A STATISTICAL APPROACH TO THE DEVELOPMENT OF FAST DISINTEGRATING TABLETS OF TELMISARTAN USING CO-PROCESSED SUPERDISINTEGRANTAbstract
The present investigation deals with fast disintegrating tablets of the model drug (Telmisartan) and to determine the influence of the excipients on physical properties of tablets. Employing a Box Behnken design, concentration of co-processed superdisintegrants (Crosspovidone: sodium starch glycolate) (X1), the concentration of meglumine (X2) and concentration of sodium lauryl sulfate (X3), selected as independent variables whereas disintegration time (Y1) selected as the dependent variable. All formulations were evaluated for pre-compression and post-compression parameters. Mathematical equations and response surface plots were used to relate the dependent and independent variables. The regression equation generated for disintegration time (DT) of Telmisartan tablets was Y1=30.25-1.6887A-1.2175B +2.7437C +0.1675AB +2.02AC+3.007BC-2.6752A2-3.62B2+ 0.0425C2. The statistical validity of the polynomial was established, and optimized formulation factors were selected by feasibility and grid search. Validation of the optimization study with 13 confirmatory runs indicated a high degree of prognostic ability of response surface methodology.