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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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Volume 12 (2021) - Issue 5, May

Review Articles

 
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1.

REVIEW: AVAILABLE ANALYTICAL METHODS FOR THE ESTIMATION OF FIRST LINE, SECOND LINE ORAL AND NEWER ANTI-TB DRUGS

Tuberculosis (TB) is one of the top ten causes of death worldwide. Presently, one-quarter of the world's population is thought to be infected with TB. New infections occur in about 1% of the population each year. Tuberculosis is a major global health threat. There is a progressive increase in multidrug-resistant (MDR) and extensively drug-resistant tuberculosis (XDR). Multi drug resistance (MDR)-T...

R. J. Jani * and P. U. Patel

Department of Quality Assurance, Shree S. K. Patel College of Pharmaceutical Education & Research, Ganpat University, Mehsana, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.12(5).2500-34

2500-2534

227

199

2.

A REVIEW ON ANTIMICROBIAL POTENTIAL OF SULFONAMIDE SCAFFOLD

Sulfonamides, sometimes called sulfa drugs, are the first drug that is largely employed and systematically essential for preventive and chemotherapeutic agents against various bacteria. Sulfonamides possess a wide range of pharmacological activities such as Oral hypoglycemic, antileprotic, anti-epileptic, anti-hypertensive, anti-bacterial, anti-protozoal, anti-fungal, antiretroviral, non-peptidic ...

P. A. Petkar and J. R. Jagtap *

Department of Pharmaceutical Chemistry, Pune District Education Association’s Seth Govind Raghunath Sable College of Pharmacy, Saswad, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(5).2535-47

2535-2547

142

99

3.

NANOROBOTICS: FUTURISTIC APPROACH IN MEDICINE

Nano robotics is an emerging, advanced and multidisciplinary field that calls for scientific and technical expertise of medical, pharmaceutical, bio-medical, engineering as well as other applied and basic scientists. Nano robots differ from macro-world robots specifically in their Nano-sized constructs. Due to their small size and wide functional properties, nano robots have created exceptional pr...

P. Harika, C. B. P. Devi * and K. Vijay

Department of Pharmacy, Joginpally BR Pharmacy College, Moinabad, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.12(5).2548-58

2548-2558

122

78

4.

A COMPREHENSIVE REVIEW ON THE GENUS LEEA (FAMILY LEEACEAE) WITH SPECIAL EMPHASIS ON THE INDIAN SPECIES

The genus Leea distributed majorly in tropical and subtropical regions of Asia, Africa, and Madagascar, belongs to the family Leeaceae. It comprises 36 species that are used worldwide for different medicinal purposes. In this decade, research interests in the genus Leea have grown in the fields of systematics, phylogenetic studies, analytical chemistry, identification and isolation of active metab...

A. Nehru, Y. Shah, J. Sharma, Y. Shah, P. Thummar, P. Verma and M. Shah *

Department of Pharmacognosy and Phytochemistry, L. M. College of Pharmacy, Ahmedabad, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.12(5).2559-69

2559-2569

112

50

5.

PYRAZOLINE HETEROCYCLIC: A REVIEW

Pharmaceutical chemistry is devoted to the discovery and development of new agents for treating diseases. Inorganic compound continues to be important in therapy, for example, as antacids, mineral supplements, and radiopharmaceuticals, but organic molecules with increasingly specific pharma-cological activities are clearly dominant. The five and six-membered heterocyclic nitrogen-containing system...

B. Dash and S. Karim *

Department of Pharmaceutical Analysis & Quality Assurance, Himalayan Pharmacy Institute, Majhitar, East Sikkim, India.

DOI: 10.13040/IJPSR.0975-8232.12(5).2570-88

2570-2588

118

226

6.

AILANTHUS EXCELSA ROXB (MAHA NEEM)- AN HOLISTIC INSIGHT OF THE MULTIPURPOSE TREE

In recent years, Plants and herbal drugs obtaining from natural resources are again gaining importance throughout the world in maintaining the healthcare conditions of individuals. The regular use of natural sources and plant-derived products throughout the world has increased serious concerns over their quality, safety, and efficacy. Adding to the natural scientific resources and knowledge, the t...

V. Srivastava * and K. S. Dubey

Smt. Vidyawati College of Pharmacy, School of Pharmacy, Jhansi, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(5).2589-95

2589-2595

58

37

7.

NEEDS OF EDUCATION ABOUT INFECTIOUS DISEASE WITH SPECIAL REFERENCE TO RESPIRATORY TRACT INFECTION (RTI) AND COVID 19

The present study reveals the importance of inclusion of knowledge regarding infectious diseases and their effect on the respiratory system in the school education system and in pharmacy courses. An integrative review of diseases that affect respiratory tract along with COVID 19. Family plays an important role to give protection from any kind of infectious diseases based on the achieved knowledge....

N. Verma * and B. De

Department of Pharmacology, R. P. S. College of Pharmacy, Barabanki, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(5).2596-02

2596-2602

47

27

Research Articles

 
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8.

NEGLIGIBLE EFFECT OF SOME COUNTERFEIT ANTI-OBESITY DRUGS

Objective: To evaluate the effect of some counterfeit anti-obesity drugs that are not licensed by the Ministry of Health. Materials and Methods: 100 male rats were divided into 10 groups. The first group received a normal diet for two months. The second group received a high-fat diet (HFD) for two months; the third group received HFD for one month then returned to a normal diet. The remaining seve...

M. A. AL-Ghamdi, E. A. Huwait, M. A. Abdelshakour, G. M. Hadad, D. M. Abo-Elmatty and A. R. Abdel-Hamed *

Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.

DOI: 10.13040/IJPSR.0975-8232.12(5).2603-12

2603-2612

104

50

9.

FREE RADICAL SCAVENGING ACTIVITY AND DETAILED FLAVONOID PROFILING OF ALGERIAN YEW (TAXUS BACCATA L.) BY LC–ESI–MS/MS

According to recent studies, the antioxidant related properties of Taxus baccata L. needle extracts are remarkable making it a possible raw material for the pharmaceutical industry, hence requiring the identification of major bioactive compounds and the assessment of the antioxidant properties of the extracts. The aim of this study was to investigate for the first time the individual flavonoids an...

M. Bekhouche *, R. Benyammi, M. K. Slaoui, L. Khelifi and A. Morsli

Department of Plant Production, Higher National Agronomic School, El Harrach-Algiers, Algeria.

DOI: 10.13040/IJPSR.0975-8232.12(5).2613-19

2613-2619

97

50

10.

SIMULTANEOUS DETERMINATION OF PREDNISOLONE AND ASPIRIN IN SYNTHETIC MIXTURE BY VIERORDT´s METHOD

Prednisolone (10mg/day) plus low dose Aspirin (80mg/day) improve the implantation rate in women with autoimmune condition who are undergoing in-vitro fertilization. A new, simple, precise, accurate, and validated simultaneous equation method (Vierordt´s Method) has been developed for simultaneous determination of Prednisolone and Aspirin in the synthetic mixture. The method was based on the measu...

P. Patel *, J. Patel and K. Detholia

Department of Pharmaceutical Quality Assurance, Smt. S.M. Shah Pharmacy College, Amsaran, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.12(5).2620-27

2620-2627

91

47

11.

DESIGN AND DEVELOPMENT OF A NOVEL GASTRORETENTIVE MULTIUNIT PARTICULATE SYSTEM AND COLON TARGETED TABLET IN CAPSULE SYSTEM FOR EFFECTIVE MANAGEMENT OF ANAEMIA

Malnutrition is a condition in which there is an imbalance in the proportion of essential nutrients that the body requires to stay healthy. The most prevalent form of malnutrition is micronutrient deficiency and of this iron deficiency anaemia is the most common type, affecting over 2 billion people worldwide. Micronutrients are a special class of vital ingredients that are required in minuscule q...

B. Pendse, S. Sawarkar * and M. Damani

Department of Pharmaceutics, SVKM’s Dr. Bhanuben Nanavati College of Pharmacy, University of Mumbai, Mithibai College Campus, Vile Parle West, Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(5).2628-40

2628-2640

103

65

12.

A SUCCESSFUL ATTEMPT TO ENHANCE SOLUBILITY OF BCS CLASS II DRUG USING LIQUISOLID COMPACT TECHNIQUE

The main purpose of the current research work is to enhance solubility and dissolution of BCS Class II drug, Flurbiprofen using liquid-solid compact technology. Flurbiprofen is a non-steroidal anti-inflammatory drug indicated for acute and chronic treatment of rheumatoid arthritis, osteoarthritis, and spondylytis. The rationale to select Flurbiprofen as the model drug is that it belongs to BCS Cla...

M. Kasturi * and N. Malviya

Department of Pharmacy, Mandsaur University, Mandsaur, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(5).2641-50

2641-2650

84

41

13.

SYNTHESIS AND CHARACTERIZATION OF NANOPARTICLES OF FERROUS SULFIDE BY TWO DIFFERENT STARTING MATERIALS IN THE PRESENCE OF IONIC LIQUID-CAPPING AGENT

Room temperature ionic liquids (RTILs), a class of green and neoteric solvents, have attracted increasing interest over recent years as environmentally benign excellent alternatives to organic solvents in homogeneous and biphasic processes synthesis of several nanoparticles. A novel magnetically recoverable ionic liquid (1,1–Bis(3-Methylimidazolium-1-yl)methanechloride)-stabilized ferrous sulfid...

K. Priya and K. Rajathi *

Department of Chemistry, Government Arts College, Tiruvannamalai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(5).2651-55

2651-2655

48

25

14.

DEVELOPMENT AND VALIDATION OF STABILITY INDICATING HPTLC METHOD FOR THE ESTIMATION OF SOFOSBUVIR

A simple stability-indicating high-performance thin-layer chromatographic method which is economic, selective, and precise for analysis of Sofosbuvir (SFB), both as a bulk drug and in formulations, was developed and validated according to ICH guidelines. The method employed HPTLC precoated Merck TLC plates RP-18 F254 as the stationary phase while the solvent system prepared by mixing n-Hexane: Eth...

M. R. Ghante *, S. D. Sawant, A. Shinde and V. K. Bhusari

Sinhgad Technical Education Society’s, Smt. Kashibai Navale College of Pharmacy (Kondhwa), Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(5).2656-61

2656-2661

44

27

15.

BIOCATALYSIS OF DIFFERENT NITRILES TO VALUABLE ACIDS

The biotransformation of different nitrile compounds into valuable acids was attempted using whole cells of nitrile hydrolyzing enzyme produced from a bacteria strain (BITSN007) isolated from sludge sample of Hot spring Surajkund, Jharkhand. Based on the biochemical characterization, the isolate producing nitrilase is predicted as Bacillus sp. The nitrilase production was observed as intracellular...

S. Sinha and V. K. Nigam *

Department of Bio-Engineering, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, India.

DOI: 10.13040/IJPSR.0975-8232.12(5).2662-69

2662-2669

50

28

16.

ROLE OF DEOXYCHOLIC ACID IN MODULATING HUMORAL AND CELL MEDIATED IMMUNE SYSTEM

Deoxycholic acid (DCA) is a secondary bile salt that is a major active constituent of Chinese traditional medicine, “Niuhuang” which is known to have immunoregulatory and anti-inflammatory properties. Although data from the literature indicate possible immunomodulatory effects of Deoxycholic acid on the immune system, little has been reported regarding the mode of activity of DCA in modulating...

M. P. K. Reddy * and P. J. M. Reddy

Department of Pharmacology and Toxicology, Biocon Biologics India Limited, Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.12(5).2670-78

2670-2678

56

28

17.

ANTIHYPERTENSIVE ACTIVITY GUIDED-FRACTIONATION OF NARDOSTACHYS JATAMANSI

The present study aimed to examine the anti-hypertensive constituents present in Nardostachys jatamansi. Crude solvent extracts (dichloromethane; ethyl acetate; methanol, and water) of this plant rhizomes based on the difference in polarity were prepared and tested for inhibition of angiotensin-converting enzyme (ACE). Preliminary phytochemical analysis showed bioactive compounds such as alkaloids...

B. B. Rachotimath, M. S. Gavimath and B. Padmashali *

Department of Chemistry, School of Basic Sciences, Rani Channamma University, Belagavi, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.12(5).2679-82

2679-2682

47

27

18.

FORCED DEGRADATION STUDY – A NEW APPROACH FOR STRESS TESTING OF DRUG SUBSTANCES AND DRUG PRODUCTS

Forced degradation studies are a vital tool in pharmaceutical research and development to predict long-term stability. Stress studies should be performed in method development to know drug behavior but can also be performed with method validation for regulatory filling predict stability, and measure impurities. It is especially valuable when little data is free about potential degradation products...

A. K. Mullani * and P. I. Nargatti

Annasaheb Dange College of Pharmacy, Ashta, Walwa, Sangli, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(5).2683-91

2683-2691

52

25

19.

A COMPARATIVE SOLUBILITY ENHANCEMENT AND DISSOLUTION STUDY OF RANOLAZINE USING DIFFERENT TECHNIQUES

The aim of the present study was to enhance the solubility of the poorly soluble drug Ranolazine. Solid dispersions were prepared using PVP K-30 and PEG 4000 & 6000 by melting, solvent evaporation using varying polymer ratios (1:1, 1:2, 1:3, 1:4). The prepared formulations were characterized for saturation solubility, IR, PXRD, SEM. The aqueous solubility of Ranolazine was favored by the prese...

B. Sharannavar * and S. Khedekar

K. L. E. College of Pharmacy, Belagavi, K. L. E. Academy of Higher Education and Research, JNMC Campus, Belagavi, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.12(5).2692-99

2692-2699

46

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20.

ANTIHYPERGLYCAEMIC AND ANTIOXIDANT ACTIVITY OF METHANOLIC EXTRACT OF CAPPARIS DECIDUA (FORSSK.) EDGEW. IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

The present study evaluates the antihyperglycaemic and antioxidant activity of the methanolic extract of Capparis decidua (CDMtE) fruits in streptozotocin (STZ) induced diabetic rats. Streptozotocin (50mg/kg body weight/) was injected intraperitoneally in rats to induce diabetes. The STZ-induced diabetic rats were treated with CDMtE (200 mg/kg body weight /day) for seven days. Biochemical analysis...

C. Mathur *, M. Soni and R. S. Gupta

Department of Zoology, University of Rajasthan, Jaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.12(5).2700-06

2700-2706

69

25

21.

EVALUATION OF ANTIDEPRESSANT ACTIVITY OF CHENOPODIUM ALBUM EXTRACTS AND FRACTIONS IN MICE

Traditional systems of medicine emphasize the importance of life-style, including dietary habits, for maintaining holistic health. Ayurveda recommends the use of fruits and vegetables in our diet for maintaining mental health. Chenopodium album is one such popular green vegetable. This plant is rich in phenolic compounds – compounds that are valued for their antioxidant activity and potential fo...

A. Sharma, S. Kaur and R. Shri *

Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Punjab India.

DOI: 10.13040/IJPSR.0975-8232.12(5).2707-15

2707-2715

42

22

22.

AN EFFICIENT AND LABORATORY FRIENDLY SYNTHESIS OF ANTI-GLAUCOMA AGENT OF BIMATOPROST

An alternative, economically viable, and laboratory-friendly synthetic method described for the preparation of Bimatoprost, an anti-glaucoma drug. Stereospecific synthesis of Bimatoprost has been achieved with commercially available (-) Corey lactone i.e., diol, as a starting material. To our delight, the replacement of the benzoyl (Bz) group with Tetrahydropyranyl ether (Thp) protection resulted ...

R. M. R. Jaggavarapu, M. Venkatanarayana *, G. V. Reddy and K. K. Gudimella

Department of Chemistry, Gitam School of Science, GITAM (Deemed to be University), Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.12(5).2716-25

2716-2725

50

26

23.

STUDIES ON ANTIMICROBIAL ACTIVITY OF CYMBOPOGON SPECIES OF KARNATAKA AGAINST CLINICAL ISOLATES

Antimicrobial activity of the various species of Cymbopogon plants like Cymbopogon citrates, Cymbopogon martini, Cymbopogon nardus, Cymbopogon flexuosus, Cymbopogon schoenanthus against various pathogens like E. coli, Bacillus subtilis, Streptococcus species, Salmonella typhimurium, Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumonia, Serratia marcescens were studied with the help ...

H. G. P. Kumari * and P. N. Narasegowda

Tumkur University, Tumkur, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.12(5).2726-34

2726-2734

43

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24.

COMBINED MIXTURE DESIGN-DOE AND ION PAIR REAGENT: A SYNERGISTIC MODEL FOR THE SEPARATION OF MULTIPLE AMINO ACIDS IN RP-HPLC

The aim of the present study is to apply the Design of Experiments (DoE) to develop an assay method for the separation of amino acids by RP-HPLC. The method used in this study is the DoE Combined- Randomized method. Design of Experiments allows interpreting the results with better outcomes and enhanced understanding process. Ion pair reagent- Octane 1 Sulphonic acid sodium salt monohydrate of 0.01...

P. S. Krishna *, P. S. Babu, K. S. Babu and A. Viswanath

Department of Pharmaceutical Analysis, Vignan Pharmacy College, Vadlamudi, Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(5).2735-42

2735-2742

52

37

25.

HAEMATOLOGICAL RESPONSES OF CLARIAS BATRACHUS (LINN.) TO SUBLETHAL CONCENTRATIONS OF LEAD

Blood parameters (Hb%, TLC, TLC, ESR, PCV, MCV and MCH) of the catfish, Clarias batrachus (Linn.) were investigated, exposed to different concentrations of lead [Group- A (control), (Group- B  (0.5ppm), Group- C (1.0ppm) and Group- D (3.0 ppm)] during different time intervals (7, 14, 21 and 28 days). Haemoglobin values fell to the maximum (11.5%) from its control value (13.0%). TEC values were al...

V. K. Verma, N. Gupta * and D. K. Gupta

Department of Life Sciences, Chhatrapati Shahu Ji Maharaj University Kanpur, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(5).2743-49

2743-2749

49

19

26.

EFFECT OF FEW INDIGENOUS PLANT EXTRACTS ON CALCIUM OXALATE CRYSTALLIZATION WITH REFERENCE TO UROLITHIASIS

Preliminary screening study had employed to extract inhibitors of calcium oxalate (CaOx) crystallization in-vitro from four plant species, namely Saraca asoca, Berginia ciliata, Boerhavia diffusa, and Crateva nurvala These plants were selected based on their frequent medicinal usage by folks. Plant material (150 g) used for this study was successively extracted with Soxhlet apparatus using the sol...

S. R. Gophane * and C. N. Khobragade

School of Life Sciences, Swami Ramanand Teerth Marathwada University, Nanded, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(5).2750-54

2750-2754

41

27

27.

PHYTOCHEMICAL SCREENING AND GC-MS ANALYSIS OF BIOACTIVE COMPOUNDS PRESENT IN ETHANOLIC EXTRACTS OF LEAF AND FRUIT OF TRICHOSANTHESIS DIOICA ROXB.

Medicinal plants are considered to be the most important in the primary health care system of developing countries. The therapeutic properties of a plant depend upon the biochemical compounds present in the plant parts employed in the preparation of a medicine. Trichosanthes dioica Roxb. is being used as popular Ayurveda and Siddha medicine used to treat various diseases. Objective: The objective ...

R. Kavitha

Department of Biotechnology, Periyar University PG Extention Centre, Dharmapuri, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(5).2755-64

2755-2764

45

29

28.

IDENTIFICATION OF LINOLENIC ACID FROM PORTULACA OLERACEA LINN., BY HPLTC

Purslane (Portulaca oleracea L.) is an herbaceous weed belonging to the family Portulacaceae. It has high nutritional value and possesses potent pharmacological actions such as analgesic, hepatoprotective, anti-inflammatory, wound healing, bronchodilator, neuropharmacological, anti-diabetic, antioxidant and antihypertensive. It is listed in a World Health Organization database because of these man...

S. G. Jagtap *, M. R. Ghante and K. N. Gujar

STES’s Smt. Kashibai Navale College of Pharmacy, Kondhwa, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(5).2765-69

2765-2769

47

29

29.

PHYTOCHEMICAL PROFILING AND ANTICANCER ACTIVITY OF DRAGON FRUIT HYLOCEREUS UNDATUS EXTRACTS AGAINST HUMAN HEPATOCELLULAR CARCINOMA CANCER (HEPG-2) CELLS

To investigate the phytoconstituents and anticancer potential followed by apoptotic studies of H. undatus fruit extracts on HepG-2 cells. Qualitative phytochemical profiling and anti-proliferation activity of Aqueous, Chloroform, Ethyl acetate, Hexane, and Methanol extracts of dragon fruit pulp was carried out. Based on the results of anti-proliferation studies, methanol extract was taken further ...

K. Padmavathy, K. Sivakumari *, S. Karthika, S. Rajesh and K. Ashok

Department of Zoology, Presidency College, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(5).2770-78

2770-2778

40

24

30.

IMPACT OF CLINICAL PHARMACIST MEDIATED PATIENT COUNSELING IN DYS-LIPIDEMIA PATIENTS BY USING LIPID LOWERING AGENTS

Aim: To estimate the impact of clinical pharmacist mediated patient counseling in dyslipidemia patients in RIMS hospital, Kadapa. Objectives: To conduct a randomized study on patients. To categorize patients on demographic basis, comorbidities. To compare the lipid levels based on 20 mg and 40 mg doses of atorvastatin, the outcome based on lipid profile. Methodology: It is a prospective observatio...

P. Y. E. Kumar *, B. G. Sruthi, P. Sivani, S. V. Reddy and D. G. Rajasekhar

Department of Pharmacy Practice, Annamacharya College of Pharmacy, Rajampet, Kadapa, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(5).2779-82

2779-2782

48

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31.

TERATOGENICITY AND BACTERICIDAL ACTIVITY OF NANOSYNTHESIZED JUSTICIA ADHATODA IN THE EMBRYOS OF DANIO RERIO

In the present study, Justicia adhatoda was used for synthesizing AgNPs and characterized using UV-visible, FTIR, XRD, and SEM analysis and checked for its teratogenic effect and bactericidal activity. UV–Vis spectra analysis revealed that the synthesized AgNPs had a peak around 434 nm, while XRD and SEM analysis showed that AgNPs have spherical shapes with sizes ranging from 22 to 29 nm. Fourie...

R. R. Freeda *, J. C. Padua and P. C. J. P. Jansi

Department of Zoology, Holy Cross College (Autonomous), Nagercoil, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(5).2783-90

2783-2790

43

21

32.

PROTECTIVE EFFECT OF CURCUMIN ON LIPID PEROXIDATION AND ANTIOXIDANT STATUS AGAINST CADMIUM CHLORIDE TOXICITY IN HEART (AURICLES AND VENTRICLES) OF ALBINO MICE

Cadmium can cause various health problems even at low concentrations by inducing oxidative damage in tissues of organisms. Nowadays, the focus has been raised toward the use of herbal treatment against heavy metal toxicity. Hence, the present research work was aimed to investigate the protective effect of curcumin against Cd-induced toxicity in the auricles and ventricles of the heart in albino mi...

A. Kumari * and S. Sharma

Department of Life Sciences and Allied Health Sciences, Faculty of Life Sciences, Sant Baba Bhag Singh University, Jalandhar, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.12(5).2791-98

2791-2798

47

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33.

ACUTE AND SUB ACUTE TOXICITY STUDIES WITH GINGER EXTRACT IN RATS

The dry ginger rhizome was extracted with ethyl acetate, and gingerol content was enriched by liquid-liquid extraction. The extract was analyzed for the percentage of 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol by HPLC. The acute toxicity was evaluated as per OECD guidelines 423. Ginger extract was fed at 2000 mg/kg body weight to overnight fasted female rats (8-10 weeks old; 160-180 g). Th...

M. Benny *, M. R. Shylaja, B. Antony, N. K. Gupta, R. Mary, A. Anto and S. Jacob

Arjuna Natural Private Ltd., Aluva, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.12(5).2799-09

2799-2809

56

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34.

MEDICINAL ATTRIBUTES OF SOLANUM CAPSICOIDES ALL.: AN ANTIOXIDANT PERSPECTIVE

The study evaluates the medicinal efficacy of Solanum capsicoides fruits as an antioxidant. Fruit extracts were prepared using acetone, ethanol, HCl, and water for the measurement of antioxidant potential by reducing power, DPPH radical scavenging activity, and CUPRAC assay and for the spectrophotometric determination of total phenol, flavonoid, anthocyanin, and carotenoid content. Chemical profil...

A. K. Dharman and M. Anilkumar *

Department of Botany, Union Christian College, Aluva, Ernakulam, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.12(5).2810-17

2810-2817

43

28

35.

SIMULTANEOUS HPTLC METHOD FOR DETERMINATION OF GALLIC ACID, VANILLIC ACID AND SYRINGIC ACID IN AGRO-INDUSTRIAL WASTE OF DATE FRUITS

Phoenix dactylifera is a medicinally important plant. Fruits are traditionally used for the nutritional purpose. Date seeds are the rich sources of phenolic acids which exhibits strong antioxidant property. HPTLC is a simple, versatile method and it provides visualization of separated constituents. The advantage of this method is this method requires a small amount of sample for analysis. The pres...

K. R. Upadhye and V. N. Jain *

Department of Quality Assurance, Oriental College of Pharmacy, Sanpada, Navi Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(5).2818-22

2818-2822

54

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36.

EVALUATION OF PHYTOCONSTITUENTS OF ERIGERON CANADENSIS L. BY FTIR AND GC-MS ANALYSIS

The Nilgiris District is one of the most botanized areas of Southern India. Asteraceae family is one of the largest families consisting of medicinal and aromatic plants in Nilgiris. The chemical compositions of Erigeron canadensis L. plant were investigated using Perkin-Elmer Gas Chromatography-Mass Spectrometry, while the mass spectra of the compounds found in the extract were matched by the Nati...

S. Mugendhiran * and B. D. Sheeja

Department of Botany, Government Arts College, Udhagamandalam, The Nilgiris District, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(5).2823-34

2823-2834

51

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37.

FORMULATION OF CINNAMOMUM ZEYLANICUM IMMEDIATE RELEASE TABLETS AS AN ANTHELMINTIC

Globally, a vast number of people are affected by helminth parasites. The emergence of anthelmintic resistance has paved the way for new leads into potential anthelmintic agents, which may be alternatives to already existing ones. The mode of presentation of herbal medicines affects patient compliance. Traditionally, Cinnamomum zeylanicum is used in the management of helminth infestations. This st...

P. Entsie, F. Owusu, M. E. Boakye-Gyasi *, Y. A. Osei, F. Adu and M. T. Bayor

Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.

DOI: 10.13040/IJPSR.0975-8232.12(5).2835-41

2835-2841

46

53

38.

QUERCETIN DEVELOPS SENSITIVITY OF ADENOCARCINOMA CELLS TO RADIATION VIA LOWERING METASTASIS AND PROMOTING CASPASE-3 INDEPENDENT CELL DEATH

Quercetin (QCN) is a flavonoid available in fruits and vegetables, and it has shown several medicinal properties, including anticancer properties. However, the radiosensitizing properties of QCN on adenocarcinoma cells have not been greatly looked into yet. Thus in the present study, we investigate the effect QCN would have on the lung adenocarcinoma cell line NCI-H23 (H23) when QCN is combined wi...

L. Kma and T. J. Baruah *

Department of Biochemistry, Assam Royal Global University, Guwahati, Assam, India.

DOI: 10.13040/IJPSR.0975-8232.12(5).2842-52

2842-2852

50

27

39.

MUCOADHESIVE BIO-FLEXY FILM OF PHOENIX DACTYLIFERA LOADED WITH PHENYTOIN FOR TRANSLABIAL DRUG DELIVERY

Translabial drug delivery system is an attractive approach for drug delivery system possess advantages as a bypass of the first-pass metabolism, prevent from digestive enzymes and rapid action of suitable drugs. The purpose of the current research work is to isolate the biopolymer from Phoenix dactylifera (date palm) and prepare mucoadhesive bio-flexy films loaded with Phenytoin. The isolated biop...

A. Ojha, S. Bhargava and Bhavna *

Faculty of Pharmacy, DIT University, Dehradun, Uttrakhand, India.

DOI: 10.13040/IJPSR.0975-8232.12(5).2853-62

2853-2862

53

21

40.

PREPARATION, CHARACTERIZATION AND EX-VIVO HUMAN SKIN PERMEATION OF IBUPROFEN-SOLUPLUS POLYMERIC NANOMICELLES

Ibuprofen is a widely used non-selective non-steroidal anti-inflammatory drug. Ibuprofen oral use is restricted by its potential gastric toxicity, which can be overcome utilizing alternative drug delivery routes. A novel micellar transdermal delivery of Ibuprofen was readily prepared herein using the solubility enhancing co-polymeric excipient polyvinyl caprolactam-polyvinyl acetate-polyethylene g...

F. Al-Akayleh *, Z. Zakari, S. Adwan and M. Al-Remawi

Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy and Medical Sciences, Petra University, Jordan.

DOI: 10.13040/IJPSR.0975-8232.12(5).2863-69

2863-2869

57

28

41.

ANTI-INFLAMMATORY ACTIVITY OF ETHANOLIC EXTRACT OF WHOLE PLANT OF MERREMIA TRIDENTATA ON MURINE MODELS

The present study aims to reveal the anti-inflammatory activity of the ethanolic plant extracts of Merremia tridentata against murine models. The Wistar Albino rats of mixed sex were induced inflammation via injecting histamine and formalin. The anti-inflammatory effect of Merremia tridetata was compared with the presence of positive control, Indomethacin. The Paw volume of the control group (grou...

M. Manimegalai *, S. S. Prasad, T. S. Subha and L. Suguna

Department of Botany, Bharathi Women’s College, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(5).2870-75

2870-2875

44

28

42.

COMPARATIVE NON-ENZYMATIC AND ENZYMATIC ANTIOXIDANT POTENTIAL SCREENING IN SPECIES OF GENUS URTICA

Objective: The current study has been conducted to analyze the potential of antioxidant activity found in two species of genus Urtica, i.e., Urtica dioica and Urtica urens. Methodology: The antioxidant analysis was performed on the crude extract of root, stem and leaves of both the plants, employing both non-enzymatic and enzymatic methods. For non-enzymatic antioxidant activity determination, met...

P. Rajput *, M. Chaudhary and R. A. Sharma

Department of Botany, University of Rajasthan, Jaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.12(5).2876-83

2876-2883

49

27

43.

THE IMPACT OF CARCINOGENIC CHEMICAL USE AMONG CARDAMOM FARMERS AND THE PREVALENCE OF CANCER IN IDUKKI DISTRICT, KERALA

The prevalence of cancer is drastically increasing among cardamom farmers using chemical pesticides in Idukki district. The chemicals, mainly Organochlorine and organophosphates, result in various disease conditions. The main aim of the study was to explore the prevalence of cancer and other disease conditions among farmers and other people who were exposed to chemical pesticides. A community-base...

B. Mishra * and D. Johnson

Department of Pharmacology and Research & Development Cell Nirmala College of Pharmacy, Muvattupuzha, Ernakulam, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.12(5).2884-91

2884-2891

44

22

44.

STABILITY INDICATING RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR DETERMINATION OF PROCESS IMPURITIES AND DEGRADATION PRODUCTS OF LEVOLEUCOVORIN CALCIUM FOR INJECTION

Levoleucovorin calcium contains amide and aldehyde groups which makes it vulnerable to degradation. Stability indicating method for determination of all seven process-related impurities and degradation impurities in Fusilev® 50 mg/mL injection was developed with the help of RP-HPLC. A Forced degradation study supports method development to ensure stability indicating conditions. Solutions of the ...

V. N. Patel, P. H. Sukharamwala and M. Mathur *

Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, PES University, HN Campus, Bengaluru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.12(5).2892-01

2892-2901

49

26

45.

SCREENING OF PHYTOCHEMICALS, GC-MS BASED PHYTOCONSTITUENTS PROFILING AND ANTIBACTERIAL EFFICIENCY OF LEAVES EXTRACTS OF ANISOMELES MALABARICA

The present study aimed to determine the phytochemical components of the leaf extracts of A. malabarica, antimicrobial, antioxidant activities and GC-MS analysis. The leaves extracts have folklore and traditional applications in India. The polar and non-polar solvents extracts such as methanol, ethyl acetate, chloroform, hexane and water were used for various phytochemical analysis proved the exis...

K. A. Supriya * and L. Growther

Department of Microbiology, Hindusthan College of Arts and Science, Coimbatore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(5).2902-12

2902-2912

46

30

46.

FORMULATION AND EVALUATION OF VALACYCLOVIR LIPOSOMES

The main aim of the present study was to formulate and evaluate valacyclovir-loaded liposomes. A drug and excipient compatibility study was performed by FT-IR, and the study revealed that there was no interaction between drug and excipients. Liposomes are prepared by using two different methods, i.e., ether injection method and thin-film hydration method. Various formulations are prepared by varyi...

K. Ramya * and A. S. Devi

Department of Pharmaceutics, Hindu College of Pharmacy, Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(5).2913-19

2913-2919

46

22

47.

USE OF ATENOLOL AND OLMESARTAN AS AN ADD-ON THERAPY WITH CALCIUM CHANNEL BLOCKER IN HEMODIALYSIS PATIENTS FOR HYPERTENSION

Background: Management of hypertension in hemodialysis patients was never the same in all and tends to involve a various classes of drugs with respect to their disease conditions, response to drug therapy, medication adherence, and many more. Atenolol and Olmesartan can be used as add-on therapy in managing hypertension with calcium channel blockers. Methodology: Blood pressure was monitored using...

G. Sampathkumar *, K. P. Athira, I. A. Smily and I. Veerappan

RVS College of Pharmaceutical Sciences, Coimbatore, Affiliated to the Tamilnadu Dr. MGR Medical University, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(5).2920-25

2920-2925

40

25

48.

PROTECTIVE EFFECT OF D-PINITOL ISOLATED FROM AERIAL PARTS OF SOYBEAN PLANTS ON HAEMATOLOGICAL PROFILE AGAINST DOXORUBICIN INDUCED CYTO-TOXICITY IN MICE

The aim of this research was to examine the protective effect of D-Pinitol on haematological profile against Doxorubicin-induced cytotoxicityin mice. Doxorubicin is a chemotherapeutic agent valuable in treating various cancers regardless of its toxicity to normal cells, including hematopoietic suppression. Oxidative stress and generation of reactive oxygen species appear to be the reason for Doxor...

M. Sudha * and T. Vetrichelvan

Department of Pharmacology, Adhiparasakthi College of Pharmacy, Melmaruvathur, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(5).2926-32

2926-2932

44

23

49.

ANTIMYCOTIC ACTIVITY OF LEAD OXIDE (PbO) NANOPARTICLES

Antimycotic activity of Lead oxide (PbO) nanoparticles prepared by the bio-safe method was evaluated for rot causing fungi. It was observed from the study that all the concentrations of nanoparticles brought about significant inhibition in the spore germination and mycelial growth of all the rot causing fungi. However, the highest inhibition in the germination of all the test fungi was observed at...

J. A. Koka *, A. H. Wani and M. Y. Bhat

Department of Botany, University of Kashmir, Hazratbal, Srinagar, Srinagar, Jammu and Kashmir, India.

DOI: 10.13040/IJPSR.0975-8232.12(5).2933-38

2933-2938

44

27

50.

AN IN-VITRO STUDY ON THE ANTI-ANGIOGENIC EFFECT OF MAJORANA HORTENSIS LEAVES

Angiogenesis is an inevitable process of tumour growth, invasion, and metastasis. Understanding the process of new blood vessel formation has gained prime importance recently, and anti-angiogenic therapy has now been considered as an important strategy for cancer therapy. Many bioactive compounds, especially of plant origin, have been explored for their anti-angiogenic potential. The present study...

S. T. Yamuna, B. Sowndharyalatha, A. Poornima and S. Sumathi *

Department of Biochemistry, Biotechnology and Bioinformatics, Avinashilingam Institute for Home Science and Higher Education for Women University, Coimbatore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(5).2939-49

2939-2949

43

23

51.

A PRELIMINARY IN-SILICO ANALYSIS OF OCIMUM SANCTUM FLAVONOIDS, ORIENTIN AND VICENIN-1, AS POTENTIAL DRUGS AGAINST SARS-COV-2 INFECTION

The SARS-CoV-2 virus is the causative agent of the Covid-19 pandemic. The major proteins of this virus, like covid main protease RNA dependent RNA polymerase, are being extensively studied with the hopes of finding an effective molecule that would bind to these proteins and lead to their inhibition. The inhibition of these critical viral proteins would hamper SARS-CoV-2 infection. With most of the...

T. J. Baruah *, S. P. Dutta and A. K. Patar

Department of Biochemistry, Assam Royal Global University, Guwahati, Assam, India.

DOI: 10.13040/IJPSR.0975-8232.12(5).2950-56

2950-2956

48

24

52.

GREEN SYNTHESIS OF SILVER NANOPARTICLES FROM MUNTINGIA CALABURA FRUIT EXTRACT AND ITS BIOLOGICAL ACTIVITY

Synthesis of silver nanoparticles using fruit extract has been gaining considerable attention as an eco-friendly approach in green chemistry. The present work reports the synthesis of Muntingia calabura silver nanoparticles (McAgNPs) by the addition of an appropriate amount of Muntingia calabura fruit extract to the aqueous AgNO3 solution under constant stirring at room temperature for 24 h. The a...

H. K. Makari, K. Ramakrishna *, G. Vaidya, P. Kulkarni, S. Balija and H. Sheikh

Department of Microbiology, Vijayanagara Sri Krishnadevaraya University, Ballari, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.12(5).2957-65

2957-2965

53

26