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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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Volume 12 (2021) - Issue 6, June

Review Articles

 
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1.

THE POTENTIAL ROLE OF NANOTECHNOLOGY TO COMBAT SARS-CoV2 -2019: DIAGNOSIS, TREATMENT OPTIONS, APPROACHES – A SCOPIOUS REVIEW

Coronavirus disease (COVID-19), an infectious disease caused by a novel coronavirus (2019-nCoV) or the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The infection began in bats and was communicated to people through yet obscure go-between creatures in Wuhan, Hubei territory, China, in December 2019. Its outbreak threatened the lives of many people throughout the world. There is no ...

S. Rajaram *, A. Prakashan, B. Pragathi, K. Saieswari, A. R. V. Sree and Y. M. Hedge

Department of Pharmaceutics, Swamy Vivekanandha College of Pharmacy, Elayampalayam, Tiruchengode, Namakkal, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).2966-81

2966-2981

281

225

2.

STRATEGIES OF TRADITIONAL SYSTEMS OF MEDICINE COMBATING WITH THE CURRENT PANDEMIC SITUATION OF COVID-19

Coronavirus disease (COVID-19) has become pandemic in no time in the world. Understanding the pathophysiological similarities with previously known viruses of the class gave opportunities to explore various molecular targets against COVID-19. Vaccines unavailability propose different research approaches of treatment, including various previously known and some new synthetic molecules, which are al...

D. Katiyar, P. Bansal, Manish and A. Kumar *

Division of Pharmacology, KIET School of Pharmacy, KIET Group of Institutions, Delhi-NCR, Ghaziabad, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).2982-94

2982-2994

183

103

3.

PHARMACEUTICAL APPLICATIONS OF NEXT GENERATION PRINTING TECHNOLOGIES: A BRIEF LITERATURE REVIEW

Next-generation printing or commonly known as three-dimensional (3D) printing (3DP), is a fabrication process of construction of a 3D object using a computer-aided design or digital 3D model. The 3D object is created layer by layer by depositing, joining, or solidifying a feedstock material such as thermoplastic polymer under the control of a computer-designed program. It is considered the latest ...

O. Baisya *, S. Bhowmick, C. Sengupta and A. D. Bhowmik

Department of Pharmaceutics, Netaji Subhas Chandra Bose Institute of Pharmacy, Chakdaha, Nadia, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).2995-05

2995-3005

154

90

4.

AYURVEDA A PROMISING TOOL FOR THE ERADICATION OF COVID-19

The COVID-19 pandemic has created a global health crisis posing an unprecedented public health emergency. The number of deaths and people being infected is increasing daily throughout the globe. This situation is much more severe due to possible devastating situations because of several social and economic factors. Effective management to address this infection is still evolving, and attempts are ...

A. S. Gadakh * and R. Chintamani

Department of Pharmaceutics, Rajmata Jijau Shikshan Prasarak Mandal's Institute of Pharmacy, Dudulgaon, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3006-09

3006-3009

165

81

5.

ALTHOLACTONE: A NATURAL LEAD SCAFFOLD AS A POTENTIAL ANTICANCER AGENT

Cancer is one of the most dreaded diseases across the globe. Drug resistance and adverse effects of various classical chemotherapeutic agents are the major challenges for cancer therapy. Cancer treatments with synthetic drugs are associated with severe side effects. Synthetic drugs address symptoms caused by diseases; on the other hand a plant-based medicine usually directs towards aiding body’s...

T. Sharma * and S. K. Paidesetty

Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3010-18

3010-3018

131

76

6.

FLOATING MICROSPHERES: A NOVEL EMERGING TREND IN GASTRO RETENTIVE DRUG DELIVERY

Oral Conventional dosage forms offer no control over the release of drug from the dosage form, which leads to variations in plasma drug levels; gastric emptying and gastric resident time are two another important factors that have a significant effect on the therapeutic efficacy of drug and it causes changes in the retention time of the drug. Accordingly, Floating microspheres is one of the most d...

A. R. Pavan *, X. F. Grace and S. R. Ramakrishnan

Department of Pharmaceutics, Sri Ramachandra institute of Higher Education and Research, Porur, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3019-33

3019-3033

62

35

7.

THERAPEUTIC AND PHARMACOLOGICAL POTENTIAL OF PRUNUS DOMESTICA: A COMPREHENSIVE REVIEW

Prune is a dry form of plum fruit; its botanical name is Prunus domestica characterized by unique nutrients and dietary bioactive profile. Prunes have wide application in traditional medicine and are known for their beneficial role as a laxative in management of non-communicable diseases and bone health. Researches have proved their antioxidant, anticancer, antihyperglycemic, anti-hyperlipidemic, ...

S. Mishra and S. Vyas *

Foods and Nutrition, IIS deemed to be a University, Gurukul Marg, SFS, Mansarovar, Jaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3034-41

3034-3041

60

30

8.

A REVIEW ON ETHNOMEDICINAL PLANTS OF ASSAM (INDIA) USED IN THE TREATMENT OF DIABETES MELLITUS

Diabetes mellitus is one of the most prevalent metabolic disorders and has been a leading cause of death in the last few decades. Oral hypoglycaemic agents are mostly used in the treatment of diabetes, but the main drawback of these agents is that they have some unavoidable side effects. Nowadays, researchers are mainly focusing on unexposed medicinal plant species as an alternative source for the...

S. Kumar *, D. Devi, S. Kushari, S. Gam and H. Sarma

Girijananda Chowdhury Institute of Pharmaceutical Science, Guwahati, Assam, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3042-50

3042-3050

132

53

9.

PHARMACOVIGILANCE SYSTEM IN INDIA IN COMPARISON WITH USA, EUROPEAN UNION AND FEW ASIAN COUNTRIES

Though the anesthesia-related death of a 15-year-old Hannah Greener marked the beginning of pharmacovigilance 160 years ago, the science of pharmacovigilance was not established as a separate field until the wake of the thalidomide tragedy in 1960’s. The World Health Organization (WHO) instituted International Drug Monitoring Program to internationalize the act of drug safety monitoring. Inspite...

T. Muthukumaran, J. S. J. U. Chander * and K. A. Kumar

Department of Pharmacology, College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore, Tamil Nadu India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3051-57

3051-3057

67

38

10.

QUALITY BY DESIGN APPROACH FOR THE FORMULATION OF DUAL RELEASE DRUG DELIVERY SYSTEM: A CHRONOMODULATED APPROACH

The focus of the current article is to prepare the chrono-modulated dual release formulation using various optimization techniques. The conventional formulations as the Controlled Release Drug Delivery System (CRDDS) are not effective in the chronomodulated formulation. The advancement in research and development in CRDDS leads to the formulation of chronomodulated formulations. Dual release table...

A. Sharma *, B. Singh and A. Choudhary

School of Pharmacy, Abhilashi University, Chailchowk, Mandi, Himachal Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3058-68

3058-3068

67

34

11.

REVIEW ON ORIGIN AND CONCATENATION OF COVID-19

Since 2019-November on world facing whole world is facing an unprecedented health problem. The WHO has said that a pandemic infection are coming with a new virus species of coronavirus is called SARS-CoV-2. Coronavirus 2019 is associated with global health and acute coronary respiratory syndrome coronavirus-2. COVID-19 is widely spread through drip channels. The virus causes mild symptoms in many ...

P. R. Dasari * and S. Pilli

Sai Life Sciences Limited, Unit-II, Shamirpet, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3069-77

3069-3077

60

23

12.

AMYOTROPHIC LATERAL SCLEROSIS: RAPIDLY ACCELERATING COMPLEX NEURO-DEGENERATIVE DISEASE

An amyotrophic lateral sclerosis is a group of progressive neurodegenerative disorders of motor neurons that leads to weakness, muscle atrophy, progressive paralysis, and respiratory insufficiency with a life anticipation of only three years after the onset of disease symptoms. It impairs the functions of both upper and lower motor neurons. The specific mechanism for the disease remains largely un...

A. Arya *, P. Tyagi, S. Yadav and R. Kadian

Department of Pharmaceutical Education and Research, BPS Women University, South Campus, Bhainswal Kalan, Sonepat, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3078-89

3078-3089

94

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13.

MANAGEMENT OF PSORIATIC ARTHRITIS: AN OVERVIEW OF SYNTHETIC, RECOMBINANT DNA, MONOCLONAL ANTIBODY AND NATURE-DERIVED AGENTS

Psoriatic arthritis is an inflammatory condition of the skin and musculoskeletal system with cutaneous psoriasis that leads to joint deformity and disability and is commonly seen in 40-50-year-old population. Clinically, TNF-α inhibitors and JAK inhibitors form the main line of treatment of this rare disorder. A systematic review was conducted via an electronic search of Google Scholar, PubMed, S...

O. Sawant and T. Khan *

Department of Pharmaceutical Chemistry and Quality Assurance , SVKM’s Dr. Bhanuben Nanavati College of Pharmacy, Mithibai Campus, Vile Parle (West), Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3090-03

3090-3103

61

25

Research Articles

 
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14.

DECIPHERING COVID-19 ENIGMA BY TARGETING SARS-COV-2 MAIN PROTEASE USING IN-SILICO APPROACHES

Covid-19 pandemic has enforced the entire scientific community to work together and find a solution for the adversity the whole world is facing. This has called for immediate actions, and the most common point of discussion and rapid way to tackle this is to repurpose the previously approved molecules and check their activity against this virus. The role of computational techniques has paved the w...

M. E. Sobhia *, K. Ghosh, S. Sivangula and G. S. Kumar

Department of Pharmacoinformatics, National Institute of Pharmaceutical Education and Research (NIPER), Mohali, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3104-19

3104-3119

143

77

15.

THE POTENTIAL PROTECTIVE EFFECT OF STRAWBERRY EXTRACT AGAINST INDOMETHACIN-INDUCED LIVER TOXICITY AND GASTRIC ULCERATION IN RATS: BIOCHEMICAL, HISTOPATHOLOGICAL AND GENETIC STUDIES

The objective of this study was to determine the hepatoprotective effect of strawberry extract (150 mg/kg.b.w) in rats against Indomethacin sodium-induced gastric ulceration. Oral indomethacin administration (5 mg/kg.b.w.) resulted in a substantial rise in total plasma cholesterol, triglycerides (HDL), factor-alfa (TNF-α), nitric oxide (NO), liver and stomach necrosis, tumor necrosis factor-alfa ...

S. A. Hassan, S. M. A. Elwafa H. A. El-Baz, M. A. Hussein * and N. A. Gobba

Biochemistry Department, Faculty of Applied Medical Sciences, October 6 University, Sixth of October City, Egypt.

DOI: 10.13040/IJPSR.0975-8232.12(6).3120-33

3120-3133

187

71

16.

ETHANOLIC SEED EXTRACT OF AFRAMOMUM MELEGUETA PROTECTS AND PRESERVES THE FUNCTIONS AND MICROARCHITECTURE OF THE OVARY OF ADULT FEMALE WISTAR RATS AGAINST PARAQUAT INDUCED TOXICITY

Aframomum melegueta (Alligator pepper) is a tropical plant that belongs to the Zingiberaceae (Ginger) family, consumed for its culinary and health benefits. This study investigated the therapeutic efficacy of ethanolic seed extract of Aframomum melegueta at ameliorating paraquat-induced ovarian toxicity in rat models. Thirty female Wistar rats were divided into control and five test groups (n=5). ...

U. C. Ofoego *, E. D. Eze, E. O. Nweke, E. C. Ijeoma, C. G. Ukamaka, K. M. Rabiu and I. Ezekiel

Department of Anatomy, Faculty of Basic Medical Sciences, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria.

DOI: 10.13040/IJPSR.0975-8232.12(6).3134-42

3134-3142

141

61

17.

EVALUATING THE EFFECTS OF COMMIPHORA MOLMOL (MYRRH) AGAINST OXIDATIVE DNA DAMAGE IN HUMAN LYMPHOCYTES

Oxidative stress is a condition that might predispose individuals to diseases, including cancer. The 8- hydroxydeoxyguanosine (8-OHdG) is an index that reflects DNA damage caused by oxidative stress in the body. In this study, Commiphora molmol (Myrrh) (C. molmol) (Myrrh) that belongs to the family Burseraceae were investigated for its potential favorable properties to blunt DNA damage induced by ...

H. M. Daradka *, H. A. Aljohani, M. K. Alotaibi, O. Flah Khabour, A. A. Eskandrani, S. M. Alsharif, R. Al-Shdefat, H. A. Abu-Harirah and Y. Bataineh

Biology Department, Faculty of Science, Taibah University, B.O. 344, Al-Madinah Al-Munawwarah, Saudi Arabia.

DOI: 10.13040/IJPSR.0975-8232.12(6).3143-49

3143-3149

116

49

18.

BIOAVAILABILITY ENHANCEMENT OF ACYCLOVIR USING HIGH-DENSITY GASTRO-RETENTIVE PELLETS

The objective of the present study was to improve the oral bioavailability using high-density gastro-retentive pellets containing solid dispersion of acyclovir. Solid dispersion prepared with polyvinylpyrrolidone (PVP K30) and hydroxypropyl methylcellulose (HPMC) using different ratios 1:1, 1:2, 1:3, 1:4, and 1:5 by solvent evaporation method and characterized for solubility study, dissolution stu...

N. Gupta, V. K. Rai, T. S. Markandeywar and G. D. Gupta *

Department of Pharmaceutics, ISF College of Pharmacy, Moga, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3150-64

3150-3164

103

56

19.

COMPARATIVE STUDIES ON THE ANTIOXIDANT, ANTI-INFLAMMATORY AND PHYTO-CHEMICAL CONSTITUENTS OF PIPER BETEL LEAVES FROM THE WESTERN GHATS AND NORTHERN REGION OF KARNATAKA

Our present study aims at analyzing and comparing the antioxidant, anti-inflammatory and phytochemical property of betel leaves from two different domains of Karnataka that includes the Western Ghats and the Northern region. Initially, the ethanol extracts of all four samples (two from each domain) were prepared and checked for their anti-inflammatory and antioxidant activity. As a result, the bet...

P. R. A. Nadig, T. G. Mandira and J. R. Kumar *

Division of Biochemistry, Course coordinator, School of Life Sciences, Department of Water & Health, JSS Academy of Higher Education & Research, Mysuru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3165-75

3165-3175

67

45

20.

IN-VITRO ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITY OF SALIX ALBA L. ALONG WITH SIMULTANEOUS HPTLC ANALYSIS OF SALICIN AND FERULIC ACID

Now a day’s interest towards natural and has been growing due to the unhealthy consequences of chemicals in the health industry; though, herbal substances possess several quality control and confirm pharmacological action issues. This present study was designed to determine the effects of Salix alba L. methanolic extract (MESAL) for its antioxidant and anti-inflammatory activity in rat models. F...

R. S. Shivatare *, S. M. Kewatkar, R. Musale, P. Lohakare, D. Patil, D. Choudhary, G. Ganu, D. H. Nagore and S. Chitlange

Department of Pharmaceuticals, JJT University, Jhunjhunu, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3176-84

3176-3184

63

28

21.

PHYTOCHEMICAL CHARACTERIZATION OF COLD MACERATED METHANOLIC LEAF EXTRACT OF CADABA INDICA LAM. USING GC-MS

Cadaba indica Lam (Indian Cadaba), an Indian traditional medicinal plant has been used for various diseases. The cold macerated methanolic leaf extract of Cadaba indica was assessed using Agilent GC 7890A gas chromatography connected with an MS- 5975C mass spectrometer and the mass spectra were matched with NIST 14.0 – data library. Several chemical constituents were identified within 28 min of ...

V. Thirumalai, P. Nirmala * and R. Venkatanarayanan

Department of Pharmacology, Rajah Muthiah Medical College, Annamalai University, Chidambaram, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3185-92

3185-3192

56

30

22.

SYNTHESIS, CHARACTERIZATION AND IN-VITRO ANTICANCER SCREENING OF VITIS VINIFERA SEED ETHANOLIC EXTRACT LOADED CHITOSAN NANOPARTICLES IN H-29 COLON CANCER CELL LINE

Nanotechnology can be applied to deliver and protect antioxidants in order to control the oxidative stress phenomena in several chronic pathologies. Chitosan (CS) and its carboxymethyl derivatives are smart biopolymers that are non-toxic, biocompatible, and biodegradable, and, hence, suitable for various biomedical applications, such as drug delivery gene therapy and tissue engineering. Vitis vini...

A. L. Kumar and K. Prabu *

Dr. M.G.R. Educational and Research Institute, Maduravoyal, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3193-00

3193-3200

55

32

23.

ISOLATION OF PHYTOCONSTITUENTS AND EVALUATION OF JUSTICIA GENDARUSSA LEAF EXTRACTS FOR ANTI PARKINSONIAN ACTIVITY

The present study investigates the anti-parkinsonian activity of various extracts of Justicia gendarussa (JG) leaves in MPTP-induced neurotoxicity mice. Parkinson’s disease (PD) is a neurodegenerative syndrome belongs to a group of motor symptoms disorders. In PD, brain cells degenerated in some parts of the brain which produce dopamine. JG herb is widely distributed in tropical regions of the w...

R. K. Banoth

Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visvavidyalayam (Women’s University) Tirupati, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3201-09

3201-3209

65

27

24.

BIOTRANSFORMATION OF QUERCETIN BY ASPERGILLUS NIGER FROM ALLIUM CEPA

Biotransformation is a biological process in which the microbes are converting one form of compound to the another form. In the present research work, we studied about the conversion of Quercetinto kaempferol, which is having more therapeutic potential. Flavonoids are diverse group of secondary metabolites found especially in all plants. Flavonoids have Anti-carcinogenic, Anti-inflammatory, antiox...

S. Chatla *, S. Gasi, S. A. Rahaman, M. Yaradla and S. Mareedu

Department of Biotechnology, Nirmala College of Pharmacy, Atmakuru, Mangalagiri, Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3210-15

3210-3215

105

39

25.

STABILITY INDICATING RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF DARUNAVIR, COBICISTAT, EMTRICITABINE AND TENOFOVIR ALAFENAMIDE IN BULK AND PHARMACEUTICAL FORMULATION

A simple, accurate & precise method was developed for the simultaneous estimation of Darunavir (DAR), Cobicistat (COB), Emtricitabine (EMT), and Tenofovir alafenamide (TEN) in their bulk and pharmaceutical formulation. The chromatogram was run through Agilent C18 (150 × 4.6 mm, 5 m) column. Mobile phase containing 0.1% Ortho Phosphoric acid (OPA) (pH 2.4) and Acetonitrile in the ratio of 55:4...

S. A. Parameswari *, A. K. R. Ankinapalli, T. Tsegaye and M. Alagusundaram

College of Pharmacy, College of Health Science, Mettu University, Mettu, Ethiopia.

DOI: 10.13040/IJPSR.0975-8232.12(6).3216-24

3216-3224

51

39

26.

STRESS STUDIES OF METFORMIN AND GLICLAZIDE BY HPLC METHOD AND EXTENSION OF METHOD APPLICATION FOR ELUTION OF SOME ANTIVIRAL, ANTI-BACTERIAL AND ANTI-INFLAMMATORY DRUGS

A simple reverse phase SI-HPLC method was developed for the simultaneous estimation of antidiabetic combination of metformin and gliclazide. The method was based on HPLC separation on a reversed-phase C18 column using a mobile phase consisting of phosphate buffer: acetonitrile (40:60, v/v) at a flow rate of 0.8 ml/min. UV determination was achieved at 240 nm. The analytes were subjected to various...

K. Chauhan * and V. Choudhari

Department of Pharmaceutical Chemistry, MCE Society’s Allana College of Pharmacy, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3225-35

3225-3235

46

25

27.

EVALUATION OF ANTI-PARKINSON’S ACTIVITY OF CYAMOPSIS TETRAGONOLOBA METHANOL PLANT EXTRACT WITH BEHAVIORAL AND BIOCHEMICAL ANALYSIS

In the present study, we evaluated the Anti-parkinson’s activity of Cyamopsis tetragonoloba methanol plant pod extract by Haloperidol Induced Catalepsy and Tacrine induced vacuous jaw movements for behavioral parameters and in-vivo assays to estimate neurochemical parameters like (GSH, LPO, and SOD). The behavioral analysis performed using Haloperidol Induced Catalepsy produces Parkinson’s dis...

B. Kaur * and J. Saxena

Department of Chemistry, Barkatullah University, Bhopal, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3236-42

3236-3242

56

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28.

DEVELOPMENT OF VALIDATED HIGH-PERFORMANCE THIN-LAYER CHROMATOGRAPHY DENSITOMETRIC METHOD FOR QUANTIFICATION OF QUERCETIN IN CAPPARIS DECIDUA EDGEW. STEM

Capparis decidua Edgew. (Capparidaceae) is an important medicinal plant widely used in Ayurveda as anti-inflammatory, anti-arthritic, hepatoprotective, diuretic, digestive, laxative, analgesic and anti-asthmatic. In this study, a sensitive and reliable high-performance thin-layer chromatography (HPTLC) method has been developed for the quantification of a flavonol quercetin as an important marker ...

P. D. Verma *, D. M. Gandhi and B. N. Suhagia

Department of Pharmacognosy, L. M. College of Pharmacy, Navrangpura, Ahmedabad, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3243-48

3243-3248

52

26

29.

FORMULATION AND EVALUATION OF CIPROFLOXACIN HYDROCHLORIDE ENCAPSULATED LIPOSOMAL HYDROGEL FOR DERMAL ADMINISTRATION

The present work aims to formulation and characterization of a topical liposomal gel for ciprofloxacin hydrochloride. The drug lipid interaction studies were carried out by FTIR analysis, X-ray diffraction study, and DSC study, and no changes of physicochemical properties of ciprofloxacin were found. The thin-film hydration method was used for the preparation of liposomes consisting of phosphatidy...

S. Paul *, A. B. Paul, S. Majumdar, T. Roy, S. Chandra and V. R. Chowdhury

Department of Pharmaceutical Technology, JIS University, Kolkata, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3249-56

3249-3256

48

29

30.

ANALYTICAL METHOD DEVELOPMENT AND VALIDATION STUDIES FOR THE ESTIMATION OF NIMESULIDE AND DICYCLOMINE HYDROCHLORIDE IN FIXED DOSE COMBINATION TABLETS

A simple, accurate, and precise reversed-phase high-pressure liquid chromatography (RP-HPLC) method was developed for the simultaneous estimation of nimesulide and dicyclomine hydro-chloride in fixed-dose combination tablets. The developed method was validated as per ICH guidelines Q2(R1). The chromatographic separation was achieved on Hypersil ODS C18 (200 × 4.6 mm 5 μ) column using methanol: p...

S. D. Cunha and T. Khan *

Department of Pharmaceutical Chemistry and Quality Assurance, SVKM’s Dr. Bhanuben Nanavati College of Pharmacy, Mumbai, Maharashtra India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3257-63

3257-3263

46

31

31.

SIMULTANEOUS ESTIMATION OF TEA TREE OIL AND NEEM SEED OIL IN BULK AND COSMECEUTICAL FORMULATION BY UV SPECTROPHOTOMETRY

Tea tree oil, an essential oil, has claims for analgesic, antimicrobial, antiseptic, and anti-inflammatory activity. Its complex composition is governed by ISO 4730:2017. It is extensively used in skin and hair care cosmeceuticals, often in combination with neem seed oil. Neem seed oil has potent antimicrobial, skin rejuvenating, and conditioning action attributed to the presence of micro constitu...

B. P. Manjula *, V. G. Joshi, S. R. Setty and M. Geetha

Department of Pharmaceutics, Government College of Pharmacy, Rajiv Gandhi University of Health Sciences, Bengaluru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3264-71

3264-3271

69

36

32.

PREPARATION AND IN-VIVO EVALUATION OF SIMVASTATIN CRYSTALLO-CO-AGGLOMERATES

The purpose of this research was to obtain directly compressible agglomerates of simvastatin using a crystallo-co-agglomeration technique and determine its in-vivo performance in rats. Simvastatin Dicalcium phosphate co agglomerates were prepared from Dichloromethane: Isopropyl Myristate: Distilled water system containing polyvinyl pyrrolidone (PVP). Dichloromethane acted as a good solvent for si...

G. S. Shinde and S. Mohite *

Department of Pharmaceutical Chemistry, Rajarambapu College of Pharmacy, Kasegaon, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3272-80

3272-3280

49

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SYNTHESIS CYTOTOXIC AND ANTIMICROBIAL EVALUATION OF SOME NOVEL BENZOXAZOLE ANALOGUES

Benzoxazole and its analogues play an important role as therapeutic agents and exhibit good cytotoxic as well as antimicrobial activity. In the present study, benzoxazole analogues have been prepared by synthetic route; their spectroscopic evaluation was carried out, and then the synthesized compounds were screened for their cytotoxic activity by Allium cepa root model as well as antimicrobial act...

M. L. Patil *, L. G. Rathi, S. N. Gaikwad and S. S. Gaikwad

University Department of Pharmaceutical Sciences, RTMNU, Nagpur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3281-90

3281-3290

47

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DESIGN, DEVELOPMENT AND EVALUATION OF POLYHERBAL TABLET OF TWO ANTI-ULCER LEAVES

Aim: The present study was to develop and evaluate antiulcer polyherbal tablet as designing of oral herbal formulation. The methanolic extracts of Abrus precatorius (MEAP) and Cordia wallichi (MECW) leaves were used in different concentrations in the formulations. Materials and Method: The current exploration was to design a gastro-retentive drug delivery system of MEAP and MECW using swelling pol...

R. Sengupta * and N. M. Zaveri

Girijananda Chowdhury Institute of Pharmaceutical Sciences, Guwahati, Assam, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3291-97

3291-3297

72

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ASSESSMENT OF PRETERM NEONATES’ RESPONSE TO TACTILE AND KINESTHETIC STIMULATION

Objective: To assess the response of Preterm neonates to Tactile and Kinesthetic Stimulation. Methods: The study was conducted in a Neonatal Intensive Care Unit of a tertiary care hospital in India. Twelve stable preterm neonates were selected as per the inclusion and exclusion criteria and randomized into the intervention and control group. Seven days of tactile and kinesthetic stimulation was gi...

J. Umarani *, S. Ramesh, P. Saldanha, R. D. Mendonsa and E. Kayalvizhi

Yenepoya Nursing College, Yenepoya Deemed to be University, Mangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3298-05

3298-3305

49

27

36.

DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF LAMIVUDINE AND TENOFOVIR DISOPROXIL FUMARATE IN COMBINED DOSAGE FORM USING QUALITY BY DESIGN APPROACH

A new, simple, rapid, accurate, and economical method has been developed for the simultaneous estimation of Lamivudine and Tenofovir Disoproxil Fumarate in formulation by using a quality by design approach. Design expert software was used for QbD analysis. 03 level factorial quadratic design models were used to analyze the response. The model generated was found to be significant. The optimized co...

A. J. Asnani *, S. M. Mohurle and K. Pratyush

Priyadarshini J. L. College of Pharmacy Electronic Zone M. I. D. C., Nagpur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3306-15

3306-3315

51

24

37.

INCREASED ENZYMATIC ACTIVITY OF THYROID PEROXIDASE-TREATMENT FOR CONGENITAL HYPOTHYROIDISM

Congenital Hypothyroidism may be defined as a heterogeneous group of disorders characterized by goiter or cretinism due to an absolute or relative deficit of the enzyme Thyroid Peroxidase (TPO), and it is action. Chronic hypothyroidism also leads to goiter and cretinism associated with end gland damage, dysfunction, cancer, and failure, including the retina, kidney, nervous system, heart, and vasc...

P. J. Sujitha and S. Arunkumar *

Department of Pharmacy Practice, J.K.K. Nattraja College of Pharmacy, Kumarapalayam, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3316-19

3316-3319

52

26

38.

ENHANCING THE EXTRACTION OF POLYPHENOLS FROM ACACIA LEUCOPHLOEA BARK BY MICROWAVE-ASSISTED ENZYMATIC EXTRACTION METHOD AND IN-VITRO STUDY OF ITS ANTIOXIDANT AND ANTIBACTERIAL ACTIVITY

This study aims to identify the suitable method for extraction of polyphenols from Acacia leucophloea bark using enzymes and to optimize the processing condition for extraction using Response Surface Methodology. A microwave-assisted enzymatic extraction (MAEE) method was developed and optimized to augment the polyphenol yield. The optimal extraction conditions were as follows: the amount of cellu...

S. Ayyasamy * and S. Velusamy

Department of Food Technology, Kongu Engineering College, Perundurai, Erode, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3320-30

3320-3330

50

29

39.

PHYTOCHEMICAL EVALUATION OF CASSIA AURICULATA USING ANALYTICAL STUDIES

Medicinal plants, herbs, spices, and herbal remedies are integral components of the alternative system of medicine since while’s ancient Cassia auriculata Linn is a potential folklore medicinal plant (Caesalpiniaceae) used for Ayurveda and Siddha systems of medicine. Plants contain a wide variety of phytochemical constituents, which are secondary metabolites and are used either directly or indir...

V. J. J. Jancy *, V. K. Kalaichelvan and N. Balakrishnan

Department of Pharmacology, S. A. Raja Pharmacy College, Vadakkankulam, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3331-38

3331-3338

62

30

40.

ANTI-INFLAMMATORY, ANALGESIC AND ANTIMICROBIAL ACTIVITIES OF SOME SYNTHETIC FURANONES AND THEIR PYRROLONE DERIVATIVES

In the present study, 3-naphthoyl propionic acid and various appropriate reagents were used to synthesize, ten new synthetic furanone derivatives, i.e. 3-arylidene-5-(naphthalen-2-yl) furan-2(3H)-one (2-11). Selected furanones were made to react with ammonia and benzylamine to yield analogous pyrrolones (12-16) and N-benzyl pyrrolones (17-21), respectively, which were characterized on the basis of...

I. Rani *, S. L. Khokra, G. Kaur and P. Sharma

MM School of Pharmacy, Maharishi Markandeshwar University, Sadopur-Ambala, Haryana India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3339-48

3339-3348

59

21

41.

ANTI-STAPHYLOCOCCUS AUREUS ACTIVITY, ADMET PROPERTIES AND MOLECULAR DOCKING STUDY OF PHYTOCOMPOUNDS FROM ERIANTHEMUM DREGEI

The constant increase in the emergence of multidrug resistance among Staphylococcus aureus strains threatens public health. The study aimed at evaluating the anti-S. aureus activity, pharmacokinetic properties and interactions of compounds from Erianthemum dregei with proteins in S. aureus. Anti-S. aureus activity was investigated by broth dilution method while gas chromatography-mass spectrometry...

T. S. Maliehe *, N. N. Mthembu and S. J. Siyabonga

Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa, South Africa.

DOI: 10.13040/IJPSR.0975-8232.12(6).3349-59

3349-3359

56

26

42.

PREPARATION AND IN-VITRO EVALUATION OF APREMILAST EFFERVESCENT FLOATING TABLETS

Apremilast, the new PDE4 inhibitor drug, exhibits low solubility and low permeability; therefore, shows variable bioavailability. Effervescent floating tablets of apremilast were developed to sustain the drug release rate by increasing gastric retention time. These tablets were prepared by wet granulation technique, using different polymers like carbopol 934P, hydroxypropyl methylcellulose K4M, tr...

R. Deshmukh, G. Jeswani and S. D. Paul *

Shri Shankaracharya Technical Campus, Shri Shankaracharya Group of Institutions, Faculty of Pharmaceutical Sciences, Bhilai, Chhattisgarh, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3360-65

3360-3365

56

35

43.

DEVELOPMENT AND EVALUATION OF GINGER TRANSDERMAL PATCH AND ITS IMPLICATIONS IN MIGRAINE THERAPY

The potential of transferosomal formulation for transdermal delivery of Ginger constituents was investigated. The aim was to reduce the dosage and improve patient acceptance. Transferosomes were formulated by ethanol injection technique using Phospholipids (Lipoid P-100), cholesterol, various edge activators (tween 80, Span 80), and other excipients. Transdermal patches were prepared by solvent ca...

J. N. Deora and S. S. Patil *

Department of Pharmacognosy, Prin. K. M. Kundnani College of Pharmacy, Mumbai University, Cuffe Parade, Colaba, Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3366-74

3366-3374

65

25

44.

A NEW RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF TOLCAPONE AND QUINAPRIL IN ITS PURE AND PHARMACEUTICAL DOSAGE FORM

A short selective, precise, accurate, and sensitive method for the estimation of Tolcapone and Quinapril was done by RP-HPLC. The assay of Tolcapone and Quinapril was performed with tablets, and the % assay was found to be 100.19 and 100.45, which shows that the method is useful for routine analysis. The linearity of Tolcapone and Quinapril was found to be linear with a correlation coefficient of ...

A. K. Begum * and S. Mubashir

Department of Pharmaceutical Analysis, Shadan Women’s College of Pharmacy, Khairatabad, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3375-80

3375-3380

44

21

45.

FORMULATION AND EVALUATION OF NANOSTRUCTURED LIPID CARRIER FOR THE MANAGEMENT OF PSORIASIS

The objective of the research work was to design NLCs gel of Acitretin and perform an in-vitro evaluation of different formulations. FTIR and DSC studies revealed that there was no interaction between drug and polymer and with the respective surfactant. A new generation of NLCs consisting of a lipid matrix with a special nanostructure has been developed. These nanostructures improve drug loading a...

K. Kumari *, A. K. Sachan, S. Singh and A. Kapoor

Dayanand Dinanath College, Institute of Pharmacy, Afzalpur, Kanpur, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3381-90

3381-3390

50

31

46.

2D QSAR ANALYSIS OF DIPEPTIDE NITRILE BASED CATHEPSIN S INHIBITORS

Cathepsin S enzyme has been considered as an evolving target for the development of novel therapeutic agents for the treatment of numerous autoimmune disorders and other inflammatory diseases. Using TSAR 3.3 2D QSAR has been performed on a series of dipeptide nitrile nucleus. Attempts have been made to derive and comprehend a correlation between biological activity and the generated descriptors. T...

S. Kushwaha * and S. K. Paliwal

Faculty of Pharmaceutical Sciences, Rama University, Mandhana, Kanpur, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3391-02

3391-3402

50

24

47.

PHARMACOGNOSTIC STANDARDIZATION OF POLYHERBAL FORMULATION PALASHA BEEJADI CHOORNA

Herbs are the main source of Ayurvedic formulations. Polyherbalism concept of Ayurveda enables fortified therapeutic effect when compared to single herb. The potency of polyherbal formulations depends on their ingredients. Plants tend to vary in their efficacy due to the influence of environmental factors, such as temperature, humidity, light, oxygen, moisture content. The quality of polyherbal fo...

K. N. Anuradha *, Harini and P. N. Rao

Faculty of Pharmaceutical Sciences, Rama University, Mandhana, Kanpur, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3403-09

3403-3409

58

29

48.

TO STUDY THE EFFECT OF NATURAL POLYMER ON THE RELEASE OF OSMOTIC TABLET FOR COLON SPECIFIC DRUG DELIVERY SYSTEM

Controlled and targeted drug delivery system is more advantages than conventional dosage in various aspects. In the case of treating colonic disorders such as inflammatory bowel disease, the drugs do not reach the site of action in appropriate concentration. Thus there is a need to develop effective and safe therapy for the treatment of these colonic disorders, using site-specific drug delivery ap...

R. Gupta *, A. Agarwal and A. Kushwaha

Kanpur Institute of Technology and Pharmacy, Kanpur, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3410-17

3410-3417

47

26

49.

INVESTIGATION OF THE ANTI-CANCER POTENCY OF NANOMEDICINE, GREEN SYNTHESIZED FROM SPIRULINA PLATENSIS, AGAINST BREAST CANCER

Breast cancer is the most common type of cancer found in women. Although considerable advances have been achieved in the diagnosis and treatment of breast cancer, medical research routinely thrives towards the development of newer technologies for the treatment of breast cancer. The current study aimed at the development of nanomedicine, in the form of silver nanoparticles from the aqueous extract...

V. D. Mendhulkar * and L. Shetye

Department of Botany, Institute of Science, Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3418-24

3418-3424

64

26

50.

HEPATOPROTECTIVE ACTIVITY AND OXIDATIVE STRESS OF THE AQUEOUS EXTRACT OF SEED FROM PINTO BEAN (PHASEOLUS VULGARIS L.) IN STREPTOZOTOCIN INDUCED ALBINO WISTAR RATS

The aim of the study was to evaluate the anti-diabetic and antioxidant effects of aqueous extract of Phaseolus vulgaris L. seeds in normal and streptozotocin (STZ) induced diabetic rats. Female Albino Wistar rats were divided into 6 groups of 6 rats; each was assigned into diabetic and non-diabetic groups. Diabetes was induced in rats by single intraperitoneal administration of STZ (55 mg/kg body ...

H. R. Obonyo *, V. S. Selvi and O. Gilbert

PG & Research Department of Biochemistry, Bharathidasan college of Arts & Science, Ellispettai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3425-32

3425-3432

52

26

51.

DEVELOPMENT AND CHARACTERIZATION OF SOLID LIPID NANOPARTICLES OF LINAGLIPTIN

The main objective of the present research work was to formulate and characterize the linagliptin-loaded solid lipid nanoparticles (SLNs). SLNs possess distinctive characteristics like small and spherical shapes with an average diameter between 1to 100 nm. Linagliptin is used for the treatment of type II diabetes and it is a dipeptidyl peptidase 4-inhibitor and its oral bioavailability is 30%. The...

N. Yamini, S. K. A. Begum * and N. R. Rao

Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3433-42

3433-3442

50

22

52.

ASSESSMENT OF THE ACUTE TOXICITY FOR ETHANOLIC EXTRACT OF POLYHERBAL FORMULATION IN SWISS ALBINO MICE

The main objective of this study was to Assessment of the acute toxicity of ethanolic extract of Polyherbal formulation in Swiss albino mice. In this study, the acute oral toxicity study of ethanolic extract of PHF1 was carried out according to Organization for Economic Co-operation and Development (OECD) guideline 423 and 407 on Swiss albino mice (20–30 g). In the study, the oral dose of 2000 m...

A. K. Srivastava *, A. Naseer, A. Gupta, B. Chauhan and R. Sanwal

Adarsh Vijendra Institute of Pharmaceutical Sciences, Shobhit University, Gangoh, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3443-48

3443-3448

58

22

53.

TOTAL PHENOLS, ALKALOIDS, TANNINS AND ANTIOXIDANT ACTIVITY OF WILD PRUNUS ARMENIACA L. SEED COLLECTED FROM GARHWAL REGION OF UTTARAKHAND, INDIA

Plants are the important constituents of folk and traditional medicines and fulfill nutrition and dietary needs from ancient times. The aim of this study to evaluate phytochemicals and antioxidant activity of seed oil of wild apricot (Prunus armeniaca L). Thenon-cultivated seed of wild Prunus armeniaca L. from the Garhwal, Uttarakhand, India was analyzed for its phytochemicals e.g., total phenols,...

I. Rai, A. J. Bachheti, D. P. Pandey and R. K. Bachheti *

Department of Industrial Chemistry, College of Applied Science, Addis Ababa Science and Technology University, Addis Ababa, Ethiopia.

DOI: 10.13040/IJPSR.0975-8232.12(6).3449-56

3449-3456

53

32

54.

A SIMPLE, SENSITIVE AND FAST SINGLE STEP EXTRACTION METHOD FOR DETERMINATION OF EMPAGLIFLOZIN IN HUMAN PLASMA USING LC-MS/MS

A simple, sensitive, and fast single-step extraction method for estimating empagliflozin in human plasma using LC-MS/MS was developed and validated for pharmacokinetics evaluations. Plasma samples were basified before solid-phase extraction on SOLA (30 mg / 1 mL cartridges). Separations were carried out on a normal reverse phase C18 column (Hypersil BDS 100 × 4.6, 5µ mm column) for 3.5 minutes a...

A. Raval, C. Prasad, R. S. R. Patil and A. C. Krishna *

College of Pharmacy, Pacific Academy of Higher Education and Research University, Udaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3457-63

3457-3463

47

26

55.

DESIGN AND DEVELOPMENT OF BUDESONIDE PRONIOSOMES FOR TARGETED DRUG DELIVERY

The aim of the present study was to formulate and evaluate Budesonide proniosomes for enhancement of solubility and bioavailability. To develop and evaluate budesonide proniosomes was the main objective of this research work. For the preparation of proniosomes slurry, a method was used using different ratios of (cholesterol: surfactant) (1:1.5) with the help of carriers. For optimization of formul...

M. M. Hiral *, D. M. Shailesh and L. L. Jha

Department of Pharmaceutical Sciences, Saurashtra University, Rajkot, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3464-74

3464-3474

56

26

56.

AN IN-SILICO APPROACH TO DRUG DESIGNING ON NOVEL TARGET FOR TUBERCULOSIS CAUSED BY MYCOBACTERIUM TUBERCULOSIS

Worldwide, Tuberculosis (TB) remains the most frequent and important infectious disease caused by Mycobacterium tuberculosis (Mtb). TB Structural Genomics Consortium (TBSGC) reported 79,144 deaths and 26.9 lakh cases in 2019 (WHO). Although tuberculosis is a curable disease, the chances of a cure become slim as the disease becomes multidrug-resistant, and the situation gets even worse as the disea...

K. R. Suriya and V. Sivakumaran *

Bharathidasan University, Tiruchirappalli, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3475-80

3475-3480

69

23

57.

CHROMATOGRAPHIC EVALUATION OF OPTIMIZATION AND SEASONAL VARIATION OF BACOSIDE A CONTENT FROM WILD AND CULTIVATED BRAHMI (BACOPA MONNIERI LINN.) PLANT

Brahmi (Bacopa monnieri Linn.) is a miraculous Ayurvedic drug used commercially in memory-enhancing formulations. Its nootropic action is due to Bacoside A, which modern parameters have proved. Bacoside A content fluctuated during the course of the whole year. In the present study, High-Performance Liquid Chromatography was conducted to evaluate total Bacoside A content (expressed as the sum of Ba...

P. Wate *, P. Khobragade and A. Pargaonkar

Department of Dravyaguna, Datta Meghe Ayurvedic Medical College, Hospital and Research Centre, Wanadongari, Nagpur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3481-89

3481-3489

51

25

58.

GANODERMA LUCIDUM TOTAL TRITERPENES ALLEVIATE INFLAMMATION AND MODULATE ANTIOXIDANT STATUS IN FREUND’S COMPLETE ADJUVANT-INDUCED ARTHRITIC RATS

Ganoderma lucidum total triterpenes were evaluated for anti-inflammatory activity using carrageenan-induced acute and formalin-induced chronic paw oedema models in Swiss albino mice. The total triterpenes, at concentrations 10, 50, and 100 mg/kg b. wt. administered orally, showed 36.96%, 54.35%, 76.09% inhibition of acute and 41.86%, 62.79% and 79.07% inhibition of chronic inflammation. Total trit...

T. P. Smina, J. Mathew, K. A. Rony and K. K. Janardhanan *

Amala Cancer Research Centre, Thrissur, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3490-97

3490-3497

50

23

59.

EVALUATION OF ANTI-OSTEOPOROTIC ACTIVITY OF ASTHIPOSHAK TABLETS IN OVARIECTOMIZED RATS

Osteoporosis is a condition that makes the bones porous, fragile, and prone to fractures.  Although it is very prevalent in elderly people, it is more common in women, especially after menopause. The present study aimed to evaluate the effect of Asthiposhak tablets on their anti-osteoporotic activity in ovariectomized (OVX) rats. Thirty-two female albino Wistar rats were randomly divided into fou...

M. Sanaye *, B. Bora, M. Chawda and V. Kshirsagar

Prin. K. M. Kundnani College of Pharmacy, Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3498-07

3498-3507

56

29

60.

EVALUATION OF ADDITION OF PARACETAMOL AS ADD ON THERAPY TO LOW DOSE ETORICOXIB FOR ANALGESIA IN ACUTE PAIN: AN EXPERIMENTAL STUDY

Objective: To study the influence of paracetamol on analgesia when given separately with low dose etoricoxib for treatment of acute pain in mice. Materials and methods: Animals were divided into 6 groups consisting of six animals in each group. Dose was calculated by using conversion factor for mice from human dose. Group I, II, III and IV received 2% Gum acacia 10ml/kg, paracetamol 84.5mg/kg, eto...

S. Kothari, T. Singhal * and H. Bansal

Department of Pharmacology, GRMC, Gwalior, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3508-12

3508-3512

42

23

61.

PHARMACOGNOSTICAL STANDARDIZATION AND HPTLC FINGERPRINT PROFILE OF ORIGANUM VULGARE L. (LAMIACEAE)

India is a great source of naturally occurring plant drugs which are having potential pharmacological activities. Origanum vulgare L. (Lamiaceae) is one of the most important medicinal plants in India, consisting of aromatic and medicinal properties which is used to cure many ailments. In spite of its plethora of uses as medicine and food additives since ancient times, it has reaped very little sc...

D. Asha * and L. Mathew

Department of Botany and Centre for Research, St. Teresa’s College (Autonomous), Ernakulam - St. Teresa’s College (Autonomous), Ernakulam, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3513-20

3513-3520

41

26