A REVIEW ON ANTIPROLIFERATIVE ACTIVITY OF PLANT EXTRACTS AGAINST BREAST CANCER CELL LINESAbstract
Breast cancer (BC) is the foremost cause of deaths among women worldwide. Plants contain diverse bioactive phytochemicals which have been explored by researchers all over the world for their cancer preventive potential. The present review tabulates in-vitro tested plants during 2014-17 against breast cancer cell line. We have collected data of 56 angiosperm families (117 plant species) which was subjected to cluster analysis. On the bases of IC50 values of plant extracts were clustered using cluster analysis Cluster analysis showed a grouping of order Brassicales, Fabales, Lamiales, Caryophyllales, Myrtales, and Apiales. It has been found that most of the plants tested against BC belong to eudicot group of plants. Active plant extract obtained after 24 h, 48 h and 72 h treatment were Mimosa caesalpinnifolia, Ferulago angulat, Magydaris tomentosa, and Ipomea batatas respectively. These plants may further be characterized for active ingredients to check their prospects in breast cancer treatment.
R. Kumar *, S. Mahey, V. Kumar, R. Arora, A. Sharma and S. Arora
Department of Botany, DAV University, Jalandhar, Punjab, India.
23 October 2018
13 February 2019
08 March 2019
01 July 2019