A JOURNEY OF DIETARY NITRATE AS A HEALTH PROMOTERAbstract
Dietary nitrate has been demonstrated to have a range of beneficial vascular effects, including reducing blood pressure, reduction in pulse wave velocity, regulation of cerebral blood flow, enhancing exercise performance in healthy individuals, stimulating angiogenesis and vasculogenesis etc. Earlier studies with nitrate or nitrite also demonstrate the synergistic effects against ischaemia-reperfusion injury and reduce arterial stiffness, inflammation and intimal thickness. However, there is a need for scientific evidences for hard endpoints beyond epidemiological studies. Although studies have suggested reduction in cardiovascular risk and cancer with diets high in nitrate-rich vegetables but still a lot remains to be elucidated. Moreover various therapeutic effects have reported that the nitrate and nitrite have more affluent biological actions till now, and numerous attempts are currently ongoing for the consideration of potential useful effects in the clinical uses. Here we corroborated a brief data regarding clinical uses of nitrite and nitrate that may serve as potential therapeutic regimes.
R. T. Rana, S. Chopra, G. Rakhra and S. N. Singh*
Nutrition Division, Defence Institute of Physiology and Allied Sciences, DRDO, New Delhi, India.
13 August, 2017
15 October, 2017
20 October, 2017
01 May, 2018