A REVIEW OF SPECTROPHOTOMETRIC DETERMINATION OF ANTIBIOTIC NORFLOXACINAbstract
Norfloxacin is one of the 4-quinolone antibacterials and have many applications in veterinary and human medicine. It is extensively used antibiotic among fluoroquinolone antibiotics in both human and animal welfare. Therefore, the estimation and monitoring of norfloxacin in pharmaceutical preparations and effluents has become a topic of interest for researchers and industries. Existing methods require much time, expenses and sophisticated laboratory facilities. Most of the methods suggest the simultaneous determination of the drug along with the similar groups. There is a thirst among researchers for the development of simple, specific, sensitive and reliable methods suitable for routine laboratory facilities. Most of the methods are based on association of the drug either with metal complexes or reaction with pigments. The main objective of this paper is to review various existing methods for spectrophotometric determination of norfloxacin in order to explore the possibilities to overcome their drawbacks to develop new methods with enhanced simplicity, sensitivity, reproducibility, etc.
D. R. Shrivastava, A. Shrivastava and R. Patel*
Department of Chemistry, Government College Bhanpuri, Bastar, Chhattisgarh, India.
02 February, 2017
28 June, 2017
12 August, 2017
01 September, 2017