ANTI-ASPERGILLUS ACTIVITY OF LANTANA CAMARA LINN.Abstract
Herbal fungicides are gaining great interest because of their cost-effective and eco-friendly attributes. If this antifungal potency resides in weeds, it will be a great advantage because of their large population and to effectively develop a novel drug from weeds being considered as waste material. The present study aims to assess the anti-aspergillus activity of a common weed Lantana camara. The crude extract of leaves was obtained using polar and non- polar solvents and tested against Aspergillus niger ATCC 16888. Results reveal, the aqueous extract showed maximum growth inhibition of 14 ± 0.142 mm zone at 30 mg/ml, and it was 37 ± 0.124 mm for the standard antifungal agent voriconazole at 30 mg/disc. Further, the minimum inhibitory concentration of the extract was calculated as 18 mg/ml. Experiments on the mode of action suggested that the extract lyse the cells and alter the membrane integrity by depleting the ergosterol content, which avoids the reoccurrence.
H. B. Nisha, S. Iswarya, V. Kavitha, A. B. Mandal and A. Gnanamani *
Microbiology Division, CSIR-CLRI, Adyar, Chennai, Tamil Nadu, India.
26 March 2014
29 May 2014
12 July 2014
01 October 2014