ANTI-DIABETIC ACTIVITY OF PSORALIA CORYLIFOLIA SEED EXTRACT IN ALLOXAN INDUCED DIABETIC RATSAbstract
Psoralia corylifolia commonly known as Babchi, Bavachi in Hindi, is a well known herb in Indian system of medicine to treat various disorders including diabetes mellitus without any scientific evidences. Therefore this study was designed to investigate in vivo hypoglycemic and antidiabetic potential of methanolic extract of seeds of Psoralia corylifolia in glucose loaded animals and alloxan induced diabetic animals. In both the models Psoralia corylifolia reduced the blood glucose level when compared to diabetic control group and exert a significant hypoglycemic and antidiabetic activity. However the potency of the herb was less than that of standard drug metformin. Psoralia corylifolia methanolic extract also reversed the body weight in normal and alloxan induced diabetic animals. The results of this study revealed the presence of a significant antidiabetic potential of methanolic extract of Psoralia corylifolia in alloxan induced diabetic rats. On the basis of this further research work is needed to investigate exact mechanism of action and also to isolate the active constituent/s responsible for the activity.
Anurag Mishra*, Rajiv Gupta and Rahul Dev Lawania
Department of Pharmacognosy, Faculty of Pharmacy, Babu Banarasi Das National Institute of Technology and Management, Lucknow, (U P) India
24 March, 2010
15 May, 2010
25 May, 2010
01 June, 2010