ANALGESIC ACTIVITY OF EXTRACTS OF EULOPHIA OCHREATA LINDL. AND ZINGIBER CASSUMUNAR ROXB. IN ANIMAL MODELAbstract
The present study was designed to investigate Analgesic activity of Chloroform extract and isolate 1 of Eulophia ochreata Lindl. and dicholoromethanolic extract and isolate 2 of Zingiber cassumunar Roxb. The analgesic activity was assessed by using acetic acid induced writhing method and hot plate method. In acetic acid induced writhing method the extracts and isolates of both plants was administered intraperitoneally at dose of 200 mg/kg to Swiss-albino mice. Chloroform extract (60.17%) Isolate 1(45.59%) and dichloromethanolic extract (55.48%) and isolate 2(48.07%) of Eulophia ochreata Lindl. and Zingiber cassumunar Roxb. respectively showed significant inhibition as in pain response as compared with standard aceclofenac (51.10%) at the dose of 10 mg/kg. In Hot plate method the extracts and isolates of both plants was administered orally at dose of 200 mg/kg to Swiss-albino mice. The chloroform extract and isolate 1 of Eulophia ochreata Lindl showed significant analgesic activity showing 55.84% and 66.25% when compared to the standard pentazocine(5mg/kg) as 50% at 60 min. Dichloromethanolic extract and isolate 2 of Zingiber cassumunar Roxb. showed significant analgesic activity showing 93.90% and 93.90% respectively when compared to the standard pentazocine (5mg/kg) as 79.26% at 90 min. Chloroform extract and isolate 1 showed peak effect at 60 min. Whereas dichlorormethanolic extract and isolate 2 showed peak effect at 90 min. The results obtained gives important information regarding use of these extracts as new potential source in the treatment of pain.
A. A. Koparde * and C. S. Magdum
Department of Pharmaceutical Chemistry, KIMSDTU’s Krishna Institute of Pharmacy, Malkapur, Karad, Maharashtra, India.
27 July, 2017
26 March, 2018
23 April, 2018
01 May, 2018