A REVIEW ON COLON TARGETED DRUG DELIVERY SYSTEMAbstract
The oral route is considered to be the most preferred route for administration of drugs for systemic effect, but the oral route is not suitable to the administration of drug for lower gastrointestinal (GI) diseases, this happened due to their release at upper GI tract (stomach, small intestine), which further minimizes the accessibility of drugs at the lower GI tract. To overcome this difficulty, colon-specific drug delivery systems have been broadly analyzed during the last two decades. Colonic drug delivery has gained increased importance not just for the delivery of the drugs for the treatment of local diseases associated with the colon like Crohn’s disease, ulcerative colitis, etc. but also for the systemic delivery of proteins, therapeutic peptides, anti-asthmatic drugs, antihypertensive drugs, and anti-diabetic agents. This review article discusses, in brief, the introduction of the colon, factor affecting the colonic transition, colonic diseases and the novel and emerging technologies for colon targeting.
Anita *, A. Singh and A. Dabral
Himalayan Garhwal University, Dhaid Gaon, Shiv Nagar, Block Pokhara, Pauri Garhwal, Uttarakhand, India.
07 May 2018
24 July 2018
02 August 2018
01 January 2019