic formulation ‘Chyavanprash’. The drug consists of root bark of Oroxylum indicum (L.) Kurz. Ayurvedic Pharmacopoeia of India (API) advocates that t...

Dinesh Kumar Yadav * and Santosh Kumar

S.G.T. College of Pharmacy, S.G.T. University, Gurgram, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6416-23

6416-6423

34

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29.

STABILITY INDICATING HPLC METHOD FOR PARACETAMOL, CAFFEINE, PHENYLEPHRINE HCL, CHLORPHENAMINE MALEATE AND ITS IMPURITIES IN FLUCOLD TABLET DOSAGE FORM

Paracetamol, caffeine, phenylephrine, and chlorphenamine maleate are available on the market to treat pains, psychoactive disorders, and bronchopulmonary disorders. The objective was to develop a single HPLC method to determine paracetamol, caffeine, phenylephrine HCl, chlorphenamine maleate, and its impurities in flu cold tablets combination dosage form. No analytical method is available to asses...

Ganpisetti Srinivasa Rao *, D. Rama Devi, P. Sunil Reddy, L. Kalyanaraman, Parimalkumar Sureshbhai Patel, B. Venkata Subbaiah, B. M. Rao, Nagaraju Rajana and K. Basavaiah

Department of Chemistry, Visakhapatnam, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6424-31

6424-6431

35

13

30.

AN EFFECTIVE AND FACILE VOLTAMMETRIC STUDY OF ATRACURIUM BESILATE AT FUNCTIONALIZED MWCNTs MODIFIED GLASSY CARBON ELECTRODE

In the present study, a modified glassy carbon electrode by a conductive film containing, i.e., functionalized multi-walled carbon nanotubes (f-MWCNTs) was selected for the determination of atracurium besilate (in short ACB), an anesthetic drug by applying the cyclic voltammetry (CV) and differential pulse anodic adsorptive stripping voltammetry (DP-AASV) techniques. Herein, nanomaterials suspensi...

Mahadeva Singh Jat, Varsha Jakhar and D. K. Sharma *

Electrochemical Sensor Research Laboratory, Department of Chemistry, University of Rajasthan, Jaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6432-41

6432-6441

31

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31.

ELECTROCHEMICAL DETERMINATION OF ANTI-DEPRESSANT DRUG MIRTAZAPINE EMPLOYING NAFION/f-MWCNTs COMPOSITE AT GLASSY CARBON ELECTRODE

A nafion plus functionalized-multiwalled carbon nanotubes modified glassy carbon electrode (f-MWCNTs/GCE) was developed for the determination of anti-depressant drug mirtazapine (MIR). The electro-chemical behavior of the molecule was investigated employing cyclic voltammetry (CV), chronocoulometry (CC), and differential pulse adsorptive stripping voltammetry (DPASV). The surface morphology of the...

Mahadeva Singh Jat, Varsha Jakhar and D. K. Sharma *

Electrochemical Sensor Research Laboratory, Department of Chemistry, University of Rajasthan, Jaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6442-52

6442-6452

31

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32.

ANALYSIS OF PHYTOCHEMICAL CONSTITUENTS, ANTI-MICROBIAL ACTIVITY AND MOLECULAR CHARACTERIZATION OF MEDICINAL WEED SONCHUS OLERACEUS L. USING RAPD MARKER

In present study, Himalayan weed Sonchus oleraceus extracts are screened for the occurrence of bioactive compounds, anti-microbial activity, and its molecular characterization using RAPD. The agar well diffusion method was used to detect anti-microbial activity of aqueous, methanol, chloroform and ethyl acetate extracts of S. oleraceus. The anti-microbial activity of different extract was checked ...

Sumeet Parkash Kaundal *, Anshul Sharma and Saurabh Kulshrestha

Faculty of Applied Sciences and Biotechnology, Shoolini University of Biotechnology and Management Sciences, Bajhol, Solan, Himachal Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6453-63

6453-6463

33

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33.

ANTI-AMNESIC ACTIVITY OF ETHANOLIC FLOWER EXTRACT OF IXORA COCCINEA

Usage of medicinal plants for the treatment of various diseases had been started from 1500 BC onwards. Loss of cognition is one of the age-related mental problems and a characteristic symptom of neurodegenerative disorders like Alzheimer’s. Various natural drugs are used for treatment of Alzheimer’s and Parkinsonism, but Available drugs provide symptomatic treatment with known side effects. So...

B. N. B. Vaidehi *, E. Sai Priyanka, J. Ramya, G. Chaitanya Sai and G. Vinaykumar

Aditya College of Pharmacy, East Godavari District, Surampalem, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6464-71

6464-6471

29

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34.

DETERMINATION OF RESIDUES OF FLUOROQUINOLONES IN POULTRY MEAT BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY

Three analytical methods were developed for the determination of selected fluoroquinolones in chicken meat by high performance liquid chromatographic technique. In each method, we took two fluoroquinolones (Danofloxacin and difloxacin; Ciprofloxacin and enrofloxacin; Ofloxacin and pefloxacin) research study. Rapid, simple and sensitive sample treatment procedures were developed and used to extract...

Rajeev Sharma * and Reena S Lawrence

Department of Chemistry, Sam Higginbottom University of Agriculture, Technology & Sciences, Prayagraj Allahabad, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6472-79

6472-6479

26

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DETECTION OF STREPTOCOCCUS MUTANS ASSOCIATED WITH DENTAL CARIES AMONG ADULTS IN JEDDAH PROVINCE

Dental caries is one of the serious bacterial diseases of the oral cavity caused by diverse Streptococcus species. Streptococcus mutans strains displayed remarkable genotypic and phenotypic diversity. Glucosyl transferase genes are recognized as essential enzymes leading to biofilm production, the destruction of the ecosystem of normal bacterial communities, and the development of dental caries. T...

Hayam S. Abdelkader *, Aisha A. Alayafi and Rawan A. Bin Osail

Department of Biology, College of Science, University of Jeddah, Jeddah, Saudi Arabia.

DOI: 10.13040/IJPSR.0975-8232.12(12).6480-87

6480-6487

31

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36.

DESIGN AND EVALUATION OF MUCOADHESIVE BUCCAL PATCHES OF SALBUTAMOL SULPHATE BY USING HUPU GUM AND LANNEA GUM

The purpose of the present investigation is to evaluate the applicability of hupu gum and lannea gum in the design of buccoadhesive patches for extended-release over a period of 6 hours, using Salbutamol sulphate as a model drug. The efficiency of these polymers was compared with already established synthetic polymer PEO coagulant. The patches were prepared by using the solvent casting method in w...

Anu Pravallika Janipalli *, K. V. Ramana Murthy and Lohithasu Duppala

Division of Pharmaceutical Technology, A. U. College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6488-97

6488-6497

42

18

37.

ANALYTICAL QUALITY BY DESIGN APPROACH FOR DEVELOPMENT AND VALIDATION OF UV-SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF CANAGLIFLOZIN IN BULK AND FORMULATION

The present work deals with the development and validation of a novel, robust, precise, and accurate UV-spectrophotometric method for the estimation of canagliflozin in bulk and formulation using the principle of Analytical Quality by Design (AQbD). A central composite design (CCD) was employed for initial parameter screening and method optimization. Different statistical parameters were evaluated...

Shraddha Parmar, Bhavna Patel * and Akshara Patel

Department of Pharmaceutical Sciences, Sardar Patel University, Vallabh Vidyanagar, Anand, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6598-09

6498-6509

34

19

38.

DESIGN AND CHARACTERIZATION OF ACECLOFENAC BIONANOCOMPOSITE USING NATURAL SOLUBILIZERS

The objective of the present research is to enhance the solubility and improve the rate of dissolution of poorly water soluble drug aceclofenac, which belongs to BCS class II. Enhancement of solubility was be achieved by converting the poorly water-soluble drugs into Bionanocomposites (BNCs) by using natural carriers, which ultimately leads to enhance the bioavailability of drug entities. Bionanoc...

Nitin S. Desai, Sunil T. Galatage *, Swapnil S. Harale, Suresh G. Killedar, Ravindra B. Kumbhar and Arehalli S. Manjappa

Sant Gajanan Maharaj College of Pharmacy, Mahagaon, Kolhapur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6510-21

6510-6521

31

20

39.

AMINO ACID PROFILING AND PROTEIN CONTENT DETERMINATION OF BOVINE MILK COLLECTED FROM DIFFERENT TEHSIL OF SINGRAULI DISTRICT

Milk and milk products are nutritious food items containing numerous essential nutrients. This study was carried out to determine the influence of variable season on profiling of amino acid and protein content from 90 bovine milk collected (March 2018 to February 2019) samples belongs to four tehsils of Singrauli district. The most abundant amino acid was glutamic acid, followed by proline and leu...

Rajesh K. Patel *, Rajesh Pandey and Babbulal Patel

Department of Chemistry, SGS Government PG College, Sidhi, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6522-29

6522-6529

33

15

40.

GENERALIZED ARTIFICIAL NEURAL NETWORK MODELLING AND ITS APPLICATION IN PERFORMANCE PREDICTION OF SUSTAINED RELEASE MONOLITHIC TABLETS

Artificial Intelligence is the simulation of human intelligence. From delivering simple groceries to doorsteps to solving the toughest task in scientists’ lab, it is surrounding human life in all the means. So how can the Pharma industry be untouched in the case of AI?! Artificial Neural Network (ANN) is a type of AI used to solve non-linear problems and predict the output for given input parame...

Tulsi H. Vyas * and Girish N. Patel

Department of Pharmaceutics, Shree S. K. Patel College of Pharmaceutical Education & Research, Ganpat University, Ganpat Vidyanagar, Mehsana-Gozaria Highway, Mehsana, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6530-39

6530-6539

37

17

41.

TASTE MASKING, DESIGN AND EVALUATION OF ORAL DISPERSIBLE TABLET OF ANTICHOLINESTERASE AGENT

This study aimed to determine for taste masking & design of Oro dispersible tablet of an anticholinesterase agent (Donepezil HCl) to achieve the patient compliance. Oral dispersible tablet prepared by compression method. The Anticholinergic activity assure by evaluation, drug dissolution, stability testing and standardize the oral dispersible tablet. On the basis of the preformulating and form...

Md Juned Ad Javed Patel *, Surajkumar B. Rathod and Swapnali S. Mankar

Department of Pharmaceutics, Vardhaman College of Pharmacy, Koli, Karanja (Lad), Washim, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6540-52

6540-6552

29

20

42.

SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL QUINAZOLINE DERIVATIVES AS ACID PUMP ANTAGONISTS

Gastric acid hypersecretion is a major cause of gastric complications like hypergastrinemia, hyperhistaminemia and Zollinger-Ellison syndrome. Out of various drug treatments used, H2-receptor antagonists possess some limitations, such as the development of tolerance when used for a long period, having a short duration of action, and no complete inhibition of acid secretion in response to a meal. I...

Dharmishtha R. Parmar * and B. N. Suhagia

Department of Pharmaceutical Chemistry, Dr. Dharmishtha R. Parmar, L. M. College of Pharmacy, Ahmedabad, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6553-66

6553-6566

32

14

43.

SYNTHESIS, SPECTRAL CHARACTERIZATION, AND IN-VITRO ANTIOXIDANT ACTIVITY SCREENING OF SOME NOVEL 2-HYDROXY QUINOLINE DERIVATIVES

In an attempt of synthesizing some novel and potent antioxidant activity having compounds, here some novel quinoline derivatives are reported. Initially using Vilsemeir-Hack reagent method 7-methyl or 8-methyl substituted 2-cholro-3-formylquinolines (Ia, b) were prepared. Further 7-methyl or 8-methyl substituted 2-hydroxy quinoline-3-carbaldehyde (IIa, b) were synthesized by the reaction of compou...

Pradeep Kumar M. R. * and Hunashal R. D.

Department of Pharmaceutical Chemistry, KLE College of Pharmacy, A Constituent Unit of KLE Academy of Higher Education and Research [KAHER], Hubli, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6567-72

6567-6572

33

15

44.

EXPLORATION OF ANTI-HYPERGLYCEMIC POTENTIAL OF HERBAL MIXTURE IN STREPTOZOTOCIN-INDUCED TYPE-II DIABETES IN RATS

Indigenous plants like Withania coagulans fruits. Alstonia scholaris bark and Aegle marmelose leaves have been used for diabetes management by traditional Indian people for a long time. The present study was carried out to investigate anti-hyperglycemic potential of an herbal mixture comprising of extracts of these three plants in streptozotocin-induced diabetes in Wistar rats and to focus on its ...

D. D. Bandawane *, P. D. Chaudhari and A. R. Juvekar

Department of Pharmacology, PES’s Modern College of Pharmacy, Sector - 21, Yamunanagar, Nigdi, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6573-81

6573-6581

31

18

45.

ANTIOXIDANT POTENTIAL OF MARINE CRAB PORTUNUS PELAGICUS FROM GULF OF MANNAR, SOUTHEAST COAST

Natural products offer great hope in the identification of bioactive compounds and their development into drugs for the treatment of various diseases. The present study aims to evaluate the antioxidant potential of Portunus pelagicus. P. pelagicus (Station-I) possessed 33.14% of inhibition, the highest DPPH activity, whereas Station II and Station III showed 31.42% and 30.85% of inhibition. Portun...

C. Shibana * and P. Subavathy

Department of Zoology, St. Mary’s College (Autonomous), Thoothukudi Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6582-86

6582-6586

35

17

46.

APPLICATION OF PLACKETT–BURMAN DESIGN OF EXPERIMENTS IN THE IDENTIFICATION OF “MAIN FACTORS” IN THE FORMULATION OF DABIGATRAN ETEXILATE MESYLATE IMMEDIATE-RELEASE TABLETS

The current research paper was focused on exploiting Plackett-Burman design to screen the effect of eight factors Pregelatinised Starch (A), Crospovidone (B), Microcrystalline Cellulose PH 101 (C), Talc (D), Magnesium Stearate (E), Hydroxy Propyl Methyl Cellulose (F), Hydroxy Propyl Cellulose (G) and Lactose Monohydrate (H) on the release of drugs from the Immediate release DEM Cocrystal tablets p...

Ashwini Gawade *, Ashwin Kuchekar and Sanjay Boldhane

School of Pharmacy, Dr. Vishwanath Karad, MIT, WPU, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6587-92

6587-6592

37

14

47.

ENHANCEMENT OF SOLUBILITY OF POORLY SOLUBLE DRUG BY INCLUSION COMPLEXATION WITH γ-CYCLODEXTRIN

Candesartan is an angiotensin receptor blocker, used as an anti-hypertensive drug. It is available in the salt form of cilexetil i.e.; Candesartan cilexetil belongs to class II of the Biopharmaceutical classification system. It is a poorly soluble drug, and the bioavailability is 15%. The intention of the study is to improve the solubility of the poorly soluble drug, Candesartan cilexetil using th...

B. Radha Madhavi *, B. Divya, K. Anusha, G. Tejaswi, G. Yamini Divya Teja and K. Kiran Kumar Reddy

Department of Pharmaceutics, Shri Vishnu College of Pharmacy, Vishnupur, Bhimavaram, West Godavari, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6593-99

6593-6599

33

18

48.

IN-VITRO AND IN-SILICO STUDIES ON SELECTED PHYTOCONSTITUENTS OF MITRAGYNA PARVIFOLIA (ROXB.) STEM BARK FOR ANTI-CANCER ACTIVITY

Cancer is a dreadful disease all over the world. The death rate had been increasing because of different types of cancers even though several drugs, treatment models and regimens are invented by scientists. Natural drugs have been showing remarkable results in the treatment of different cancers with less or no side effects. Advancements in screening methods using computer aided tools helping the r...

P. Ravi Kumar *, Srinu Naik Sapavatu and Madhava Reddy B

Department of Pharmacognosy, G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6600-07

6600-6607

40

17

49.

ISOLATION AND IDENTIFICATION OF STREPTOCOCCUS MUTANS FROM PATIENTS WITH DENTAL CARIES: EVALUATING THE ANTI-BACTERIAL EFFICACY OF THE AZADIRACHTA INDICA EXTRACTS FOR THE TREATMENT OF PERIODONTITIS

Periodontitis is a common infection occurring among a wide range of population globally. Streptococcus mutans is found to be the predominant pathogen responsible for dental caries. The present study concentrates on isolation and identification of the predominant pathogen from patients suffering from dental caries. The isolates were grown on various selective and differential media. Biochemical tes...

Ponmurugan Karuppiah, K. P. Shamna, Muhammad Musthafa Poyil *, Kuppannan Gobianand and P. Sasikumar

Department of Basic Medical Sciences, College of Medicine, Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi Arabia.

DOI: 10.13040/IJPSR.0975-8232.12(12).6608-14

6608-6614

31

17

50.

TOPICAL DRUG DELIVERY OF KETOCONAZOLE ENTRAPPED TRANSFEROSOMAL GEL WITH DESIGN AND ENACTMENT

In pharmaceutical research, the transdermal route of drug delivery has gained great interest, Trasferosomes is a novel vesicular drug carrier system that is composed of water, surfactant, and phospholipids; these were introduced in the early 1990s. The mechanism on which drugs absorb through skin is “osmotic gradient”. Transferosomes, when applied on the skin surface it diffuses into skin laye...

Lovely Chaurasia *, Anuj Pradhania, Sakshi Garg and Gargi Gupta

IIMT College of Medical Sciences, Meerut, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6615-21

6615-6621

33

18

51.

WRIST ACTION SHAKER: A NOVEL METHOD FOR COLLECTING POLLEN GRAINS FROM THE INFLORESCENCE OF COCONUT (COCOS NUCIFERA L.) FOR ITS STABLE NUTRITIONAL COMPONENTS

To predict the cocos anther dehiscence, a novel method was devised to compile the colossal amount of pollen grains. The matured inflorescence enveloped by the spathe was collected and the anther dehiscence were noticed day by day until the shedding of entire pollen. This study was experimented for a period of eight months between (February) 2018 to 2018 (September). After an experimental trails, s...

B. Kavitha, V. Gopal *, K. Joshna and N. Balachandran

Department of Pharmacognosy, College of Pharmacy, Mother Theresa Post-Graduate and Research Institute of Health Sciences (A Government of Puducherry Institution), Puducherry, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6622-28

6622-6628

32

16

52.

VALIDATED UFLC-MS/MS METHOD FOR THE QUANTITATIVE ESTIMATION OF PALIPERIDONE IN RABBIT PLASMA; ADAPTABILITY TO IN-VIVO BIOAVAILABILITY STUDY

A simple gradient ultrafast liquid chromatography-tandem mass spectrometry method was developed and validated for the quantitative estimation of paliperidone in rabbit plasma matrix as per USFDA, and EMA guidelines using a stable isotope-labeled paliperidone-d4 was added as an internal standard. The separation was achieved on a Hypersil BDS C18 column (4.6 mm × 10 cm, 5 µm) with the mobile phase...

R. Sadashivaiah and B. K. Satheeshababu *

Department of Pharmaceutics, Government College of Pharmacy, #2, P. Kalingarao Road, Subbaiah Circle, Bengaluru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6629-37

6629-6637

34

26

53.

GERMINATION STUDIES AND BIOCHEMICAL PROFILE IN SEEDS OF WHEAT EXPOSED TO MAGNESIUM NANOPARTICLES

Nanotechnology has gained a lot of importance and application in agriculture in the last decade. The present work was focused on the synthesis and characterization of magnesium oxide nanoparticles and on studying the effect of these nanoparticles on wheat (PBW-677 variety). Magnesium oxide nanoparticles were synthesized by chemical synthesis method and were characterised by using UV- Visible spect...

A. Pathak *, Rajwinder Kaur and Neetu Thakur

Goswami Ganesh Dutta Sanatan Dharma College, Sector 32, Chandigarh, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6638-41

6638-6641

37

17

54.

CYTOTOXICITY, ANTIMICROBIAL ACTIVITIES AND CHEMICAL PROPERTIES OF TEN PLANTS FROM THE BENIN PHARMACOPOEIA USED FOR ORAL CARE

This study aims to valorizeten medicinal plants traditionally used for oral care in Benin by producing scientific data on their toxicities, antimicrobial activities, and chemical properties. The ten medicinal plants (Zanthoxylum zanthoxyloides, Vitellaria paradoxa, Prosopis africana, Dialium guineense, Pseudocedrela kotschyi, Parkia biglobosa, Azadirachta indica, Diospyros mespiliformis, Anogeissu...

T. G. P. Guezodje *, A. J. Agbankpe, G. H. Dassou, T. V. Dougnon, A. Dicko and H. Yedomonhan

Laboratory of Chemistry and Physics-Multi-scale Approach of Complex Media (LCP-A2MC), University of Lorraine in France.

DOI: 10.13040/IJPSR.0975-8232.12(12).6642-52

6642-6652

35

16

55.

ANTI-MICROBIAL ACTIVITY AND FTIR SPECTROSCOPIC ANALYSIS OF ARGEMONE MEXICANA L. LEAVES EXTRACTS

The Screening of medicinal plants for the new bioactive compounds leads to the development of new anti-microbial drugs that possess lesser cost and greater safety and efficacy. The increasing bacterial resistance exhibited by microorganisms causing skin infections has led to the research on medicinal plants. Argemone Mexicana Linn is a weed that shows multiple health benefits. All the parts of the...

A. A Yelmate * and S. S Thonte

Channabashweshvar College of Pharmacy, Latur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(10). 6653-59

6653-6659

30

14

56.

NEUROPROTECTIVE EFFECT OF MADHUCA LONGIFOLIA LEAF EXTRACT AGAINST COLCHICINE: AN EXPERIMENTAL STUDY ON COGNITIVE DYSFUNCTION AND BIOCHEMICAL ALTERATIONS IN MICE

The goal of the research was to explain as a cognition enhancer the traditional claim of Madhuca longifolia (Sapotaceae) leaves. Dementia was activated by intracerebrovascular colchicine administration for 28 days. Madhuca longifolia leaves ethanolic extract was evaluated in mice for cognition-enhancing activity in colchicine-induced dementia using elevated plus maze (EPM), actophotometer, and bio...

Pragati Khare *, Kamal Kishore and Dinesh Kumar Sharma

Department of Pharmacy, Shri Ram Murti Smarak, C.E.T., Bareilly, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6660-67

6660-6667

31

17

57.

IN-VITRO STUDIES OF EXTRACTS OF PLUMBAGO ZEYLANICA IN CERVIX CARCINOMA CELLS

The present study evaluated the antimicrobial and cytotoxic activities of chloroform, hexane methanol, and petroleum ether extracts of Plumbago zeylanica (PEC, PEH, PEM, and PEP). Antimicrobial activities of the extracts were evaluated against gram-positive bacteria (Staphylococcus aureus-ATCC 6538 and Bacillus cereus-NCIM 2155) and gram-negative bacteria (E. coli-ATCC 8739) along with cytotoxicit...

L. V. Rama Devi, K. Ganesh Kadiyala and Amrutha V. Audipudi *

Department of Botany and Microbiology, Acharya Nagarjuna University, Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6668-74

6668-6674

34

18

58.

PHYTOCHEMICAL SCREENING, GC-MS ANALYSIS AND ANTIBACTERIAL ACTIVITY OF CHLOROFORM AND ETHANOL EXTRACTS FROM PANICUM TRYPHERON LEAVES

This study was designed to evaluate the phytochemical findings for the presence of Alkaloids, Flavonoids, Phenols, and Terpenoids, and the phytochemical profile of chloroform and ethanol extracts of Panicum trypheron were analyzed using GC-MS (Gas Chromatography-Mass Spectrometry) method. The leaves were dried, powdered, and soaked in chloroform and ethanol, then subjected to GC-MS analysis by usi...

Anantha Reddi Yaswanth, Mandem Venkata Sai Reddy and K. S. Ramya *

Department of Biotechnology, Shri Gnanambica Degree & P. G. College, Madanapalle, Chittoor, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6675-80

6675-6680

68

26

59.

METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF CILNIDIPINE AND OLMESARTAN MEDOXOMIL IN TABLET DOSAGE FORM BY UPLC USING DAD

Olmesartan Medoxomil and Cilnidipine combination lowers blood pressure effectively. Olmesartan Medoxomil is an angiotensin receptor blocker (ARB), and Cilnidipine is a calcium channel blocker (CCB). Cilnidipine and Olmesartan Medoxomil are widely used in hypertension. The scope of the study is to optimize the chromatographic conditions to develop a new RP-UPLC method for the simultaneous estimatio...

H. Vakeesan, C. N. Nalini * and K. Sahini

Department of Pharmaceutical Analysis, C. L. Baid Metha College of Pharmacy, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6681-91

6681-6691

72

10

60.

EFFECTS OF TEMPERATURE AND TIME OF ROASTING ON THE PHYSICOCHEMICAL AND ANTIMICROBIAL CHARACTERISTICS OF CINNAMON BARK OIL

The purpose of the present study was to examine the influences of roasting and the effects of roasting temperature and duration on the chemical composition of cinnamon bark oil and to extend our knowledge concerning the changes in antioxidant activity, antimicrobial activity, physical properties such as colour, refractive index, density and contents of cinnamaldehyde and other components of cinnam...

Moumita Dev, Minakshi Ghosh * and Dipak Kumar Bhattacharyya

Scholar of School of Community Science and Technology, Indian Institute of Engineering Science and Technology, Shibpur, Howrah, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6692-02

6692-6702

33

10

61.

MAPPING PROTEIN INTERACTIONS BETWEEN RABIES VIRUS AND ITS HUMAN HOST

Rabies is a fatal viral disease which is caused by negative sense, single-stranded RNA virus belonging to Rhabdoviridae family of genus Lyssavirus, Rabies Virus (RABV). It is transmitted by the bite of a rabid animal and directly affects the CNS of the host (neurotropic). Sources of human rabies deaths are dogs (99%), cats, bats, etc. Rabies holds the seventh position in the world for causing the ...

K. Singla, K. Jatwani, A. Pandey, D. Malik, P. Chauhan, M. Rajbhar, A. Singh and K. Kumar *

Department of Biotechnology, Manav Rachna International Institute of Research and Studies, Faridabad, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6703-14

6703-6714

34

18

62.

OPTIMIZATION OF CULTURAL CONDITIONS TO ENHANCE BIOACTIVE METABOLITE PRODUCTION BY STREPTOMYCES OLIVOVERTICILLATUS VLK-15

The study was designed to optimize cultural conditions for enhanced production of bioactive compounds by Streptomyces olivo-verticillatus VLK-15 isolated from mangrove ecosystem of South Coast of Andhra Pradesh, India.  The soil dilution plate technique was employed for the isolation of actinobacteria using starch-casein agar (ISP-6) medium. The potent strain was identified as Streptomyces olivov...

Krishna Naragani *, Mani Deepa Indupalli and Vijayalakshmi Muvva

Department of Botany, Hindu College, Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6715-20

6715-6720

30

15

63.

DEVELOPMENT AND VALIDATION OF FIRST-ORDER DERIVATIVE UV-SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF FLUVASTATIN SODIUM IN FORMULATION

A simple, accurate, precise and sensitive first-order UV - Spectrophotometric assay method has been developed and validated for the quantitative estimation of fluvastatin sodium in pharmaceutical dosage forms. The solvent to dissolve the drug and for dilutions, methanol was used. The absorption maxima of fluvastatin sodium in methanol after derivatized into the first-order derivative was found to ...

Jahnavi Bandla *, Nameera Jabeen and Ashok Gorja

Department of Pharmaceutical Analysis and QA, Faculty of Pharmacy, Vishnu Institute of Pharmaceutical Education and Research, Narsapur, Medak, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6721-24

6721-6724

32

10

64.

NEUROPHARMACOLOGICAL EVALUATION OF INTRANASAL GUAR GUM LOADED OLANZAPINE MICROSPHERES

Background: The present work aimed to evaluate the sustained release antipsychotic activity of formulated biodegradable mucoadhesive guar gum microspheres of atypical antipsychotic drug Olanzapine (OLZ) for intranasal delivery and to reduce the dose-related side effects of the drug olanzapine. Guar gum microspheres of Olanzapine were fabricated and designed by O/W emulsion solvent evaporation tech...

Chitra Singh

Department of Pharmacology, Rama Medical College Hospital and Research center 38, Sahibabad, Block 10, Sector 3, Rajendra Nagar Pilkhuwa, Hapur, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6725-35

6725-6735

29

17

65.

IN-VITRO ANTHELMINTIC EFFECTS OF MEDICINAL PLANT CASSIA FISTULA EXTRACT ON THE TEGUMENT OF FASCIOLA GIGANTICA BY LIGHT MICROSCOPE

The efficacy of alcoholic Cassia fistula leaves extract on the tegument of Fasciola gigantic was studied by light microscopy. Live liver fluke Fasciola gigantica parasites were collected from the infected liver and bile duct of freshly slaughtered domestic goat (Capra hircus) at the local zoo abattoir in Udaipur. Liver flukes F. gigantica were maintained in 0.9% physiological saline and divided in...

Hemlata Sen, Raj Narayan Damor and Gayatri Swarnakar *

Department of Zoology, Government P. G. Meera Girls College, M. L. S. University, Udaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.12(12).6736-43

6736-6743

28

15