ANTI- DIABETIC ACTIVITY OF BRUGUIERA GYMNORHIZA ROOTAbstract
The different extracts of the roots of Bruguiera gymnorhiza (Family- Rhizophoraceae) were tested for anti-diabetic activity, by glucose tolerance test in normal rats and alloxan induced diabetic rats. Aqueous ethanol and butanol extracts had shown significant protection and lowered the blood glucose levels to normal in glucose tolerance test. In alloxan induced diabetic rats the maximum reduction in blood glucose was observed after 3h at a dose level of 250 mg/kg of body weight. The percentage protections by aqueous ethanol and butanol extracts were 30 and 48% respectively. In long term treatment of alloxan induced diabetic rats, the degree of protection was determined by measuring blood glucose, triglycerides, cholesterol and urea levels on 0,3,5,7 and 10th day. Both the extracts showed a significant anti- diabetic activity comparable with that of glibenclamide. The histopathological studies during the long-term treatment have shown to ameliorate the biochemical damages caused by alloxan. These results indicate that the B. gymnorhiza root possess significant anti -diabetic activity.
Namrata Singh , Atul Vikram Patel, Shashi Alok, Pushpendra Kannojia
Pranav Institute of Pharmaceutical Sciences and Research, Gwalior (MP), India
02 February, 2010
15 April, 2010
22 April, 2010
01 May, 2010