A DETAILED REVIEW ON NANOEMULSION DRUG DELIVERY SYSTEMAbstract
Nanoemulsions are submicron sized emulsions that are under investigation as drug carriers for improving the delivery of therapeutic agents. These are the thermodynamically stable isotropic system in which two immiscible liquids are mixed to form a single phase by means of appropriate surfactant and cosurfactant. Nanoemulsion droplet sizes fall typically in the range of 20-200nm and shows narrow size distribution. In this review attention is focused to give the brief regarding formulation aspect, method of preparation characterization techniques, evaluation parameters and various application of the nanoemulsions, several techniques are to be used for preparation of nanoemulsions like microfluidization, high pressure homogenization, low energy emulsification and solvent evaporation method and parameter that are to be used for its characterization like droplet size analysis ,viscosity determination, drug content, refractive index, pH, zeta potential, Transmission electron microscopy, thermal stability, release and in vitro skin permeation study. These are applicable in drug targeting.
P. Bhatt and S. Madhav*
DIT- Faculty of Pharmacy, Dehradun-248001, Uttarakhand, India
09 May, 2011
11 September, 2011
29 September, 2011
01 October, 2011