A REVIEW ON DELIVERY OF ANTIHYPERTENSIVE DRUGS THROUGH SUBLINGUAL ROUTEAbstract
Hypertension is a major risk factor in the development of cardiovascular diseases and has emerged as one of the largest death causing diseases for mankind. There are number of medicines useful for treatment of high blood pressure but the main obstacle for the oral delivery of antihypertensive drugs is low bioavailability due to first pass metabolism. Also, if there is sudden increase in blood pressure, rapid onset of pharmacological action becomes necessary to enable the patients to resume their functional activities. The drug absorbed via sublingual blood vessels bypasses the hepatic first pass metabolism processes giving acceptable bioavailability with low doses and hence decreases the side effects. As sublingual area is more permeable than cheeks and palatal area of mouth, delivery by this route leads to rapid onset of action of drug. It is also convenient for patients having difficulty in swallowing. The present article gives a brief view on various research studies undertaken in the areas of sublingual delivery of antihypertensive drugs to improve the bioavailability and patient compliance.
S. K. Batra * and S. Sardana
Department of Pharmaceutics, Hindu College of Pharmacy, Sonepat, Haryana, India.
28 February, 2017
26 April, 2017
27 May, 2017
01 October, 2017