A STUDY TO COMPARE EFFICACY OF METFORMIN-GLIMEPIRIDE VERSUS METFORMIN-TENELIGLIPTIN IN TYPE II DIABETIC PATIENTSAbstract
Diabetes mellitus relates a metabolic disorder of collective aetiology which is characterized by chronic hyperglycaemia caused due to disturbances of carbohydrate, lipid and protein metabolism due to impaired β cell function of pancreas or insulin resistance or both. Biguanides and Sulphonylureas are the most commonly prescribed drugs due to their efficacy and safety. A total of 60 patients were enclosed in the present study who met the inclusion criteria. They were divided into two groups based on their treatment plan-Group A and Group B. The Group B (P = 0.001) exhibited a significantly greater reduction in HbA1c as compared to Group A (P = 0.002). The reductions in FPG and PPG were also found to be significantly more in the Group B. In the present study, we observed that patients on Metformin-Teneligliptin exhibited better control over glycemic profile as well as lipid profile when compared to patients who are on Metformin-Glimepiride combination. Since, this study was conducted in less number of patients, to make consecutive remarks about the superiority of either of the treatment regimen, furthermore analysis of clinical trials is required for appropriate selection of best combination of anti-diabetic medication.
T. Nishanth, C. U. Maheshwari, R. S. Lakshmi, D. Sri, P. Goud, K. Tabassum and M. T. Nadeem *
Department of Endocrinology, Super Speciality Block, Jawaharlal Institute of Post graduate Medical Education and Research, Dhanvantrinagar, Puducherry, Tamil Nadu, India.
13 April, 2018
06 June, 2018
08 July, 2018
01 December, 2018