A NOVEL APPROACH FOR TOPICAL GEL CONTAINING SMEDDS LOADED WITH HERBAL DRUGAbstract
The present study was approached to prepare SMEDDS loaded herbal drug (THDC4-0475RD) for the arthritis through topical delivery by gel formulation(s). The efficiency of prepared SMEDDS and SMEDDS loaded gel to enhance the delivery of anti arthritic drug were also evaluated. Labrafil and Stelliester were used as oil phase. Cremophor used as surfactant and sodium caprylate, cutina HR pH, Lutrol Micro127, Sepitrap 4000, GMS 40-PW-(SG) as co-surfactant. Formulations were optimized using pseudoternary phase diagram. The finalized formulations (F21 and F24) and the optimized formulation F36 were characterized for various parameters. It is concluded that the research proves, the formulated SMEDDS loaded with drug has increased the solubility of poorly water soluble THDC4-0475RD and thereby increases therapeutic efficiency. It fulfilled all the required criteria of a stable SMEDDS such as globule size, size distribution, in vitro diffusion study, and in vitro anti-arthritic study. The SMEDDS gel loaded with THDC4-0475RD would be effective against arthritis through topical delivery.
X. F. Grace*, K. Krishnaraj, C. Darsika, H. B. Pushpalatha and P. S. Chaudhari
Department of Pharmaceutics, Faculty of Pharmacy, Sri Ramachandra University, Chennai, Tamil Nadu, India.
09 June, 2017
09 August, 2017
17 August, 2017
01 March, 2018