A REVIEW ON NANOPARTICULATE MUCOADHESIVE SYSTEMAbstract
Peptide drugs are poorly absorbable and are also susceptible to enzymatic degradation in the gastrointestinal tract (GIT). To overcome the physiological and morphological barriers for the peptide / poorly absorbable drug delivery, mucopenetrative and mucoadhesive properties of drug carriers have to be considered. Mucoadhesion can prolong the residence time of drug carriers at the absorption sites, improved drug absorption and controlled release of drug from the device used. The particles with smaller size were likely to diffuse much faster into the mucus layer, provided that diffusion of the particles into the mucus layer should obey Stokes-Einstein equation. The adhesiveness of the nanoparticles (NPs) in suspension form helps to improve bioavailability. Chitosan (CS) based or CS-coated NPs represent another common group of mucoadhesive systems. Moreover, NPs made of such polymers were used to enhance the bioavailability, and also the mucoadhesion of proteins, peptides and DNA to the mucosal tissues. This review focuses on the mechanism of gastrointestinal mucoadhesion of NPs for peptide/poorly absorbable drugs.
G. Shankar* and Y. K. Agrawal
Institute of Research and Development, Gujarat Forensic Sciences University, DFS Head Quarters, Sector 18-A, Near Police Bhavan, Gandhinagar, Gujarat, India.
19 April, 2017
01 July, 2017
25 July, 2017
01 December, 2017