ANTI-EDEMATOUS AND ANTIHYPERALGESIC ACTIVITIES OF ROSUVASTATIN IN INFLAMMATORY PAIN MODEL IN RATSAbstract
Statins exhibit their pharmalogical effects by competitive inhibition trough binding with active sites of enzymes. Rosuvastatin, of all statines, has the most binding interactions with the enzyme, and being the most potent statin, it is presumed that the strength of enzyme binding directly influences its potency. Reduction of derivatives of mevalonic acids results with decreased risk of cardiovascular diseases and very significant pleotropic effect of statins. Rosuvastatin comes in the form of calcium salt. During the clinical trial it has been marked as superstatin with its proven activity in lowering cholesterol levels. Aim of this paper was to examine the pleotropic properties of rosuvastatin trough investigate if rosuvastatin shows antihyperalgesic / antiedemic effects by inflammatory pain model in rats trough effects of systemically applied rosuvastatin in inflammatory pain model in rats and effects of locally, peripherally applied rosuvastatin in inflammatory pain model in rats.
L. Alagić- Džambić *, F. Bečić, E. Bečić, M. Pašić- Kulenović, S. Muratović and T. Bego
Development and Registration Department, Bosnalijek, Jukićeva, Sarajevo, Bosnia and Herzegovina.
10 December, 2017
13 February, 2018
18 February, 2018
01 September, 2018