ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF MARAVIROC IN BULK AND PHARMACEUTICAL FORMULATION BY UV SPECTROSCOPYAbstract
The aim of present work is to develop and validate simple, sensitive, economical and accurate Spectrophotometric methodhas been developed for determination of Maraviroc in pure form and in pharmaceutical formulations. Maraviroc in Phosphate buffer pH 7.4 shows maximum absorbance at 210 nm. Beer’s law was obeyed in the concentration range of 5-25 µg/mL, The LOD and LOQ were found to be 0.10428 μg/ml and 0.315 μg/ml respectively. A recovery of Maraviroc in tablet formulation was observed in the range of 100.70-103.90%. Percentages assay of Maraviroc in tablet was more than 99.73%. The proposed method is precise simple, accurate, precise, economical and robust and can be used for routine analysis of Maraviroc in bulk and pharmaceutical formulations.
Sellappan Velmurugan* and Mohamed Ashraf Ali
Department of Pharmaceutics, Sunrise University, Alwar, Rajasthan, India
24 June, 2013
29 July, 2013
25 October, 2013
01 November, 2013