A REVIEW ON QUORUM SENSING INHIBITORSAbstract
Antibiotic is the powerful invention of science to damage bacterial infections. But nowadays, the use of careless increasing doses of this antibiotic has led to increasing the resistant power of enemy bacteria. Bacteria are caused by many infectious diseases by proliferation within quorum sensing (QS) mediated biofilms. Quorum sensing can develop microbial pathogenic traits, including biofilm formation. Try to smash biofilms have led the identification of bioactive molecules evolved by prokaryotes and eukaryotes. The activity of these bioactive molecules is done by quenching the QS systems. For this reason, we need to inhibit quorum sensing, which may be done by various types of inhibitors called quorum sensing inhibitors (QSI). Synthetic and natural QSIs plays a vital role to inhibit QS. In this review, some examples of QS inhibitors like synthetic and natural based QS inhibitors are highlighted. This review is also focused on the inhibition of QS mechanisms and the application of QSI in various fields.
Kaushik Sarkar and Rajesh Kumar Das *
Department of Chemistry, University of North Bengal, Raja Rammohunpur, Darjeeling, West Bengal, India.
08 March 2019
11 June 2019
17 July 2019
01 December 2019