A REVIEW ON ORAL MUCOSAL DRUG DELIVERY SYSTEMAbstract
Despite of tremendous advancement in drug delivery the oral route of drug administration is the most important method of administration of drug for systemic effect. The parenteral route is not routinely used for self administration of medication. It has been known for centuries that buccal and sublingual administration of drug solute is rapidly absorbed into the reticulated vein, which lies underneath the oral mucosa. The oral mucosa has rich blood supply and it is relatively permeable. The permeability of the buccal mucosa is 4- 1000 time greater then that of skin. the administration of drugs by the buccal route has several advantage over per oral administration such as QWICK ACTION, avoid of first pass metabolism , drug is not subject to acidic environment of the stomach and also the improved patient compliance particularly with pediatric & geriatric patient. It is the objective of this article to review the oral mucosal drug delivery by discussing briefly the structural feature of mucosa as drug delivery such as buccoadheshive film & tablet, medicated chew gum, fast dissolving tablet, film & capsule etc.
Dhaneshwar Kumar *, Lokesh rathi, Avinash Tripathi and Yogesh P. Maddheshiya
Kalka Institute for Research and Advanced Studies (Pharmacy Department), Meerut (UP), India
10 March, 2010
15 April, 2010
25 April, 2010
01 May, 2010